Q9HSG0 - HALSA - GREMLIN Contacts

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Q9HSG0 - Uncharacterized protein

UniProt:	Q9HSG0	Sequences: MTEIPEDHPRHDSLVTRHRIEDGVDDGITSRQGLIAQGRGEAYDYLLGEETIPSADAAERAAAAQLLTADHPVVSVNGNVAALVPDALVALAAATGADLAVNLFNRTEERVERIADHLREHGASGVLGTKADARIPGLDHERATVDSDGIYDADVVLVPLEDGDRAAALAEMGKTELVIDLNPLSRSAQAASVPIIDNVVRAVPNITAHARDLSEAENAAREECIQEFDREAALRAAEERIRGGMSGGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	249 (240)
Sequences:	181 (129)
Seq/√Len:	8.3

HALSA - Q9HSG0
SULSO - Q97W45

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
63_A	206_I	5.999	1.00
7_D	139_D	5.038	1.00
228_F	233_A	4.568	0.99
69_A	155_V	4.542	0.99
170_A	192_S	4.038	0.98
59_E	205_N	3.760	0.96
206_I	210_A	3.380	0.94
54_S	237_A	3.102	0.90
84_V	199_V	2.868	0.86
59_E	206_I	2.791	0.84
89_V	123_A	2.758	0.84
63_A	210_A	2.741	0.83
92_A	98_D	2.482	0.76
61_A	193_V	2.477	0.76
88_L	99_L	2.474	0.76
194_P	230_R	2.350	0.72
23_G	29_T	2.311	0.71
221_R	224_C	2.296	0.70
115_A	119_R	2.265	0.69
65_Q	175_T	2.243	0.69
221_R	225_I	2.241	0.68
93_A	130_K	2.233	0.68
140_H	166_A	2.154	0.65
188_A	194_P	2.153	0.65
81_A	118_L	2.012	0.60
65_Q	193_V	2.006	0.59
99_L	123_A	1.962	0.58
123_A	126_V	1.948	0.57
68_T	221_R	1.941	0.57
30_S	159_P	1.870	0.54
71_H	120_E	1.850	0.53
71_H	98_D	1.846	0.53
108_E	112_E	1.787	0.50
151_Y	157_L	1.757	0.49
134_R	143_A	1.745	0.49
119_R	199_V	1.614	0.43
222_E	226_Q	1.593	0.42
157_L	179_I	1.578	0.42
84_V	198_N	1.578	0.42
94_A	214_S	1.544	0.40
25_D	70_D	1.537	0.40
126_V	198_N	1.517	0.39
203_V	207_T	1.509	0.39
47_L	137_G	1.488	0.38
178_V	187_S	1.447	0.37
141_E	144_T	1.442	0.36
20_I	34_L	1.405	0.35
89_V	99_L	1.399	0.35
71_H	152_D	1.381	0.34
24_V	29_T	1.376	0.34
59_E	209_H	1.358	0.33
42_A	137_G	1.347	0.33
28_I	140_H	1.319	0.32
65_Q	225_I	1.318	0.32
105_N	141_E	1.310	0.31
56_D	209_H	1.307	0.31
99_L	199_V	1.296	0.31
64_A	221_R	1.276	0.30
133_A	147_S	1.261	0.30
57_A	236_A	1.249	0.29
167_A	171_E	1.235	0.29
205_N	209_H	1.219	0.28
119_R	211_R	1.202	0.28
47_L	241_I	1.193	0.27
18_H	21_E	1.191	0.27
203_V	206_I	1.188	0.27
50_E	53_P	1.184	0.27
23_G	198_N	1.181	0.27
21_E	32_Q	1.177	0.27
84_V	126_V	1.172	0.27
13_S	41_E	1.169	0.27
205_N	208_A	1.166	0.26
47_L	172_M	1.161	0.26
84_V	99_L	1.156	0.26
52_I	240_R	1.155	0.26
56_D	208_A	1.155	0.26
