GREMLIN Database
Q9HSE4 - Uncharacterized protein
UniProt: Q9HSE4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 364 (358)
Sequences: 274 (168)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_L351_V4.7760.99
68_V72_R4.6010.99
64_P67_R4.5650.99
3_Y6_E4.4670.99
38_A67_R4.2760.99
29_V115_L4.1220.98
193_L271_L3.4970.96
170_F199_A3.4950.96
34_D70_A3.4060.95
30_V129_A3.3300.94
96_L99_A3.3200.94
299_V322_I3.2870.94
254_V321_Q3.2440.93
27_A121_H2.9930.90
40_L43_E2.9670.90
26_A143_L2.9060.89
153_S205_G2.8790.88
85_L92_V2.8730.88
68_V84_L2.8600.88
32_M42_T2.8250.87
12_H305_D2.8070.87
14_Y141_K2.6530.83
150_F304_A2.5670.81
58_V118_A2.4730.79
175_T194_G2.4070.77
217_Q225_G2.3100.74
3_Y123_F2.2120.70
98_D354_A2.1700.69
210_A234_A2.1490.68
155_G247_Y2.1400.68
102_D113_L2.1200.67
27_A308_F2.1190.67
126_L204_C2.0810.65
211_A308_F2.0740.65
173_F211_A2.0390.64
224_V270_A2.0170.63
179_A194_G2.0170.63
58_V79_D2.0040.62
27_A55_A1.9690.61
29_V118_A1.9450.60
52_V55_A1.9310.59
47_S77_G1.8920.58
72_R84_L1.8880.57
264_S328_A1.8880.57
350_D354_A1.8770.57
60_P110_D1.8720.57
231_F278_T1.7620.52
11_L261_S1.7360.51
105_R235_G1.6970.49
261_S328_A1.6500.47
29_V99_A1.5990.45
152_F156_Y1.5970.45
270_A313_Y1.5920.45
299_V350_D1.5790.44
272_L275_V1.5720.44
173_F268_G1.5680.44
303_S315_A1.5630.43
122_D209_E1.5570.43
46_F243_D1.5510.43
43_E47_S1.5470.43
206_L210_A1.5330.42
13_D141_K1.5290.42
205_G298_L1.5230.42
92_V270_A1.5210.42
89_G350_D1.5160.41
180_A184_T1.5140.41
81_D120_R1.5000.41
68_V303_S1.5000.41
56_A83_T1.4980.41
44_R156_Y1.4930.40
139_V146_L1.4870.40
10_T84_L1.4740.40
83_T360_A1.4640.39
89_G92_V1.4580.39
29_V308_F1.4570.39
173_F261_S1.4570.39
127_H134_Y1.4480.39
43_E77_G1.4430.38
15_G224_V1.4360.38
8_V192_F1.4210.38
18_D287_V1.4170.37
24_G105_R1.4040.37
84_L322_I1.4010.37
37_Y71_F1.3990.37
3_Y8_V1.3880.36
257_P351_V1.3840.36
131_T247_Y1.3830.36
143_L205_G1.3790.36
10_T201_A1.3740.36
135_E322_I1.3670.35
195_S331_P1.3610.35
115_L211_A1.3590.35
123_F205_G1.3560.35
56_A120_R1.3450.35
95_L224_V1.3420.34
255_S261_S1.3370.34
158_A271_L1.3280.34
69_P73_E1.3250.34
65_A69_P1.3250.34
201_A351_V1.3240.34
178_V224_V1.3120.33
46_F299_V1.2890.32
193_L208_S1.2860.32
110_D114_A1.2800.32
3_Y7_R1.2780.32
44_R50_E1.2760.32
48_E209_E1.2620.31
230_A239_V1.2610.31
23_A268_G1.2530.31
58_V350_D1.2500.31
138_D247_Y1.2480.31
206_L303_S1.2460.31
3_Y196_F1.2460.31
39_S74_W1.2460.31
282_I328_A1.2410.31
276_A344_V1.2380.30
25_R238_G1.2360.30
352_A356_R1.2310.30
12_H101_L1.2260.30
52_V139_V1.1900.29
3_Y158_A1.1890.29
122_D201_A1.1870.29
276_A289_E1.1820.28
42_T75_L1.1820.28
44_R192_F1.1810.28
242_V339_P1.1700.28
101_L305_D1.1690.28
3_Y205_G1.1590.28
189_V228_G1.1560.28
9_A342_S1.1340.27
29_V262_E1.1300.27
96_L143_L1.1230.26
76_A79_D1.1220.26
124_V208_S1.1170.26
