GREMLIN Database
Q9HSG0 - Uncharacterized protein
UniProt: Q9HSG0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (240)
Sequences: 181 (129)
Seq/√Len: 8.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_A206_I5.9991.00
7_D139_D5.0381.00
228_F233_A4.5680.99
69_A155_V4.5420.99
170_A192_S4.0380.98
59_E205_N3.7600.96
206_I210_A3.3800.94
54_S237_A3.1020.90
84_V199_V2.8680.86
59_E206_I2.7910.84
89_V123_A2.7580.84
63_A210_A2.7410.83
92_A98_D2.4820.76
61_A193_V2.4770.76
88_L99_L2.4740.76
194_P230_R2.3500.72
23_G29_T2.3110.71
221_R224_C2.2960.70
115_A119_R2.2650.69
65_Q175_T2.2430.69
221_R225_I2.2410.68
93_A130_K2.2330.68
140_H166_A2.1540.65
188_A194_P2.1530.65
81_A118_L2.0120.60
65_Q193_V2.0060.59
99_L123_A1.9620.58
123_A126_V1.9480.57
68_T221_R1.9410.57
30_S159_P1.8700.54
71_H120_E1.8500.53
71_H98_D1.8460.53
108_E112_E1.7870.50
151_Y157_L1.7570.49
134_R143_A1.7450.49
119_R199_V1.6140.43
222_E226_Q1.5930.42
157_L179_I1.5780.42
84_V198_N1.5780.42
94_A214_S1.5440.40
25_D70_D1.5370.40
126_V198_N1.5170.39
203_V207_T1.5090.39
47_L137_G1.4880.38
178_V187_S1.4470.37
141_E144_T1.4420.36
20_I34_L1.4050.35
89_V99_L1.3990.35
71_H152_D1.3810.34
24_V29_T1.3760.34
59_E209_H1.3580.33
42_A137_G1.3470.33
28_I140_H1.3190.32
65_Q225_I1.3180.32
105_N141_E1.3100.31
56_D209_H1.3070.31
99_L199_V1.2960.31
64_A221_R1.2760.30
133_A147_S1.2610.30
57_A236_A1.2490.29
167_A171_E1.2350.29
205_N209_H1.2190.28
119_R211_R1.2020.28
47_L241_I1.1930.27
18_H21_E1.1910.27
203_V206_I1.1880.27
50_E53_P1.1840.27
23_G198_N1.1810.27
21_E32_Q1.1770.27
84_V126_V1.1720.27
13_S41_E1.1690.27
205_N208_A1.1660.26
47_L172_M1.1610.26
84_V99_L1.1560.26
52_I240_R1.1550.26
56_D208_A1.1550.26
218_N222_E1.1520.26
111_V129_T1.1510.26
30_S140_H1.1400.26
68_T224_C1.1390.26
42_A146_D1.1380.26
217_E220_A1.1370.26
11_H166_A1.1340.25
209_H212_D1.1330.25
80_V159_P1.1300.25
84_V203_V1.1260.25
93_A124_S1.1160.25
61_A224_C1.0920.24
28_I172_M1.0900.24
94_A207_T1.0760.24
233_A237_A1.0750.24
151_Y179_I1.0720.24
65_Q192_S1.0720.24
196_I220_A1.0680.23
88_L235_R1.0660.23
136_P172_M1.0650.23
133_A193_V1.0640.23
63_A207_T1.0620.23
60_R209_H1.0610.23
50_E240_R1.0540.23
80_V88_L1.0480.23
206_I212_D1.0450.23
63_A209_H1.0430.23
147_S166_A1.0400.23
153_A156_V1.0250.22
35_I135_I1.0240.22
60_R225_I1.0240.22
35_I210_A1.0150.22
206_I209_H1.0090.22
132_D140_H1.0060.22
32_Q37_Q1.0020.21
7_D137_G1.0000.21
111_V137_G1.0000.21
59_E210_A0.9980.21
4_I130_K0.9970.21
66_L188_A0.9920.21
11_H15_V0.9850.21
112_E217_E0.9780.21
105_N166_A0.9740.21
25_D31_R0.9680.21
20_I28_I0.9650.20