218_N	222_E	1.152	0.26
111_V	129_T	1.151	0.26
30_S	140_H	1.140	0.26
68_T	224_C	1.139	0.26
42_A	146_D	1.138	0.26
217_E	220_A	1.137	0.26
11_H	166_A	1.134	0.25
209_H	212_D	1.133	0.25
80_V	159_P	1.130	0.25
84_V	203_V	1.126	0.25
93_A	124_S	1.116	0.25
61_A	224_C	1.092	0.24
28_I	172_M	1.090	0.24
94_A	207_T	1.076	0.24
233_A	237_A	1.075	0.24
151_Y	179_I	1.072	0.24
65_Q	192_S	1.072	0.24
196_I	220_A	1.068	0.23
88_L	235_R	1.066	0.23
136_P	172_M	1.065	0.23
133_A	193_V	1.064	0.23
63_A	207_T	1.062	0.23
60_R	209_H	1.061	0.23
50_E	240_R	1.054	0.23
80_V	88_L	1.048	0.23
206_I	212_D	1.045	0.23
63_A	209_H	1.043	0.23
147_S	166_A	1.040	0.23
153_A	156_V	1.025	0.22
35_I	135_I	1.024	0.22
60_R	225_I	1.024	0.22
35_I	210_A	1.015	0.22
206_I	209_H	1.009	0.22
132_D	140_H	1.006	0.22
32_Q	37_Q	1.002	0.21
7_D	137_G	1.000	0.21
111_V	137_G	1.000	0.21
59_E	210_A	0.998	0.21
4_I	130_K	0.997	0.21
66_L	188_A	0.992	0.21
11_H	15_V	0.985	0.21
112_E	217_E	0.978	0.21
105_N	166_A	0.974	0.21
25_D	31_R	0.968	0.21
20_I	28_I	0.965	0.20
51_T	59_E	0.959	0.20
148_D	194_P	0.954	0.20
14_L	27_G	0.952	0.20
23_G	191_A	0.950	0.20
95_T	98_D	0.949	0.20
123_A	198_N	0.949	0.20
129_T	144_T	0.943	0.20
55_A	101_V	0.943	0.20
59_E	63_A	0.939	0.20
214_S	218_N	0.938	0.20
35_I	136_P	0.929	0.19
29_T	140_H	0.927	0.19
70_D	231_E	0.925	0.19
136_P	168_A	0.920	0.19
85_P	198_N	0.915	0.19
33_G	140_H	0.911	0.19
24_V	166_A	0.909	0.19
112_E	159_P	0.908	0.19
21_E	105_N	0.906	0.19
42_A	139_D	0.900	0.19
80_V	136_P	0.897	0.19
51_T	205_N	0.896	0.19
106_R	192_S	0.896	0.19
85_P	123_A	0.895	0.19
98_D	120_E	0.887	0.18
73_V	192_S	0.885	0.18
166_A	191_A	0.885	0.18
21_E	144_T	0.878	0.18
12_D	51_T	0.870	0.18
63_A	66_L	0.870	0.18
80_V	135_I	0.866	0.18
22_D	228_F	0.864	0.18
106_R	170_A	0.860	0.18
56_D	109_E	0.849	0.17
42_A	118_L	0.847	0.17
178_V	190_A	0.844	0.17
74_V	200_V	0.844	0.17
35_I	167_A	0.843	0.17
228_F	231_E	0.837	0.17
138_L	172_M	0.835	0.17
120_E	243_G	0.834	0.17
170_A	190_A	0.833	0.17
30_S	37_Q	0.832	0.17
95_T	210_A	0.825	0.17
58_A	191_A	0.820	0.17
19_R	119_R	0.820	0.17
4_I	52_I	0.820	0.17
7_D	105_N	0.817	0.17
37_Q	133_A	0.816	0.17
28_I	94_A	0.815	0.17
112_E	166_A	0.814	0.17
118_L	126_V	0.814	0.17
51_T	204_P	0.813	0.17
21_E	194_P	0.809	0.17
16_T	42_A	0.801	0.16
55_A	58_A	0.790	0.16
216_A	222_E	0.790	0.16
