GREMLIN Database
Q9HSE1 - Phytoene dehydrogenase
UniProt: Q9HSE1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 541 (441)
Sequences: 14525 (11685)
Seq/√Len: 556.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_R29_D4.1721.00
238_L243_V3.9651.00
8_A273_A3.7861.00
31_T246_R3.6451.00
35_A250_P3.5161.00
6_R274_D3.5031.00
39_L247_L3.4401.00
253_E265_V3.3871.00
19_A277_V3.1791.00
278_A285_L3.1071.00
39_L235_H2.9501.00
33_Y271_V2.9241.00
255_H265_V2.8411.00
37_D248_D2.8261.00
8_A33_Y2.8211.00
12_G39_L2.7811.00
8_A271_V2.7431.00
478_G482_A2.7391.00
265_V270_S2.6501.00
87_D223_D2.6181.00
386_T389_E2.5811.00
249_S266_I2.5691.00
228_E232_D2.4691.00
29_D244_D2.4341.00
235_H239_D2.4221.00
227_S232_D2.3561.00
8_A264_A2.3431.00
161_Q169_A2.3361.00
279_A458_A2.2901.00
33_Y246_R2.2791.00
10_L278_A2.2691.00
246_R269_E2.2431.00
266_I271_V2.1531.00
456_A488_A2.1521.00
22_E479_R2.1361.00
47_P55_L2.0871.00
235_H245_V2.0531.00
246_R249_S2.0291.00
15_A279_A2.0081.00
330_V333_D2.0051.00
7_V28_L1.9901.00
275_H456_A1.9781.00
10_L280_L1.9281.00
33_Y273_A1.9131.00
132_P136_L1.8941.00
14_I471_M1.8821.00
252_T265_V1.8781.00
277_V485_V1.8521.00
257_D262_T1.8501.00
6_R31_T1.8411.00
45_S55_L1.8181.00
399_Q406_T1.8151.00
329_A332_A1.8071.00
392_A396_A1.8031.00
5_Q31_T1.7941.00
440_G443_Q1.7801.00
233_H236_D1.7701.00
266_I269_E1.7641.00
117_E120_S1.7631.00
253_E290_T1.7621.00
21_Q237_Y1.7611.00
26_R486_L1.7521.00
18_T475_N1.7211.00
262_T272_T1.7181.00
164_W168_D1.7171.00
388_E392_A1.7141.00
168_D177_R1.7101.00
255_H270_S1.6761.00
246_R271_V1.6591.00
38_R44_R1.6451.00
89_L223_D1.6421.00
22_E25_E1.6311.00
7_V275_H1.6031.00
280_L285_L1.5761.00
261_V276_Y1.5761.00
54_L317_Y1.5741.00
132_P135_E1.5731.00
28_L486_L1.5621.00
31_T244_D1.5451.00
399_Q408_P1.5381.00
22_E483_N1.5361.00
254_L261_V1.5351.00
20_A32_V1.5201.00
162_S165_E1.5131.00
249_S267_D1.5091.00
255_H262_T1.5081.00
25_E76_R1.5051.00
458_A481_A1.5041.00
43_A231_L1.5011.00
118_W122_I1.5011.00
7_V23_L1.5001.00
437_N440_G1.4931.00
236_D239_D1.4871.00
9_V16_G1.4681.00
16_G279_A1.4481.00
164_W193_E1.4371.00
133_R139_F1.4241.00
364_V368_A1.4231.00
129_G132_P1.4071.00
75_A80_G1.4021.00
261_V454_N1.3961.00
39_L231_L1.3931.00
33_Y251_V1.3921.00
251_V264_A1.3821.00
15_A477_A1.3801.00
437_N441_S1.3731.00
39_L245_V1.3641.00
114_T118_W1.3631.00
32_V245_V1.3561.00
72_K76_R1.3541.00
249_S269_E1.3531.00
419_P422_A1.3511.00
238_L245_V1.3491.00
365_S368_A1.3421.00
21_Q234_W1.3421.00
232_D236_D1.3411.00
438_T441_S1.3401.00
318_L395_W1.3391.00
237_Y241_Q1.3321.00
275_H485_V1.3211.00
47_P53_G1.3181.00
42_K460_D1.3121.00
8_A31_T1.3091.00
437_N443_Q1.3031.00
116_R120_S1.2981.00
135_E139_F1.2931.00
31_T271_V1.2931.00
262_T270_S1.2861.00
456_A481_A1.2831.00
130_E133_R1.2791.00
