GREMLIN Database
IPYR - Inorganic pyrophosphatase
UniProt: Q9HSF3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (164)
Sequences: 2288 (1184)
Seq/√Len: 92.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_V109_A3.9891.00
156_G160_A3.1301.00
163_D167_H2.9951.00
158_A162_K2.5941.00
96_E156_G2.5281.00
128_D132_A2.4501.00
166_E170_D2.4371.00
122_D157_D2.3971.00
17_V88_E2.3841.00
66_D103_Q2.3711.00
20_A73_V2.3671.00
13_D16_D2.3491.00
81_T85_C2.2791.00
135_A139_E2.1921.00
113_E118_D2.1661.00
140_T143_N2.0311.00
90_R121_E1.9061.00
22_V75_V1.9021.00
98_D153_L1.8751.00
121_E125_D1.8681.00
30_N43_L1.8511.00
122_D158_A1.8381.00
94_L156_G1.8371.00
71_F168_A1.8291.00
88_E112_E1.8261.00
66_D171_L1.8221.00
16_D162_K1.7981.00
17_V112_E1.7661.00
167_H171_L1.7111.00
157_D160_A1.7021.00
96_E105_D1.6821.00
132_A135_A1.6611.00
18_I91_P1.6281.00
105_D164_A1.6161.00
81_T87_I1.5661.00
92_V120_V1.5461.00
11_G15_P1.5441.00
82_F85_C1.5301.00
60_I165_I1.5211.00
14_A169_Q1.5131.00
162_K166_E1.4360.99
13_D17_V1.4250.99
170_D173_D1.4120.99
163_D166_E1.4120.99
20_A89_A1.3770.99
18_I89_A1.3550.99
18_I73_V1.3490.99
34_Y59_F1.3490.99
19_Y42_V1.3470.99
94_L164_A1.3450.99
136_E143_N1.3350.99
136_E140_T1.3340.99
35_D38_I1.2990.99
87_I111_P1.2940.99
91_P107_V1.2890.99
91_P165_I1.2650.99
65_Y168_A1.2380.98
123_V126_L1.2340.98
40_G86_V1.2250.98
18_I60_I1.2160.98
94_L161_A1.1930.98
10_T60_I1.1690.98
30_N56_D1.1670.98
96_E153_L1.1500.97
98_D102_E1.1480.97
160_A163_D1.1440.97
48_H115_P1.1390.97
55_S74_L1.1260.97
119_D128_D1.0970.97
124_D157_D1.0910.97
98_D103_Q1.0840.96
34_Y38_I1.0670.96
135_A154_G1.0610.96
145_E148_K1.0580.96
108_I131_K1.0570.96
51_V140_T1.0520.96
89_A109_A1.0510.96
62_Q172_Y1.0470.96
159_Q162_K1.0450.96
129_Q133_E1.0410.95
116_R130_Q1.0400.95
96_E160_A1.0350.95
164_A167_H1.0230.95
42_V88_E1.0220.95
41_V83_P1.0190.95
19_Y88_E1.0190.95
98_D151_A1.0180.95
94_L107_V0.9970.94
34_Y41_V0.9930.94
159_Q163_D0.9890.94
107_V165_I0.9870.94
65_Y103_Q0.9810.94
94_L105_D0.9710.93
43_L46_V0.9710.93
65_Y164_A0.9670.93
19_Y61_P0.9520.93
11_G14_A0.9410.92
108_I123_V0.9290.92
88_E113_E0.9260.92
33_E57_Y0.9150.91
169_Q173_D0.9130.91
33_E142_K0.8980.90
51_V136_E0.8950.90
65_Y171_L0.8910.90
76_L126_L0.8890.90
122_D159_Q0.8890.90
47_L137_F0.8880.90
46_V77_V0.8830.90
57_Y106_K0.8790.89
57_Y142_K0.8790.89
26_K77_V0.8720.89
164_A168_A0.8650.89
60_I71_F0.8570.88
10_T169_Q0.8530.88
30_N82_F0.8510.88
93_A123_V0.8290.87
35_D42_V0.8250.86
49_S136_E0.8180.86
108_I126_L0.8060.85
120_V130_Q0.7990.84
56_D81_T0.7940.84
22_V87_I0.7930.84
135_A152_V0.7930.84
36_K172_Y0.7920.84
95_M134_I0.7880.84
78_E116_R0.7870.84
57_Y99_D0.7800.83
124_D131_K0.7740.83
135_A155_W0.7700.82
71_F101_G0.7690.82
