Q9HSF9 - HALSA - GREMLIN Contacts

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Q9HSF9 - Uncharacterized protein

UniProt:	Q9HSF9	Sequences: MSDGESAVAFAPGHVTGFFSVDTGATEAAVASGSRGAGVALSAGVTVTVTRAENTGVVLNGTPTEIASVRGVLDALGVTARVTAETPLPLGAGFGVSGATALAAALAANEVFGCGCSENELVQVAHVADAEAGTGLGDVVAQARGGLPVRVEPGAPPHGSLDGVPASGRIEYVSFGGLSTSDVIGGETDALSAAGADALAALRADPTVAEFVAASRRFARAAGLVDAAVADAIAAVQAAGGEAAMAMLGRTVFALGTGLSDAGYDAASCAIHHGGASLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	279 (259)
Sequences:	199 (156)
Seq/√Len:	9.7

HALSA - Q9HSF9
SULSO - Q97W46

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_H	141_A	4.179	0.99
246_A	251_T	3.928	0.98
17_G	211_F	3.755	0.98
11_A	103_A	3.119	0.94
14_H	37_A	2.712	0.87
10_F	44_G	2.692	0.87
155_A	159_G	2.532	0.83
37_A	202_L	2.521	0.83
47_V	103_A	2.521	0.83
228_A	250_R	2.515	0.83
14_H	150_R	2.498	0.82
226_D	250_R	2.451	0.81
34_S	180_T	2.328	0.78
194_A	198_A	2.292	0.76
138_D	180_T	2.247	0.75
40_A	45_V	2.240	0.75
34_S	150_R	2.220	0.74
16_T	195_G	2.165	0.72
217_R	221_A	2.150	0.72
24_G	31_A	2.128	0.71
141_A	150_R	2.111	0.70
236_V	241_G	2.105	0.70
23_T	32_S	2.077	0.69
47_V	84_A	2.071	0.69
14_H	38_G	2.065	0.68
244_A	253_F	2.054	0.68
14_H	34_S	2.022	0.67
72_V	105_A	1.884	0.61
14_H	202_L	1.880	0.61
13_G	19_F	1.875	0.60
47_V	186_G	1.847	0.59
57_V	223_G	1.825	0.58
94_F	245_M	1.813	0.58
15_V	34_S	1.811	0.58
9_A	107_A	1.798	0.57
46_T	79_T	1.740	0.55
16_T	150_R	1.740	0.55
216_R	237_Q	1.739	0.54
49_V	99_A	1.724	0.54
16_T	34_S	1.703	0.53
17_G	253_F	1.703	0.53
98_G	132_A	1.675	0.52
138_D	150_R	1.649	0.50
13_G	88_L	1.619	0.49
138_D	248_L	1.615	0.49
91_G	215_S	1.612	0.49
16_T	246_A	1.608	0.49
170_I	209_A	1.597	0.48
17_G	215_S	1.596	0.48
90_L	100_T	1.592	0.48
60_N	142_Q	1.584	0.47
123_Q	157_P	1.576	0.47
21_V	184_I	1.573	0.47
41_L	170_I	1.560	0.46
142_Q	198_A	1.554	0.46
14_H	180_T	1.520	0.45
15_V	43_A	1.510	0.44
102_L	142_Q	1.487	0.43
164_V	211_F	1.485	0.43
38_G	141_A	1.484	0.43
59_L	241_G	1.476	0.43
185_G	244_A	1.461	0.42
138_D	141_A	1.441	0.41
127_V	131_E	1.435	0.41
88_L	222_A	1.428	0.41
52_A	56_G	1.408	0.40
149_V	202_L	1.403	0.39
150_R	180_T	1.400	0.39
14_H	17_G	1.369	0.38
39_V	228_A	1.366	0.38
49_V	107_A	1.337	0.37
120_E	207_T	1.336	0.37
16_T	251_T	1.315	0.36
39_V	150_R	1.309	0.36
84_A	100_T	1.308	0.35
86_T	90_L	1.304	0.35
18_F	101_A	1.288	0.35
176_G	245_M	1.281	0.34
7_A	184_I	1.274	0.34
30_V	127_V	1.273	0.34
211_F	253_F	1.271	0.34
13_G	256_G	1.259	0.33
19_F	44_G	1.250	0.33
