GREMLIN Database
Q9HSF0 - Uncharacterized protein
UniProt: Q9HSF0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 452 (364)
Sequences: 3098 (2370)
Seq/√Len: 124.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_N242_G7.3701.00
64_S74_T4.3811.00
100_T108_D3.3351.00
73_E443_D3.3291.00
15_V429_L3.0721.00
130_R133_S2.8931.00
334_S370_L2.8251.00
227_E230_F2.8051.00
334_S338_T2.6301.00
253_T413_D2.6251.00
39_H43_A2.5861.00
187_Q206_F2.5721.00
241_I245_R2.5551.00
106_V111_R2.4971.00
100_T105_R2.4741.00
191_L243_E2.4571.00
190_F204_G2.4251.00
255_V429_L2.3601.00
16_A252_V2.3381.00
127_N133_S2.3331.00
191_L247_A2.2441.00
129_Q133_S2.2171.00
188_E243_E2.2011.00
63_P97_V2.1861.00
107_T133_S2.1511.00
19_G62_W2.1231.00
127_N134_G2.1211.00
40_D44_A2.0791.00
354_E357_A2.0361.00
16_A254_L2.0341.00
128_V131_M2.0171.00
352_V370_L2.0171.00
44_A410_D2.0141.00
128_V134_G2.0001.00
40_D249_A1.9621.00
14_R200_D1.9541.00
424_D444_G1.9401.00
210_D214_H1.9201.00
111_R200_D1.9161.00
184_D188_E1.8961.00
15_V253_T1.8941.00
127_N130_R1.8791.00
128_V133_S1.8631.00
38_L256_V1.8391.00
53_I64_S1.8261.00
310_L313_E1.8231.00
66_T203_F1.8121.00
35_F39_H1.8051.00
245_R254_L1.7931.00
406_T409_T1.7871.00
38_L241_I1.7841.00
127_N131_M1.7831.00
69_V73_E1.7561.00
109_A436_Q1.7401.00
374_P380_L1.7281.00
41_A408_V1.7201.00
329_V332_E1.7191.00
131_M134_G1.7031.00
146_P149_F1.6951.00
103_W201_L1.6881.00
22_G262_F1.6811.00
18_V254_L1.6761.00
258_S405_A1.6551.00
17_F203_F1.6301.00
106_V113_A1.6231.00
327_D331_A1.6061.00
17_F257_A1.5831.00
69_V99_A1.5801.00
34_T235_E1.5691.00
333_V336_A1.5591.00
214_H259_D1.5461.00
64_S422_L1.5431.00
70_N423_Y1.5281.00
213_N262_F1.5221.00
253_T412_P1.5051.00
127_N132_S1.4931.00
58_S62_W1.4851.00
248_I254_L1.4801.00
242_G246_A1.4721.00
187_Q244_I1.4711.00
132_S135_F1.4651.00
37_N40_D1.4601.00
65_L257_A1.4481.00
330_L334_S1.4441.00
50_I425_I1.4401.00
61_C422_L1.4131.00
52_S61_C1.4111.00
332_E335_D1.4041.00
184_D240_Y1.3881.00
209_T212_V1.3851.00
17_F201_L1.3841.00
130_R134_G1.3781.00
92_P95_Q1.3701.00
82_R87_Y1.3701.00
300_V303_F1.3661.00
214_H260_H1.3621.00
425_I429_L1.3591.00
111_R433_M1.3581.00
253_T432_L1.3531.00
411_A414_V1.3521.00
62_W79_F1.3491.00
183_I186_R1.3461.00
334_S354_E1.3411.00
437_Y440_R1.3391.00
210_D259_D1.3371.00
228_A232_E1.3351.00
40_D245_R1.3231.00
263_T402_F1.3181.00
101_R104_D1.3161.00
65_L425_I1.3091.00
48_G420_T1.3091.00
335_D338_T1.3021.00
309_Y368_P1.2901.00
210_D394_G1.2871.00
186_R190_F1.2751.00
118_V121_T1.2741.00
104_D125_Q1.2691.00
187_Q191_L1.2410.99
29_R47_G1.2350.99
299_Q302_S1.2320.99
36_P238_D1.2310.99
129_Q134_G1.2280.99
212_V233_F1.2230.99
396_R401_S1.2170.99
54_V373_I1.2150.99
30_D231_F1.2150.99
51_E421_N1.2120.99
232_E236_K1.2110.99
224_G227_E1.2050.99
255_V409_T1.2020.99
14_R198_D1.1940.99
21_D259_D1.1930.99
298_T301_Y1.1890.99
58_S259_D1.1820.99
46_S414_V1.1810.99
