GREMLIN Database
Q9HSE6 - Uncharacterized protein
UniProt: Q9HSE6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 362 (296)
Sequences: 18725 (12471)
Seq/√Len: 724.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_A341_T3.7391.00
48_D83_R3.6841.00
86_R157_G3.0501.00
150_D200_D2.8111.00
309_A356_A2.7111.00
307_Q359_A2.6941.00
57_A61_A2.6481.00
193_E197_A2.5871.00
146_D198_A2.4061.00
353_G356_A2.3911.00
76_R79_R2.3761.00
149_V195_R2.3531.00
25_R30_A2.3161.00
99_T161_I2.2891.00
24_R33_S2.2721.00
35_G65_V2.2111.00
146_D194_Q2.1401.00
61_A341_T2.1381.00
302_S306_T2.1251.00
160_T202_T2.0471.00
142_P194_Q2.0371.00
47_V50_A2.0121.00
165_Y223_D2.0111.00
101_G145_I1.9851.00
354_A358_D1.9651.00
91_P94_A1.8941.00
194_Q197_A1.8921.00
149_V161_I1.8871.00
165_Y250_V1.8851.00
61_A344_A1.8721.00
237_T240_N1.8631.00
300_I303_A1.8621.00
142_P146_D1.8231.00
345_D348_T1.8181.00
58_G63_V1.7971.00
38_T66_I1.7671.00
149_V164_Y1.7601.00
323_S357_F1.7491.00
52_Y84_A1.6981.00
98_A165_Y1.6911.00
55_V84_A1.6901.00
70_V148_M1.6861.00
22_Y33_S1.6841.00
311_E349_F1.6831.00
147_A151_R1.6611.00
48_D52_Y1.6611.00
201_I204_Y1.6581.00
307_Q356_A1.6541.00
319_N349_F1.6431.00
303_A359_A1.6191.00
232_R235_A1.6151.00
97_L158_V1.6121.00
215_P244_H1.6091.00
29_C96_F1.5991.00
57_A337_A1.5761.00
312_T342_E1.5671.00
101_G164_Y1.5641.00
241_T245_L1.5621.00
210_E213_R1.5481.00
311_E315_Q1.5431.00
52_Y56_R1.5381.00
166_V192_L1.5361.00
194_Q198_A1.5111.00
312_T315_Q1.4801.00
99_T152_S1.4761.00
169_P213_R1.4621.00
242_A249_Q1.4621.00
59_L95_V1.4551.00
275_L279_H1.4361.00
23_F30_A1.4231.00
191_R194_Q1.4071.00
337_A341_T1.4011.00
52_Y83_R1.3971.00
195_R201_I1.3941.00
25_R28_D1.3861.00
243_T325_P1.3831.00
50_A53_E1.3771.00
303_A307_Q1.3761.00
265_Q302_S1.3741.00
302_S313_P1.3671.00
151_R154_S1.3661.00
161_I201_I1.3631.00
324_A361_F1.3471.00
215_P219_D1.3341.00
243_T326_G1.3341.00
54_T340_V1.3271.00
66_I81_V1.3181.00
55_V66_I1.3161.00
311_E316_R1.3131.00
64_N96_F1.3121.00
211_A241_T1.3101.00
53_E337_A1.2921.00
234_A249_Q1.2901.00
321_A330_A1.2811.00
70_V144_Y1.2791.00
299_G302_S1.2741.00
204_Y221_Y1.2701.00
146_D191_R1.2671.00
338_D341_T1.2391.00
190_E194_Q1.2381.00
79_R155_N1.2361.00
56_R60_T1.2271.00
206_V221_Y1.2221.00
92_R158_V1.2141.00
300_I359_A1.2091.00
151_R155_N1.2011.00
295_E298_S1.1981.00
79_R154_S1.1981.00
33_S347_G1.1951.00
22_Y350_E1.1911.00
192_L204_Y1.1821.00
315_Q342_E1.1721.00
49_D53_E1.1711.00
27_G222_L1.1711.00
83_R157_G1.1701.00
341_T345_D1.1631.00
33_S322_R1.1551.00
293_Q297_V1.1521.00
104_V139_S1.1511.00
146_D195_R1.1471.00
315_Q345_D1.1381.00
65_V98_A1.1371.00
79_R83_R1.1261.00
226_E249_Q1.1251.00
56_R84_A1.1131.00
29_C203_H1.1101.00
243_T327_V1.1091.00
324_A357_F1.1061.00
61_A345_D1.1041.00
85_I95_V1.1001.00
265_Q299_G1.0981.00
38_T81_V1.0961.00
248_I328_T1.0961.00
218_H245_L1.0961.00
276_W280_E1.0921.00
274_V278_A1.0911.00
146_D150_D1.0841.00
216_A219_D1.0811.00
150_D198_A1.0811.00
218_H241_T1.0761.00
143_G147_A1.0751.00
275_L278_A1.0731.00
215_P241_T1.0681.00
289_A292_G1.0641.00
82_G157_G1.0641.00
293_Q296_V1.0621.00
92_R160_T1.0621.00
32_S63_V1.0621.00
239_G249_Q1.0591.00