13_G	41_L	1.247	0.33
19_F	89_P	1.246	0.33
37_A	149_V	1.237	0.33
124_V	175_F	1.224	0.32
175_F	228_A	1.207	0.31
204_A	211_F	1.205	0.31
10_F	19_F	1.201	0.31
15_V	150_R	1.195	0.31
159_G	205_D	1.190	0.31
209_A	213_A	1.187	0.31
149_V	212_V	1.184	0.31
17_G	149_V	1.179	0.30
12_P	91_G	1.175	0.30
14_H	138_D	1.172	0.30
45_V	251_T	1.171	0.30
117_S	206_P	1.169	0.30
210_E	214_A	1.159	0.30
101_A	156_P	1.153	0.29
14_H	211_F	1.120	0.28
162_D	195_G	1.112	0.28
41_L	222_A	1.092	0.27
22_D	153_P	1.088	0.27
40_A	149_V	1.085	0.27
175_F	223_G	1.079	0.27
34_S	138_D	1.077	0.27
149_V	170_I	1.076	0.27
244_A	248_L	1.075	0.27
21_V	175_F	1.075	0.27
109_N	121_L	1.072	0.26
133_G	184_I	1.070	0.26
16_T	222_A	1.070	0.26
176_G	248_L	1.067	0.26
19_F	247_M	1.064	0.26
27_E	74_D	1.062	0.26
80_A	112_F	1.048	0.26
210_E	213_A	1.046	0.26
42_S	198_A	1.040	0.25
17_G	202_L	1.039	0.25
98_G	236_V	1.039	0.25
8_V	182_D	1.038	0.25
44_G	249_G	1.038	0.25
49_V	82_V	1.036	0.25
245_M	254_A	1.033	0.25
37_A	253_F	1.028	0.25
46_T	85_E	1.023	0.25
20_S	196_A	1.023	0.25
109_N	195_G	1.020	0.25
66_I	84_A	1.002	0.24
104_A	243_A	1.002	0.24
88_L	96_V	1.002	0.24
202_L	212_V	0.998	0.24
68_S	130_A	0.995	0.24
132_A	172_Y	0.994	0.24
98_G	263_G	0.993	0.24
59_L	246_A	0.989	0.24
57_V	170_I	0.987	0.24
100_T	219_A	0.980	0.23
13_G	259_L	0.978	0.23
33_G	150_R	0.974	0.23
7_A	111_V	0.974	0.23
111_V	116_C	0.971	0.23
37_A	211_F	0.970	0.23
72_V	82_V	0.970	0.23
131_E	203_R	0.961	0.23
41_L	175_F	0.959	0.23
18_F	195_G	0.958	0.23
134_T	175_F	0.954	0.22
243_A	248_L	0.945	0.22
92_A	151_V	0.944	0.22
117_S	203_R	0.943	0.22
151_V	221_A	0.942	0.22
14_H	248_L	0.938	0.22
180_T	248_L	0.938	0.22
138_D	246_A	0.937	0.22
77_G	234_A	0.927	0.22
84_A	103_A	0.925	0.22
76_L	114_C	0.912	0.21
12_P	44_G	0.912	0.21
67_A	74_D	0.907	0.21
176_G	212_V	0.907	0.21
178_L	258_G	0.907	0.21
94_F	247_M	0.905	0.21
11_A	41_L	0.902	0.21
33_G	38_G	0.896	0.21
202_L	214_A	0.893	0.21
113_G	234_A	0.892	0.21
17_G	37_A	0.889	0.21
35_R	246_A	0.881	0.20
73_L	108_A	0.879	0.20
71_G	127_V	0.878	0.20
104_A	255_L	0.877	0.20
82_V	240_G	0.871	0.20
247_M	254_A	0.865	0.20
33_G	36_G	0.859	0.20
91_G	253_F	0.859	0.20
263_G	266_A	0.858	0.20
183_V	254_A	0.857	0.20
18_F	198_A	0.855	0.20
176_G	222_A	0.855	0.20
7_A	193_A	0.854	0.20
125_A	139_V	0.845	0.19
45_V	99_A	0.843	0.19
243_A	247_M	0.839	0.19
95_G	249_G	0.837	0.19
84_A	90_L	0.832	0.19
118_E	163_G	0.831	0.19
184_I	242_E	0.828	0.19
42_S	244_A	0.827	0.19
53_E	69_V	0.825	0.19