438_T443_Q1.2751.00
365_S369_S1.2741.00
226_T471_M1.2701.00
24_A241_Q1.2621.00
239_D244_D1.2611.00
9_V20_A1.2571.00
72_K479_R1.2451.00
31_T273_A1.2411.00
440_G444_H1.2381.00
273_A276_Y1.2321.00
329_A333_D1.2311.00
12_G32_V1.2301.00
142_R145_V1.2281.00
21_Q25_E1.2281.00
319_D410_E1.2221.00
339_T343_Q1.2221.00
161_Q165_E1.2211.00
192_P195_G1.2211.00
282_V461_Y1.2201.00
362_G366_V1.2161.00
364_V367_I1.2131.00
343_Q346_F1.2041.00
141_S145_V1.1981.00
114_T117_E1.1951.00
438_T444_H1.1931.00
222_L230_W1.1931.00
143_L147_L1.1881.00
103_D175_A1.1861.00
281_P284_V1.1771.00
403_G406_T1.1751.00
257_D272_T1.1721.00
33_Y266_I1.1711.00
459_G477_A1.1641.00
22_E478_G1.1631.00
6_R28_L1.1621.00
24_A30_V1.1591.00
33_Y249_S1.1551.00
135_E138_H1.1451.00
132_P137_A1.1441.00
191_R194_I1.1371.00
363_V366_V1.1361.00
462_A480_R1.1351.00
71_V75_A1.1301.00
130_E136_L1.1201.00
9_V30_V1.1181.00
256_S261_V1.1141.00
392_A408_P1.1081.00
239_D242_G1.1051.00
22_E76_R1.1041.00
385_C389_E1.1041.00
284_V287_A1.1031.00
341_V345_Q1.1021.00
391_V395_W1.0971.00
481_A484_A1.0951.00
129_G133_R1.0941.00
260_R272_T1.0901.00
24_A243_V1.0891.00
21_Q238_L1.0881.00
335_P339_T1.0881.00
116_R119_V1.0811.00
23_L482_A1.0761.00
407_L410_E1.0661.00
397_Q400_A1.0651.00
14_I43_A1.0621.00
254_L276_Y1.0531.00
115_P118_W1.0511.00
368_A371_W1.0501.00
316_F395_W1.0501.00
351_D354_A1.0491.00
480_R484_A1.0491.00
115_P119_V1.0491.00
456_A485_V1.0421.00
113_D117_E1.0381.00
24_A238_L1.0371.00
389_E392_A1.0361.00
132_P139_F1.0351.00
382_G385_C1.0351.00
129_G136_L1.0331.00
235_H247_L1.0311.00
366_V372_D1.0251.00
366_V371_W1.0241.00
365_S372_D1.0241.00
363_V368_A1.0221.00
232_D235_H1.0201.00
15_A458_A1.0161.00
369_S372_D1.0131.00
414_A418_D1.0131.00
364_V370_D1.0071.00
249_S271_V1.0061.00
389_E393_E1.0041.00
143_L146_L1.0021.00
113_D116_R0.9981.00
363_V367_I0.9951.00
136_L139_F0.9931.00
414_A417_L0.9921.00
407_L412_R0.9911.00
136_L140_V0.9881.00
333_D336_W0.9861.00
340_S343_Q0.9851.00
47_P227_S0.9841.00
300_L304_D0.9841.00
352_L355_R0.9811.00
110_E113_D0.9801.00
161_Q166_F0.9771.00
74_M77_I0.9761.00
445_R448_P0.9721.00
224_G228_E0.9711.00
257_D260_R0.9691.00
362_G368_A0.9691.00
291_P294_R0.9651.00
365_S370_D0.9641.00
154_R157_A0.9641.00
5_Q29_D0.9641.00
129_G137_A0.9641.00
5_Q274_D0.9601.00
131_V135_E0.9591.00
275_H454_N0.9531.00
117_E121_A0.9501.00
80_G223_D0.9501.00
114_T122_I0.9491.00
228_E233_H0.9491.00
329_A335_P0.9481.00
21_Q76_R0.9481.00
320_R410_E0.9461.00
411_A414_A0.9451.00
456_A484_A0.9451.00
254_L278_A0.9391.00
74_M79_D0.9361.00
452_A455_L0.9321.00
6_R271_V0.9301.00
299_S302_G0.9271.00
341_V344_R0.9261.00
69_N479_R0.9231.00
367_I370_D0.9191.00
409_D412_R0.9181.00
301_R304_D0.9171.00
361_Q366_V0.9161.00
275_H489_A0.9141.00
262_T265_V0.9131.00