137_G	143_A	0.789	0.16
156_V	229_D	0.788	0.16
132_D	166_A	0.787	0.16
192_S	213_L	0.781	0.16
76_V	218_N	0.778	0.16
166_A	176_E	0.774	0.16
18_H	176_E	0.774	0.16
74_V	171_E	0.773	0.16
176_E	187_S	0.772	0.16
7_D	141_E	0.771	0.16
146_D	198_N	0.771	0.16
179_I	240_R	0.769	0.16
80_V	158_V	0.769	0.16
111_V	132_D	0.768	0.16
32_Q	191_A	0.763	0.15
30_S	92_A	0.762	0.15
121_H	170_A	0.755	0.15
27_G	173_G	0.755	0.15
53_P	107_T	0.754	0.15
147_S	231_E	0.752	0.15
54_S	228_F	0.751	0.15
29_T	32_Q	0.749	0.15
7_D	11_H	0.749	0.15
58_A	153_A	0.748	0.15
22_D	236_A	0.743	0.15
86_D	235_R	0.741	0.15
95_T	109_E	0.738	0.15
35_I	144_T	0.736	0.15
140_H	188_A	0.735	0.15
56_D	205_N	0.729	0.15
56_D	59_E	0.727	0.15
5_P	191_A	0.727	0.15
24_V	212_D	0.725	0.15
193_V	225_I	0.724	0.15
188_A	202_A	0.719	0.15
29_T	191_A	0.716	0.14
103_L	106_R	0.715	0.14
130_K	146_D	0.714	0.14
90_A	222_E	0.711	0.14
116_D	227_E	0.711	0.14
118_L	198_N	0.711	0.14
118_L	123_A	0.707	0.14
29_T	85_P	0.701	0.14
50_E	235_R	0.698	0.14
132_D	137_G	0.696	0.14
135_I	168_A	0.695	0.14
4_I	238_E	0.693	0.14
212_D	221_R	0.691	0.14
16_T	148_D	0.690	0.14
68_T	96_G	0.689	0.14
137_G	198_N	0.688	0.14
70_D	226_Q	0.687	0.14
7_D	132_D	0.686	0.14
175_T	192_S	0.685	0.14
24_V	105_N	0.684	0.14
136_P	144_T	0.679	0.14
21_E	176_E	0.677	0.14
32_Q	97_A	0.670	0.14
131_A	144_T	0.669	0.14
155_V	232_A	0.663	0.13
231_E	238_E	0.663	0.13
218_N	225_I	0.662	0.13
65_Q	170_A	0.662	0.13
85_P	97_A	0.655	0.13
26_D	113_R	0.652	0.13
87_A	167_A	0.649	0.13
88_L	92_A	0.649	0.13
71_H	242_R	0.648	0.13
89_V	126_V	0.648	0.13
6_E	159_P	0.647	0.13
138_L	194_P	0.647	0.13
35_I	41_E	0.640	0.13
7_D	148_D	0.640	0.13
34_L	41_E	0.638	0.13
171_E	229_D	0.638	0.13
92_A	137_G	0.638	0.13
101_V	228_F	0.636	0.13
47_L	214_S	0.635	0.13
25_D	218_N	0.634	0.13
124_S	218_N	0.632	0.13
67_L	213_L	0.631	0.13
159_P	184_L	0.630	0.13
90_A	120_E	0.626	0.13
123_A	175_T	0.626	0.13
18_H	194_P	0.623	0.13
145_V	198_N	0.621	0.13
20_I	99_L	0.619	0.13
32_Q	35_I	0.619	0.13
129_T	135_I	0.618	0.13
66_L	95_T	0.616	0.13
16_T	140_H	0.613	0.12
20_I	213_L	0.610	0.12
96_G	175_T	0.609	0.12
61_A	217_E	0.608	0.12
54_S	240_R	0.607	0.12
18_H	187_S	0.607	0.12
26_D	157_L	0.601	0.12
85_P	145_V	0.600	0.12
98_D	127_L	0.600	0.12
35_I	179_I	0.599	0.12
65_Q	189_Q	0.597	0.12
92_A	232_A	0.597	0.12
54_S	159_P	0.597	0.12
