GREMLIN Database
GGGPS - Geranylgeranylglyceryl phosphate synthase
UniProt: Q9HSF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 236 (217)
Sequences: 641 (488)
Seq/√Len: 33.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_V129_V7.9611.00
193_D197_A4.6851.00
181_V186_V4.1031.00
194_G197_A3.9851.00
39_I57_C3.7981.00
121_I160_V3.5781.00
93_D134_G3.5741.00
94_P97_I3.0141.00
87_V157_Q2.9501.00
185_A207_T2.7481.00
11_V209_V2.6711.00
193_D216_E2.4441.00
14_I53_V2.4010.99
106_R143_E2.3160.99
95_F100_A2.2950.99
68_P85_V2.2660.99
152_E184_A2.2640.99
38_E84_L2.2490.99
74_V83_Y2.2090.99
130_A137_C2.1880.99
39_I54_I2.1340.99
43_L128_S2.0600.98
145_G173_V2.0340.98
10_H34_T1.9200.97
17_D43_L1.8990.97
208_I229_V1.8900.97
159_V187_F1.8320.96
124_N139_L1.7910.96
168_L200_R1.7900.96
17_D44_D1.7870.96
198_A208_I1.7300.95
195_Y199_Y1.7250.95
39_I64_L1.7110.95
217_A221_A1.6700.94
47_T75_V1.6250.93
150_V154_L1.6070.93
119_A157_Q1.5830.92
25_T219_V1.5660.92
171_P201_M1.5550.91
29_I37_I1.5500.91
51_R75_V1.5370.91
94_P99_G1.5300.91
70_N73_V1.5040.90
50_M66_Q1.4910.89
84_L118_E1.4740.89
175_E179_G1.4430.88
187_F209_V1.4270.87
221_A224_E1.4190.87
51_R79_A1.4080.86
14_I32_T1.4000.86
149_T153_R1.3840.85
172_A175_E1.3750.85
21_V25_T1.3710.85
125_P139_L1.3580.84
87_V155_L1.3570.84
213_L221_A1.3300.83
192_I198_A1.3280.83
11_V36_A1.3280.83
58_R64_L1.3260.83
194_G200_R1.3180.82
127_A135_A1.3120.82
14_I20_L1.2900.81
10_H210_V1.2820.81
156_G204_H1.2780.80
66_Q177_A1.2710.80
150_V182_D1.2710.80
168_L201_M1.2680.80
11_V38_E1.2540.79
109_D153_R1.2540.79
82_G116_T1.2530.79
144_V177_A1.2500.79
55_D79_A1.2450.79
65_Y82_G1.2420.79
98_T155_L1.2240.77
122_V135_A1.1700.74
149_T180_G1.1620.74
86_P133_T1.1570.73
54_I58_R1.1540.73
29_I32_T1.1490.73
56_A59_T1.1310.72
26_F56_A1.1170.71
176_A179_G1.0990.69
141_A145_G1.0820.68
105_V152_E1.0750.68
194_G208_I1.0700.67
42_T201_M1.0560.66
103_E140_D1.0460.66
116_T159_V1.0450.65
12_L214_V1.0410.65
219_V223_R1.0400.65
14_I125_P1.0390.65
14_I26_F1.0240.64
34_T226_V1.0240.64
98_T105_V1.0210.64
148_A152_E1.0210.64
116_T194_G1.0140.63
52_R56_A1.0030.62
12_L34_T0.9970.62
74_V224_E0.9930.61
30_A62_V0.9820.61
91_A133_T0.9750.60
48_E52_R0.9740.60
32_T53_V0.9710.60
212_D215_H0.9700.60
20_L56_A0.9700.60
89_L119_A0.9670.59
168_L171_P0.9640.59
90_N122_V0.9590.59
223_R227_S0.9540.58
17_D128_S0.9520.58
108_A115_T0.9450.58
101_H155_L0.9440.57
164_Y169_G0.9420.57
101_H145_G0.9420.57
60_H64_L0.9380.57
98_T102_K0.9280.56
139_L170_D0.9270.56
76_E79_A0.9250.56
94_P137_C0.9230.56
119_A160_V0.9230.56
109_D149_T0.9040.54
106_R147_Y0.9010.54
130_A135_A0.8980.54
101_H150_V0.8960.54
146_A176_A0.8850.53
57_C64_L0.8810.52
89_L157_Q0.8710.51
42_T97_I0.8650.51
67_E88_V0.8590.50
117_T151_A0.8550.50
161_Y189_G0.8500.50
178_A196_D0.8490.50
98_T117_T0.8480.50
49_K52_R0.8430.49
73_V91_A0.8390.49
39_I62_V0.8380.49
171_P200_R0.8360.49
181_V184_A0.8340.48
88_V133_T0.8320.48
10_H90_N0.8250.48
54_I185_A0.8200.47
107_I160_V0.8190.47
198_A201_M0.8120.47
55_D58_R0.7990.45
217_A224_E0.7970.45
34_T163_E0.7960.45
44_D49_K0.7860.44
124_N129_V0.7860.44
48_E175_E0.7840.44
173_V204_H0.7790.44
48_E55_D0.7790.44
145_G177_A0.7710.43
105_V154_L0.7640.43
93_D99_G0.7640.43
145_G176_A0.7580.42
58_R203_A0.7550.42
162_V188_Y0.7550.42
121_I177_A0.7540.42
62_V116_T0.7540.42
116_T184_A0.7500.41
152_E160_V0.7480.41
87_V173_V0.7470.41
18_K128_S0.7470.41
131_E144_V0.7430.41
122_V127_A0.7420.41
34_T210_V0.7380.40
143_E158_E0.7380.40
138_G173_V0.7380.40
89_L155_L0.7360.40
87_V97_I0.7320.40
