GREMLIN Database
Q9HSD9 - Sarcosine oxidase
UniProt: Q9HSD9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (334)
Sequences: 26037 (18497)
Seq/√Len: 1012.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_A169_V5.1361.00
10_R36_T4.0601.00
11_R192_D3.2321.00
13_A191_Y2.9731.00
11_R34_D2.8581.00
40_R176_P2.8541.00
76_R88_E2.8331.00
226_D293_A2.8081.00
36_T172_R2.7891.00
127_L142_A2.6731.00
13_A38_Y2.6551.00
123_D126_A2.5801.00
12_V28_L2.5351.00
30_E81_H2.5111.00
70_R338_A2.5041.00
29_A167_R2.4261.00
33_V345_L2.4261.00
34_D170_E2.3531.00
120_E126_A2.2351.00
102_A141_A2.2091.00
29_A169_V2.1791.00
12_V33_V2.0921.00
24_A195_V2.0821.00
220_V302_C2.0771.00
27_D338_A2.0721.00
77_E81_H2.0401.00
126_A129_A2.0141.00
9_D190_A1.9721.00
22_L157_A1.9481.00
322_A336_T1.9321.00
193_D320_Y1.9101.00
22_L161_A1.8971.00
342_D347_G1.8921.00
31_R345_L1.8731.00
26_H163_R1.8711.00
325_W336_T1.8601.00
9_D192_D1.8431.00
31_R347_G1.8331.00
118_A147_D1.8031.00
43_V173_T1.7881.00
277_D281_D1.7821.00
29_A164_A1.7731.00
120_E146_R1.7711.00
110_A114_R1.7611.00
26_H30_E1.7531.00
320_Y340_L1.7451.00
322_A340_L1.7441.00
27_D337_G1.7411.00
106_R121_H1.7351.00
17_A43_V1.7311.00
202_T323_A1.7171.00
74_R338_A1.7081.00
30_E167_R1.6971.00
124_A128_A1.6931.00
195_V344_V1.6881.00
233_P236_Y1.6791.00
320_Y344_V1.6741.00
85_T155_A1.6661.00
10_R170_E1.6651.00
109_V113_Q1.6561.00
10_R13_A1.6541.00
163_R166_D1.6311.00
43_V161_A1.6171.00
163_R167_R1.6031.00
196_V202_T1.5951.00
225_A228_P1.5901.00
90_P144_I1.5841.00
110_A113_Q1.5531.00
27_D31_R1.5461.00
74_R77_E1.5461.00
120_E144_I1.5391.00
20_V322_A1.5211.00
75_F156_Y1.5201.00
162_D166_D1.5201.00
106_R110_A1.5021.00
162_D165_R1.4981.00
31_R341_A1.4961.00
20_V325_W1.4951.00
193_D344_V1.4931.00
31_R342_D1.4781.00
24_A322_A1.4681.00
152_D155_A1.4631.00
38_Y191_Y1.4571.00
161_A171_I1.4531.00
42_T173_T1.4501.00
17_A37_V1.4391.00
226_D295_E1.4341.00
161_A165_R1.4151.00
70_R73_E1.4111.00
27_D30_E1.4111.00
122_A126_A1.4081.00
13_A36_T1.4071.00
11_R33_V1.4001.00
276_V297_S1.4001.00
280_D284_R1.3831.00
196_V319_L1.3791.00
232_L235_V1.3741.00
28_L341_A1.3641.00
23_T27_D1.3511.00
196_V321_V1.3441.00
41_D45_A1.3261.00
273_D277_D1.3211.00
11_R36_T1.3121.00
103_D106_R1.3111.00
172_R175_E1.3091.00
15_I198_A1.3071.00
86_V149_A1.3041.00
41_D46_A1.2981.00
98_P140_V1.2911.00
19_A333_A1.2891.00
130_A144_I1.2851.00
73_E77_E1.2831.00
12_V193_D1.2801.00
102_A106_R1.2741.00
191_Y194_V1.2651.00
233_P237_D1.2571.00
338_A342_D1.2541.00
322_A325_W1.2491.00
125_D129_A1.2421.00
50_R298_W1.2391.00
337_G341_A1.2371.00
315_L321_V1.2231.00
320_Y343_D1.2181.00
185_R190_A1.2181.00
