GREMLIN Database
Q9HSE9 - Cell division protein
UniProt: Q9HSE9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (302)
Sequences: 3490 (1589)
Seq/√Len: 91.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_V54_I5.0591.00
72_A152_T4.3501.00
136_R166_D4.0391.00
229_S309_K4.0151.00
109_S149_S3.9781.00
79_V117_K3.5891.00
79_V118_E3.5851.00
152_T155_R3.1821.00
8_V111_G3.1411.00
129_A157_A3.1281.00
78_D81_E2.9891.00
84_G87_D2.9211.00
157_A160_T2.8801.00
117_K156_E2.8181.00
242_T281_G2.7941.00
21_A48_D2.6671.00
231_E309_K2.6571.00
268_V286_R2.6321.00
234_A245_S2.6261.00
99_V112_A2.4691.00
274_S306_D2.4401.00
133_L143_Q2.4141.00
13_G43_D2.3901.00
181_E184_S2.3871.00
117_K121_R2.3421.00
272_G277_V2.2621.00
140_G144_A2.2311.00
184_S187_A2.1631.00
217_L317_A2.1071.00
41_K45_E2.1061.00
72_A76_T2.0601.00
214_I218_Q2.0541.00
4_A94_T2.0521.00
103_L150_L2.0381.00
83_M122_V1.9951.00
129_A160_T1.9621.00
133_L147_G1.9331.00
83_M121_R1.9301.00
73_E76_T1.9131.00
94_T97_I1.8591.00
229_S311_A1.8321.00
79_V83_M1.8301.00
151_K155_R1.8211.00
6_I86_L1.8121.00
69_E73_E1.8081.00
247_A289_V1.7841.00
37_V115_L1.7821.00
86_L122_V1.7751.00
35_L49_I1.7411.00
144_A148_R1.7381.00
287_T291_D1.6881.00
83_M118_E1.6471.00
244_T248_R1.6301.00
17_E47_L1.6221.00
35_L50_D1.6221.00
18_A183_N1.6131.00
245_S248_R1.6131.00
159_S217_L1.5981.00
16_T36_A1.5901.00
10_Q14_K1.5871.00
80_R83_M1.5841.00
204_G303_F1.5611.00
17_E48_D1.5601.00
282_V300_G1.5551.00
76_T117_K1.5491.00
230_A245_S1.5471.00
187_A191_G1.5371.00
52_M85_G1.5291.00
9_G12_G1.5211.00
275_E308_D1.4761.00
20_L49_I1.4711.00
148_R152_T1.4551.00
118_E122_V1.4310.99
216_T265_A1.4290.99
248_R252_L1.4250.99
196_A208_V1.4220.99
251_L314_V1.4210.99
36_A44_L1.4020.99
81_E84_G1.4000.99
244_T284_K1.3990.99
88_G94_T1.3960.99
189_R225_I1.3800.99
205_E302_D1.3570.99
4_A33_G1.3550.99
8_V115_L1.3480.99
173_D178_A1.3400.99
243_I247_A1.3330.99
141_I145_N1.3220.99
206_S300_G1.3210.99
129_A153_L1.3180.99
101_A131_G1.3130.99
75_M111_G1.2960.99
86_L97_I1.2930.99
266_A293_T1.2920.99
275_E307_S1.2870.99
60_K95_E1.2790.99
133_L257_V1.2480.98
283_E287_T1.2430.98
83_M87_D1.2400.98
176_T304_P1.2380.98
37_V82_V1.2240.98
323_Q326_Q1.1980.98
36_A47_L1.1940.98
66_A299_R1.1930.98
167_A170_S1.1860.98
97_I124_E1.1850.98
141_I297_Q1.1830.98
174_S177_E1.1810.98
321_R324_R1.1800.98
264_G294_R1.1780.98
64_V70_L1.1770.98
285_A310_I1.1770.98
