Q9HSD4 - HALSA - GREMLIN Contacts

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Q9HSD4 - Uncharacterized protein

UniProt:	Q9HSD4	Sequences: MQRNVSTTVRVKLHSLTNRKADLLAREYEAFQTEVHDGDADLYSATDQQASKVQRQKDPNPGTEQPVVLRNDVFDVSHDEDTVLSSWWVNVPVYDPERGRGNSIWCPAHIPRKDEQLVREGDVRDSELVRRDGDWYVHLVVKRSVTVADEYDDVLAIDMGARWVATCAFLSDRTTTFYGEEVRRIREHYKQLRKSIGKAKPRQGQQVVERIGDAEARKVDDRLHKIARQIVEDAEERNAVIVVGDLGGIRKDNDKGRYVNDKTHKMPFARLLNCIEYKAHDAGIDVQLVNEYDTSKTCNRCACEGVRATQGRFECPECGLDDNADKNGALNIGKRALGKFSKPLSEAGAVLAQPETQVIVHRDDEPANLSVSVDSTPSGGTPRL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	384 (319)
Sequences:	4310 (2762)
Seq/√Len:	154.6

ECOLI - INSQ
HALSA - Q9HSD4 Q9HSW9 Q9HHJ9 Q9HHG8 Q9HSZ6 Q9HSW7 Q9HHU6 Q9HM87 Q9HSY4 Q9HHX8
SULSO - Q97V53 Q97XQ8 Q97XA4 Q97YI2 Q97V25 Q97V47 Q97Y44 Q97YW4 Q97XP1 Q97X39 Q97YU1 Q97WZ3 Q7LXH2 Q97WY6 Q7LXD9 Q97UQ8 Q97U68 Q97YI5 Q97Y48 Q97YW9 Q97XQ0 Q97Y67 Q97Z61 Q97U51 Q97XB6 Q7LXH6 Q97YF7 Q97U09 Q7LX59 Q97YK6 Y2105

