Q9HSE2 - HALSA - GREMLIN Contacts

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Q9HSE2 - Uncharacterized protein

UniProt:	Q9HSE2	Sequences: MDLSGVAAHRPVRVTDQDRAAAVLVPVVDAADGAALVFTKRAADLSDHPGQMSFPGGGCEPRDPDCRSTAAREANEEIGLGRDEVAFAGQLDDIATITEYAVTPFVGRVPDREFDPDEREVDEVAVLSVSALTDPSNYDLEKRIHPEYGTALVHFFHVDGYTVWGATARILVQFLDLAAGWTPPDRDPTVVELDPDYPETS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	201 (164)
Sequences:	3081 (2257)
Seq/√Len:	176.2

ECOLI - NUDL
HALSA - Q9HSE2
SULSO - Q97U56

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_C	69_T	5.146	1.00
38_F	171_L	3.652	1.00
64_P	68_S	3.085	1.00
67_R	105_F	2.861	1.00
75_N	82_R	2.669	1.00
24_L	74_A	2.649	1.00
85_V	107_G	2.644	1.00
33_G	130_S	2.493	1.00
35_A	126_V	2.377	1.00
123_E	161_Y	2.372	1.00
59_C	66_C	2.348	1.00
39_T	53_S	2.300	1.00
116_P	124_V	2.290	1.00
24_L	107_G	2.228	1.00
27_V	34_A	2.060	1.00
25_V	170_I	1.977	1.00
74_A	85_V	1.901	1.00
67_R	87_F	1.831	1.00
67_R	90_Q	1.827	1.00
36_L	171_L	1.820	1.00
65_D	68_S	1.817	1.00
68_S	82_R	1.797	1.00
166_A	170_I	1.770	1.00
25_V	174_F	1.754	1.00
30_A	35_A	1.753	1.00
172_V	176_D	1.745	1.00
43_A	122_D	1.722	1.00
66_C	105_F	1.688	1.00
74_A	80_L	1.680	1.00
40_K	43_A	1.673	1.00
30_A	33_G	1.652	1.00
102_V	166_A	1.604	1.00
26_P	109_V	1.559	1.00
87_F	107_G	1.513	1.00
92_D	173_Q	1.504	1.00
40_K	123_E	1.499	1.00
20_A	59_C	1.461	1.00
66_C	69_T	1.445	1.00
58_G	100_Y	1.437	1.00
40_K	122_D	1.428	1.00
60_E	117_D	1.426	1.00
48_H	51_Q	1.424	1.00
163_V	171_L	1.423	1.00
30_A	126_V	1.422	1.00
37_V	78_I	1.421	1.00
140_L	152_L	1.417	1.00
81_G	84_E	1.405	1.00
28_V	126_V	1.396	1.00
40_K	161_Y	1.380	1.00
63_D	68_S	1.379	1.00
44_D	119_R	1.366	1.00
52_M	161_Y	1.349	1.00
133_T	175_L	1.347	1.00
52_M	125_A	1.329	1.00
125_A	161_Y	1.311	1.00
155_F	162_T	1.286	1.00
96_T	166_A	1.286	1.00
90_Q	105_F	1.250	1.00
144_I	150_T	1.231	1.00
79_G	116_P	1.228	1.00
71_A	75_N	1.227	1.00
38_F	167_T	1.221	1.00
75_N	81_G	1.206	1.00
20_A	101_A	1.178	1.00
28_V	35_A	1.175	1.00
106_V	174_F	1.162	1.00
131_A	137_N	1.156	1.00
39_T	45_L	1.156	1.00
93_D	101_A	1.139	1.00
26_P	107_G	1.125	1.00
142_K	150_T	1.121	1.00
94_I	169_R	1.107	1.00
39_T	48_H	1.100	1.00
19_R	58_G	1.099	1.00
132_L	175_L	1.095	1.00
158_V	163_V	1.094	1.00
128_S	131_A	1.085	1.00
52_M	163_V	1.072	1.00
93_D	103_T	1.068	1.00
45_L	49_P	1.066	1.00
134_D	137_N	1.061	1.00
42_A	45_L	1.039	0.99
29_D	34_A	1.008	0.99
127_L	163_V	0.997	0.99
138_Y	172_V	0.994	0.99
25_V	36_L	0.991	0.99
102_V	170_I	0.988	0.99
54_F	170_I	0.988	0.99
39_T	121_V	0.975	0.99
62_R	68_S	0.967	0.99
98_T	166_A	0.956	0.99
132_L	171_L	0.955	0.99
138_Y	156_F	0.934	0.99
21_A	100_Y	0.924	0.99
19_R	100_Y	0.916	0.99
43_A	49_P	0.910	0.99
66_C	103_T	0.909	0.99
142_K	152_L	0.902	0.99
29_D	108_R	0.902	0.99
130_S	134_D	0.892	0.98
157_H	160_G	0.885	0.98
38_F	52_M	0.885	0.98
63_D	69_T	0.881	0.98
84_E	112_R	0.873	0.98
23_V	170_I	0.871	0.98
34_A	108_R	0.863	0.98
87_F	105_F	0.858	0.98
24_L	87_F	0.857	0.98
91_L	106_V	0.848	0.98
114_F	124_V	0.845	0.98
38_F	54_F	0.844	0.98
38_F	175_L	0.838	0.98
37_V	109_V	0.837	0.98
138_Y	175_L	0.828	0.97
147_E	155_F	0.823	0.97
71_A	87_F	0.821	0.97
74_A	105_F	0.820	0.97
27_V	129_V	0.797	0.97
86_A	108_R	0.797	0.97
82_R	85_V	0.795	0.97
131_A	159_D	0.792	0.97
22_A	66_C	0.788	0.97