42_M47_G1.1780.99
50_I405_A1.1760.99
240_Y243_E1.1730.99
272_N275_L1.1690.99
20_I241_I1.1680.99
232_E235_E1.1620.99
112_D197_D1.1570.99
114_T199_W1.1560.99
336_A339_A1.1550.99
35_F234_Y1.1550.99
102_V429_L1.1420.99
129_Q132_S1.1410.99
21_D214_H1.1410.99
79_F394_G1.1380.99
188_E191_L1.1330.99
214_H394_G1.1320.99
275_L280_W1.1270.99
269_V275_L1.1240.99
307_R368_P1.1200.99
58_S260_H1.1190.99
37_N245_R1.1180.99
407_L420_T1.1150.99
182_T186_R1.1060.99
48_G407_L1.1050.99
326_A330_L1.1030.99
421_N424_D1.1020.99
332_E336_A1.0920.99
16_A202_F1.0920.99
270_H273_S1.0890.99
312_R326_A1.0870.99
330_L354_E1.0850.99
14_R252_V1.0810.99
192_E196_A1.0780.99
253_T414_V1.0760.99
41_A245_R1.0710.98
420_T424_D1.0690.98
106_V433_M1.0670.98
183_I194_I1.0660.98
331_A335_D1.0620.98
119_P125_Q1.0610.98
355_G358_V1.0570.98
350_D375_N1.0460.98
70_N443_D1.0320.98
114_T118_V1.0260.98
271_L372_A1.0250.98
330_L370_L1.0240.98
376_H402_F1.0230.98
204_G244_I1.0230.98
36_P242_G1.0170.98
41_A256_V1.0170.98
349_V372_A1.0110.98
208_S212_V1.0070.98
97_V101_R0.9990.98
248_I252_V0.9950.98
131_M135_F0.9940.98
268_E271_L0.9920.98
20_I209_T0.9910.98
376_H400_H0.9880.97
15_V433_M0.9840.97
56_P395_P0.9790.97
55_P71_P0.9780.97
13_G413_D0.9750.97
53_I71_P0.9710.97
206_F244_I0.9680.97
14_R251_D0.9670.97
354_E358_V0.9630.97
305_P308_F0.9620.97
119_P122_F0.9580.97
342_S349_V0.9550.97
305_P312_R0.9540.97
83_E86_S0.9480.97
128_V132_S0.9400.97
276_A279_G0.9400.97
105_R108_D0.9390.97
284_D287_D0.9360.96
18_V241_I0.9360.96
213_N230_F0.9340.96
238_D242_G0.9310.96
34_T231_F0.9300.96
58_S210_D0.9270.96
189_A192_E0.9260.96
49_A418_S0.9250.96
273_S277_D0.9200.96
40_D410_D0.9190.96
23_V234_Y0.9180.96
334_S352_V0.9180.96
298_T303_F0.9170.96
58_S79_F0.9150.96
106_V201_L0.9150.96
182_T185_A0.9140.96
226_N264_S0.9120.96
119_P123_P0.9120.96
128_V135_F0.9090.96
209_T237_V0.9080.96
184_D243_E0.9070.96
84_T369_D0.8990.96
52_S56_P0.8960.95
339_A415_S0.8950.95
40_D43_A0.8950.95
262_F392_R0.8910.95
337_L372_A0.8880.95
351_R375_N0.8870.95
13_G251_D0.8870.95
136_L139_D0.8830.95
41_A410_D0.8820.95
225_D264_S0.8810.95
276_A280_W0.8800.95
299_Q303_F0.8780.95
79_F395_P0.8770.95
352_V372_A0.8720.95
84_T309_Y0.8710.95
216_L229_A0.8700.95
121_T125_Q0.8680.95
298_T302_S0.8680.95
267_Y378_F0.8670.95
192_E195_D0.8660.95
100_T104_D0.8620.94
22_G213_N0.8610.94
27_L213_N0.8600.94
69_V443_D0.8500.94
58_S214_H0.8470.94
144_A147_P0.8470.94
70_N361_G0.8410.94
23_V27_L0.8390.94
62_W214_H0.8310.93
183_I189_A0.8300.93
35_F38_L0.8280.93
103_W115_V0.8270.93
199_W202_F0.8270.93
115_V121_T0.8240.93
117_N121_T0.8240.93
308_F311_N0.8220.93
37_N241_I0.8220.93
398_G401_S0.8180.93
21_D260_H0.8160.93
331_A354_E0.8150.93
132_S138_P0.8150.93
255_V432_L0.8110.92
409_T414_V0.8100.92
270_H275_L0.8060.92
20_I23_V0.8040.92
118_V122_F0.8020.92
329_V337_L0.7980.92
187_Q194_I0.7950.92
134_G138_P0.7950.92
330_L369_D0.7940.92
