GREMLIN Database
Q9HSE7 - Uncharacterized protein
UniProt: Q9HSE7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (272)
Sequences: 59034 (41807)
Seq/√Len: 2534.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_W281_R2.8811.00
196_V211_A2.6991.00
18_R195_G2.6891.00
207_D267_R2.5441.00
82_E86_D2.4681.00
108_T197_V2.3551.00
65_A201_L2.3481.00
209_L270_E2.3141.00
279_T282_S2.2311.00
29_V49_A2.1891.00
68_F107_Y2.1781.00
18_R198_A2.1531.00
104_Q155_D2.1431.00
228_D281_R2.1351.00
58_A97_G2.1061.00
18_R22_A2.0521.00
195_G276_A2.0331.00
229_E285_Q2.0321.00
123_D126_T1.9781.00
161_F197_V1.9671.00
27_V63_A1.9621.00
165_Y283_G1.9571.00
269_T274_S1.9541.00
53_D56_S1.9541.00
6_L68_F1.9521.00
67_V201_L1.9421.00
220_W224_D1.8891.00
4_A63_A1.8841.00
76_G79_A1.8661.00
49_A56_S1.8411.00
225_W228_D1.8381.00
27_V45_T1.8351.00
191_D286_A1.8231.00
159_V200_A1.8031.00
5_I16_A1.7991.00
195_G199_F1.7851.00
22_A202_T1.7721.00
218_S221_A1.7701.00
145_A156_P1.7471.00
27_V47_V1.7041.00
15_L194_A1.6961.00
214_D269_T1.6781.00
89_R144_V1.6241.00
52_T82_E1.6031.00
109_S113_V1.5871.00
15_L67_V1.5781.00
22_A198_A1.5741.00
189_H286_A1.5741.00
58_A94_Q1.5711.00
139_V143_R1.5471.00
198_A202_T1.5471.00
89_R93_E1.5461.00
32_S35_S1.5401.00
81_R140_D1.5261.00
54_A93_E1.5211.00
25_D45_T1.5201.00
86_D89_R1.5031.00
161_F193_A1.4711.00
104_Q157_T1.4711.00
18_R21_A1.4711.00
15_L69_A1.4451.00
225_W229_E1.4441.00
134_K138_L1.4421.00
64_D103_E1.4401.00
162_A263_C1.4401.00
159_V197_V1.4371.00
88_L141_A1.4301.00
285_Q289_R1.4301.00
268_L271_L1.4271.00
265_N269_T1.4191.00
189_H283_G1.4171.00
124_E267_R1.4081.00
67_V197_V1.3971.00
78_D82_E1.3911.00
18_R194_A1.3861.00
173_T177_D1.3801.00
128_L139_V1.3801.00
17_R168_D1.3761.00
114_Y210_L1.3701.00
11_V164_L1.3551.00
69_A108_T1.3521.00
173_T176_L1.3501.00
108_T161_F1.3381.00
16_A28_G1.3291.00
3_V24_H1.3281.00
24_H202_T1.3251.00
54_A58_A1.3171.00
221_A224_D1.3021.00
184_Y216_P1.2921.00
190_R194_A1.2701.00
68_F88_L1.2681.00
277_H286_A1.2671.00
54_A90_T1.2661.00
171_R175_Y1.2601.00
66_V95_F1.2591.00
188_I193_A1.2581.00
282_S285_Q1.2581.00
199_F203_D1.2331.00
160_R208_V1.2311.00
143_R146_L1.2231.00
84_Y137_A1.2121.00
107_Y141_A1.2111.00
173_T178_G1.1991.00
19_L198_A1.1881.00
146_L158_V1.1841.00
174_R178_G1.1781.00
93_E96_G1.1681.00
207_D270_E1.1671.00
186_N214_D1.1561.00
123_D264_S1.1521.00
8_C30_C1.1341.00
282_S286_A1.1331.00
267_R270_E1.1301.00
28_G44_A1.1261.00
91_V105_L1.1251.00
136_A140_D1.1251.00
10_Y166_G1.1241.00
179_P237_K1.1211.00
196_V268_L1.1211.00
51_V87_G1.1201.00
119_G126_T1.1201.00
122_V126_T1.1161.00
14_A191_D1.1161.00
217_V280_F1.1101.00
119_G123_D1.1081.00
142_E160_R1.1021.00
96_G152_H1.1011.00
18_R191_D1.0951.00
17_R21_A1.0941.00
93_E97_G1.0931.00
160_R210_L1.0881.00
107_Y158_V1.0851.00
195_G273_Y1.0781.00
56_S59_A1.0761.00
144_V147_T1.0741.00
265_N275_F1.0731.00
4_A29_V1.0721.00
37_D40_R1.0671.00