77_E80_G1.2111.00
25_A35_V1.2081.00
22_L37_V1.2061.00
126_A130_A1.2061.00
22_L164_A1.1981.00
14_V25_A1.1931.00
95_A105_I1.1841.00
122_A130_A1.1801.00
232_L236_Y1.1781.00
339_A342_D1.1671.00
10_R34_D1.1611.00
15_I194_V1.1601.00
97_E100_A1.1571.00
17_A39_E1.1551.00
38_Y172_R1.1491.00
76_R80_G1.1461.00
24_A197_A1.1421.00
82_G163_R1.1381.00
37_V171_I1.1261.00
198_A202_T1.1241.00
198_A205_V1.1231.00
26_H167_R1.1191.00
36_T170_E1.1081.00
107_E110_A1.0971.00
44_A157_A1.0901.00
120_E130_A1.0831.00
196_V206_L1.0811.00
109_V143_A1.0801.00
193_D314_E1.0761.00
102_A121_H1.0741.00
154_T158_R1.0611.00
14_V24_A1.0571.00
98_P103_D1.0481.00
23_T160_I1.0481.00
43_V171_I1.0431.00
23_T337_G1.0431.00
109_V121_H1.0381.00
79_S84_F1.0371.00
151_V156_Y1.0351.00
179_V194_V1.0351.00
25_A37_V1.0341.00
204_R207_A1.0301.00
40_R175_E1.0301.00
75_F333_A1.0281.00
24_A337_G1.0261.00
312_L336_T1.0251.00
151_V330_F1.0231.00
182_D190_A1.0211.00
90_P146_R1.0181.00
102_A140_V1.0141.00
71_A75_F1.0131.00
27_D74_R1.0121.00
156_Y334_P1.0121.00
159_L163_R1.0111.00
253_A283_L1.0081.00
243_Y254_G1.0071.00
72_I76_R1.0011.00
194_V318_G0.9891.00
38_Y177_A0.9881.00
28_L33_V0.9871.00
314_E317_D0.9811.00
281_D285_D0.9801.00
70_R74_R0.9791.00
13_A186_V0.9741.00
281_D284_R0.9661.00
310_P313_G0.9651.00
272_D275_F0.9501.00
103_D107_E0.9481.00
22_L171_I0.9461.00
25_A169_V0.9451.00
23_T333_A0.9451.00
35_V169_V0.9381.00
70_R335_A0.9381.00
234_T237_D0.9371.00
205_V208_D0.9371.00
197_A322_A0.9371.00
310_P314_E0.9231.00
314_E343_D0.9221.00
156_Y330_F0.9181.00
314_E318_G0.9171.00
33_V193_D0.9161.00
121_H141_A0.9121.00
282_R285_D0.9111.00
314_E320_Y0.9091.00
92_V127_L0.9071.00
31_R338_A0.9051.00
69_A73_E0.9001.00
10_R192_D0.8981.00
193_D318_G0.8951.00
193_D196_V0.8951.00
341_A344_V0.8941.00
92_V142_A0.8931.00
224_T252_L0.8921.00
78_L82_G0.8901.00
19_A48_T0.8851.00
53_G153_T0.8831.00
87_A150_V0.8821.00
218_Y304_A0.8791.00
71_A335_A0.8781.00
118_A146_R0.8661.00
39_E42_T0.8631.00
224_T296_R0.8611.00
182_D185_R0.8611.00
181_T184_V0.8571.00
75_F79_S0.8481.00
231_E235_V0.8431.00
164_A171_I0.8421.00
31_R346_G0.8401.00
276_V280_D0.8391.00
56_Y328_H0.8341.00
92_V144_I0.8311.00
50_R300_G0.8301.00
225_A253_A0.8281.00
97_E101_T0.8271.00
9_D34_D0.8261.00
124_A127_L0.8261.00
305_T324_G0.8261.00
221_Q258_E0.8251.00
12_V195_V0.8221.00
25_A164_A0.8191.00
113_Q119_V0.8191.00
225_A294_V0.8181.00
113_Q118_A0.8171.00
219_R258_E0.8121.00
75_F334_P0.8121.00
23_T156_Y0.8081.00
159_L162_D0.8061.00
223_L294_V0.8031.00
215_L303_T0.8031.00
85_T152_D0.8021.00
308_R312_L0.8001.00
42_T174_H0.7971.00
328_H331_M0.7961.00
122_A127_L0.7931.00
47_S200_A0.7901.00