221_E229_S1.1720.98
269_V303_F1.1710.98
130_L190_V1.1690.98
265_A296_M1.1420.97
277_V310_I1.1330.97
261_T292_E1.1290.97
172_G280_K1.1240.97
166_D169_R1.0800.96
67_D215_N1.0770.96
277_V282_V1.0690.96
169_R283_E1.0620.96
271_A303_F1.0590.96
106_G110_G1.0560.96
69_E72_A1.0560.96
176_T274_S1.0550.96
22_E187_A1.0500.96
177_E180_D1.0300.95
35_L85_G1.0280.95
147_G151_K1.0280.95
13_G36_A1.0270.95
305_L311_A1.0270.95
63_G106_G1.0210.95
172_G278_S1.0210.95
33_G50_D1.0200.95
159_S220_G1.0170.95
220_G227_F1.0020.94
265_A294_R0.9970.94
173_D280_K0.9930.94
204_G269_V0.9910.94
145_N148_R0.9810.94
66_A215_N0.9770.93
82_V118_E0.9720.93
293_T296_M0.9700.93
99_V116_V0.9680.93
97_I115_L0.9640.93
231_E308_D0.9630.93
46_G287_T0.9610.93
20_L34_T0.9590.93
56_Q81_E0.9580.93
65_G106_G0.9470.92
24_Q187_A0.9440.92
133_L164_D0.9430.92
180_D183_N0.9380.92
40_A43_D0.9360.92
282_V286_R0.9350.92
242_T278_S0.9350.92
221_E232_A0.9340.92
233_A242_T0.9320.92
221_E230_A0.9270.91
18_A189_R0.9240.91
17_E46_G0.9200.91
19_L34_T0.9140.91
18_A22_E0.9140.91
75_M82_V0.9100.91
20_L23_D0.9090.91
246_T312_V0.9080.91
53_L56_Q0.9050.90
152_T156_E0.9020.90
18_A21_A0.9010.90
288_W291_D0.9000.90
245_S249_K0.8990.90
103_L131_G0.8980.90
50_D85_G0.8920.90
54_I111_G0.8920.90
216_T299_R0.8880.90
286_R300_G0.8820.89
67_D73_E0.8810.89
114_V118_E0.8790.89
15_V19_L0.8790.89
175_V302_D0.8780.89
118_E121_R0.8740.89
244_T288_W0.8700.89
148_R151_K0.8690.89
11_A15_V0.8690.89
287_T290_E0.8640.88
322_S326_Q0.8630.88
151_K154_V0.8600.88
20_L24_Q0.8600.88
86_L94_T0.8560.88
95_E169_R0.8540.88
94_T124_E0.8540.88
143_Q147_G0.8520.88
96_A217_L0.8400.87
191_G195_A0.8400.87
224_A258_P0.8370.87
33_G94_T0.8300.86
61_G65_G0.8250.86
25_R202_G0.8130.85
19_L23_D0.8100.85
167_A253_S0.8060.85
36_A49_I0.8060.85
168_W182_I0.8040.84
322_S325_L0.8040.84
228_A246_T0.7980.84
259_Q266_A0.7950.84
4_A35_L0.7930.84
21_A180_D0.7890.83
321_R326_Q0.7890.83
168_W279_R0.7880.83
38_N43_D0.7880.83
136_R287_T0.7860.83
321_R325_L0.7840.83
266_A316_L0.7780.82
101_A112_A0.7780.82
6_I37_V0.7730.82
141_I144_A0.7690.82
96_A127_V0.7630.81
6_I97_I0.7610.81
6_I124_E0.7590.81
11_A20_L0.7580.81
99_V115_L0.7580.81
58_R73_E0.7560.81
11_A319_I0.7550.81
288_W292_E0.7550.81
52_M82_V0.7540.80
22_E180_D0.7490.80
243_I310_I0.7490.80
15_V34_T0.7470.80
56_Q78_D0.7440.80
144_A147_G0.7440.80
47_L51_T0.7440.80
58_R70_L0.7400.79
173_D177_E0.7370.79
