GREMLIN Database
Q9HSF9 - Uncharacterized protein
UniProt: Q9HSF9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 279 (259)
Sequences: 199 (156)
Seq/√Len: 9.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_H141_A4.1790.99
246_A251_T3.9280.98
17_G211_F3.7550.98
11_A103_A3.1190.94
14_H37_A2.7120.87
10_F44_G2.6920.87
155_A159_G2.5320.83
37_A202_L2.5210.83
47_V103_A2.5210.83
228_A250_R2.5150.83
14_H150_R2.4980.82
226_D250_R2.4510.81
34_S180_T2.3280.78
194_A198_A2.2920.76
138_D180_T2.2470.75
40_A45_V2.2400.75
34_S150_R2.2200.74
16_T195_G2.1650.72
217_R221_A2.1500.72
24_G31_A2.1280.71
141_A150_R2.1110.70
236_V241_G2.1050.70
23_T32_S2.0770.69
47_V84_A2.0710.69
14_H38_G2.0650.68
244_A253_F2.0540.68
14_H34_S2.0220.67
72_V105_A1.8840.61
14_H202_L1.8800.61
13_G19_F1.8750.60
47_V186_G1.8470.59
57_V223_G1.8250.58
94_F245_M1.8130.58
15_V34_S1.8110.58
9_A107_A1.7980.57
46_T79_T1.7400.55
16_T150_R1.7400.55
216_R237_Q1.7390.54
49_V99_A1.7240.54
16_T34_S1.7030.53
17_G253_F1.7030.53
98_G132_A1.6750.52
138_D150_R1.6490.50
13_G88_L1.6190.49
138_D248_L1.6150.49
91_G215_S1.6120.49
16_T246_A1.6080.49
170_I209_A1.5970.48
17_G215_S1.5960.48
90_L100_T1.5920.48
60_N142_Q1.5840.47
123_Q157_P1.5760.47
21_V184_I1.5730.47
41_L170_I1.5600.46
142_Q198_A1.5540.46
14_H180_T1.5200.45
15_V43_A1.5100.44
102_L142_Q1.4870.43
164_V211_F1.4850.43
38_G141_A1.4840.43
59_L241_G1.4760.43
185_G244_A1.4610.42
138_D141_A1.4410.41
127_V131_E1.4350.41
88_L222_A1.4280.41
52_A56_G1.4080.40
149_V202_L1.4030.39
150_R180_T1.4000.39
14_H17_G1.3690.38
39_V228_A1.3660.38
49_V107_A1.3370.37
120_E207_T1.3360.37
16_T251_T1.3150.36
39_V150_R1.3090.36
84_A100_T1.3080.35
86_T90_L1.3040.35
18_F101_A1.2880.35
176_G245_M1.2810.34
7_A184_I1.2740.34
30_V127_V1.2730.34
211_F253_F1.2710.34
13_G256_G1.2590.33
19_F44_G1.2500.33
13_G41_L1.2470.33
19_F89_P1.2460.33
37_A149_V1.2370.33
124_V175_F1.2240.32
175_F228_A1.2070.31
204_A211_F1.2050.31
10_F19_F1.2010.31
15_V150_R1.1950.31
159_G205_D1.1900.31
209_A213_A1.1870.31
149_V212_V1.1840.31
17_G149_V1.1790.30
12_P91_G1.1750.30
14_H138_D1.1720.30
45_V251_T1.1710.30
117_S206_P1.1690.30
210_E214_A1.1590.30
101_A156_P1.1530.29
14_H211_F1.1200.28
162_D195_G1.1120.28
41_L222_A1.0920.27
22_D153_P1.0880.27
40_A149_V1.0850.27
175_F223_G1.0790.27
34_S138_D1.0770.27
149_V170_I1.0760.27
244_A248_L1.0750.27
21_V175_F1.0750.27
109_N121_L1.0720.26
133_G184_I1.0700.26
16_T222_A1.0700.26
176_G248_L1.0670.26
19_F247_M1.0640.26
27_E74_D1.0620.26
80_A112_F1.0480.26
210_E213_A1.0460.26
42_S198_A1.0400.25
17_G202_L1.0390.25
98_G236_V1.0390.25
8_V182_D1.0380.25
44_G249_G1.0380.25
49_V82_V1.0360.25
245_M254_A1.0330.25
37_A253_F1.0280.25
46_T85_E1.0230.25
20_S196_A1.0230.25
109_N195_G1.0200.25
66_I84_A1.0020.24