395_W399_Q0.9121.00
108_S113_D0.9111.00
131_V136_L0.9101.00
252_T268_G0.9081.00
132_P140_V0.9041.00
396_A400_A0.9001.00
12_G247_L0.8991.00
260_R453_P0.8981.00
474_A478_G0.8981.00
21_Q77_I0.8951.00
360_V364_V0.8931.00
18_T478_G0.8911.00
130_E135_E0.8901.00
88_H92_T0.8901.00
250_P420_E0.8881.00
278_A455_L0.8881.00
15_A474_A0.8871.00
252_T267_D0.8871.00
134_R138_H0.8871.00
416_F419_P0.8851.00
22_E26_R0.8851.00
339_T342_S0.8851.00
286_P304_D0.8841.00
481_A485_V0.8811.00
462_A477_A0.8781.00
366_V370_D0.8771.00
393_E396_A0.8771.00
237_Y240_A0.8741.00
46_I58_H0.8741.00
256_S452_A0.8731.00
418_D421_L0.8711.00
254_L264_A0.8701.00
130_E139_F0.8681.00
236_D240_A0.8661.00
133_R137_A0.8631.00
19_A478_G0.8621.00
482_A485_V0.8611.00
280_L288_L0.8601.00
331_Y336_W0.8591.00
368_A372_D0.8591.00
91_S94_E0.8531.00
133_R136_L0.8521.00
42_K59_G0.8481.00
330_V335_P0.8461.00
367_I372_D0.8451.00
331_Y335_P0.8431.00
222_L228_E0.8411.00
396_A408_P0.8411.00
79_D240_A0.8401.00
364_V369_S0.8391.00
449_D488_A0.8391.00
36_N421_L0.8371.00
479_R483_N0.8351.00
361_Q368_A0.8341.00
294_R452_A0.8321.00
72_K75_A0.8291.00
36_N44_R0.8281.00
70_V475_N0.8261.00
441_S444_H0.8251.00
330_V334_S0.8241.00
252_T255_H0.8231.00
252_T266_I0.8231.00
114_T119_V0.8211.00
231_L235_H0.8181.00
318_L322_I0.8181.00
329_A334_S0.8161.00
123_Q127_A0.8151.00
17_L238_L0.8141.00
114_T123_Q0.8131.00
96_L106_V0.8121.00
398_L402_L0.8121.00
34_E247_L0.8121.00
256_S454_N0.8111.00
181_A192_P0.8101.00
413_V416_F0.8101.00
45_S227_S0.8091.00
449_D484_A0.8091.00
413_V417_L0.8091.00
67_Y472_E0.8091.00
197_A200_V0.8071.00
361_Q364_V0.8071.00
173_S177_R0.8061.00
142_R146_L0.8051.00
391_V394_I0.8041.00
119_V122_I0.8001.00
415_H418_D0.7981.00
361_Q365_S0.7971.00
197_A201_G0.7961.00
6_R272_T0.7931.00
140_V144_A0.7921.00
119_V123_Q0.7881.00
28_L489_A0.7851.00
362_G365_S0.7811.00
186_A189_A0.7811.00
411_A416_F0.7791.00
174_P177_R0.7771.00
437_N444_H0.7771.00
60_F226_T0.7761.00
413_V418_D0.7751.00
340_S344_R0.7741.00
140_V143_L0.7741.00
10_L251_V0.7721.00
29_D274_D0.7701.00
14_I474_A0.7691.00
72_K77_I0.7671.00
276_Y454_N0.7661.00
483_N487_D0.7661.00
14_I231_L0.7621.00
333_D339_T0.7611.00
391_V414_A0.7601.00
144_A147_L0.7601.00
154_R158_F0.7591.00
88_H94_E0.7581.00
275_H278_A0.7571.00
396_A399_Q0.7571.00
299_S303_V0.7561.00
130_E134_R0.7561.00
20_A238_L0.7551.00
28_L31_T0.7541.00
93_S96_L0.7541.00
418_D422_A0.7511.00
73_T77_I0.7501.00
342_S345_Q0.7491.00
277_V458_A0.7471.00
138_H141_S0.7461.00
9_V19_A0.7461.00
192_P198_R0.7461.00
360_V366_V0.7441.00
26_R483_N0.7431.00
439_V442_L0.7401.00
32_V238_L0.7371.00
282_V303_V0.7371.00
335_P338_I0.7351.00
112_P115_P0.7351.00
364_V371_W0.7351.00
25_E241_Q0.7351.00
145_V148_T0.7331.00
118_W121_A0.7321.00
338_I342_S0.7291.00