155_A158_R0.7891.00
28_L344_V0.7881.00
342_D349_G0.7861.00
284_R291_E0.7851.00
156_Y160_I0.7831.00
26_H160_I0.7811.00
88_E147_D0.7811.00
66_R70_R0.7751.00
278_A281_D0.7721.00
258_E275_F0.7701.00
180_A185_R0.7701.00
309_D312_L0.7691.00
312_L340_L0.7661.00
219_R299_A0.7651.00
310_P315_L0.7631.00
52_A243_Y0.7601.00
19_A157_A0.7601.00
121_H143_A0.7571.00
13_A194_V0.7571.00
128_A135_H0.7551.00
37_V169_V0.7551.00
125_D128_A0.7531.00
24_A344_V0.7531.00
48_T51_A0.7521.00
165_R171_I0.7521.00
42_T45_A0.7511.00
284_R290_Y0.7461.00
127_L130_A0.7451.00
280_D297_S0.7441.00
34_D192_D0.7441.00
217_P301_L0.7421.00
256_G302_C0.7391.00
222_A298_W0.7381.00
127_L139_I0.7361.00
278_A282_R0.7331.00
71_A74_R0.7331.00
181_T318_G0.7271.00
179_V209_A0.7261.00
231_E237_D0.7241.00
56_Y331_M0.7241.00
95_A102_A0.7221.00
48_T157_A0.7221.00
192_D318_G0.7221.00
157_A161_A0.7181.00
30_E163_R0.7171.00
74_R334_P0.7171.00
223_L279_M0.7161.00
122_A144_I0.7131.00
92_V122_A0.7121.00
207_A212_P0.7101.00
174_H177_A0.7091.00
242_Y245_R0.7061.00
23_T334_P0.7051.00
181_T317_D0.7051.00
15_I196_V0.7041.00
238_A241_G0.7041.00
40_R201_H0.7011.00
109_V119_V0.7011.00
24_A340_L0.7001.00
106_R141_A0.7001.00
175_E187_N0.6991.00
37_V161_A0.6981.00
341_A345_L0.6971.00
195_V340_L0.6941.00
135_H138_D0.6941.00
232_L237_D0.6931.00
11_R191_Y0.6931.00
104_A107_E0.6871.00
11_R190_A0.6861.00
220_V256_G0.6851.00
54_I243_Y0.6841.00
206_L321_V0.6831.00
201_H204_R0.6771.00
29_A34_D0.6751.00
74_R335_A0.6741.00
111_A114_R0.6731.00
214_P306_P0.6731.00
161_A173_T0.6681.00
112_M119_V0.6681.00
335_A338_A0.6681.00
19_A330_F0.6651.00
27_D341_A0.6651.00
305_T311_L0.6621.00
40_R46_A0.6591.00
108_Q112_M0.6581.00
322_A337_G0.6571.00
57_D69_A0.6551.00
68_A332_R0.6541.00
155_A159_L0.6531.00
20_V336_T0.6501.00
91_Y148_A0.6501.00
164_A168_G0.6481.00
66_R69_A0.6481.00
240_A245_R0.6471.00
165_R170_E0.6471.00
303_T325_W0.6461.00
38_Y175_E0.6461.00
231_E234_T0.6441.00
73_E76_R0.6431.00
36_T191_Y0.6421.00
59_F331_M0.6421.00
55_C86_V0.6411.00
180_A183_P0.6371.00
105_I109_V0.6371.00
65_A69_A0.6361.00
325_W333_A0.6341.00
37_V164_A0.6331.00
13_A192_D0.6311.00
84_F159_L0.6291.00
315_L319_L0.6251.00
39_E173_T0.6241.00
231_E236_Y0.6191.00
15_I177_A0.6171.00
219_R268_G0.6161.00
138_D285_D0.6151.00
106_R109_V0.6141.00
56_Y59_F0.6101.00
51_A330_F0.6081.00
123_D127_L0.6051.00
339_A350_V0.6041.00
64_D68_A0.6021.00
179_V186_V0.6021.00
274_W277_D0.6011.00
325_W329_G0.6011.00
111_A115_H0.6001.00
333_A337_G0.5991.00
97_E140_V0.5981.00
119_V145_A0.5971.00
67_V339_A0.5951.00
309_D313_G0.5951.00
26_H164_A0.5951.00
123_D129_A0.5951.00
237_D240_A0.5941.00
335_A339_A0.5941.00