51_T59_E0.9590.20
148_D194_P0.9540.20
14_L27_G0.9520.20
23_G191_A0.9500.20
95_T98_D0.9490.20
123_A198_N0.9490.20
129_T144_T0.9430.20
55_A101_V0.9430.20
59_E63_A0.9390.20
214_S218_N0.9380.20
35_I136_P0.9290.19
29_T140_H0.9270.19
70_D231_E0.9250.19
136_P168_A0.9200.19
85_P198_N0.9150.19
33_G140_H0.9110.19
24_V166_A0.9090.19
112_E159_P0.9080.19
21_E105_N0.9060.19
42_A139_D0.9000.19
80_V136_P0.8970.19
51_T205_N0.8960.19
106_R192_S0.8960.19
85_P123_A0.8950.19
98_D120_E0.8870.18
73_V192_S0.8850.18
166_A191_A0.8850.18
21_E144_T0.8780.18
12_D51_T0.8700.18
63_A66_L0.8700.18
80_V135_I0.8660.18
22_D228_F0.8640.18
106_R170_A0.8600.18
56_D109_E0.8490.17
42_A118_L0.8470.17
178_V190_A0.8440.17
74_V200_V0.8440.17
35_I167_A0.8430.17
228_F231_E0.8370.17
138_L172_M0.8350.17
120_E243_G0.8340.17
170_A190_A0.8330.17
30_S37_Q0.8320.17
95_T210_A0.8250.17
58_A191_A0.8200.17
19_R119_R0.8200.17
4_I52_I0.8200.17
7_D105_N0.8170.17
37_Q133_A0.8160.17
28_I94_A0.8150.17
112_E166_A0.8140.17
118_L126_V0.8140.17
51_T204_P0.8130.17
21_E194_P0.8090.17
16_T42_A0.8010.16
55_A58_A0.7900.16
216_A222_E0.7900.16
137_G143_A0.7890.16
156_V229_D0.7880.16
132_D166_A0.7870.16
192_S213_L0.7810.16
76_V218_N0.7780.16
166_A176_E0.7740.16
18_H176_E0.7740.16
74_V171_E0.7730.16
176_E187_S0.7720.16
7_D141_E0.7710.16
146_D198_N0.7710.16
179_I240_R0.7690.16
80_V158_V0.7690.16
111_V132_D0.7680.16
32_Q191_A0.7630.15
30_S92_A0.7620.15
121_H170_A0.7550.15
27_G173_G0.7550.15
53_P107_T0.7540.15
147_S231_E0.7520.15
54_S228_F0.7510.15
29_T32_Q0.7490.15
7_D11_H0.7490.15
58_A153_A0.7480.15
22_D236_A0.7430.15
86_D235_R0.7410.15
95_T109_E0.7380.15
35_I144_T0.7360.15
140_H188_A0.7350.15
56_D205_N0.7290.15
56_D59_E0.7270.15
5_P191_A0.7270.15
24_V212_D0.7250.15
193_V225_I0.7240.15
188_A202_A0.7190.15
29_T191_A0.7160.14
103_L106_R0.7150.14
130_K146_D0.7140.14
90_A222_E0.7110.14
116_D227_E0.7110.14
118_L198_N0.7110.14
118_L123_A0.7070.14
29_T85_P0.7010.14
50_E235_R0.6980.14
132_D137_G0.6960.14
135_I168_A0.6950.14
4_I238_E0.6930.14
212_D221_R0.6910.14
16_T148_D0.6900.14
68_T96_G0.6890.14
137_G198_N0.6880.14
70_D226_Q0.6870.14
7_D132_D0.6860.14
175_T192_S0.6850.14
24_V105_N0.6840.14
136_P144_T0.6790.14
21_E176_E0.6770.14
32_Q97_A0.6700.14
131_A144_T0.6690.14
155_V232_A0.6630.13
231_E238_E0.6630.13
218_N225_I0.6620.13
65_Q170_A0.6620.13
85_P97_A0.6550.13
26_D113_R0.6520.13
87_A167_A0.6490.13
88_L92_A0.6490.13
71_H242_R0.6480.13
89_V126_V0.6480.13
6_E159_P0.6470.13
138_L194_P0.6470.13
35_I41_E0.6400.13
7_D148_D0.6400.13
34_L41_E0.6380.13
171_E229_D0.6380.13
92_A137_G0.6380.13
