Q9HSE6 - HALSA - GREMLIN Contacts

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Q9HSE6 - Uncharacterized protein

UniProt:	Q9HSE6	Sequences: MATADATFQYKQRFGDATARTYFRRVGDCAVSSVGLGTYLGAPTAAVDDALYETVRAGLTAGVNVIDTAVNYRHQRSERVVGRAIRDSEIPRDAVFLATKGGFVPFDGAQPDAPGEYVRREFVDRGVVDGDDLAAGSHSIAPGYIDAMVDRSLSNLGVDTIDLYYVHNPETQLDERPASAVYDHLEATFERLEQRVAAGDITHYGVATWEAFRVPADHDHYLDLGEIISRARAAAKTVGNTATHLRAIQVPFNVYMADAFTVAAQEGPDGPQSVLWYAHEAGLNVFTSASLGQGEVVSGIPSAVDTQLAGETPAQRGVNFARSAPGVTSALAGTTDADHVTENADAGTFEPLGANAFDAIFE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	362 (296)
Sequences:	18725 (12471)
Seq/√Len:	724.8

ECOLI - YDJG TAS GPR YAJO YDHF YDBC YEAE DKGA DKGB
BACSU - IOLS GS69 YRPG YCSN YCCK YQKF YTBE GR
HALSA - Q9HSE6 Q9HQU7 Q9HPH9 Q9HNN3 Q9HS02 Q9HQT1
SULSO - Q97UG6 Q97ZZ1 Q97UJ7 Q97UV9 Q97V56 Q97U17

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
57_A	341_T	3.739	1.00
48_D	83_R	3.684	1.00
86_R	157_G	3.050	1.00
150_D	200_D	2.811	1.00
309_A	356_A	2.711	1.00
307_Q	359_A	2.694	1.00
57_A	61_A	2.648	1.00
193_E	197_A	2.587	1.00
146_D	198_A	2.406	1.00
353_G	356_A	2.391	1.00
76_R	79_R	2.376	1.00
149_V	195_R	2.353	1.00
25_R	30_A	2.316	1.00
99_T	161_I	2.289	1.00
24_R	33_S	2.272	1.00
35_G	65_V	2.211	1.00
146_D	194_Q	2.140	1.00
61_A	341_T	2.138	1.00
302_S	306_T	2.125	1.00
160_T	202_T	2.047	1.00
142_P	194_Q	2.037	1.00
47_V	50_A	2.012	1.00
165_Y	223_D	2.011	1.00
101_G	145_I	1.985	1.00
354_A	358_D	1.965	1.00
91_P	94_A	1.894	1.00
194_Q	197_A	1.892	1.00
149_V	161_I	1.887	1.00
165_Y	250_V	1.885	1.00
61_A	344_A	1.872	1.00
237_T	240_N	1.863	1.00
300_I	303_A	1.862	1.00
142_P	146_D	1.823	1.00
345_D	348_T	1.818	1.00
58_G	63_V	1.797	1.00
38_T	66_I	1.767	1.00
149_V	164_Y	1.760	1.00
323_S	357_F	1.749	1.00
52_Y	84_A	1.698	1.00
98_A	165_Y	1.691	1.00
55_V	84_A	1.690	1.00
70_V	148_M	1.686	1.00
22_Y	33_S	1.684	1.00
311_E	349_F	1.683	1.00
147_A	151_R	1.661	1.00
48_D	52_Y	1.661	1.00
201_I	204_Y	1.658	1.00
307_Q	356_A	1.654	1.00
319_N	349_F	1.643	1.00
303_A	359_A	1.619	1.00
232_R	235_A	1.615	1.00
97_L	158_V	1.612	1.00
215_P	244_H	1.609	1.00
29_C	96_F	1.599	1.00
57_A	337_A	1.576	1.00
312_T	342_E	1.567	1.00
101_G	164_Y	1.564	1.00
241_T	245_L	1.562	1.00
210_E	213_R	1.548	1.00
311_E	315_Q	1.543	1.00
52_Y	56_R	1.538	1.00
166_V	192_L	1.536	1.00
194_Q	198_A	1.511	1.00