83_E366_I0.7930.92
79_F210_D0.7830.91
275_L279_G0.7800.91
266_D377_G0.7790.91
277_D283_F0.7780.91
116_M190_F0.7760.91
284_D288_P0.7760.91
118_V125_Q0.7700.90
265_E393_H0.7690.90
351_R357_A0.7690.90
426_A430_L0.7690.90
112_D200_D0.7680.90
257_A405_A0.7650.90
20_I256_V0.7640.90
135_F138_P0.7640.90
330_L356_D0.7640.90
50_I420_T0.7640.90
23_V406_T0.7630.90
121_T124_P0.7620.90
149_F154_E0.7610.90
413_D432_L0.7600.90
54_V397_N0.7600.90
17_F255_V0.7560.90
107_T113_A0.7540.89
336_A340_L0.7520.89
274_W340_L0.7510.89
271_L275_L0.7460.89
150_A154_E0.7450.89
274_W278_Q0.7430.89
263_T376_H0.7420.89
62_W205_V0.7420.89
20_I406_T0.7410.89
231_F235_E0.7390.88
268_E273_S0.7380.88
271_L277_D0.7380.88
147_P152_A0.7380.88
62_W210_D0.7380.88
334_S340_L0.7380.88
122_F125_Q0.7370.88
66_T201_L0.7260.88
145_H148_E0.7210.87
186_R189_A0.7190.87
52_S422_L0.7190.87
130_R135_F0.7190.87
195_D247_A0.7170.87
33_D36_P0.7170.87
305_P311_N0.7140.87
271_L276_A0.7130.87
17_F65_L0.7130.87
310_L329_V0.7130.87
46_S416_I0.7110.86
430_L437_Y0.7100.86
268_E272_N0.7050.86
135_F139_D0.7040.86
282_S287_D0.7030.86
191_L194_I0.7010.86
145_H150_A0.7010.86
257_A406_T0.7000.86
275_L281_L0.6990.86
304_I308_F0.6980.85
18_V244_I0.6980.85
189_A193_Y0.6960.85
414_V428_T0.6960.85
309_Y312_R0.6940.85
427_P443_D0.6920.85
113_A118_V0.6920.85
332_E339_A0.6920.85
70_N421_N0.6910.85
19_G205_V0.6910.85
182_T189_A0.6900.85
310_L330_L0.6890.85
313_E328_A0.6860.84
335_D339_A0.6850.84
244_I247_A0.6840.84
188_E192_E0.6830.84
274_W280_W0.6830.84
66_T102_V0.6800.84
243_E246_A0.6780.84
105_R109_A0.6770.84
307_R312_R0.6770.84
280_W333_V0.6750.84
20_I237_V0.6740.83
63_P99_A0.6730.83
235_E239_R0.6680.83
53_I61_C0.6670.83
272_N279_G0.6660.83
79_F214_H0.6640.83
257_A407_L0.6640.83
249_A252_V0.6640.83
62_W394_G0.6630.82
362_D367_A0.6600.82
36_P246_A0.6580.82
258_S261_G0.6560.82
115_V125_Q0.6560.82
82_R89_T0.6550.82
302_S308_F0.6540.82
335_D356_D0.6510.81
12_A200_D0.6500.81
186_R193_Y0.6490.81
120_V123_P0.6490.81
102_V430_L0.6480.81
103_W119_P0.6470.81
107_T131_M0.6470.81
427_P444_G0.6460.81
420_T428_T0.6430.80
245_R249_A0.6430.80
279_G284_D0.6420.80
210_D260_H0.6420.80
72_G363_H0.6420.80
361_G367_A0.6410.80
195_D243_E0.6400.80
225_D230_F0.6390.80
59_S62_W0.6390.80
72_G361_G0.6360.80
106_V435_V0.6360.80
33_D39_H0.6350.80
116_M193_Y0.6350.80
243_E247_A0.6340.80
82_R86_S0.6340.80
272_N280_W0.6310.79
253_T409_T0.6290.79
185_A194_I0.6270.79
69_V438_D0.6260.79
183_I187_Q0.6240.78
42_M271_L0.6240.78
40_D246_A0.6210.78
44_A335_D0.6190.78
269_V272_N0.6190.78
184_D236_K0.6180.78
337_L340_L0.6180.78
56_P396_R0.6170.78
327_D332_E0.6170.78
306_G312_R0.6160.78
334_S337_L0.6130.77
377_G380_L0.6130.77
428_T444_G0.6120.77
145_H154_E0.6120.77
430_L440_R0.6080.77
190_F202_F0.6080.77
96_D99_A0.6050.76
41_A254_L0.6040.76
194_I247_A0.6040.76
101_R105_R0.6040.76
185_A189_A0.6030.76
269_V277_D0.6010.76