112_E	189_Q	0.596	0.12
19_R	120_E	0.596	0.12
124_S	203_V	0.596	0.12
35_I	204_P	0.595	0.12
87_A	130_K	0.592	0.12
133_A	151_Y	0.592	0.12
80_V	175_T	0.591	0.12
99_L	203_V	0.587	0.12
211_R	219_A	0.586	0.12
135_I	144_T	0.584	0.12
146_D	210_A	0.580	0.12
229_D	232_A	0.580	0.12
59_E	202_A	0.577	0.12
111_V	170_A	0.577	0.12
42_A	54_S	0.575	0.12
147_S	151_Y	0.574	0.12
125_G	166_A	0.572	0.12
193_V	228_F	0.571	0.12
37_Q	61_A	0.570	0.12
8_H	17_R	0.568	0.12
9_P	17_R	0.568	0.12
10_R	17_R	0.568	0.12
74_V	178_V	0.568	0.12
51_T	179_I	0.567	0.12
6_E	15_V	0.567	0.12
15_V	234_L	0.565	0.12
67_L	95_T	0.563	0.12
92_A	127_L	0.563	0.12
50_E	211_R	0.563	0.12
112_E	200_V	0.562	0.12
68_T	225_I	0.562	0.12
21_E	187_S	0.562	0.12
130_K	179_I	0.561	0.12
29_T	166_A	0.561	0.12
131_A	145_V	0.560	0.12
53_P	227_E	0.558	0.12
5_P	114_I	0.558	0.12
50_E	88_L	0.557	0.11
5_P	20_I	0.557	0.11
55_A	157_L	0.556	0.11
189_Q	233_A	0.554	0.11
61_A	65_Q	0.553	0.11
85_P	121_H	0.553	0.11
63_A	91_L	0.553	0.11
131_A	135_I	0.552	0.11
73_V	160_L	0.551	0.11
12_D	217_E	0.548	0.11
18_H	166_A	0.547	0.11
31_R	140_H	0.544	0.11
64_A	68_T	0.544	0.11
122_G	126_V	0.543	0.11
199_V	202_A	0.542	0.11
6_E	144_T	0.541	0.11
84_V	146_D	0.540	0.11
67_L	221_R	0.540	0.11
134_R	139_D	0.539	0.11
189_Q	231_E	0.536	0.11
196_I	230_R	0.533	0.11
4_I	234_L	0.531	0.11
6_E	11_H	0.525	0.11
68_T	177_L	0.525	0.11
46_L	106_R	0.523	0.11
18_H	191_A	0.523	0.11
71_H	121_H	0.522	0.11
27_G	107_T	0.521	0.11
11_H	139_D	0.520	0.11
20_I	175_T	0.518	0.11
112_E	223_E	0.514	0.11
145_V	241_I	0.514	0.11
117_H	121_H	0.510	0.11
68_T	195_I	0.508	0.11
211_R	243_G	0.508	0.11
30_S	105_N	0.506	0.11
35_I	199_V	0.506	0.11
96_G	211_R	0.505	0.11
50_E	223_E	0.503	0.11
126_V	207_T	0.501	0.11
111_V	131_A	0.500	0.11
71_H	113_R	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mb0A	2	0.996	100	0.027	Contact Map
2q28A	4	0.8755	93.9	0.952	Contact Map
3cf4G	2	0.6345	93.4	0.953	Contact Map
2c31A	4	0.8715	92.7	0.954	Contact Map
4kgdA	4	0.8313	92.6	0.955	Contact Map
2x7jA	4	0.9116	92.3	0.955	Contact Map
1v5eA	4	0.8956	92.2	0.955	Contact Map
3eyaA	5	0.8916	92.1	0.955	Contact Map
4q9dA	4	0.8876	91.6	0.956	Contact Map
1q6zA	4	0.8835	91.4	0.956	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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