312_T	315_Q	1.480	1.00
99_T	152_S	1.476	1.00
169_P	213_R	1.462	1.00
242_A	249_Q	1.462	1.00
59_L	95_V	1.455	1.00
275_L	279_H	1.436	1.00
23_F	30_A	1.423	1.00
191_R	194_Q	1.407	1.00
337_A	341_T	1.401	1.00
52_Y	83_R	1.397	1.00
195_R	201_I	1.394	1.00
25_R	28_D	1.386	1.00
243_T	325_P	1.383	1.00
50_A	53_E	1.377	1.00
303_A	307_Q	1.376	1.00
265_Q	302_S	1.374	1.00
302_S	313_P	1.367	1.00
151_R	154_S	1.366	1.00
161_I	201_I	1.363	1.00
324_A	361_F	1.347	1.00
215_P	219_D	1.334	1.00
243_T	326_G	1.334	1.00
54_T	340_V	1.327	1.00
66_I	81_V	1.318	1.00
55_V	66_I	1.316	1.00
311_E	316_R	1.313	1.00
64_N	96_F	1.312	1.00
211_A	241_T	1.310	1.00
53_E	337_A	1.292	1.00
234_A	249_Q	1.290	1.00
321_A	330_A	1.281	1.00
70_V	144_Y	1.279	1.00
299_G	302_S	1.274	1.00
204_Y	221_Y	1.270	1.00
146_D	191_R	1.267	1.00
338_D	341_T	1.239	1.00
190_E	194_Q	1.238	1.00
79_R	155_N	1.236	1.00
56_R	60_T	1.227	1.00
206_V	221_Y	1.222	1.00
92_R	158_V	1.214	1.00
300_I	359_A	1.209	1.00
151_R	155_N	1.201	1.00
295_E	298_S	1.198	1.00
79_R	154_S	1.198	1.00
33_S	347_G	1.195	1.00
22_Y	350_E	1.191	1.00
192_L	204_Y	1.182	1.00
315_Q	342_E	1.172	1.00
49_D	53_E	1.171	1.00
27_G	222_L	1.171	1.00
83_R	157_G	1.170	1.00
341_T	345_D	1.163	1.00
33_S	322_R	1.155	1.00
293_Q	297_V	1.152	1.00
104_V	139_S	1.151	1.00
146_D	195_R	1.147	1.00
315_Q	345_D	1.138	1.00
65_V	98_A	1.137	1.00
79_R	83_R	1.126	1.00
226_E	249_Q	1.125	1.00
56_R	84_A	1.113	1.00
29_C	203_H	1.110	1.00
243_T	327_V	1.109	1.00
324_A	357_F	1.106	1.00
61_A	345_D	1.104	1.00
85_I	95_V	1.100	1.00
265_Q	299_G	1.098	1.00
38_T	81_V	1.096	1.00
248_I	328_T	1.096	1.00
218_H	245_L	1.096	1.00
276_W	280_E	1.092	1.00
274_V	278_A	1.091	1.00
146_D	150_D	1.084	1.00
216_A	219_D	1.081	1.00
150_D	198_A	1.081	1.00
218_H	241_T	1.076	1.00
143_G	147_A	1.075	1.00
275_L	278_A	1.073	1.00
215_P	241_T	1.068	1.00
289_A	292_G	1.064	1.00
82_G	157_G	1.064	1.00
293_Q	296_V	1.062	1.00
92_R	160_T	1.062	1.00
32_S	63_V	1.062	1.00
239_G	249_Q	1.059	1.00
303_A	306_T	1.054	1.00
292_G	295_E	1.054	1.00
55_V	81_V	1.052	1.00
96_F	163_L	1.049	1.00
272_Q	275_L	1.045	1.00
304_V	316_R	1.040	1.00
190_E	193_E	1.036	1.00
266_E	299_G	1.022	1.00
340_V	344_A	1.015	1.00
146_D	149_V	1.014	1.00
288_S	291_L	1.007	1.00
57_A	60_T	1.004	1.00
355_N	358_D	0.995	1.00
142_P	187_A	0.994	1.00
38_T	77_S	0.992	1.00