101_V228_F0.6360.13
47_L214_S0.6350.13
25_D218_N0.6340.13
124_S218_N0.6320.13
67_L213_L0.6310.13
159_P184_L0.6300.13
90_A120_E0.6260.13
123_A175_T0.6260.13
18_H194_P0.6230.13
145_V198_N0.6210.13
20_I99_L0.6190.13
32_Q35_I0.6190.13
129_T135_I0.6180.13
66_L95_T0.6160.13
16_T140_H0.6130.12
20_I213_L0.6100.12
96_G175_T0.6090.12
61_A217_E0.6080.12
54_S240_R0.6070.12
18_H187_S0.6070.12
26_D157_L0.6010.12
85_P145_V0.6000.12
98_D127_L0.6000.12
35_I179_I0.5990.12
65_Q189_Q0.5970.12
92_A232_A0.5970.12
54_S159_P0.5970.12
112_E189_Q0.5960.12
19_R120_E0.5960.12
124_S203_V0.5960.12
35_I204_P0.5950.12
87_A130_K0.5920.12
133_A151_Y0.5920.12
80_V175_T0.5910.12
99_L203_V0.5870.12
211_R219_A0.5860.12
135_I144_T0.5840.12
146_D210_A0.5800.12
229_D232_A0.5800.12
59_E202_A0.5770.12
111_V170_A0.5770.12
42_A54_S0.5750.12
147_S151_Y0.5740.12
125_G166_A0.5720.12
193_V228_F0.5710.12
37_Q61_A0.5700.12
8_H17_R0.5680.12
9_P17_R0.5680.12
10_R17_R0.5680.12
74_V178_V0.5680.12
51_T179_I0.5670.12
6_E15_V0.5670.12
15_V234_L0.5650.12
67_L95_T0.5630.12
92_A127_L0.5630.12
50_E211_R0.5630.12
112_E200_V0.5620.12
68_T225_I0.5620.12
21_E187_S0.5620.12
130_K179_I0.5610.12
29_T166_A0.5610.12
131_A145_V0.5600.12
53_P227_E0.5580.12
5_P114_I0.5580.12
50_E88_L0.5570.11
5_P20_I0.5570.11
55_A157_L0.5560.11
189_Q233_A0.5540.11
61_A65_Q0.5530.11
85_P121_H0.5530.11
63_A91_L0.5530.11
131_A135_I0.5520.11
73_V160_L0.5510.11
12_D217_E0.5480.11
18_H166_A0.5470.11
31_R140_H0.5440.11
64_A68_T0.5440.11
122_G126_V0.5430.11
199_V202_A0.5420.11
6_E144_T0.5410.11
84_V146_D0.5400.11
67_L221_R0.5400.11
134_R139_D0.5390.11
189_Q231_E0.5360.11
196_I230_R0.5330.11
4_I234_L0.5310.11
6_E11_H0.5250.11
68_T177_L0.5250.11
46_L106_R0.5230.11
18_H191_A0.5230.11
71_H121_H0.5220.11
27_G107_T0.5210.11
11_H139_D0.5200.11
20_I175_T0.5180.11
112_E223_E0.5140.11
145_V241_I0.5140.11
117_H121_H0.5100.11
68_T195_I0.5080.11
211_R243_G0.5080.11
30_S105_N0.5060.11
35_I199_V0.5060.11
96_G211_R0.5050.11
50_E223_E0.5030.11
126_V207_T0.5010.11
111_V131_A0.5000.11
71_H113_R0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mb0A 2 0.996 100 0.027 Contact Map
2q28A 4 0.8755 93.9 0.952 Contact Map
3cf4G 2 0.6345 93.4 0.953 Contact Map
2c31A 4 0.8715 92.7 0.954 Contact Map
4kgdA 4 0.8313 92.6 0.955 Contact Map
2x7jA 4 0.9116 92.3 0.955 Contact Map
1v5eA 4 0.8956 92.2 0.955 Contact Map
3eyaA 5 0.8916 92.1 0.955 Contact Map
4q9dA 4 0.8876 91.6 0.956 Contact Map
1q6zA 4 0.8835 91.4 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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