208_S253_A1.1130.26
195_S360_A1.1110.26
92_V322_I1.1100.26
9_A119_A1.1050.26
67_R99_A1.1020.26
234_A287_V1.1010.26
87_C110_D1.0880.25
48_E51_R1.0800.25
218_R248_E1.0780.25
83_T120_R1.0730.25
278_T287_V1.0710.25
41_A186_D1.0680.25
65_A180_A1.0640.24
303_S313_Y1.0490.24
147_A334_A1.0480.24
5_Q195_S1.0470.24
129_A269_A1.0440.24
149_G209_E1.0410.24
299_V315_A1.0400.24
67_R93_E1.0370.24
158_A178_V1.0320.23
160_V248_E1.0190.23
61_L68_V1.0170.23
281_D284_Y1.0120.23
53_D329_V1.0110.23
205_G210_A1.0110.23
148_D329_V1.0060.23
8_V327_Q1.0060.23
178_V194_G0.9990.22
9_A95_L0.9980.22
73_E322_I0.9980.22
96_L113_L0.9970.22
178_V209_E0.9950.22
59_V75_L0.9940.22
297_R319_R0.9890.22
229_E232_R0.9880.22
75_L174_Y0.9840.22
17_A38_A0.9830.22
175_T179_A0.9810.22
158_A298_L0.9730.22
15_G165_L0.9710.22
48_E136_A0.9690.22
138_D146_L0.9590.21
74_W256_G0.9570.21
254_V346_L0.9560.21
72_R201_A0.9560.21
59_V244_L0.9550.21
59_V217_Q0.9500.21
17_A67_R0.9470.21
135_E256_G0.9450.21
27_A56_A0.9430.21
178_V199_A0.9420.21
64_P77_G0.9420.21
256_G320_D0.9400.21
193_L230_A0.9390.21
208_S357_A0.9360.21
39_S210_A0.9340.21
156_Y243_D0.9330.21
293_E297_R0.9230.20
98_D270_A0.9210.20
54_P136_A0.9190.20
230_A345_S0.9170.20
13_D17_A0.9150.20
50_E253_A0.9100.20
319_R343_T0.9050.20
248_E293_E0.8960.20
49_L66_E0.8940.19
300_D310_D0.8940.19
208_S313_Y0.8940.19
60_P114_A0.8910.19
77_G253_A0.8910.19
183_D280_V0.8880.19
93_E299_V0.8870.19
14_Y139_V0.8790.19
153_S242_V0.8780.19
139_V255_S0.8770.19
99_A115_L0.8740.19
27_A179_A0.8730.19
297_R343_T0.8710.19
165_L265_R0.8690.19
196_F283_A0.8670.19
29_V211_A0.8670.19
115_L280_V0.8670.19
178_V356_R0.8660.19
178_V190_L0.8660.19
71_F75_L0.8660.19
270_A337_R0.8650.19
19_P95_L0.8640.19
85_L322_I0.8630.19
316_E343_T0.8620.19
140_N359_A0.8600.19
147_A270_A0.8580.19
44_R65_A0.8570.18
123_F238_G0.8550.18
91_R247_Y0.8540.18
353_A360_A0.8540.18
149_G175_T0.8500.18
135_E280_V0.8480.18
146_L224_V0.8450.18
197_R273_R0.8430.18
45_V332_P0.8420.18
164_R292_R0.8410.18
248_E319_R0.8390.18
150_F246_R0.8380.18
86_W116_G0.8350.18
81_D132_D0.8350.18
57_V144_F0.8320.18
92_V291_Y0.8290.18
218_R337_R0.8290.18
18_D143_L0.8240.18
59_V82_L0.8220.18
39_S65_A0.8170.17
61_L262_E0.8150.17
140_N195_S0.8140.17
112_W127_H0.8100.17
143_L301_A0.8080.17
233_L316_E0.8030.17
25_R56_A0.8030.17
11_L156_Y0.7990.17
226_T246_R0.7990.17
98_D327_Q0.7990.17
46_F230_A0.7970.17
9_A158_A0.7970.17
118_A348_P0.7970.17
265_R315_A0.7930.17
189_V244_L0.7930.17
5_Q149_G0.7920.17
70_A236_A0.7900.17
123_F141_K0.7870.17
59_V228_G0.7850.17
85_L109_R0.7850.17
96_L164_R0.7850.17
131_T262_E0.7840.17
93_E230_A0.7830.17
32_M71_F0.7820.17
55_A195_S0.7810.17
85_L134_Y0.7780.17
247_Y324_T0.7780.17
115_L193_L0.7770.16
109_R190_L0.7740.16
205_G230_A0.7720.16
42_T59_V0.7720.16
332_P338_L0.7670.16
