GREMLIN Database
Q9HSE2 - Uncharacterized protein
UniProt: Q9HSE2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 201 (164)
Sequences: 3081 (2257)
Seq/√Len: 176.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_C69_T5.1461.00
38_F171_L3.6521.00
64_P68_S3.0851.00
67_R105_F2.8611.00
75_N82_R2.6691.00
24_L74_A2.6491.00
85_V107_G2.6441.00
33_G130_S2.4931.00
35_A126_V2.3771.00
123_E161_Y2.3721.00
59_C66_C2.3481.00
39_T53_S2.3001.00
116_P124_V2.2901.00
24_L107_G2.2281.00
27_V34_A2.0601.00
25_V170_I1.9771.00
74_A85_V1.9011.00
67_R87_F1.8311.00
67_R90_Q1.8271.00
36_L171_L1.8201.00
65_D68_S1.8171.00
68_S82_R1.7971.00
166_A170_I1.7701.00
25_V174_F1.7541.00
30_A35_A1.7531.00
172_V176_D1.7451.00
43_A122_D1.7221.00
66_C105_F1.6881.00
74_A80_L1.6801.00
40_K43_A1.6731.00
30_A33_G1.6521.00
102_V166_A1.6041.00
26_P109_V1.5591.00
87_F107_G1.5131.00
92_D173_Q1.5041.00
40_K123_E1.4991.00
20_A59_C1.4611.00
66_C69_T1.4451.00
58_G100_Y1.4371.00
40_K122_D1.4281.00
60_E117_D1.4261.00
48_H51_Q1.4241.00
163_V171_L1.4231.00
30_A126_V1.4221.00
37_V78_I1.4211.00
140_L152_L1.4171.00
81_G84_E1.4051.00
28_V126_V1.3961.00
40_K161_Y1.3801.00
63_D68_S1.3791.00
44_D119_R1.3661.00
52_M161_Y1.3491.00
133_T175_L1.3471.00
52_M125_A1.3291.00
125_A161_Y1.3111.00
155_F162_T1.2861.00
96_T166_A1.2861.00
90_Q105_F1.2501.00
144_I150_T1.2311.00
79_G116_P1.2281.00
71_A75_N1.2271.00
38_F167_T1.2211.00
75_N81_G1.2061.00
20_A101_A1.1781.00
28_V35_A1.1751.00
106_V174_F1.1621.00
131_A137_N1.1561.00
39_T45_L1.1561.00
93_D101_A1.1391.00
26_P107_G1.1251.00
142_K150_T1.1211.00
94_I169_R1.1071.00
39_T48_H1.1001.00
19_R58_G1.0991.00
132_L175_L1.0951.00
158_V163_V1.0941.00
128_S131_A1.0851.00
52_M163_V1.0721.00
93_D103_T1.0681.00
45_L49_P1.0661.00
134_D137_N1.0611.00
42_A45_L1.0390.99
29_D34_A1.0080.99
127_L163_V0.9970.99
138_Y172_V0.9940.99
25_V36_L0.9910.99
102_V170_I0.9880.99
54_F170_I0.9880.99
39_T121_V0.9750.99
62_R68_S0.9670.99
98_T166_A0.9560.99
132_L171_L0.9550.99
138_Y156_F0.9340.99
21_A100_Y0.9240.99
19_R100_Y0.9160.99
43_A49_P0.9100.99
66_C103_T0.9090.99
142_K152_L0.9020.99
29_D108_R0.9020.99
130_S134_D0.8920.98
157_H160_G0.8850.98
38_F52_M0.8850.98
63_D69_T0.8810.98
84_E112_R0.8730.98
23_V170_I0.8710.98
34_A108_R0.8630.98
87_F105_F0.8580.98
24_L87_F0.8570.98
91_L106_V0.8480.98
114_F124_V0.8450.98
38_F54_F0.8440.98
38_F175_L0.8380.98
37_V109_V0.8370.98
138_Y175_L0.8280.97
147_E155_F0.8230.97
71_A87_F0.8210.97
74_A105_F0.8200.97
27_V129_V0.7970.97
86_A108_R0.7970.97
82_R85_V0.7950.97
131_A159_D0.7920.97
22_A66_C0.7880.97
15_T18_D0.7880.97
141_E155_F0.7810.96
71_A85_V0.7780.96
131_A158_V0.7710.96
26_P54_F0.7680.96
42_A49_P0.7650.96
96_T100_Y0.7620.96
27_V106_V0.7560.96
129_V133_T0.7520.96