160_I333_A0.5911.00
280_D294_V0.5901.00
14_V35_V0.5901.00
145_A148_A0.5891.00
257_T327_G0.5871.00
176_P204_R0.5861.00
185_R318_G0.5851.00
305_T326_Q0.5831.00
256_G275_F0.5771.00
277_D280_D0.5761.00
313_G321_V0.5751.00
56_Y60_A0.5751.00
206_L209_A0.5731.00
340_L343_D0.5731.00
52_A245_R0.5721.00
72_I75_F0.5721.00
271_G297_S0.5701.00
131_V232_L0.5681.00
334_P337_G0.5671.00
185_R317_D0.5671.00
302_C325_W0.5671.00
12_V35_V0.5661.00
221_Q272_D0.5641.00
303_T324_G0.5641.00
32_G35_V0.5631.00
54_I148_A0.5631.00
62_A66_R0.5621.00
67_V335_A0.5611.00
184_V319_L0.5611.00
44_A49_G0.5601.00
128_A137_T0.5601.00
113_Q116_G0.5601.00
200_A301_L0.5571.00
46_A50_R0.5561.00
33_V344_V0.5551.00
152_D248_P0.5551.00
164_A167_R0.5541.00
59_F93_W0.5541.00
282_R286_R0.5541.00
302_C327_G0.5541.00
17_A161_A0.5531.00
178_S208_D0.5521.00
158_R162_D0.5521.00
202_T215_L0.5511.00
54_I59_F0.5511.00
26_H81_H0.5491.00
195_V320_Y0.5481.00
221_Q275_F0.5471.00
127_L134_L0.5471.00
75_F78_L0.5471.00
29_A32_G0.5441.00
122_A142_A0.5441.00
107_E111_A0.5421.00
29_A35_V0.5411.00
294_V297_S0.5401.00
47_S53_G0.5401.00
179_V196_V0.5391.00
226_D229_A0.5391.00
96_T138_D0.5371.00
235_V244_V0.5361.00
27_D78_L0.5351.00
287_F290_Y0.5341.00
92_V130_A0.5331.00
47_S303_T0.5331.00
98_P102_A0.5331.00
124_A137_T0.5321.00
206_L319_L0.5311.00
271_G276_V0.5311.00
308_R313_G0.5281.00
313_G316_R0.5281.00
211_V321_V0.5271.00
221_Q299_A0.5251.00
342_D346_G0.5241.00
55_C151_V0.5241.00
223_L276_V0.5241.00
196_V205_V0.5231.00
218_Y257_T0.5231.00
55_C331_M0.5211.00
112_M116_G0.5211.00
76_R86_V0.5191.00
17_A25_A0.5191.00
153_T330_F0.5191.00
304_A327_G0.5181.00
108_Q111_A0.5171.00
133_A289_G0.5171.00
55_C75_F0.5161.00
33_V36_T0.5151.00
242_Y282_R0.5151.00
273_D276_V0.5131.00
180_A189_T0.5131.00
154_T296_R0.5121.00
215_L323_A0.5121.00
179_V319_L0.5111.00
120_E129_A0.5111.00
19_A156_Y0.5111.00
308_R311_L0.5101.00
73_E147_D0.5081.00
69_A147_D0.5081.00
69_A72_I0.5071.00
200_A217_P0.5071.00
252_L298_W0.5061.00
77_E338_A0.5061.00
39_E171_I0.5061.00
88_E149_A0.5061.00
194_V319_L0.5051.00
59_F148_A0.5041.00
60_A328_H0.5031.00
179_V208_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h1bA 1 0.9437 100 0.319 Contact Map
1y56B 1 0.9491 100 0.351 Contact Map
3axbA 2 0.9464 100 0.352 Contact Map
2gf3A 1 0.9571 100 0.361 Contact Map
2gagB 1 0.9866 100 0.363 Contact Map
4x9mA 1 0.9357 100 0.374 Contact Map
4rslA 1 0.9812 100 0.377 Contact Map
1ryiA 4 0.9088 100 0.379 Contact Map
3pvcA 1 0.933 100 0.381 Contact Map
1pj5A 3 0.9678 100 0.388 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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