103_L149_S0.7360.79
265_A297_Q0.7340.79
272_G280_K0.7290.78
112_A116_V0.7250.78
175_V179_F0.7240.78
71_G106_G0.7200.77
120_Q158_D0.7190.77
9_G15_V0.7170.77
138_E179_F0.7150.77
221_E228_A0.7140.77
184_S188_R0.7140.77
280_K286_R0.7120.77
76_T79_V0.7110.76
272_G282_V0.7090.76
18_A37_V0.7080.76
36_A51_T0.7070.76
15_V186_I0.7060.76
66_A145_N0.7030.76
285_A312_V0.7030.76
24_Q27_E0.7020.76
10_Q40_A0.7010.75
219_S222_M0.6980.75
7_G12_G0.6950.75
264_G320_S0.6940.75
215_N299_R0.6940.75
222_M268_V0.6930.75
310_I323_Q0.6900.74
164_D185_R0.6880.74
282_V292_E0.6870.74
174_S278_S0.6870.74
208_V213_V0.6850.74
75_M114_V0.6840.74
205_E304_P0.6830.74
111_G115_L0.6820.73
6_I115_L0.6800.73
222_M320_S0.6790.73
268_V282_V0.6780.73
315_L319_I0.6780.73
21_A24_Q0.6770.73
98_F223_S0.6770.73
183_N286_R0.6750.73
98_F127_V0.6740.73
192_I313_L0.6730.72
265_A318_G0.6730.72
190_V193_L0.6720.72
277_V300_G0.6700.72
200_I213_V0.6680.72
220_G265_A0.6670.72
171_T280_K0.6630.71
208_V299_R0.6620.71
145_N297_Q0.6620.71
264_G318_G0.6590.71
248_R288_W0.6580.71
38_N65_G0.6560.71
11_A19_L0.6540.70
169_R280_K0.6510.70
201_E204_G0.6500.70
132_I135_G0.6450.69
70_L73_E0.6440.69
37_V85_G0.6420.69
64_V106_G0.6420.69
133_L315_L0.6410.69
78_D83_M0.6380.68
150_L162_L0.6360.68
164_D258_P0.6360.68
250_A255_M0.6310.68
205_E282_V0.6310.68
105_G165_N0.6300.67
16_T19_L0.6300.67
11_A132_I0.6300.67
176_T205_E0.6270.67
139_G298_V0.6260.67
99_V129_A0.6240.67
204_G207_V0.6230.67
9_G16_T0.6210.66
247_A270_A0.6210.66
253_S319_I0.6200.66
143_Q166_D0.6190.66
59_V65_G0.6180.66
202_G303_F0.6170.66
219_S230_A0.6160.66
63_G108_G0.6130.65
270_A285_A0.6130.65
277_V284_K0.6110.65
65_G68_N0.6070.65
141_I295_S0.6050.64
246_T250_A0.6040.64
211_S214_I0.6010.64
219_S229_S0.6010.64
114_V117_K0.6010.64
278_S304_P0.5990.64
85_G94_T0.5960.63
271_A278_S0.5960.63
145_N222_M0.5950.63
208_V212_E0.5920.63
43_D66_A0.5920.63
79_V115_L0.5910.63
38_N42_T0.5910.63
280_K284_K0.5890.62
183_N300_G0.5880.62
159_S223_S0.5870.62
20_L47_L0.5860.62
289_V292_E0.5860.62
219_S264_G0.5850.62
10_Q16_T0.5840.62
20_L48_D0.5840.62
226_G250_A0.5840.62
38_N106_G0.5840.62
221_E227_F0.5820.61
216_T296_M0.5810.61
228_A250_A0.5810.61
292_E319_I0.5800.61
304_P307_S0.5800.61
133_L150_L0.5790.61
282_V285_A0.5780.61
154_V222_M0.5780.61
87_D122_V0.5770.61
59_V70_L0.5760.61
17_E20_L0.5760.61
196_A315_L0.5750.60
10_Q15_V0.5740.60
298_V305_L0.5730.60