36_L132_L0.7440.95
45_L48_H0.7340.95
154_H172_V0.7330.95
75_N83_D0.7260.95
45_L119_R0.7250.95
67_R71_A0.7220.95
24_L85_V0.7220.95
131_A163_V0.7180.94
24_L70_A0.7180.94
25_V54_F0.7120.94
20_A66_C0.7080.94
82_R107_G0.7070.94
20_A93_D0.6960.93
51_Q100_Y0.6910.93
90_Q103_T0.6900.93
74_A78_I0.6850.93
73_E120_E0.6850.93
91_L104_P0.6840.93
51_Q97_I0.6830.93
43_A50_G0.6830.93
78_I116_P0.6790.93
169_R173_Q0.6770.92
46_S52_M0.6760.92
78_I124_V0.6690.92
100_Y166_A0.6660.92
26_P55_P0.6660.92
135_P175_L0.6640.92
156_F175_L0.6630.92
65_D69_T0.6620.92
88_A108_R0.6500.91
175_L178_A0.6490.91
71_A82_R0.6470.91
36_L129_V0.6450.91
140_L159_D0.6440.90
39_T78_I0.6430.90
30_A110_P0.6370.90
79_G117_D0.6270.89
45_L53_S0.6200.89
39_T42_A0.6190.89
38_F125_A0.6120.88
47_D98_T0.6120.88
62_R136_S0.6100.88
22_A104_P0.6100.88
78_I121_V0.6100.88
30_A111_D0.6090.88
115_D136_S0.6060.88
47_D97_I0.6020.87
157_H162_T0.6000.87
173_Q177_L0.6000.87
54_F175_L0.5990.87
85_V109_V0.5960.87
71_A107_G0.5950.87
138_Y154_H0.5900.86
137_N156_F0.5900.86
90_Q93_D0.5880.86
96_T99_E0.5880.86
33_G128_S0.5870.86
172_V175_L0.5850.86
74_A79_G0.5820.85
166_A173_Q0.5810.85
37_V54_F0.5810.85
48_H98_T0.5770.85
52_M158_V0.5760.85
145_H148_Y0.5730.85
14_V17_Q0.5710.84
41_R121_V0.5690.84
21_A123_E0.5680.84
133_T178_A0.5670.84
163_V168_A0.5630.84
75_N115_D0.5620.83
42_A118_E0.5620.83
27_V35_A0.5610.83
147_E150_T0.5600.83
27_V174_F0.5590.83
96_T169_R0.5570.83
139_D152_L0.5570.83
158_V161_Y0.5560.83
26_P37_V0.5550.83
123_E159_D0.5530.82
47_D100_Y0.5510.82
54_F164_W0.5470.82
94_I173_Q0.5420.81
54_F171_L0.5400.81
28_V170_I0.5400.81
154_H169_R0.5390.81
64_P113_E0.5360.80
54_F107_G0.5360.80
141_E144_I0.5350.80
44_D47_D0.5350.80
62_R65_D0.5340.80
92_D104_P0.5330.80
111_D114_F0.5330.80
26_P38_F0.5320.80
97_I100_Y0.5320.80
48_H168_A0.5320.80
78_I114_F0.5300.80
53_S74_A0.5300.80
54_F94_I0.5300.80
142_K145_H0.5220.79
70_A74_A0.5190.78
89_G106_V0.5160.78
40_K52_M0.5120.77
39_T47_D0.5120.77
18_D95_A0.5100.77
18_D123_E0.5090.77
29_D33_G0.5090.77
26_P29_D0.5070.77
140_L144_I0.5040.76
79_G91_L0.5040.76
116_P121_V0.5030.76
51_Q98_T0.5010.76
104_P170_I0.5010.76
24_L54_F0.5010.76
148_Y151_A0.5000.76
127_L131_A0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nqzA 1 0.7711 99.9 0.546 Contact Map
3h95A 2 0.7711 99.8 0.67 Contact Map
4c9xA 2 0.7313 99.8 0.676 Contact Map
3kvhA 2 0.8408 99.7 0.686 Contact Map
5bonA 4 0.7463 99.7 0.687 Contact Map
4nfwA 6 0.7264 99.7 0.696 Contact Map
3qsjA 1 0.7861 99.7 0.696 Contact Map
2xsqA 2 0.7811 99.7 0.702 Contact Map
1u20A 2 0.8607 99.7 0.704 Contact Map
2w4eA 2 0.6766 99.6 0.705 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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