40_L193_L0.7650.16
231_F270_A0.7630.16
214_L360_A0.7600.16
140_N146_L0.7560.16
63_A279_G0.7550.16
287_V304_A0.7550.16
9_A212_R0.7510.16
25_R262_E0.7490.16
195_S351_V0.7490.16
197_R222_L0.7440.16
127_H142_L0.7440.16
11_L320_D0.7430.16
110_D189_V0.7410.16
14_Y117_V0.7410.16
64_P253_A0.7390.16
52_V141_K0.7390.16
50_E79_D0.7380.16
95_L354_A0.7350.16
54_P141_K0.7340.15
210_A239_V0.7330.15
25_R209_E0.7320.15
74_W201_A0.7320.15
272_L304_A0.7320.15
64_P93_E0.7310.15
150_F321_Q0.7310.15
255_S266_G0.7290.15
158_A360_A0.7280.15
5_Q205_G0.7270.15
10_T261_S0.7220.15
204_C224_V0.7220.15
278_T326_A0.7180.15
40_L353_A0.7180.15
20_P121_H0.7170.15
268_G272_L0.7160.15
11_L304_A0.7160.15
30_V35_R0.7140.15
201_A321_Q0.7140.15
7_R210_A0.7120.15
117_V141_K0.7120.15
74_W245_G0.7120.15
210_A231_F0.7100.15
71_F199_A0.7100.15
180_A281_D0.7080.15
16_D46_F0.7030.15
7_R205_G0.7020.15
173_F180_A0.7000.15
206_L265_R0.7000.15
59_V305_D0.6990.15
164_R243_D0.6970.15
135_E257_P0.6950.15
95_L321_Q0.6940.15
129_A276_A0.6900.15
75_L319_R0.6890.14
65_A262_E0.6860.14
191_D331_P0.6860.14
8_V313_Y0.6830.14
74_W99_A0.6810.14
68_V262_E0.6800.14
27_A115_L0.6790.14
92_V277_D0.6780.14
8_V320_D0.6780.14
74_W258_T0.6760.14
79_D322_I0.6750.14
60_P264_S0.6740.14
26_A299_V0.6700.14
277_D316_E0.6670.14
99_A185_H0.6660.14
160_V243_D0.6660.14
213_G293_E0.6660.14
205_G262_E0.6650.14
149_G278_T0.6630.14
174_Y297_R0.6630.14
98_D151_D0.6610.14
204_C217_Q0.6610.14
75_L217_Q0.6590.14
75_L293_E0.6590.14
184_T344_V0.6580.14
25_R243_D0.6570.14
142_L152_F0.6570.14
285_D333_G0.6560.14
252_R325_Y0.6540.14
243_D305_D0.6520.14
84_L178_V0.6510.14
265_R271_L0.6490.14
56_A148_D0.6480.14
206_L211_A0.6470.14
270_A314_D0.6470.14
274_A296_T0.6460.14
43_E74_W0.6450.14
217_Q229_E0.6440.14
174_Y293_E0.6430.14
96_L298_L0.6430.14
44_R253_A0.6430.14
132_D355_A0.6420.14
250_D325_Y0.6420.14
101_L160_V0.6420.14
192_F199_A0.6410.13
61_L88_D0.6390.13
151_D212_R0.6390.13
12_H59_V0.6390.13
64_P165_L0.6390.13
93_E329_V0.6370.13
11_L237_A0.6370.13
85_L114_A0.6360.13
38_A73_E0.6340.13
166_Y248_E0.6340.13
89_G247_Y0.6340.13
135_E327_Q0.6330.13
158_A278_T0.6320.13
6_E195_S0.6310.13
261_S264_S0.6310.13
209_E301_A0.6300.13
21_A340_A0.6270.13
92_V161_E0.6270.13
187_H299_V0.6250.13
97_A201_A0.6240.13
123_F149_G0.6220.13
96_L335_D0.6180.13
265_R331_P0.6170.13
139_V326_A0.6170.13
244_L272_L0.6170.13
133_T319_R0.6170.13
206_L253_A0.6160.13
188_D333_G0.6160.13
294_H298_L0.6150.13
50_E77_G0.6130.13
208_S231_F0.6130.13
209_E352_A0.6120.13
229_E295_A0.6100.13
96_L195_S0.6090.13
13_D308_F0.6090.13
104_P211_A0.6090.13
112_W222_L0.6080.13
174_Y219_E0.6080.13
69_P72_R0.6010.13
8_V210_A0.6010.13
66_E120_R0.6010.13
164_R329_V0.5990.13
343_T347_T0.5980.13
46_F355_A0.5950.13
92_V113_L0.5950.13
8_V329_V0.5940.13
134_Y155_G0.5930.13