189_F	217_D	0.988	1.00
228_I	235_A	0.986	1.00
148_M	151_R	0.984	1.00
279_H	283_L	0.983	1.00
231_A	259_A	0.978	1.00
48_D	76_R	0.973	1.00
294_G	298_S	0.972	1.00
248_I	329_S	0.971	1.00
208_T	252_F	0.971	1.00
319_N	323_S	0.969	1.00
59_L	91_P	0.963	1.00
163_L	223_D	0.962	1.00
34_V	322_R	0.958	1.00
291_L	297_V	0.955	1.00
334_T	340_V	0.954	1.00
299_G	303_A	0.950	1.00
236_K	240_N	0.946	1.00
195_R	200_D	0.943	1.00
335_T	339_H	0.943	1.00
23_F	64_N	0.942	1.00
86_R	90_I	0.941	1.00
51_L	80_V	0.936	1.00
142_P	190_E	0.928	1.00
32_S	64_N	0.925	1.00
294_G	297_V	0.924	1.00
36_L	58_G	0.920	1.00
230_R	360_I	0.917	1.00
251_P	330_A	0.915	1.00
35_G	329_S	0.908	1.00
291_L	296_V	0.907	1.00
292_G	296_V	0.902	1.00
78_E	152_S	0.900	1.00
93_D	160_T	0.899	1.00
168_N	208_T	0.898	1.00
301_P	313_P	0.897	1.00
277_Y	280_E	0.895	1.00
145_I	195_R	0.895	1.00
195_R	198_A	0.894	1.00
98_A	163_L	0.893	1.00
193_E	196_V	0.892	1.00
50_A	337_A	0.887	1.00
185_L	188_T	0.885	1.00
334_T	339_H	0.883	1.00
196_V	201_I	0.883	1.00
203_H	222_L	0.883	1.00
162_D	202_T	0.882	1.00
277_Y	281_A	0.878	1.00
216_A	244_H	0.877	1.00
273_S	276_W	0.877	1.00
233_A	236_K	0.870	1.00
186_E	216_A	0.868	1.00
254_V	332_A	0.866	1.00
35_G	332_A	0.865	1.00
150_D	154_S	0.860	1.00
53_E	57_A	0.859	1.00
65_V	250_V	0.850	1.00
191_R	195_R	0.845	1.00
56_R	90_I	0.844	1.00
41_G	51_L	0.839	1.00
54_T	337_A	0.838	1.00
140_I	166_V	0.837	1.00
48_D	80_V	0.836	1.00
322_R	330_A	0.835	1.00
63_V	344_A	0.829	1.00
234_A	239_G	0.828	1.00
291_L	295_E	0.826	1.00
76_R	80_V	0.826	1.00
68_T	81_V	0.824	1.00
214_V	247_A	0.821	1.00
49_D	52_Y	0.817	1.00
322_R	346_A	0.817	1.00
41_G	54_T	0.816	1.00
101_G	140_I	0.814	1.00
144_Y	147_A	0.813	1.00
59_L	94_A	0.813	1.00
188_T	191_R	0.807	1.00
274_V	280_E	0.805	1.00
55_V	59_L	0.805	1.00
274_V	277_Y	0.804	1.00
304_V	359_A	0.804	1.00
314_A	342_E	0.802	1.00
228_I	324_A	0.802	1.00
26_V	248_I	0.798	1.00
142_P	191_R	0.797	1.00
46_A	51_L	0.794	1.00
305_D	316_R	0.793	1.00
230_R	317_G	0.792	1.00
206_V	209_W	0.789	1.00
156_L	161_I	0.784	1.00
166_V	188_T	0.782	1.00
275_L	280_E	0.782	1.00
304_V	356_A	0.780	1.00
215_P	245_L	0.774	1.00
169_P	209_W	0.774	1.00
75_Q	155_N	0.772	1.00
53_E	56_R	0.772	1.00
70_V	155_N	0.769	1.00
323_S	354_A	0.769	1.00
276_W	279_H	0.767	1.00
266_E	272_Q	0.766	1.00
31_V	65_V	0.765	1.00
