GREMLIN Database
Q9HSF1 - Uncharacterized protein
UniProt: Q9HSF1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (300)
Sequences: 4058 (3231)
Seq/√Len: 186.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_A197_G3.7601.00
177_R212_D3.7081.00
86_E187_D3.6591.00
215_R222_E3.6491.00
180_E219_F3.1941.00
65_V73_A2.8771.00
211_A222_E2.8421.00
253_E345_S2.7881.00
83_L179_F2.7701.00
81_C85_E2.7451.00
58_V61_V2.4251.00
163_I174_I2.4181.00
62_A126_D2.3551.00
176_S219_F2.2941.00
336_V344_V2.2661.00
51_L148_A2.2571.00
225_D228_T2.1951.00
61_V127_G2.1501.00
264_G267_P2.1211.00
60_S90_T2.1151.00
215_R218_T2.0491.00
79_G175_V1.9911.00
81_C91_G1.9871.00
63_F131_V1.9381.00
54_A146_V1.9251.00
300_T334_A1.9191.00
84_C93_V1.8681.00
82_D190_V1.8651.00
205_F217_A1.8551.00
187_D190_V1.8491.00
198_I217_A1.8331.00
257_S286_S1.8041.00
345_S349_R1.8041.00
313_D316_A1.7911.00
63_F81_C1.7831.00
176_S216_A1.7601.00
169_G173_T1.7551.00
302_C311_A1.7451.00
302_C315_L1.7251.00
195_Q224_V1.7211.00
192_T224_V1.7201.00
214_F221_E1.7181.00
259_A285_V1.7121.00
252_R279_L1.7101.00
251_N261_T1.7061.00
262_N345_S1.6831.00
60_S92_R1.6781.00
55_I129_V1.6781.00
63_F80_L1.6651.00
239_G243_D1.6641.00
297_T337_P1.6571.00
310_S313_D1.6541.00
63_F77_A1.6481.00
247_A250_E1.6481.00
351_T354_D1.6461.00
346_A350_A1.6301.00
304_A311_A1.6231.00
76_A172_A1.5771.00
165_G212_D1.5681.00
339_G344_V1.5621.00
131_V171_T1.5521.00
71_V196_H1.5451.00
318_A347_D1.5391.00
215_R219_F1.5331.00
50_R53_D1.5191.00
135_G138_P1.5161.00
54_A57_S1.5111.00
242_F282_L1.5081.00
78_T193_A1.4981.00
188_Q224_V1.4961.00
245_I278_T1.4871.00
298_V341_F1.4771.00
146_V160_P1.4701.00
64_V128_A1.4671.00
128_A144_P1.4471.00
168_A174_I1.4351.00
286_S307_V1.4211.00
172_A198_I1.4181.00
104_A108_C1.4001.00
60_S126_D1.3981.00
317_S347_D1.3951.00
343_R347_D1.3761.00
293_V296_D1.3761.00
209_R214_F1.3691.00
130_A133_G1.3631.00
76_A171_T1.3591.00
317_S351_T1.3561.00
71_V200_A1.3501.00
219_F222_E1.3281.00
52_R56_A1.3211.00
77_A93_V1.3171.00
239_G254_R1.3141.00
169_G202_T1.3051.00
318_A351_T1.3011.00
83_L184_H1.2981.00
92_R125_Y1.2901.00
248_A261_T1.2701.00
82_D189_D1.2591.00
350_A353_D1.2471.00
147_V159_H1.2461.00
339_G343_R1.2441.00
80_L129_V1.2421.00
317_S354_D1.2391.00
81_C93_V1.2351.00
82_D187_D1.2271.00
108_C111_F1.2231.00
173_T213_D1.2171.00
188_Q192_T1.2151.00
311_A332_A1.2131.00
53_D57_S1.2041.00
253_E260_V1.1981.00
212_D216_A1.1961.00