69_D99_D0.7640.82
62_Q169_Q0.7630.82
99_D106_K0.7610.81
56_D82_F0.7510.81
33_E99_D0.7500.81
95_M152_V0.7430.80
55_S134_I0.7420.80
99_D104_D0.7390.80
118_D163_D0.7280.79
115_P118_D0.7250.78
41_V82_F0.7220.78
10_T62_Q0.7200.78
69_D72_D0.7130.77
52_H79_D0.7100.77
65_Y105_D0.7060.76
165_I169_Q0.7050.76
128_D131_K0.7030.76
157_D163_D0.7020.76
47_L53_Y0.7020.76
55_S76_L0.6940.75
43_L56_D0.6930.75
131_K155_W0.6920.75
27_G79_D0.6780.73
11_G18_I0.6720.73
92_V126_L0.6720.73
21_V138_F0.6720.73
160_A164_A0.6710.73
23_E31_K0.6700.73
95_M155_W0.6670.72
106_K142_K0.6670.72
76_L130_Q0.6640.72
32_Y44_D0.6630.72
50_N136_E0.6580.71
29_R133_E0.6570.71
40_G61_P0.6560.71
32_Y83_P0.6550.71
99_D142_K0.6540.71
65_Y71_F0.6520.71
46_V56_D0.6520.71
57_Y104_D0.6510.70
144_L148_K0.6480.70
30_N80_Q0.6470.70
67_D72_D0.6440.70
41_V84_G0.6360.69
108_I155_W0.6300.68
16_D166_E0.6280.68
116_R120_V0.6250.67
24_C33_E0.6240.67
79_D115_P0.6180.66
139_E152_V0.6150.66
159_Q166_E0.6150.66
92_V124_D0.6080.65
125_D131_K0.6070.65
160_A167_H0.6060.65
92_V122_D0.6050.65
123_V131_K0.6010.64
25_L82_F0.6010.64
78_E114_D0.5980.64
36_K168_A0.5910.63
20_A109_A0.5890.63
33_E106_K0.5870.62
24_C142_K0.5860.62
100_D152_V0.5850.62
91_P162_K0.5810.62
33_E44_D0.5810.62
49_S53_Y0.5810.62
119_D167_H0.5780.61
77_V81_T0.5770.61
167_H170_D0.5770.61
81_T89_A0.5750.61
96_E103_Q0.5720.60
74_L138_F0.5710.60
132_A146_A0.5690.60
47_L50_N0.5680.60
120_V127_T0.5670.60
75_V87_I0.5640.59
63_S70_P0.5640.59
10_T14_A0.5610.59
97_M153_L0.5580.59
24_C106_K0.5580.59
63_S165_I0.5570.58
97_M142_K0.5550.58
163_D170_D0.5550.58
163_D173_D0.5550.58
46_V81_T0.5530.58
56_D77_V0.5490.57
64_Y68_G0.5490.57
35_D39_P0.5470.57
90_R118_D0.5430.57
92_V123_V0.5420.56
129_Q132_A0.5400.56
54_P134_I0.5400.56
29_R56_D0.5380.56
97_M100_D0.5350.55
158_A161_A0.5350.55
20_A75_V0.5330.55
35_D44_D0.5310.55
33_E104_D0.5290.55
42_V86_V0.5280.54
107_V161_A0.5280.54
21_V61_P0.5230.54
126_L131_K0.5190.53
143_N149_E0.5160.53
123_V158_A0.5160.53
35_D74_L0.5140.53
76_L169_Q0.5120.52
75_V89_A0.5120.52
168_A171_L0.5110.52
66_D105_D0.5090.52
43_L85_C0.5080.52
48_H114_D0.5050.51
120_V126_L0.5050.51
76_L134_I0.5030.51
14_A17_V0.5030.51
46_V78_E0.5030.51
18_I162_K0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q46A 5 0.9831 100 0.073 Contact Map
4lugA 3 0.9887 100 0.073 Contact Map
2prdA 5 0.9718 100 0.095 Contact Map
3gvfA 5 0.9661 100 0.099 Contact Map
1e9gA 2 1 100 0.105 Contact Map
3fq3A 6 0.9605 100 0.111 Contact Map
2au7A 5 0.9718 100 0.112 Contact Map
3ld3A 5 0.9492 100 0.114 Contact Map
2bqxA 5 0.9266 100 0.127 Contact Map
3tr4A 5 0.9492 100 0.128 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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