193_A	196_A	0.822	0.19
173_V	225_V	0.821	0.19
183_V	212_V	0.818	0.19
98_G	128_A	0.815	0.18
77_G	185_G	0.814	0.18
43_A	87_P	0.809	0.18
103_A	129_D	0.808	0.18
113_G	221_A	0.804	0.18
194_A	247_M	0.801	0.18
93_G	135_G	0.801	0.18
93_G	97_S	0.801	0.18
93_G	218_F	0.801	0.18
97_S	218_F	0.801	0.18
97_S	135_G	0.801	0.18
135_G	218_F	0.801	0.18
39_V	191_L	0.801	0.18
57_V	216_R	0.799	0.18
120_E	175_F	0.799	0.18
75_A	127_V	0.794	0.18
190_A	201_A	0.789	0.18
49_V	170_I	0.787	0.18
91_G	99_A	0.784	0.18
17_G	21_V	0.784	0.18
117_S	162_D	0.783	0.18
57_V	108_A	0.782	0.18
11_A	102_L	0.779	0.17
107_A	183_V	0.773	0.17
39_V	182_D	0.768	0.17
19_F	249_G	0.763	0.17
60_N	199_L	0.763	0.17
74_D	114_C	0.759	0.17
102_L	146_G	0.755	0.17
183_V	247_M	0.753	0.17
24_G	32_S	0.747	0.17
106_L	121_L	0.745	0.17
220_R	230_A	0.743	0.17
212_V	253_F	0.741	0.16
35_R	148_P	0.737	0.16
94_F	251_T	0.734	0.16
201_A	217_R	0.730	0.16
245_M	248_L	0.730	0.16
23_T	184_I	0.727	0.16
175_F	232_A	0.726	0.16
122_V	143_A	0.725	0.16
124_V	200_A	0.722	0.16
129_D	180_T	0.722	0.16
205_D	234_A	0.721	0.16
95_G	215_S	0.715	0.16
44_G	95_G	0.713	0.16
140_V	155_A	0.712	0.16
10_F	253_F	0.711	0.16
164_V	177_G	0.711	0.16
16_T	133_G	0.711	0.16
69_V	100_T	0.709	0.16
151_V	160_S	0.705	0.16
20_S	191_L	0.703	0.16
50_T	223_G	0.702	0.16
213_A	217_R	0.702	0.16
94_F	107_A	0.701	0.16
111_V	193_A	0.699	0.15
119_N	162_D	0.697	0.15
21_V	192_S	0.696	0.15
59_L	174_S	0.694	0.15
71_G	75_A	0.694	0.15
101_A	124_V	0.693	0.15
187_E	222_A	0.686	0.15
40_A	90_L	0.686	0.15
107_A	190_A	0.684	0.15
67_A	217_R	0.683	0.15
176_G	183_V	0.680	0.15
41_L	206_P	0.680	0.15
248_L	254_A	0.676	0.15
10_F	39_V	0.672	0.15
10_F	150_R	0.671	0.15
10_F	41_L	0.671	0.15
148_P	164_V	0.669	0.15
49_V	71_G	0.669	0.15
46_T	83_T	0.668	0.15
126_H	136_L	0.668	0.15
205_D	210_E	0.665	0.15
123_Q	155_A	0.664	0.15
82_V	105_A	0.664	0.15
49_V	83_T	0.661	0.15
252_V	260_S	0.660	0.15
232_A	235_A	0.660	0.15
103_A	107_A	0.660	0.15
92_A	159_G	0.659	0.15
141_A	233_I	0.658	0.15
98_G	142_Q	0.657	0.15
85_E	99_A	0.656	0.14
109_N	133_G	0.654	0.14
207_T	219_A	0.650	0.14
179_S	257_T	0.647	0.14
58_V	83_T	0.644	0.14
65_E	201_A	0.637	0.14
69_V	117_S	0.636	0.14
116_C	131_E	0.634	0.14
49_V	188_T	0.634	0.14
147_L	228_A	0.631	0.14
18_F	103_A	0.629	0.14
133_G	206_P	0.628	0.14
261_D	264_Y	0.626	0.14
226_D	230_A	0.622	0.14
47_V	66_I	0.617	0.14
243_A	252_V	0.616	0.14
156_P	202_L	0.614	0.14
184_I	219_A	0.611	0.14
56_G	234_A	0.610	0.13
52_A	60_N	0.609	0.13