350_A354_D1.1881.00
194_L220_L1.1731.00
79_G194_L1.1711.00
310_S329_T1.1701.00
82_D85_E1.1671.00
62_A125_Y1.1671.00
65_V77_A1.1661.00
177_R181_R1.1621.00
247_A267_P1.1601.00
291_F345_S1.1511.00
338_L343_R1.1471.00
82_D86_E1.1401.00
297_T335_R1.1381.00
253_E349_R1.1381.00
255_R353_D1.1381.00
148_A161_L1.1371.00
343_R346_A1.1341.00
58_V127_G1.1251.00
75_A172_A1.1221.00
175_V179_F1.1081.00
55_I84_C1.1061.00
243_D246_G1.0991.00
149_V159_H1.0941.00
100_T103_D1.0921.00
262_N342_S1.0901.00
188_Q225_D1.0841.00
83_L182_A1.0821.00
80_L131_V1.0821.00
168_A177_R1.0811.00
252_R259_A1.0731.00
176_S180_E1.0721.00
76_A131_V1.0671.00
211_A218_T1.0671.00
59_E90_T1.0651.00
86_E190_V1.0571.00
83_L190_V1.0521.00
264_G293_V1.0511.00
265_S293_V1.0441.00
150_I178_F1.0381.00
291_F298_V1.0331.00
239_G252_R1.0211.00
127_G146_V1.0191.00
254_R285_V1.0191.00
55_I58_V1.0151.00
261_T279_L1.0131.00
157_V164_T1.0070.99
79_G190_V1.0060.99
59_E123_D1.0020.99
54_A148_A1.0010.99
339_G347_D1.0000.99
221_E226_Q0.9970.99
238_S283_D0.9910.99
247_A251_N0.9890.99
129_V148_A0.9860.99
230_D234_A0.9850.99
56_A88_G0.9810.99
165_G177_R0.9740.99
230_D233_R0.9740.99
244_V263_V0.9720.99
104_A107_F0.9650.99
87_W184_H0.9580.99
54_A58_V0.9560.99
211_A215_R0.9550.99
286_S306_D0.9530.99
276_A288_A0.9510.99
85_E112_D0.9490.99
154_P329_T0.9350.99
195_Q199_R0.9320.99
200_A233_R0.9310.99
347_D350_A0.9310.99
289_A348_R0.9310.99
105_K108_C0.9300.99
304_A330_D0.9290.99
80_L175_V0.9280.99
224_V229_I0.9270.99
108_C192_T0.9250.99
287_S309_T0.9200.99
243_D247_A0.9070.99
191_A224_V0.9050.99
54_A127_G0.9020.99
61_V89_V0.9000.99
88_G91_G0.8990.99
109_N112_D0.8980.99
314_V352_L0.8980.99
235_P283_D0.8960.99
63_F91_G0.8930.99
302_C314_V0.8900.99
188_Q223_F0.8850.99
59_E126_D0.8830.99
268_A271_S0.8820.99
191_A220_L0.8790.99
104_A111_F0.8730.99
101_S283_D0.8670.98
77_A131_V0.8660.98
53_D56_A0.8630.98
192_T229_I0.8610.98
212_D215_R0.8590.98
107_F193_A0.8580.98
260_V349_R0.8570.98
301_A333_T0.8570.98
199_R204_E0.8550.98
59_E89_V0.8520.98
279_L288_A0.8510.98
260_V291_F0.8510.98
106_A110_L0.8480.98
170_A173_T0.8440.98
192_T228_T0.8440.98
218_T222_E0.8400.98
347_D351_T0.8390.98
296_D337_P0.8330.98
125_Y145_P0.8310.98
289_A314_V0.8230.98
228_T232_L0.8220.98
287_S311_A0.8210.98
336_V339_G0.8200.98
246_G250_E0.8200.98
344_V347_D0.8150.98
121_P124_D0.8140.98
107_F111_F0.8130.98
171_T175_V0.8130.98
131_V172_A0.8050.98