303_A306_T1.0541.00
292_G295_E1.0541.00
55_V81_V1.0521.00
96_F163_L1.0491.00
272_Q275_L1.0451.00
304_V316_R1.0401.00
190_E193_E1.0361.00
266_E299_G1.0221.00
340_V344_A1.0151.00
146_D149_V1.0141.00
288_S291_L1.0071.00
57_A60_T1.0041.00
355_N358_D0.9951.00
142_P187_A0.9941.00
38_T77_S0.9921.00
189_F217_D0.9881.00
228_I235_A0.9861.00
148_M151_R0.9841.00
279_H283_L0.9831.00
231_A259_A0.9781.00
48_D76_R0.9731.00
294_G298_S0.9721.00
248_I329_S0.9711.00
208_T252_F0.9711.00
319_N323_S0.9691.00
59_L91_P0.9631.00
163_L223_D0.9621.00
34_V322_R0.9581.00
291_L297_V0.9551.00
334_T340_V0.9541.00
299_G303_A0.9501.00
236_K240_N0.9461.00
195_R200_D0.9431.00
335_T339_H0.9431.00
23_F64_N0.9421.00
86_R90_I0.9411.00
51_L80_V0.9361.00
142_P190_E0.9281.00
32_S64_N0.9251.00
294_G297_V0.9241.00
36_L58_G0.9201.00
230_R360_I0.9171.00
251_P330_A0.9151.00
35_G329_S0.9081.00
291_L296_V0.9071.00
292_G296_V0.9021.00
78_E152_S0.9001.00
93_D160_T0.8991.00
168_N208_T0.8981.00
301_P313_P0.8971.00
277_Y280_E0.8951.00
145_I195_R0.8951.00
195_R198_A0.8941.00
98_A163_L0.8931.00
193_E196_V0.8921.00
50_A337_A0.8871.00
185_L188_T0.8851.00
334_T339_H0.8831.00
196_V201_I0.8831.00
203_H222_L0.8831.00
162_D202_T0.8821.00
277_Y281_A0.8781.00
216_A244_H0.8771.00
273_S276_W0.8771.00
233_A236_K0.8701.00
186_E216_A0.8681.00
254_V332_A0.8661.00
35_G332_A0.8651.00
150_D154_S0.8601.00
53_E57_A0.8591.00
65_V250_V0.8501.00
191_R195_R0.8451.00
56_R90_I0.8441.00
41_G51_L0.8391.00
54_T337_A0.8381.00
140_I166_V0.8371.00
48_D80_V0.8361.00
322_R330_A0.8351.00
63_V344_A0.8291.00
234_A239_G0.8281.00
291_L295_E0.8261.00
76_R80_V0.8261.00
68_T81_V0.8241.00
214_V247_A0.8211.00
49_D52_Y0.8171.00
322_R346_A0.8171.00
41_G54_T0.8161.00
101_G140_I0.8141.00
144_Y147_A0.8131.00
59_L94_A0.8131.00
188_T191_R0.8071.00
274_V280_E0.8051.00
55_V59_L0.8051.00
274_V277_Y0.8041.00
304_V359_A0.8041.00
314_A342_E0.8021.00
228_I324_A0.8021.00
26_V248_I0.7981.00
142_P191_R0.7971.00
46_A51_L0.7941.00
305_D316_R0.7931.00
230_R317_G0.7921.00
206_V209_W0.7891.00
156_L161_I0.7841.00
166_V188_T0.7821.00
275_L280_E0.7821.00
304_V356_A0.7801.00
215_P245_L0.7741.00
169_P209_W0.7741.00
75_Q155_N0.7721.00
53_E56_R0.7721.00
70_V155_N0.7691.00
323_S354_A0.7691.00
276_W279_H0.7671.00
266_E272_Q0.7661.00
31_V65_V0.7651.00
223_D250_V0.7631.00
290_S293_Q0.7631.00
22_Y348_T0.7621.00
336_D339_H0.7621.00
56_R91_P0.7611.00
272_Q276_W0.7601.00
35_G331_L0.7601.00
170_E183_D0.7511.00
316_R349_F0.7491.00
36_L41_G0.7471.00
338_D342_E0.7471.00
153_L200_D0.7471.00
276_W281_A0.7441.00
251_P327_V0.7431.00
355_N359_A0.7391.00
58_G66_I0.7381.00
342_E345_D0.7331.00
147_A150_D0.7261.00
273_S277_Y0.7231.00
304_V309_A0.7221.00
104_V138_H0.7221.00
59_L64_N0.7211.00
68_T77_S0.7201.00
106_F137_S0.7191.00
218_H247_A0.7191.00
288_S292_G0.7171.00
351_P357_F0.7131.00
241_T244_H0.7091.00
187_A190_E0.7091.00
206_V214_V0.7061.00
145_I188_T0.7031.00
339_H342_E0.7021.00
291_L294_G0.7011.00
66_I95_V0.7011.00
189_F221_Y0.6981.00
316_R360_I0.6981.00
192_L196_V0.6911.00
185_L217_D0.6881.00
145_I191_R0.6861.00
67_D225_G0.6821.00
209_W214_V0.6791.00
292_G298_S0.6791.00
211_A237_T0.6791.00
103_F168_N0.6791.00