129_D	138_D	0.608	0.13
219_A	225_V	0.607	0.13
56_G	83_T	0.603	0.13
56_G	63_P	0.602	0.13
191_L	222_A	0.600	0.13
19_F	36_G	0.599	0.13
75_A	153_P	0.595	0.13
99_A	138_D	0.593	0.13
73_L	78_V	0.592	0.13
66_I	103_A	0.590	0.13
72_V	125_A	0.589	0.13
92_A	148_P	0.589	0.13
113_G	151_V	0.587	0.13
38_G	153_P	0.587	0.13
103_A	212_V	0.585	0.13
86_T	142_Q	0.584	0.13
219_A	250_R	0.581	0.13
36_G	218_F	0.580	0.13
36_G	97_S	0.580	0.13
36_G	135_G	0.580	0.13
36_G	93_G	0.580	0.13
150_R	253_F	0.578	0.13
16_T	72_V	0.575	0.13
34_S	141_A	0.573	0.13
57_V	65_E	0.572	0.13
27_E	167_S	0.568	0.13
14_H	41_L	0.561	0.12
77_G	131_E	0.561	0.12
133_G	207_T	0.558	0.12
109_N	115_G	0.558	0.12
21_V	47_V	0.558	0.12
92_A	175_F	0.554	0.12
137_G	218_F	0.554	0.12
97_S	137_G	0.554	0.12
93_G	137_G	0.554	0.12
121_L	267_A	0.554	0.12
161_L	175_F	0.553	0.12
117_S	217_R	0.553	0.12
101_A	195_G	0.552	0.12
80_A	111_V	0.550	0.12
151_V	159_G	0.545	0.12
16_T	180_T	0.545	0.12
78_V	124_V	0.545	0.12
88_L	168_G	0.541	0.12
31_A	209_A	0.540	0.12
28_A	133_G	0.540	0.12
90_L	211_F	0.540	0.12
19_F	183_V	0.540	0.12
77_G	226_D	0.539	0.12
125_A	137_G	0.537	0.12
42_S	256_G	0.535	0.12
71_G	124_V	0.531	0.12
148_P	194_A	0.531	0.12
83_T	116_C	0.531	0.12
40_A	86_T	0.530	0.12
70_R	73_L	0.530	0.12
141_A	211_F	0.529	0.12
42_S	260_S	0.527	0.12
104_A	190_A	0.526	0.12
208_V	254_A	0.525	0.12
203_R	206_P	0.523	0.12
69_V	128_A	0.523	0.12
129_D	224_L	0.523	0.12
176_G	202_L	0.522	0.12
155_A	227_A	0.522	0.12
15_V	134_T	0.521	0.12
60_N	206_P	0.520	0.12
60_N	205_D	0.519	0.12
202_L	248_L	0.519	0.12
136_L	249_G	0.519	0.12
12_P	17_G	0.518	0.12
205_D	220_R	0.518	0.12
23_T	168_G	0.517	0.12
10_F	37_A	0.517	0.12
184_I	238_A	0.515	0.12
12_P	19_F	0.514	0.12
111_V	182_D	0.513	0.12
32_S	153_P	0.511	0.12
59_L	86_T	0.507	0.11
203_R	222_A	0.506	0.11
233_I	251_T	0.505	0.11
32_S	159_G	0.504	0.11
128_A	245_M	0.504	0.11
31_A	160_S	0.503	0.11
71_G	131_E	0.503	0.11
222_A	246_A	0.503	0.11
15_V	141_A	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pyfA	1	0.9283	99.9	0.757	Contact Map
4hacA	2	0.9391	99.9	0.759	Contact Map
4n3oA	2	0.9462	99.9	0.767	Contact Map
4rpfA	2	0.9391	99.9	0.772	Contact Map
3k85A	3	0.8674	99.9	0.772	Contact Map
1h72C	2	0.9211	99.8	0.78	Contact Map
2hfsA	1	0.9391	99.8	0.781	Contact Map
4p52A	2	0.9427	99.8	0.786	Contact Map
3gonA	1	0.9427	99.8	0.788	Contact Map
1uekA	1	0.8925	99.8	0.792	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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