104_A243_A1.0020.24
88_L96_V1.0020.24
202_L212_V0.9980.24
68_S130_A0.9950.24
132_A172_Y0.9940.24
98_G263_G0.9930.24
59_L246_A0.9890.24
57_V170_I0.9870.24
100_T219_A0.9800.23
13_G259_L0.9780.23
33_G150_R0.9740.23
7_A111_V0.9740.23
111_V116_C0.9710.23
37_A211_F0.9700.23
72_V82_V0.9700.23
131_E203_R0.9610.23
41_L175_F0.9590.23
18_F195_G0.9580.23
134_T175_F0.9540.22
243_A248_L0.9450.22
92_A151_V0.9440.22
117_S203_R0.9430.22
151_V221_A0.9420.22
14_H248_L0.9380.22
180_T248_L0.9380.22
138_D246_A0.9370.22
77_G234_A0.9270.22
84_A103_A0.9250.22
76_L114_C0.9120.21
12_P44_G0.9120.21
67_A74_D0.9070.21
176_G212_V0.9070.21
178_L258_G0.9070.21
94_F247_M0.9050.21
11_A41_L0.9020.21
33_G38_G0.8960.21
202_L214_A0.8930.21
113_G234_A0.8920.21
17_G37_A0.8890.21
35_R246_A0.8810.20
73_L108_A0.8790.20
71_G127_V0.8780.20
104_A255_L0.8770.20
82_V240_G0.8710.20
247_M254_A0.8650.20
33_G36_G0.8590.20
91_G253_F0.8590.20
263_G266_A0.8580.20
183_V254_A0.8570.20
18_F198_A0.8550.20
176_G222_A0.8550.20
7_A193_A0.8540.20
125_A139_V0.8450.19
45_V99_A0.8430.19
243_A247_M0.8390.19
95_G249_G0.8370.19
84_A90_L0.8320.19
118_E163_G0.8310.19
184_I242_E0.8280.19
42_S244_A0.8270.19
53_E69_V0.8250.19
193_A196_A0.8220.19
173_V225_V0.8210.19
183_V212_V0.8180.19
98_G128_A0.8150.18
77_G185_G0.8140.18
43_A87_P0.8090.18
103_A129_D0.8080.18
113_G221_A0.8040.18
194_A247_M0.8010.18
93_G135_G0.8010.18
93_G97_S0.8010.18
93_G218_F0.8010.18
97_S218_F0.8010.18
97_S135_G0.8010.18
135_G218_F0.8010.18
39_V191_L0.8010.18
57_V216_R0.7990.18
120_E175_F0.7990.18
75_A127_V0.7940.18
190_A201_A0.7890.18
49_V170_I0.7870.18
91_G99_A0.7840.18
17_G21_V0.7840.18
117_S162_D0.7830.18
57_V108_A0.7820.18
11_A102_L0.7790.17
107_A183_V0.7730.17
39_V182_D0.7680.17
19_F249_G0.7630.17
60_N199_L0.7630.17
74_D114_C0.7590.17
102_L146_G0.7550.17
183_V247_M0.7530.17
24_G32_S0.7470.17
106_L121_L0.7450.17
220_R230_A0.7430.17
212_V253_F0.7410.16
35_R148_P0.7370.16
94_F251_T0.7340.16
201_A217_R0.7300.16
245_M248_L0.7300.16
23_T184_I0.7270.16
175_F232_A0.7260.16
122_V143_A0.7250.16
124_V200_A0.7220.16
129_D180_T0.7220.16
205_D234_A0.7210.16
95_G215_S0.7150.16
44_G95_G0.7130.16
140_V155_A0.7120.16
10_F253_F0.7110.16
164_V177_G0.7110.16
16_T133_G0.7110.16
69_V100_T0.7090.16
151_V160_S0.7050.16
20_S191_L0.7030.16
50_T223_G0.7020.16
213_A217_R0.7020.16
94_F107_A0.7010.16
111_V193_A0.6990.15
119_N162_D0.6970.15
21_V192_S0.6960.15
59_L174_S0.6940.15
71_G75_A0.6940.15
101_A124_V0.6930.15
187_E222_A0.6860.15
40_A90_L0.6860.15
107_A190_A0.6840.15
67_A217_R0.6830.15
176_G183_V0.6800.15
41_L206_P0.6800.15
248_L254_A0.6760.15
10_F39_V0.6720.15
10_F150_R0.6710.15
10_F41_L0.6710.15
148_P164_V0.6690.15
49_V71_G0.6690.15
46_T83_T0.6680.15
126_H136_L0.6680.15