212_F215_P0.6791.00
165_Y205_G0.6791.00
292_G297_V0.6751.00
56_R89_E0.6711.00
240_N244_H0.6711.00
278_A281_A0.6711.00
144_Y148_M0.6701.00
149_V191_R0.6661.00
163_L205_G0.6661.00
71_N103_F0.6651.00
290_S294_G0.6631.00
274_V279_H0.6621.00
219_D245_L0.6611.00
234_A238_V0.6611.00
306_T310_G0.6601.00
164_Y201_I0.6581.00
196_V204_Y0.6581.00
189_F204_Y0.6561.00
287_T290_S0.6531.00
65_V96_F0.6511.00
287_T291_L0.6461.00
193_E204_Y0.6451.00
100_K167_H0.6441.00
205_G223_D0.6431.00
216_A245_L0.6421.00
280_E284_N0.6401.00
85_I91_P0.6391.00
106_F109_A0.6381.00
23_F32_S0.6341.00
42_A77_S0.6331.00
161_I164_Y0.6311.00
31_V96_F0.6311.00
91_P95_V0.6291.00
251_P254_V0.6281.00
59_L90_I0.6261.00
280_E283_L0.6251.00
315_Q349_F0.6251.00
212_F244_H0.6241.00
172_Q183_D0.6201.00
319_N351_P0.6161.00
70_V151_R0.6161.00
78_E99_T0.6121.00
141_A144_Y0.6111.00
66_I85_I0.6111.00
301_P316_R0.6101.00
285_V289_A0.6101.00
39_Y253_N0.6091.00
32_S65_V0.6071.00
284_N287_T0.6071.00
289_A293_Q0.6061.00
311_E345_D0.6041.00
139_S144_Y0.6031.00
46_A335_T0.5991.00
59_L84_A0.5961.00
36_L54_T0.5881.00
309_A353_G0.5871.00
309_A316_R0.5871.00
285_V290_S0.5861.00
214_V238_V0.5861.00
99_T167_H0.5841.00
286_F289_A0.5841.00
31_V329_S0.5841.00
291_L298_S0.5841.00
34_V332_A0.5831.00
79_R157_G0.5821.00
318_V332_A0.5791.00
213_R216_A0.5771.00
171_T213_R0.5771.00
47_V51_L0.5761.00
309_A349_F0.5751.00
55_V85_I0.5721.00
337_A340_V0.5711.00
50_A338_D0.5711.00
311_E319_N0.5681.00
318_V343_N0.5681.00
72_Y100_K0.5671.00
307_Q353_G0.5641.00
290_S298_S0.5631.00
69_A167_H0.5631.00
101_G148_M0.5621.00
140_I188_T0.5601.00
242_A247_A0.5601.00
59_L66_I0.5591.00
316_R356_A0.5571.00
27_G203_H0.5541.00
104_V137_S0.5541.00
36_L334_T0.5511.00
217_D221_Y0.5481.00
211_A238_V0.5461.00
43_P76_R0.5461.00
289_A294_G0.5441.00
54_T334_T0.5431.00
358_D361_F0.5421.00
214_V224_L0.5411.00
317_G321_A0.5411.00
211_A215_P0.5381.00
319_N350_E0.5381.00
293_Q298_S0.5381.00
40_L335_T0.5351.00
224_L242_A0.5341.00
85_I97_L0.5331.00
279_H282_G0.5311.00
272_Q281_A0.5311.00
284_N290_S0.5311.00
90_I95_V0.5311.00
351_P356_A0.5301.00
226_E234_A0.5281.00
284_N288_S0.5271.00
263_A339_H0.5271.00
73_R76_R0.5241.00
281_A284_N0.5231.00
239_G326_G0.5221.00
101_G166_V0.5221.00
318_V346_A0.5221.00
34_V347_G0.5211.00
152_S164_Y0.5211.00
153_L159_D0.5211.00
48_D51_L0.5201.00
78_E167_H0.5191.00
38_T68_T0.5181.00
57_A344_A0.5151.00
58_G340_V0.5131.00
184_H188_T0.5121.00
285_V288_S0.5101.00
301_P360_I0.5101.00
261_T314_A0.5081.00
334_T343_N0.5081.00
190_E197_A0.5061.00
52_Y80_V0.5050.99
251_P321_A0.5040.99
30_A33_S0.5030.99
83_R86_R0.5020.99
196_V222_L0.5020.99
36_L66_I0.5010.99
67_D167_H0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.8204 100 0.227 Contact Map
1pz1A 1 0.826 100 0.23 Contact Map
4xk2A 5 0.7707 100 0.231 Contact Map
3v0sA 1 0.7265 100 0.236 Contact Map
3eauA 3 0.8287 100 0.24 Contact Map
3n2tA 1 0.8343 100 0.243 Contact Map
1lqaA 2 0.8591 100 0.247 Contact Map
3erpA 6 0.8011 100 0.248 Contact Map
3lutA 3 0.826 100 0.248 Contact Map
3n6qA 5 0.8039 100 0.254 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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