281_L284_D0.6010.76
333_V337_L0.6010.76
239_R242_G0.6010.76
24_P27_L0.6010.76
349_V352_V0.5990.76
28_I408_V0.5990.76
117_N120_V0.5980.76
337_L370_L0.5980.76
75_G366_I0.5980.76
152_A155_A0.5970.75
208_S233_F0.5960.75
34_T38_L0.5950.75
108_D360_D0.5940.75
83_E90_Y0.5940.75
405_A409_T0.5920.75
55_P395_P0.5910.75
274_W277_D0.5890.74
110_G114_T0.5880.74
282_S286_P0.5870.74
59_S79_F0.5860.74
44_A416_I0.5860.74
30_D226_N0.5860.74
285_S288_P0.5840.74
118_V124_P0.5830.74
57_E78_G0.5810.73
115_V203_F0.5800.73
396_R400_H0.5800.73
30_D33_D0.5800.73
207_M211_R0.5790.73
304_I307_R0.5790.73
55_P361_G0.5760.73
259_D394_G0.5760.73
414_V432_L0.5760.73
353_V358_V0.5740.73
423_Y443_D0.5720.72
406_T410_D0.5720.72
115_V120_V0.5710.72
132_S137_S0.5680.72
38_L42_M0.5670.72
353_V373_I0.5660.71
76_V97_V0.5650.71
67_T101_R0.5650.71
134_G139_D0.5620.71
41_A241_I0.5610.71
56_P62_W0.5600.71
337_L349_V0.5540.70
62_W260_H0.5530.70
281_L287_D0.5520.70
55_P58_S0.5510.69
187_Q193_Y0.5510.69
439_S443_D0.5500.69
237_V256_V0.5490.69
306_G309_Y0.5490.69
205_V394_G0.5480.69
148_E152_A0.5480.69
190_F370_L0.5450.69
50_I53_I0.5450.69
25_F402_F0.5450.69
334_S357_A0.5450.69
236_K239_R0.5450.69
146_P154_E0.5440.68
310_L326_A0.5440.68
29_R33_D0.5440.68
328_A332_E0.5430.68
355_G371_V0.5420.68
129_Q135_F0.5420.68
275_L278_Q0.5410.68
79_F259_D0.5410.68
205_V210_D0.5400.68
70_N360_D0.5390.68
192_E197_D0.5390.68
150_A153_L0.5360.67
146_P152_A0.5330.67
23_V209_T0.5330.67
254_L258_S0.5310.67
76_V90_Y0.5300.67
114_T121_T0.5290.66
326_A329_V0.5270.66
331_A334_S0.5270.66
145_H151_D0.5250.66
337_L341_E0.5240.66
276_A282_S0.5230.65
120_V125_Q0.5230.65
250_D410_D0.5220.65
276_A281_L0.5210.65
145_H149_F0.5200.65
350_D353_V0.5200.65
279_G288_P0.5200.65
273_S276_A0.5200.65
281_L285_S0.5190.65
187_Q243_E0.5190.65
64_S283_F0.5180.65
12_A111_R0.5180.65
69_V440_R0.5170.65
119_P205_V0.5170.65
146_P153_L0.5160.64
132_S139_D0.5150.64
272_N277_D0.5140.64
115_V119_P0.5140.64
229_A232_E0.5140.64
253_T411_A0.5130.64
127_N135_F0.5130.64
246_A331_A0.5130.64
33_D234_Y0.5120.64
190_F244_I0.5110.64
306_G310_L0.5090.63
98_Q364_D0.5090.63
84_T271_L0.5080.63
21_D62_W0.5060.63
326_A333_V0.5050.63
51_E419_S0.5050.63
353_V357_A0.5040.63
305_P309_Y0.5040.63
114_T125_Q0.5040.63
308_F312_R0.5040.63
66_T115_V0.5030.63
133_S139_D0.5030.63
92_P258_S0.5020.62
391_F394_G0.5010.62
276_A283_F0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q3qA 2 0.9204 100 0.431 Contact Map
2gsoA 1 0.7788 100 0.466 Contact Map
3nkqA 1 0.7743 100 0.469 Contact Map
4lr2A 1 0.7721 100 0.475 Contact Map
1ei6A 2 0.8341 100 0.477 Contact Map
3szyA 1 0.8429 100 0.477 Contact Map
4gtwA 1 0.8296 100 0.486 Contact Map
3b5qA 1 0.6195 100 0.663 Contact Map
4fdiA 2 0.7013 100 0.665 Contact Map
4upkA 3 0.6659 100 0.666 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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