338_I341_V0.7281.00
332_A335_P0.7271.00
250_P287_A0.7261.00
251_V266_I0.7231.00
362_G369_S0.7221.00
166_F170_D0.7211.00
406_T409_D0.7201.00
363_V369_S0.7191.00
75_A78_P0.7161.00
342_S346_F0.7141.00
331_Y334_S0.7111.00
77_I234_W0.7101.00
191_R195_G0.7091.00
366_V369_S0.7091.00
128_G131_V0.7061.00
31_T274_D0.7061.00
17_L32_V0.7051.00
18_T22_E0.7031.00
332_A336_W0.7011.00
18_T234_W0.7011.00
5_Q8_A0.6981.00
196_S199_T0.6971.00
329_A339_T0.6971.00
192_P199_T0.6971.00
332_A337_A0.6961.00
195_G200_V0.6941.00
195_G198_R0.6931.00
439_V443_Q0.6931.00
43_A471_M0.6931.00
28_L274_D0.6911.00
458_A478_G0.6911.00
439_V444_H0.6891.00
57_E226_T0.6871.00
118_W123_Q0.6861.00
17_L231_L0.6851.00
89_L92_T0.6841.00
364_V372_D0.6841.00
199_T202_T0.6821.00
341_V346_F0.6781.00
14_I475_N0.6771.00
397_Q401_H0.6771.00
233_H237_Y0.6761.00
360_V368_A0.6741.00
132_P138_H0.6731.00
128_G132_P0.6731.00
485_V489_A0.6731.00
155_E159_E0.6721.00
191_R196_S0.6701.00
20_A243_V0.6701.00
88_H91_S0.6691.00
235_H243_V0.6681.00
388_E391_V0.6661.00
6_R273_A0.6661.00
335_P343_Q0.6631.00
43_A60_F0.6631.00
476_E480_R0.6621.00
71_V220_R0.6601.00
339_T344_R0.6591.00
73_T475_N0.6581.00
277_V456_A0.6571.00
202_T205_L0.6551.00
410_E415_H0.6541.00
90_V94_E0.6521.00
412_R415_H0.6511.00
21_Q241_Q0.6501.00
277_V481_A0.6481.00
90_V93_S0.6481.00
350_H353_G0.6481.00
362_G370_D0.6471.00
406_T410_E0.6461.00
330_V336_W0.6461.00
337_A341_V0.6441.00
437_N442_L0.6421.00
166_F197_A0.6421.00
111_S115_P0.6411.00
144_A148_T0.6401.00
74_M222_L0.6391.00
387_R391_V0.6391.00
94_E97_I0.6391.00
70_V471_M0.6381.00
14_I18_T0.6351.00
264_A276_Y0.6331.00
139_F143_L0.6331.00
359_D365_S0.6331.00
334_S338_I0.6261.00
333_D337_A0.6251.00
339_T345_Q0.6221.00
137_A140_V0.6221.00
129_G139_F0.6191.00
122_I129_G0.6191.00
91_S96_L0.6171.00
331_Y340_S0.6171.00
256_S259_H0.6151.00
398_L407_L0.6151.00
66_Y69_N0.6141.00
321_D324_I0.6131.00
113_D118_W0.6111.00
47_P51_S0.6081.00
295_R301_R0.6071.00
19_A481_A0.6071.00
159_E162_S0.6061.00
363_V370_D0.6051.00
367_I371_W0.6051.00
336_W340_S0.6041.00
198_R201_G0.6041.00
340_S345_Q0.6021.00
129_G135_E0.6021.00
25_E237_Y0.6021.00
244_D247_L0.6011.00
361_Q367_I0.6001.00
164_W181_A0.5991.00
45_S57_E0.5981.00
360_V363_V0.5961.00
194_I198_R0.5961.00
22_E73_T0.5961.00
128_G136_L0.5951.00
134_R137_A0.5941.00
298_P301_R0.5941.00
320_R323_P0.5941.00
182_Q185_Q0.5931.00
336_W339_T0.5921.00
411_A419_P0.5911.00
88_H93_S0.5891.00
184_T188_V0.5891.00
139_F147_L0.5891.00
299_S451_D0.5871.00
33_Y264_A0.5871.00
95_T99_S0.5851.00
316_F407_L0.5841.00
482_A486_L0.5831.00
383_R387_R0.5831.00
136_L143_L0.5821.00
140_V147_L0.5821.00
334_S339_T0.5821.00
68_T72_K0.5821.00
69_N476_E0.5821.00
332_A340_S0.5801.00
282_V286_P0.5801.00
333_D338_I0.5791.00
225_P228_E0.5791.00