223_D	250_V	0.763	1.00
290_S	293_Q	0.763	1.00
22_Y	348_T	0.762	1.00
336_D	339_H	0.762	1.00
56_R	91_P	0.761	1.00
272_Q	276_W	0.760	1.00
35_G	331_L	0.760	1.00
170_E	183_D	0.751	1.00
316_R	349_F	0.749	1.00
36_L	41_G	0.747	1.00
338_D	342_E	0.747	1.00
153_L	200_D	0.747	1.00
276_W	281_A	0.744	1.00
251_P	327_V	0.743	1.00
355_N	359_A	0.739	1.00
58_G	66_I	0.738	1.00
342_E	345_D	0.733	1.00
147_A	150_D	0.726	1.00
273_S	277_Y	0.723	1.00
304_V	309_A	0.722	1.00
104_V	138_H	0.722	1.00
59_L	64_N	0.721	1.00
68_T	77_S	0.720	1.00
106_F	137_S	0.719	1.00
218_H	247_A	0.719	1.00
288_S	292_G	0.717	1.00
351_P	357_F	0.713	1.00
241_T	244_H	0.709	1.00
187_A	190_E	0.709	1.00
206_V	214_V	0.706	1.00
145_I	188_T	0.703	1.00
339_H	342_E	0.702	1.00
291_L	294_G	0.701	1.00
66_I	95_V	0.701	1.00
189_F	221_Y	0.698	1.00
316_R	360_I	0.698	1.00
192_L	196_V	0.691	1.00
185_L	217_D	0.688	1.00
145_I	191_R	0.686	1.00
67_D	225_G	0.682	1.00
209_W	214_V	0.679	1.00
292_G	298_S	0.679	1.00
211_A	237_T	0.679	1.00
103_F	168_N	0.679	1.00
212_F	215_P	0.679	1.00
165_Y	205_G	0.679	1.00
292_G	297_V	0.675	1.00
56_R	89_E	0.671	1.00
240_N	244_H	0.671	1.00
278_A	281_A	0.671	1.00
144_Y	148_M	0.670	1.00
149_V	191_R	0.666	1.00
163_L	205_G	0.666	1.00
71_N	103_F	0.665	1.00
290_S	294_G	0.663	1.00
274_V	279_H	0.662	1.00
219_D	245_L	0.661	1.00
234_A	238_V	0.661	1.00
306_T	310_G	0.660	1.00
164_Y	201_I	0.658	1.00
196_V	204_Y	0.658	1.00
189_F	204_Y	0.656	1.00
287_T	290_S	0.653	1.00
65_V	96_F	0.651	1.00
287_T	291_L	0.646	1.00
193_E	204_Y	0.645	1.00
100_K	167_H	0.644	1.00
205_G	223_D	0.643	1.00
216_A	245_L	0.642	1.00
280_E	284_N	0.640	1.00
85_I	91_P	0.639	1.00
106_F	109_A	0.638	1.00
23_F	32_S	0.634	1.00
42_A	77_S	0.633	1.00
161_I	164_Y	0.631	1.00
31_V	96_F	0.631	1.00
91_P	95_V	0.629	1.00
251_P	254_V	0.628	1.00
59_L	90_I	0.626	1.00
280_E	283_L	0.625	1.00
315_Q	349_F	0.625	1.00
212_F	244_H	0.624	1.00
172_Q	183_D	0.620	1.00
319_N	351_P	0.616	1.00
70_V	151_R	0.616	1.00
78_E	99_T	0.612	1.00
141_A	144_Y	0.611	1.00
66_I	85_I	0.611	1.00
301_P	316_R	0.610	1.00
285_V	289_A	0.610	1.00
39_Y	253_N	0.609	1.00
32_S	65_V	0.607	1.00
284_N	287_T	0.607	1.00
289_A	293_Q	0.606	1.00
311_E	345_D	0.604	1.00
139_S	144_Y	0.603	1.00
46_A	335_T	0.599	1.00
59_L	84_A	0.596	1.00
36_L	54_T	0.588	1.00
309_A	353_G	0.587	1.00