214_L313_Y0.5920.13
243_D301_A0.5910.13
13_D117_V0.5900.12
12_H319_R0.5900.12
126_L229_E0.5900.12
206_L315_A0.5900.12
15_G20_P0.5880.12
109_R152_F0.5870.12
191_D342_S0.5870.12
232_R293_E0.5860.12
193_L206_L0.5830.12
89_G322_I0.5820.12
91_R358_D0.5810.12
58_V360_A0.5800.12
194_G212_R0.5790.12
40_L124_V0.5780.12
75_L305_D0.5780.12
43_E238_G0.5770.12
163_D191_D0.5760.12
91_R273_R0.5760.12
23_A180_A0.5760.12
57_V312_S0.5740.12
230_A261_S0.5740.12
156_Y308_F0.5730.12
246_R312_S0.5710.12
56_A121_H0.5710.12
26_A138_D0.5710.12
71_F174_Y0.5710.12
182_E201_A0.5710.12
114_A277_D0.5690.12
105_R315_A0.5690.12
12_H225_G0.5680.12
8_V265_R0.5680.12
29_V327_Q0.5670.12
14_Y71_F0.5660.12
60_P87_C0.5630.12
193_L205_G0.5630.12
210_A287_V0.5630.12
89_G358_D0.5620.12
126_L350_D0.5610.12
217_Q316_E0.5610.12
273_R297_R0.5600.12
5_Q243_D0.5600.12
69_P84_L0.5600.12
34_D38_A0.5580.12
135_E303_S0.5570.12
80_L338_L0.5570.12
199_A231_F0.5570.12
51_R65_A0.5560.12
214_L271_L0.5550.12
36_E60_P0.5540.12
192_F315_A0.5530.12
296_T319_R0.5520.12
12_H75_L0.5520.12
89_G93_E0.5500.12
59_V225_G0.5500.12
62_R179_A0.5500.12
211_A329_V0.5490.12
53_D66_E0.5470.12
132_D188_D0.5460.12
230_A299_V0.5450.12
73_E103_G0.5450.12
56_A236_A0.5440.12
222_L273_R0.5440.12
320_D334_A0.5440.12
110_D248_E0.5430.12
127_H155_G0.5420.12
131_T266_G0.5420.12
15_G243_D0.5410.12
117_V344_V0.5400.12
67_R105_R0.5390.12
21_A170_F0.5390.12
7_R214_L0.5370.12
143_L210_A0.5360.12
219_E297_R0.5360.12
26_A56_A0.5360.12
39_S114_A0.5350.11
142_L156_Y0.5340.11
94_G271_L0.5340.11
257_P357_A0.5330.11
43_E280_V0.5330.11
142_L302_Y0.5320.11
212_R298_L0.5310.11
178_V297_R0.5290.11
117_V247_Y0.5280.11
226_T342_S0.5280.11
187_H280_V0.5250.11
206_L352_A0.5250.11
81_D354_A0.5250.11
28_V54_P0.5240.11
50_E299_V0.5240.11
206_L294_H0.5240.11
125_V240_A0.5220.11
189_V288_R0.5210.11
165_L331_P0.5210.11
230_A348_P0.5200.11
9_A355_A0.5200.11
345_S348_P0.5190.11
40_L72_R0.5180.11
79_D82_L0.5180.11
92_V153_S0.5160.11
213_G326_A0.5150.11
138_D206_L0.5120.11
47_S64_P0.5110.11
71_F219_E0.5100.11
43_E214_L0.5100.11
92_V114_A0.5090.11
174_Y319_R0.5080.11
193_L242_V0.5080.11
342_S352_A0.5060.11
193_L224_V0.5060.11
42_T126_L0.5040.11
110_D261_S0.5030.11
122_D151_D0.5020.11
54_P252_R0.5000.11
55_A358_D0.5000.11
178_V348_P0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zu9A 2 0.8049 100 0.784 Contact Map
2wvlA 2 0.8269 100 0.815 Contact Map
3f1yA 2 0.7445 99.9 0.855 Contact Map
3ckjA 2 0.7692 99.7 0.894 Contact Map
2bo4A 4 0.8297 99.7 0.898 Contact Map
4evwA 1 0.5632 86.1 0.971 Contact Map
4y7uA 1 0.5577 83.7 0.972 Contact Map
3jukA 3 0.6071 78.7 0.974 Contact Map
1qg8A 1 0.6126 75.1 0.974 Contact Map
4jd0A 1 0.5632 72.3 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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