88_H95_T0.5780.99
337_A340_S0.5780.99
281_P461_Y0.5760.99
57_E227_S0.5750.99
171_A180_L0.5750.99
318_L407_L0.5740.99
177_R181_A0.5740.99
137_A141_S0.5720.99
5_Q28_L0.5710.99
129_G140_V0.5710.99
289_L292_A0.5680.99
311_M434_L0.5680.99
92_T95_T0.5670.99
73_T76_R0.5660.99
306_I309_A0.5650.99
278_A457_V0.5650.99
130_E137_A0.5650.99
219_E222_L0.5650.99
357_D360_V0.5650.99
411_A415_H0.5640.99
37_D247_L0.5640.99
114_T121_A0.5630.99
393_E397_Q0.5630.99
69_N472_E0.5610.99
280_L284_V0.5600.99
18_T73_T0.5600.99
12_G16_G0.5590.99
415_H419_P0.5590.99
57_E62_F0.5580.99
282_V285_L0.5570.99
338_I343_Q0.5560.99
285_L288_L0.5560.99
123_Q129_G0.5560.99
282_V306_I0.5560.99
415_H420_E0.5550.99
195_G201_G0.5550.99
450_T457_V0.5540.99
157_A160_H0.5540.99
165_E168_D0.5540.99
135_E142_R0.5530.99
69_N475_N0.5530.99
362_G367_I0.5500.99
301_R305_R0.5480.99
239_D243_V0.5480.99
362_G371_W0.5470.99
330_V341_V0.5470.99
138_H142_R0.5450.99
360_V365_S0.5440.99
96_L99_S0.5430.99
392_A395_W0.5420.99
139_F145_V0.5420.99
140_V146_L0.5410.99
130_E144_A0.5400.99
139_F142_R0.5390.99
318_L323_P0.5390.99
459_G462_A0.5390.99
332_A339_T0.5390.99
232_D239_D0.5390.99
115_P120_S0.5380.99
62_F187_L0.5380.99
27_G30_V0.5370.99
100_A103_D0.5370.99
387_R390_A0.5370.99
410_E414_A0.5360.99
254_L288_L0.5350.99
380_K383_R0.5340.99
283_D286_P0.5340.99
57_E61_R0.5330.99
166_F169_A0.5320.99
46_I51_S0.5320.99
168_D193_E0.5320.99
179_H183_S0.5290.99
314_V391_V0.5280.99
185_Q189_A0.5270.99
115_P122_I0.5260.99
228_E236_D0.5260.99
38_R227_S0.5250.99
91_S95_T0.5250.99
221_V226_T0.5250.99
9_V32_V0.5250.99
336_W343_Q0.5240.99
381_P384_E0.5240.99
24_A244_D0.5240.99
274_D454_N0.5230.99
195_G199_T0.5230.99
334_S337_A0.5190.99
153_R156_Q0.5170.99
190_L436_I0.5160.99
36_N418_D0.5150.99
60_F64_P0.5150.99
14_I234_W0.5140.99
64_P219_E0.5140.99
115_P121_A0.5130.99
28_L275_H0.5110.99
127_A133_R0.5110.99
360_V367_I0.5110.99
202_T206_Q0.5100.99
38_R232_D0.5100.99
12_G235_H0.5090.99
13_G16_G0.5090.99
182_Q186_A0.5090.99
438_T442_L0.5070.99
101_D104_G0.5070.99
235_H238_L0.5070.99
131_V137_A0.5060.99
5_Q275_H0.5060.99
146_L149_S0.5060.99
128_G135_E0.5040.99
132_P142_R0.5040.99
120_S123_Q0.5030.99
9_V277_V0.5020.99
303_V306_I0.5020.99
363_V371_W0.5010.99
60_F472_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s3eA 2 0.902 100 0.387 Contact Map
4i59A 1 0.8133 100 0.391 Contact Map
2yg5A 2 0.8115 100 0.413 Contact Map
2vvmA 2 0.8115 100 0.451 Contact Map
3x0vA 2 0.8558 100 0.453 Contact Map
4dgkA 1 0.7061 100 0.453 Contact Map
2ivdA 1 0.7819 100 0.459 Contact Map
1b37A 4 0.7967 100 0.462 Contact Map
3i6dA 1 0.7486 100 0.463 Contact Map
3we0A 3 0.8558 100 0.466 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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