274_S304_P0.5720.60
55_G61_G0.5720.60
62_H66_A0.5700.60
271_A311_A0.5690.60
299_R302_D0.5680.59
163_V193_L0.5660.59
131_G162_L0.5650.59
192_I203_V0.5640.59
59_V62_H0.5630.59
36_A48_D0.5620.59
116_V153_L0.5590.58
17_E36_A0.5560.58
191_G227_F0.5540.58
135_G138_E0.5530.57
121_R215_N0.5530.57
144_A295_S0.5530.57
95_E211_S0.5520.57
96_A284_K0.5510.57
38_N63_G0.5510.57
242_T310_I0.5500.57
103_L129_A0.5500.57
264_G295_S0.5490.57
81_E87_D0.5470.57
14_K109_S0.5450.56
188_R227_F0.5450.56
120_Q249_K0.5430.56
5_L168_W0.5430.56
222_M229_S0.5420.56
112_A153_L0.5390.56
60_K304_P0.5380.55
38_N64_V0.5380.55
24_Q195_A0.5370.55
174_S187_A0.5360.55
46_G203_V0.5360.55
166_D170_S0.5360.55
262_E294_R0.5360.55
210_S213_V0.5360.55
99_V124_E0.5350.55
63_G67_D0.5350.55
79_V121_R0.5340.55
62_H65_G0.5330.55
164_D204_G0.5330.55
163_V209_D0.5330.55
67_D70_L0.5320.55
228_A232_A0.5300.54
44_L54_I0.5300.54
294_R307_S0.5280.54
230_A233_A0.5280.54
243_I288_W0.5270.54
68_N109_S0.5270.54
190_V216_T0.5270.54
82_V86_L0.5260.54
136_R261_T0.5250.54
273_E280_K0.5250.54
124_E224_A0.5250.54
207_V210_S0.5250.54
274_S290_E0.5230.53
249_K295_S0.5220.53
137_D300_G0.5210.53
266_A269_V0.5210.53
25_R81_E0.5210.53
9_G14_K0.5200.53
12_G15_V0.5200.53
80_R84_G0.5200.53
144_A323_Q0.5190.53
249_K252_L0.5190.53
260_T264_G0.5190.53
134_P146_A0.5180.53
248_R267_L0.5180.53
35_L82_V0.5180.53
8_V13_G0.5160.52
17_E49_I0.5160.52
279_R282_V0.5150.52
103_L112_A0.5150.52
23_D312_V0.5120.52
76_T80_R0.5120.52
297_Q302_D0.5120.52
61_G106_G0.5120.52
7_G16_T0.5120.52
14_K20_L0.5100.52
202_G302_D0.5100.52
203_V303_F0.5090.51
137_D179_F0.5080.51
5_L34_T0.5080.51
264_G290_E0.5070.51
288_W293_T0.5060.51
140_G294_R0.5040.51
268_V312_V0.5030.51
247_A259_Q0.5030.51
75_M125_I0.5020.50
113_P138_E0.5020.50
78_D111_G0.5010.50
273_E278_S0.5010.50
217_L223_S0.5010.50
63_G113_P0.5000.50
54_I176_T0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4b45A 1 0.9356 100 0.19 Contact Map
4b46A 1 0.9076 100 0.217 Contact Map
4ei7A 1 0.93 100 0.237 Contact Map
2vapA 1 0.8711 100 0.254 Contact Map
1rq2A 2 0.8207 100 0.263 Contact Map
2vawA 1 0.8319 100 0.264 Contact Map
2vxyA 2 0.8347 100 0.265 Contact Map
1w5fA 2 0.8543 100 0.265 Contact Map
2r751 1 0.8824 100 0.266 Contact Map
4m8iA 1 0.8487 100 0.266 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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