280_L288_A0.8010.97
342_S346_A0.7980.97
147_V160_P0.7980.97
206_R235_P0.7970.97
266_V293_V0.7960.97
139_S142_N0.7920.97
338_L344_V0.7910.97
231_T305_D0.7900.97
169_G213_D0.7850.97
136_T142_N0.7840.97
55_I61_V0.7830.97
51_L163_I0.7830.97
272_L292_G0.7820.97
252_R261_T0.7810.97
214_F217_A0.7780.97
189_D192_T0.7760.97
318_A336_V0.7730.97
216_A219_F0.7720.97
214_F218_T0.7700.97
155_A162_V0.7690.97
205_F214_F0.7680.97
165_G168_A0.7590.96
106_A111_F0.7580.96
324_G337_P0.7560.96
58_V126_D0.7530.96
298_V344_V0.7500.96
275_A290_A0.7480.96
207_R330_D0.7470.96
108_C193_A0.7460.96
57_S146_V0.7460.96
134_G159_H0.7450.96
314_V351_T0.7420.96
81_C95_A0.7380.96
306_D330_D0.7370.96
173_T212_D0.7360.96
251_N267_P0.7360.96
195_Q217_A0.7330.96
103_D106_A0.7320.96
123_D126_D0.7310.96
269_V294_H0.7260.95
244_V248_A0.7230.95
63_F93_V0.7210.95
60_S124_D0.7150.95
176_S194_L0.7140.95
149_V164_T0.7120.95
248_A275_A0.7100.95
209_R226_Q0.7080.95
178_F182_A0.7060.95
177_R180_E0.7060.95
158_D162_V0.7040.95
251_N262_N0.7020.95
201_A325_L0.7010.95
204_E234_A0.6980.94
157_V160_P0.6970.94
100_T104_A0.6960.94
79_G172_A0.6960.94
346_A349_R0.6950.94
171_T174_I0.6950.94
165_G174_I0.6890.94
73_A77_A0.6890.94
49_A53_D0.6880.94
52_R178_F0.6840.94
56_A87_W0.6830.94
115_L119_D0.6800.94
61_V129_V0.6790.94
149_V162_V0.6790.94
77_A172_A0.6780.93
146_V161_L0.6770.93
157_V162_V0.6760.93
318_A344_V0.6740.93
248_A263_V0.6720.93
291_F348_R0.6720.93
179_F190_V0.6710.93
198_I216_A0.6670.93
211_A221_E0.6650.93
206_R230_D0.6650.93
51_L161_L0.6640.93
326_G333_T0.6640.93
265_S295_E0.6610.93
52_R182_A0.6600.93
83_L87_W0.6590.93
136_T156_A0.6590.93
73_A131_V0.6570.92
241_T271_S0.6570.92
101_S105_K0.6560.92
155_A312_M0.6560.92
243_D250_E0.6520.92
302_C334_A0.6470.92
245_I248_A0.6460.92
336_V347_D0.6410.91
318_A324_G0.6410.91
175_V194_L0.6360.91
242_F246_G0.6350.91
287_S314_V0.6330.91
197_G201_A0.6330.91
105_K109_N0.6320.91
236_G283_D0.6320.91
137_V156_A0.6310.91
177_R216_A0.6300.91
312_M316_A0.6270.91
59_E125_Y0.6260.90
48_Y163_I0.6250.90
289_A302_C0.6240.90
170_A197_G0.6240.90
190_V194_L0.6220.90
154_P312_M0.6200.90
51_L80_L0.6190.90
207_R227_G0.6170.90
173_T210_S0.6170.90
273_E301_A0.6160.90
334_A344_V0.6140.90
141_A144_P0.6140.90
159_H162_V0.6140.90
203_R331_T0.6120.89
179_F184_H0.6120.89
244_V275_A0.6120.89
300_T348_R0.6110.89
277_D280_L0.6080.89
276_A290_A0.6080.89
172_A194_L0.6070.89
87_W182_A0.6060.89