15_T	18_D	0.788	0.97
141_E	155_F	0.781	0.96
71_A	85_V	0.778	0.96
131_A	158_V	0.771	0.96
26_P	54_F	0.768	0.96
42_A	49_P	0.765	0.96
96_T	100_Y	0.762	0.96
27_V	106_V	0.756	0.96
129_V	133_T	0.752	0.96
36_L	132_L	0.744	0.95
45_L	48_H	0.734	0.95
154_H	172_V	0.733	0.95
75_N	83_D	0.726	0.95
45_L	119_R	0.725	0.95
67_R	71_A	0.722	0.95
24_L	85_V	0.722	0.95
131_A	163_V	0.718	0.94
24_L	70_A	0.718	0.94
25_V	54_F	0.712	0.94
20_A	66_C	0.708	0.94
82_R	107_G	0.707	0.94
20_A	93_D	0.696	0.93
51_Q	100_Y	0.691	0.93
90_Q	103_T	0.690	0.93
74_A	78_I	0.685	0.93
73_E	120_E	0.685	0.93
91_L	104_P	0.684	0.93
51_Q	97_I	0.683	0.93
43_A	50_G	0.683	0.93
78_I	116_P	0.679	0.93
169_R	173_Q	0.677	0.92
46_S	52_M	0.676	0.92
78_I	124_V	0.669	0.92
100_Y	166_A	0.666	0.92
26_P	55_P	0.666	0.92
135_P	175_L	0.664	0.92
156_F	175_L	0.663	0.92
65_D	69_T	0.662	0.92
88_A	108_R	0.650	0.91
175_L	178_A	0.649	0.91
71_A	82_R	0.647	0.91
36_L	129_V	0.645	0.91
140_L	159_D	0.644	0.90
39_T	78_I	0.643	0.90
30_A	110_P	0.637	0.90
79_G	117_D	0.627	0.89
45_L	53_S	0.620	0.89
39_T	42_A	0.619	0.89
38_F	125_A	0.612	0.88
47_D	98_T	0.612	0.88
62_R	136_S	0.610	0.88
22_A	104_P	0.610	0.88
78_I	121_V	0.610	0.88
30_A	111_D	0.609	0.88
115_D	136_S	0.606	0.88
47_D	97_I	0.602	0.87
157_H	162_T	0.600	0.87
173_Q	177_L	0.600	0.87
54_F	175_L	0.599	0.87
85_V	109_V	0.596	0.87
71_A	107_G	0.595	0.87
138_Y	154_H	0.590	0.86
137_N	156_F	0.590	0.86
90_Q	93_D	0.588	0.86
96_T	99_E	0.588	0.86
33_G	128_S	0.587	0.86
172_V	175_L	0.585	0.86
74_A	79_G	0.582	0.85
166_A	173_Q	0.581	0.85
37_V	54_F	0.581	0.85
48_H	98_T	0.577	0.85
52_M	158_V	0.576	0.85
145_H	148_Y	0.573	0.85
14_V	17_Q	0.571	0.84
41_R	121_V	0.569	0.84
21_A	123_E	0.568	0.84
133_T	178_A	0.567	0.84
163_V	168_A	0.563	0.84
75_N	115_D	0.562	0.83
42_A	118_E	0.562	0.83
27_V	35_A	0.561	0.83
147_E	150_T	0.560	0.83
27_V	174_F	0.559	0.83
96_T	169_R	0.557	0.83
139_D	152_L	0.557	0.83
158_V	161_Y	0.556	0.83
26_P	37_V	0.555	0.83
123_E	159_D	0.553	0.82
47_D	100_Y	0.551	0.82
54_F	164_W	0.547	0.82
94_I	173_Q	0.542	0.81
54_F	171_L	0.540	0.81
28_V	170_I	0.540	0.81
154_H	169_R	0.539	0.81
64_P	113_E	0.536	0.80
54_F	107_G	0.536	0.80
141_E	144_I	0.535	0.80
44_D	47_D	0.535	0.80
62_R	65_D	0.534	0.80
92_D	104_P	0.533	0.80
111_D	114_F	0.533	0.80
26_P	38_F	0.532	0.80
97_I	100_Y	0.532	0.80
48_H	168_A	0.532	0.80
78_I	114_F	0.530	0.80
53_S	74_A	0.530	0.80
54_F	94_I	0.530	0.80
142_K	145_H	0.522	0.79
70_A	74_A	0.519	0.78
89_G	106_V	0.516	0.78
40_K	52_M	0.512	0.77
39_T	47_D	0.512	0.77
18_D	95_A	0.510	0.77
18_D	123_E	0.509	0.77
29_D	33_G	0.509	0.77
26_P	29_D	0.507	0.77
140_L	144_I	0.504	0.76
79_G	91_L	0.504	0.76
116_P	121_V	0.503	0.76
51_Q	98_T	0.501	0.76
104_P	170_I	0.501	0.76
24_L	54_F	0.501	0.76
148_Y	151_A	0.500	0.76
127_L	131_A	0.500	0.76

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nqzA	1	0.7711	99.9	0.546	Contact Map
3h95A	2	0.7711	99.8	0.67	Contact Map
4c9xA	2	0.7313	99.8	0.676	Contact Map
3kvhA	2	0.8408	99.7	0.686	Contact Map
5bonA	4	0.7463	99.7	0.687	Contact Map
4nfwA	6	0.7264	99.7	0.696	Contact Map
3qsjA	1	0.7861	99.7	0.696	Contact Map
2xsqA	2	0.7811	99.7	0.702	Contact Map
1u20A	2	0.8607	99.7	0.704	Contact Map
2w4eA	2	0.6766	99.6	0.705	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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