309_A	316_R	0.587	1.00
285_V	290_S	0.586	1.00
214_V	238_V	0.586	1.00
99_T	167_H	0.584	1.00
286_F	289_A	0.584	1.00
31_V	329_S	0.584	1.00
291_L	298_S	0.584	1.00
34_V	332_A	0.583	1.00
79_R	157_G	0.582	1.00
318_V	332_A	0.579	1.00
213_R	216_A	0.577	1.00
171_T	213_R	0.577	1.00
47_V	51_L	0.576	1.00
309_A	349_F	0.575	1.00
55_V	85_I	0.572	1.00
337_A	340_V	0.571	1.00
50_A	338_D	0.571	1.00
311_E	319_N	0.568	1.00
318_V	343_N	0.568	1.00
72_Y	100_K	0.567	1.00
307_Q	353_G	0.564	1.00
290_S	298_S	0.563	1.00
69_A	167_H	0.563	1.00
101_G	148_M	0.562	1.00
140_I	188_T	0.560	1.00
242_A	247_A	0.560	1.00
59_L	66_I	0.559	1.00
316_R	356_A	0.557	1.00
27_G	203_H	0.554	1.00
104_V	137_S	0.554	1.00
36_L	334_T	0.551	1.00
217_D	221_Y	0.548	1.00
211_A	238_V	0.546	1.00
43_P	76_R	0.546	1.00
289_A	294_G	0.544	1.00
54_T	334_T	0.543	1.00
358_D	361_F	0.542	1.00
214_V	224_L	0.541	1.00
317_G	321_A	0.541	1.00
211_A	215_P	0.538	1.00
319_N	350_E	0.538	1.00
293_Q	298_S	0.538	1.00
40_L	335_T	0.535	1.00
224_L	242_A	0.534	1.00
85_I	97_L	0.533	1.00
279_H	282_G	0.531	1.00
272_Q	281_A	0.531	1.00
284_N	290_S	0.531	1.00
90_I	95_V	0.531	1.00
351_P	356_A	0.530	1.00
226_E	234_A	0.528	1.00
284_N	288_S	0.527	1.00
263_A	339_H	0.527	1.00
73_R	76_R	0.524	1.00
281_A	284_N	0.523	1.00
239_G	326_G	0.522	1.00
101_G	166_V	0.522	1.00
318_V	346_A	0.522	1.00
34_V	347_G	0.521	1.00
152_S	164_Y	0.521	1.00
153_L	159_D	0.521	1.00
48_D	51_L	0.520	1.00
78_E	167_H	0.519	1.00
38_T	68_T	0.518	1.00
57_A	344_A	0.515	1.00
58_G	340_V	0.513	1.00
184_H	188_T	0.512	1.00
285_V	288_S	0.510	1.00
301_P	360_I	0.510	1.00
261_T	314_A	0.508	1.00
334_T	343_N	0.508	1.00
190_E	197_A	0.506	1.00
52_Y	80_V	0.505	0.99
251_P	321_A	0.504	0.99
30_A	33_S	0.503	0.99
83_R	86_R	0.502	0.99
196_V	222_L	0.502	0.99
36_L	66_I	0.501	0.99
67_D	167_H	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pyfA	1	0.8204	100	0.227	Contact Map
1pz1A	1	0.826	100	0.23	Contact Map
4xk2A	5	0.7707	100	0.231	Contact Map
3v0sA	1	0.7265	100	0.236	Contact Map
3eauA	3	0.8287	100	0.24	Contact Map
3n2tA	1	0.8343	100	0.243	Contact Map
1lqaA	2	0.8591	100	0.247	Contact Map
3erpA	6	0.8011	100	0.248	Contact Map
3lutA	3	0.826	100	0.248	Contact Map
3n6qA	5	0.8039	100	0.254	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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