119_A206_D0.7320.40
58_R160_V0.7310.40
90_N148_A0.7290.40
36_A163_E0.7220.39
138_G167_T0.7190.39
63_P127_A0.7160.39
47_T173_V0.7130.38
126_D167_T0.7120.38
85_V101_H0.7090.38
97_I126_D0.7070.38
74_V109_D0.7040.38
73_V122_V0.7020.38
30_A60_H0.7000.37
101_H117_T0.7000.37
34_T62_V0.6980.37
11_V127_A0.6980.37
12_L222_V0.6970.37
141_A176_A0.6950.37
50_M119_A0.6940.37
8_W206_D0.6940.37
91_A135_A0.6930.37
130_A139_L0.6930.37
117_T154_L0.6920.37
144_V164_Y0.6900.37
69_S129_V0.6890.37
142_D146_A0.6850.36
195_Y221_A0.6850.36
9_D45_V0.6840.36
17_D49_K0.6810.36
199_Y202_G0.6810.36
156_G203_A0.6790.36
93_D97_I0.6780.36
160_V184_A0.6760.36
96_W112_W0.6730.35
26_F53_V0.6720.35
181_V185_A0.6710.35
92_G134_G0.6690.35
38_E118_E0.6680.35
123_M146_A0.6670.35
106_R110_L0.6610.34
12_L53_V0.6610.34
151_A160_V0.6600.34
14_I54_I0.6580.34
54_I62_V0.6580.34
45_V180_G0.6580.34
102_K167_T0.6560.34
217_A220_D0.6530.34
87_V126_D0.6510.34
50_M63_P0.6480.33
103_E106_R0.6480.33
54_I64_L0.6480.33
152_E207_T0.6460.33
90_N135_A0.6410.33
162_V173_V0.6380.33
197_A200_R0.6350.33
82_G193_D0.6340.32
75_V79_A0.6310.32
71_P104_W0.6290.32
146_A180_G0.6270.32
189_G211_G0.6260.32
10_H33_G0.6240.32
118_E148_A0.6240.32
67_E188_Y0.6220.32
146_A178_A0.6190.31
42_T116_T0.6160.31
174_V206_D0.6160.31
71_P100_A0.6140.31
105_V207_T0.6130.31
46_T169_G0.6120.31
50_M109_D0.6110.31
32_T158_E0.6090.31
7_D182_D0.6060.30
31_Q51_R0.6020.30
156_G193_D0.6020.30
37_I83_Y0.6020.30
54_I82_G0.6010.30
32_T79_A0.5990.30
173_V176_A0.5970.30
68_P126_D0.5920.29
28_D74_V0.5890.29
71_P127_A0.5880.29
80_L83_Y0.5870.29
134_G140_D0.5870.29
91_A97_I0.5860.29
126_D209_V0.5860.29
82_G185_A0.5850.29
97_I150_V0.5840.29
90_N130_A0.5820.29
133_T148_A0.5810.29
174_V216_E0.5800.29
86_P90_N0.5790.29
37_I57_C0.5790.29
161_Y166_G0.5760.28
140_D209_V0.5710.28
134_G173_V0.5710.28
21_V206_D0.5710.28
121_I181_V0.5700.28
26_F186_V0.5690.28
115_T135_A0.5690.28
97_I102_K0.5680.28
39_I175_E0.5670.28
29_I203_A0.5660.28
141_A173_V0.5660.28
54_I75_V0.5630.27
9_D134_G0.5610.27
113_E116_T0.5610.27
55_D220_D0.5570.27
84_L87_V0.5570.27
164_Y188_Y0.5570.27
131_E134_G0.5560.27
7_D115_T0.5540.27
54_I66_Q0.5480.26
66_Q80_L0.5460.26
122_V172_A0.5460.26
94_P98_T0.5450.26
36_A65_Y0.5450.26
90_N133_T0.5430.26
179_G182_D0.5420.26
87_V94_P0.5420.26
57_C87_V0.5380.26
166_G209_V0.5380.26
159_V214_V0.5360.26
119_A151_A0.5350.26
93_D98_T0.5340.26
65_Y84_L0.5330.26
123_M173_V0.5310.25
100_A103_E0.5280.25
90_N125_P0.5270.25
38_E213_L0.5270.25
17_D105_V0.5270.25
29_I57_C0.5250.25
152_E181_V0.5250.25
104_W160_V0.5230.25
58_R62_V0.5220.25
213_L216_E0.5210.25
14_I75_V0.5200.25
132_Y216_E0.5190.25
42_T49_K0.5180.25
68_P105_V0.5170.25
93_D136_D0.5160.24
74_V106_R0.5160.24
131_E141_A0.5160.24
162_V177_A0.5150.24
163_E189_G0.5150.24
70_N100_A0.5140.24
163_E188_Y0.5140.24
101_H112_W0.5130.24
97_I101_H0.5120.24
17_D55_D0.5100.24
122_V133_T0.5080.24
86_P148_A0.5050.24
204_H217_A0.5040.24
10_H198_A0.5040.24
81_D178_A0.5010.24
92_G213_L0.5000.23
93_D209_V0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f6uA 2 0.9364 100 0.591 Contact Map
3vzxA 2 0.9576 100 0.599 Contact Map
3w01A 2 0.9619 100 0.605 Contact Map
4nafA 2 0.9364 100 0.659 Contact Map
3vk5A 2 0.9237 100 0.682 Contact Map
4mm1A 3 0.9449 100 0.686 Contact Map
3ktsA 1 0.7669 99.9 0.718 Contact Map
4jejA 2 0.9322 99.9 0.725 Contact Map
3thaA 2 0.8517 99.6 0.816 Contact Map
1ujpA 1 0.822 99.5 0.823 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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