3_V19_L1.0571.00
182_E218_S1.0561.00
212_V263_C1.0541.00
182_E220_W1.0531.00
51_V70_A1.0461.00
20_L44_A1.0461.00
107_Y145_A1.0451.00
227_A233_P1.0451.00
69_A197_V1.0451.00
106_V159_V1.0401.00
125_E267_R1.0391.00
92_V105_L1.0381.00
224_D227_A1.0351.00
146_L156_P1.0351.00
281_R285_Q1.0331.00
14_A190_R1.0331.00
146_L208_V1.0281.00
199_F271_L1.0241.00
220_W238_Q1.0231.00
58_A100_D1.0211.00
192_D213_D1.0201.00
13_C168_D1.0091.00
95_F105_L1.0091.00
216_P260_S1.0041.00
189_H277_H0.9931.00
230_A288_I0.9881.00
33_P48_R0.9871.00
83_V87_G0.9831.00
227_A234_Q0.9751.00
165_Y189_H0.9671.00
229_E288_I0.9621.00
90_T93_E0.9621.00
216_P262_R0.9571.00
3_V65_A0.9531.00
149_A156_P0.9521.00
164_L193_A0.9511.00
92_V148_D0.9391.00
6_L91_V0.9381.00
189_H192_D0.9351.00
80_A137_A0.9281.00
195_G277_H0.9281.00
157_T200_A0.9211.00
217_V221_A0.9181.00
209_L267_R0.9171.00
86_D90_T0.9151.00
175_Y178_G0.9071.00
184_Y218_S0.9031.00
105_L145_A0.9031.00
57_L94_Q0.9031.00
10_Y190_R0.9031.00
109_S142_E0.9001.00
29_V57_L0.8991.00
6_L70_A0.8981.00
171_R174_R0.8891.00
81_R85_V0.8861.00
96_G154_L0.8841.00
15_L19_L0.8821.00
55_A58_A0.8771.00
286_A289_R0.8761.00
111_T162_A0.8741.00
196_V273_Y0.8711.00
29_V56_S0.8661.00
14_A17_R0.8661.00
199_F202_T0.8631.00
27_V62_D0.8631.00
92_V145_A0.8631.00
212_V265_N0.8621.00
171_R178_G0.8601.00
30_C46_A0.8571.00
158_V208_V0.8571.00
159_V211_A0.8551.00
94_Q97_G0.8541.00
104_Q204_A0.8541.00
191_D277_H0.8521.00
85_V140_D0.8511.00
229_E281_R0.8481.00
24_H64_D0.8431.00
20_L26_V0.8351.00
140_D143_R0.8321.00
164_L188_I0.8271.00
184_Y260_S0.8261.00
81_R86_D0.8231.00
229_E284_Y0.8211.00
215_D279_T0.8121.00
174_R177_D0.8111.00
31_R50_D0.8101.00
52_T83_V0.8101.00
65_A104_Q0.8081.00
88_L145_A0.8011.00
227_A232_V0.8011.00
92_V144_V0.7951.00
11_V193_A0.7911.00
146_L150_S0.7901.00
90_T94_Q0.7891.00
214_D265_N0.7891.00
200_A271_L0.7881.00
3_V67_V0.7881.00
16_A26_V0.7851.00
266_A269_T0.7841.00
54_A97_G0.7821.00
199_F273_Y0.7811.00
217_V222_F0.7801.00
14_A194_A0.7751.00
111_T263_C0.7741.00
200_A268_L0.7741.00
94_Q100_D0.7691.00
79_A83_V0.7621.00
113_V142_E0.7601.00
120_D126_T0.7591.00
195_G198_A0.7561.00
14_A18_R0.7551.00
102_P155_D0.7541.00
96_G153_G0.7451.00
221_A225_W0.7441.00
162_A212_V0.7431.00
199_F272_G0.7431.00
60_V63_A0.7431.00
61_P100_D0.7421.00
3_V201_L0.7411.00
66_V91_V0.7391.00
277_H282_S0.7351.00
234_Q237_K0.7321.00
79_A82_E0.7321.00
148_D152_H0.7311.00
143_R147_T0.7261.00
15_L197_V0.7221.00
81_R137_A0.7171.00
224_D228_D0.7171.00
58_A61_P0.7151.00
97_G100_D0.7151.00
113_V128_L0.7151.00
130_P135_T0.7141.00
167_P286_A0.7131.00
32_S46_A0.7121.00
88_L92_V0.7101.00
96_G148_D0.7071.00
124_E268_L0.7061.00
277_H283_G0.7001.00
211_A268_L0.6971.00
163_G185_L0.6951.00
68_F91_V0.6911.00
229_E289_R0.6911.00
87_G90_T0.6901.00
36_L40_R0.6871.00
32_S36_L0.6861.00
95_F102_P0.6841.00
205_D270_E0.6841.00
95_F101_P0.6831.00
