GREMLIN Database
Q9HSF4 - Uncharacterized protein
UniProt: Q9HSF4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 116 (88)
Sequences: 277 (115)
Seq/√Len: 12.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_G55_P3.0120.96
50_H53_L2.6390.92
48_V62_N2.3000.85
71_L77_E2.2520.84
34_L40_L2.1880.82
41_E48_V2.0760.78
26_L38_R1.9790.75
46_E99_F1.8310.69
51_G68_K1.7590.65
63_K86_D1.7130.63
32_Y40_L1.6370.60
69_S77_E1.6270.59
91_D95_T1.6240.59
83_E86_D1.5910.57
92_L95_T1.5830.57
39_E51_G1.5780.57
36_I57_L1.5490.55
12_A94_W1.5450.55
83_E87_A1.5170.54
32_Y35_A1.5040.53
88_V96_L1.4830.52
50_H65_L1.4620.51
21_N91_D1.4460.50
49_N73_K1.4320.49
31_R77_E1.4080.48
48_V83_E1.3830.47
30_A79_A1.3810.47
24_T91_D1.3480.45
55_P59_D1.3290.44
43_Y94_W1.3260.44
64_G83_E1.2940.42
27_G84_G1.2900.42
12_A31_R1.2880.42
14_D44_Y1.2820.42
68_K94_W1.2770.42
16_T84_G1.2720.41
84_G89_V1.2650.41
48_V69_S1.2340.39
55_P68_K1.2180.39
17_A20_K1.1380.35
20_K59_D1.1230.34
52_R65_L1.1140.34
55_P58_D1.0800.32
32_Y71_L1.0750.32
43_Y81_T1.0720.32
68_K91_D1.0710.32
30_A77_E1.0660.32
27_G95_T1.0500.31
62_N82_N1.0300.30
17_A21_N1.0190.30
26_L31_R0.9990.29
55_P84_G0.9920.28
59_D63_K0.9870.28
26_L80_L0.9820.28
51_G75_T0.9590.27
20_K31_R0.9250.26
22_I59_D0.9220.26
19_Q37_K0.9190.26
16_T19_Q0.9180.26
37_K72_D0.9090.25
66_V79_A0.9080.25
36_I51_G0.9080.25
51_G61_V0.8850.24
26_L66_V0.8810.24
13_R84_G0.8580.23
14_D97_S0.8480.23
66_V85_F0.8330.22
36_I89_V0.8280.22
16_T56_N0.8250.22
18_F74_R0.8070.21
30_A80_L0.8060.21
70_E82_N0.8050.21
87_A90_D0.8040.21
27_G98_K0.8010.21
45_G88_V0.7820.21
58_D84_G0.7740.20
13_R99_F0.7520.20
92_L99_F0.7430.19
14_D50_H0.7430.19
39_E90_D0.7390.19
49_N82_N0.7320.19
22_I85_F0.7310.19
21_N52_R0.7170.19
33_G76_N0.7130.18
29_E61_V0.7020.18
29_E59_D0.6990.18
34_L44_Y0.6930.18
14_D86_D0.6880.18
16_T52_R0.6880.18
49_N72_D0.6810.17
20_K89_V0.6720.17
12_A43_Y0.6530.17
34_L50_H0.6520.17
16_T98_K0.6520.17
18_F75_T0.6510.17
33_G74_R0.6500.17
17_A73_K0.6500.17
44_Y49_N0.6420.16
40_L79_A0.6300.16
92_L96_L0.6290.16
82_N89_V0.6260.16
16_T37_K0.6210.16
45_G58_D0.6120.16
32_Y87_A0.6080.15
71_L85_F0.6020.15
20_K26_L0.6000.15
86_D90_D0.5980.15
57_L78_Y0.5880.15
45_G90_D0.5840.15
52_R80_L0.5830.15
31_R88_V0.5780.15
47_E97_S0.5750.15
55_P79_A0.5710.14
50_H70_E0.5650.14
61_V68_K0.5640.14
22_I47_E0.5640.14
38_R89_V0.5610.14
17_A85_F0.5580.14
14_D66_V0.5560.14
18_F72_D0.5530.14
23_L80_L0.5410.14
27_G39_E0.5400.14
53_L65_L0.5250.13
12_A27_G0.5230.13
57_L75_T0.5220.13
12_A91_D0.5170.13
83_E95_T0.5130.13
28_E31_R0.5100.13
63_K98_K0.5090.13
90_D95_T0.5060.13
39_E68_K0.5000.13
32_Y75_T0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co5A 2 0.8276 98.7 0.775 Contact Map
3l9fA 2 0.8362 98.7 0.781 Contact Map
1yg2A 2 0.7931 98.6 0.789 Contact Map
2e1nA 2 0.8448 98.4 0.799 Contact Map
2eshA 2 0.8707 98.4 0.8 Contact Map
2zfwA 2 0.7931 98.4 0.801 Contact Map
3elkA 3 0.8707 98.3 0.803 Contact Map
2dqlA 2 0.8966 98.3 0.803 Contact Map
3f8bA 2 0.8534 98.3 0.805 Contact Map
1xmaA 2 0.8103 98.3 0.805 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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