205_D210_E0.6650.15
123_Q155_A0.6640.15
82_V105_A0.6640.15
49_V83_T0.6610.15
252_V260_S0.6600.15
232_A235_A0.6600.15
103_A107_A0.6600.15
92_A159_G0.6590.15
141_A233_I0.6580.15
98_G142_Q0.6570.15
85_E99_A0.6560.14
109_N133_G0.6540.14
207_T219_A0.6500.14
179_S257_T0.6470.14
58_V83_T0.6440.14
65_E201_A0.6370.14
69_V117_S0.6360.14
116_C131_E0.6340.14
49_V188_T0.6340.14
147_L228_A0.6310.14
18_F103_A0.6290.14
133_G206_P0.6280.14
261_D264_Y0.6260.14
226_D230_A0.6220.14
47_V66_I0.6170.14
243_A252_V0.6160.14
156_P202_L0.6140.14
184_I219_A0.6110.14
56_G234_A0.6100.13
52_A60_N0.6090.13
129_D138_D0.6080.13
219_A225_V0.6070.13
56_G83_T0.6030.13
56_G63_P0.6020.13
191_L222_A0.6000.13
19_F36_G0.5990.13
75_A153_P0.5950.13
99_A138_D0.5930.13
73_L78_V0.5920.13
66_I103_A0.5900.13
72_V125_A0.5890.13
92_A148_P0.5890.13
113_G151_V0.5870.13
38_G153_P0.5870.13
103_A212_V0.5850.13
86_T142_Q0.5840.13
219_A250_R0.5810.13
36_G218_F0.5800.13
36_G97_S0.5800.13
36_G135_G0.5800.13
36_G93_G0.5800.13
150_R253_F0.5780.13
16_T72_V0.5750.13
34_S141_A0.5730.13
57_V65_E0.5720.13
27_E167_S0.5680.13
14_H41_L0.5610.12
77_G131_E0.5610.12
133_G207_T0.5580.12
109_N115_G0.5580.12
21_V47_V0.5580.12
92_A175_F0.5540.12
137_G218_F0.5540.12
97_S137_G0.5540.12
93_G137_G0.5540.12
121_L267_A0.5540.12
161_L175_F0.5530.12
117_S217_R0.5530.12
101_A195_G0.5520.12
80_A111_V0.5500.12
151_V159_G0.5450.12
16_T180_T0.5450.12
78_V124_V0.5450.12
88_L168_G0.5410.12
31_A209_A0.5400.12
28_A133_G0.5400.12
90_L211_F0.5400.12
19_F183_V0.5400.12
77_G226_D0.5390.12
125_A137_G0.5370.12
42_S256_G0.5350.12
71_G124_V0.5310.12
148_P194_A0.5310.12
83_T116_C0.5310.12
40_A86_T0.5300.12
70_R73_L0.5300.12
141_A211_F0.5290.12
42_S260_S0.5270.12
104_A190_A0.5260.12
208_V254_A0.5250.12
203_R206_P0.5230.12
69_V128_A0.5230.12
129_D224_L0.5230.12
176_G202_L0.5220.12
155_A227_A0.5220.12
15_V134_T0.5210.12
60_N206_P0.5200.12
60_N205_D0.5190.12
202_L248_L0.5190.12
136_L249_G0.5190.12
12_P17_G0.5180.12
205_D220_R0.5180.12
23_T168_G0.5170.12
10_F37_A0.5170.12
184_I238_A0.5150.12
12_P19_F0.5140.12
111_V182_D0.5130.12
32_S153_P0.5110.12
59_L86_T0.5070.11
203_R222_A0.5060.11
233_I251_T0.5050.11
32_S159_G0.5040.11
128_A245_M0.5040.11
31_A160_S0.5030.11
71_G131_E0.5030.11
222_A246_A0.5030.11
15_V141_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pyfA 1 0.9283 99.9 0.757 Contact Map
4hacA 2 0.9391 99.9 0.759 Contact Map
4n3oA 2 0.9462 99.9 0.767 Contact Map
4rpfA 2 0.9391 99.9 0.772 Contact Map
3k85A 3 0.8674 99.9 0.772 Contact Map
1h72C 2 0.9211 99.8 0.78 Contact Map
2hfsA 1 0.9391 99.8 0.781 Contact Map
4p52A 2 0.9427 99.8 0.786 Contact Map
3gonA 1 0.9427 99.8 0.788 Contact Map
1uekA 1 0.8925 99.8 0.792 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.