19_L201_L0.6831.00
60_V66_V0.6821.00
66_V105_L0.6821.00
103_E155_D0.6781.00
140_D144_V0.6761.00
258_R261_K0.6751.00
225_W280_F0.6751.00
13_C17_R0.6741.00
167_P189_H0.6671.00
68_F105_L0.6661.00
186_N213_D0.6661.00
184_Y262_R0.6631.00
136_A143_R0.6631.00
4_A49_A0.6621.00
110_S138_L0.6591.00
194_A198_A0.6581.00
156_P206_A0.6581.00
53_D57_L0.6571.00
231_G235_P0.6551.00
117_H122_V0.6521.00
4_A66_V0.6501.00
118_D126_T0.6461.00
50_D53_D0.6401.00
141_A145_A0.6391.00
222_F280_F0.6381.00
22_A195_G0.6381.00
93_E148_D0.6371.00
269_T275_F0.6371.00
121_W264_S0.6331.00
161_F164_L0.6301.00
34_D37_D0.6281.00
20_L43_G0.6271.00
32_S37_D0.6271.00
112_G135_T0.6271.00
8_C28_G0.6261.00
236_A240_V0.6241.00
183_G219_K0.6211.00
132_T135_T0.6191.00
115_G129_D0.6181.00
147_T151_E0.6171.00
65_A106_V0.6151.00
57_L90_T0.6131.00
40_R43_G0.6111.00
71_S84_Y0.6091.00
136_A147_T0.6091.00
121_W262_R0.6081.00
192_D195_G0.6061.00
24_H65_A0.6031.00
133_E136_A0.6011.00
192_D276_A0.6001.00
69_A161_F0.5981.00
22_A199_F0.5941.00
128_L143_R0.5911.00
186_N216_P0.5901.00
227_A230_A0.5861.00
137_A141_A0.5841.00
155_D205_D0.5841.00
14_A168_D0.5831.00
106_V201_L0.5801.00
15_L198_A0.5801.00
227_A236_A0.5801.00
65_A103_E0.5781.00
159_V196_V0.5781.00
223_A227_A0.5731.00
231_G234_Q0.5711.00
37_D41_E0.5711.00
215_D281_R0.5691.00
106_V197_V0.5691.00
33_P37_D0.5681.00
254_E257_L0.5681.00
171_R176_L0.5681.00
106_V200_A0.5671.00
134_K137_A0.5661.00
232_V235_P0.5661.00
17_R191_D0.5661.00
124_E210_L0.5641.00
193_A211_A0.5631.00
123_D266_A0.5631.00
88_L107_Y0.5571.00
81_R136_A0.5551.00
276_A282_S0.5521.00
162_A186_N0.5491.00
4_A60_V0.5481.00
39_V43_G0.5481.00
235_P238_Q0.5481.00
185_L219_K0.5481.00
130_P133_E0.5471.00
35_S39_V0.5431.00
165_Y213_D0.5431.00
77_A136_A0.5421.00
47_V56_S0.5411.00
84_Y134_K0.5411.00
16_A20_L0.5401.00
47_V59_A0.5401.00
28_G46_A0.5371.00
167_P191_D0.5361.00
145_A158_V0.5351.00
225_W284_Y0.5331.00
130_P139_V0.5301.00
110_S113_V0.5301.00
234_Q238_Q0.5291.00
19_L24_H0.5291.00
61_P66_V0.5201.00
19_L67_V0.5191.00
172_L175_Y0.5161.00
23_G26_V0.5161.00
217_V225_W0.5161.00
209_L268_L0.5161.00
111_T261_K0.5141.00
117_H120_D0.5141.00
120_D260_S0.5131.00
5_I19_L0.5131.00
163_G187_M0.5101.00
198_A201_L0.5091.00
109_S160_R0.5091.00
128_L208_V0.5081.00
221_A281_R0.5071.00
234_Q240_V0.5071.00
158_V206_A0.5051.00
54_A94_Q0.5021.00
149_A154_L0.5011.00
268_L275_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gpiA 1 0.8788 100 0.244 Contact Map
1rkxA 3 0.9394 100 0.249 Contact Map
1sb8A 2 0.963 100 0.25 Contact Map
2c20A 2 0.9529 100 0.251 Contact Map
1rpnA 4 0.9596 100 0.257 Contact Map
3rufA 2 0.9461 100 0.258 Contact Map
1gy8A 2 0.9529 100 0.259 Contact Map
3m2pA 2 0.9259 100 0.261 Contact Map
1n7hA 4 0.9596 100 0.262 Contact Map
2c5aA 2 0.9461 100 0.264 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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