80_L84_C0.6040.89
258_F349_R0.6040.89
82_D193_A0.6030.89
255_R349_R0.5980.88
258_F314_V0.5980.88
61_V84_C0.5970.88
153_R201_A0.5970.88
60_S123_D0.5970.88
86_E185_T0.5950.88
307_V330_D0.5900.88
168_A212_D0.5880.88
249_I252_R0.5870.87
262_N298_V0.5850.87
69_P73_A0.5840.87
245_I275_A0.5840.87
291_F344_V0.5830.87
63_F175_V0.5830.87
299_V335_R0.5820.87
179_F182_A0.5820.87
155_A310_S0.5810.87
348_R352_L0.5800.87
293_V298_V0.5770.87
58_V146_V0.5750.86
233_R236_G0.5740.86
114_T117_I0.5710.86
71_V104_A0.5710.86
338_L347_D0.5690.86
237_M241_T0.5660.86
287_S304_A0.5650.85
128_A147_V0.5640.85
61_V91_G0.5620.85
113_L118_A0.5620.85
180_E216_A0.5600.85
238_S241_T0.5600.85
70_S132_G0.5600.85
124_D143_Q0.5600.85
258_F289_A0.5580.85
202_T208_V0.5580.85
254_R259_A0.5570.85
300_T315_L0.5560.85
103_D107_F0.5540.84
245_I249_I0.5540.84
198_I213_D0.5540.84
294_H297_T0.5530.84
210_S218_T0.5530.84
274_E279_L0.5520.84
237_M281_R0.5510.84
141_A147_V0.5500.84
62_A144_P0.5480.84
67_E138_P0.5480.84
291_F341_F0.5460.83
49_A52_R0.5450.83
262_N341_F0.5430.83
342_S345_S0.5430.83
70_S153_R0.5430.83
78_T82_D0.5410.83
99_V110_L0.5400.83
153_R326_G0.5360.82
100_T106_A0.5350.82
186_P191_A0.5350.82
351_T355_L0.5340.82
341_F345_S0.5310.82
254_R282_L0.5280.81
70_S201_A0.5280.81
315_L333_T0.5260.81
235_P280_L0.5260.81
131_V175_V0.5250.81
133_G149_V0.5240.81
352_L355_L0.5240.81
256_A353_D0.5240.81
210_S213_D0.5230.81
103_D108_C0.5230.81
187_D286_S0.5230.81
196_H233_R0.5220.81
276_A280_L0.5210.81
77_A95_A0.5200.80
70_S328_D0.5190.80
204_E230_D0.5170.80
199_R230_D0.5160.80
304_A309_T0.5160.80
73_A79_G0.5140.80
119_D139_S0.5140.80
180_E186_P0.5130.80
303_R328_D0.5120.79
55_I127_G0.5120.79
65_V95_A0.5100.79
84_C129_V0.5090.79
273_E292_G0.5070.79
82_D179_F0.5050.78
184_H190_V0.5040.78
325_L331_T0.5030.78
104_A110_L0.5030.78
174_I179_F0.5020.78
86_E184_H0.5020.78
260_V289_A0.5020.78
349_R352_L0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4py9A 2 0.8437 100 0.346 Contact Map
4ls9A 2 0.8059 100 0.36 Contact Map
3devA 2 0.8086 100 0.37 Contact Map
2hawA 2 0.7709 100 0.482 Contact Map
4rpaA 3 0.7709 100 0.49 Contact Map
1k20A 2 0.7655 100 0.516 Contact Map
2eb0A 2 0.7439 100 0.526 Contact Map
2qb7A 1 0.8437 100 0.58 Contact Map
1wpnA 2 0.4771 100 0.582 Contact Map
2zxrA 1 0.8221 100 0.603 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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