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
221_D	225_K	5.662	1.00
247_G	252_D	4.428	1.00
299_N	327_N	3.818	1.00
279_A	286_V	3.620	1.00
164_V	271_L	3.354	1.00
272_L	288_L	3.091	1.00
243_V	275_I	2.991	1.00
242_V	336_A	2.902	1.00
270_R	274_C	2.827	1.00
228_R	232_E	2.817	1.00
126_S	137_V	2.685	1.00
307_R	310_Q	2.566	1.00
182_V	261_D	2.553	1.00
335_R	338_G	2.479	1.00
270_R	273_N	2.435	1.00
224_H	274_C	2.260	1.00
231_V	279_A	2.252	1.00
271_L	275_I	2.240	1.00
276_E	288_L	2.223	1.00
164_V	222_R	2.219	1.00
224_H	277_Y	2.214	1.00
289_V	332_I	2.206	1.00
241_I	279_A	2.191	1.00
293_D	296_K	2.123	1.00
124_R	142_K	2.082	1.00
256_G	260_N	2.081	1.00
204_G	208_V	2.053	1.00
227_A	274_C	2.007	1.00
314_E	321_D	2.003	1.00
243_V	286_V	1.987	1.00
25_A	29_E	1.983	1.00
311_G	324_A	1.934	1.00
220_D	270_R	1.925	1.00
294_T	332_I	1.921	1.00
224_H	227_A	1.917	1.00
224_H	278_K	1.898	1.00
301_C	318_C	1.872	1.00
257_R	260_N	1.871	1.00
188_H	204_G	1.867	1.00
276_E	280_H	1.857	1.00
301_C	315_C	1.821	1.00
313_F	322_D	1.819	1.00
300_R	320_L	1.813	1.00
239_A	284_I	1.809	1.00
69_L	72_D	1.792	1.00
223_L	274_C	1.780	1.00
202_R	205_Q	1.778	1.00
181_E	218_K	1.776	1.00
315_C	318_C	1.768	1.00
298_C	315_C	1.746	1.00
199_A	202_R	1.725	1.00
298_C	301_C	1.659	1.00
298_C	318_C	1.644	1.00
157_I	165_A	1.625	1.00
296_K	306_V	1.587	1.00
245_D	288_L	1.573	1.00
223_L	270_R	1.567	1.00
227_A	277_Y	1.567	1.00
134_D	213_D	1.561	1.00
191_Q	195_S	1.553	1.00
26_R	29_E	1.548	1.00
192_L	205_Q	1.547	1.00
243_V	288_L	1.545	1.00
243_V	272_L	1.539	1.00
254_D	264_H	1.539	1.00
167_C	171_S	1.535	1.00
104_I	137_V	1.508	1.00
192_L	195_S	1.508	1.00
188_H	211_I	1.471	1.00
244_G	291_E	1.464	1.00
163_W	166_T	1.445	1.00
13_L	17_T	1.440	1.00
13_L	73_V	1.436	1.00
195_S	204_G	1.427	1.00
313_F	320_L	1.423	1.00
227_A	278_K	1.416	1.00
308_A	311_G	1.406	1.00
307_R	324_A	1.404	1.00
63_T	73_V	1.389	1.00
303_C	316_P	1.389	1.00
166_T	326_K	1.382	1.00
60_N	64_E	1.377	1.00
49_Q	92_P	1.374	1.00
312_R	321_D	1.371	1.00
213_D	217_R	1.360	1.00
154_V	333_G	1.353	1.00
132_D	213_D	1.341	1.00
263_T	268_F	1.333	1.00
65_Q	71_N	1.329	1.00
89_V	93_V	1.328	1.00
307_R	311_G	1.313	1.00
151_Y	239_A	1.305	1.00
330_L	334_K	1.299	1.00
254_D	260_N	1.288	1.00
276_E	286_V	1.281	1.00
168_A	329_A	1.270	1.00
231_V	282_A	1.258	1.00
48_Q	52_K	1.248	1.00
114_D	117_L	1.239	1.00
26_R	30_A	1.236	1.00
129_V	138_H	1.231	1.00
188_H	208_V	1.229	1.00
30_A	33_T	1.225	1.00
65_Q	70_R	1.223	1.00
24_L	27_E	1.216	1.00
12_K	28_Y	1.210	1.00
155_L	167_C	1.205	1.00
49_Q	53_V	1.203	1.00
58_D	90_N	1.198	1.00
157_I	167_C	1.197	1.00
156_A	333_G	1.190	1.00
103_S	111_P	1.174	1.00
247_G	291_E	1.167	1.00
322_D	330_L	1.162	1.00
14_H	18_N	1.158	1.00
155_L	168_A	1.155	1.00
161_A	266_M	1.146	1.00
11_V	14_H	1.139	1.00
100_R	103_S	1.137	1.00
191_Q	194_K	1.133	1.00
228_R	282_A	1.130	1.00
89_V	92_P	1.113	1.00
242_V	332_I	1.110	0.99
289_V	335_R	1.108	0.99
91_V	95_D	1.105	0.99
181_E	215_E	1.105	0.99
47_D	50_A	1.104	0.99
185_I	208_V	1.102	0.99
53_V	56_Q	1.100	0.99
192_L	204_G	1.099	0.99
159_M	268_F	1.095	0.99
274_C	277_Y	1.091	0.99
106_C	128_L	1.091	0.99
11_V	31_F	1.078	0.99
25_A	56_Q	1.077	0.99
66_P	73_V	1.072	0.99
166_T	172_D	1.070	0.99
16_L	20_K	1.068	0.99
90_N	93_V	1.067	0.99
248_G	269_A	1.065	0.99
223_L	271_L	1.063	0.99
61_P	65_Q	1.061	0.99
154_V	240_V	1.054	0.99
278_K	281_D	1.043	0.99
310_Q	313_F	1.035	0.99
304_E	313_F	1.033	0.99
187_E	191_Q	1.032	0.99
289_V	336_A	1.030	0.99
294_T	335_R	1.023	0.99
227_A	271_L	1.019	0.99
223_L	227_A	1.019	0.99
63_T	66_P	1.017	0.99
154_V	337_L	1.014	0.99
216_A	220_D	1.012	0.99
73_V	76_V	1.009	0.99
299_N	330_L	1.009	0.99
32_Q	36_H	1.005	0.99
33_T	36_H	1.003	0.99
25_A	28_Y	1.002	0.99
227_A	275_I	0.994	0.99
92_P	95_D	0.992	0.99
220_D	274_C	0.990	0.99
64_E	68_V	0.988	0.99
201_P	205_Q	0.987	0.99
104_I	126_S	0.983	0.99
43_Y	51_S	0.979	0.99
159_M	272_L	0.976	0.99
326_K	330_L	0.976	0.99
127_E	138_H	0.972	0.99
232_E	282_A	0.970	0.99
186_R	190_K	0.965	0.99
15_S	19_R	0.963	0.99
240_V	285_D	0.961	0.99
230_I	241_I	0.961	0.99
49_Q	93_V	0.959	0.99
185_I	212_G	0.953	0.98
311_G	323_N	0.945	0.98
65_Q	68_V	0.942	0.98
310_Q	324_A	0.941	0.98
231_V	284_I	0.941	0.98
98_R	101_G	0.941	0.98
188_H	191_Q	0.937	0.98
222_R	226_I	0.935	0.98
154_V	242_V	0.934	0.98
207_V	210_R	0.931	0.98
172_D	323_N	0.927	0.98
297_T	335_R	0.926	0.98
98_R	105_W	0.920	0.98
23_L	28_Y	0.918	0.98
59_P	63_T	0.917	0.98
312_R	322_D	0.916	0.98
163_W	172_D	0.916	0.98
163_W	173_R	0.912	0.98
299_N	320_L	0.911	0.98
291_E	294_T	0.910	0.98
296_K	305_G	0.910	0.98
32_Q	55_R	0.910	0.98
308_A	324_A	0.908	0.98
273_N	276_E	0.908	0.98
161_A	262_K	0.907	0.98
335_R	339_K	0.906	0.98
29_E	55_R	0.904	0.98
304_E	307_R	0.904	0.98
299_N	322_D	0.904	0.98
303_C	317_E	0.903	0.98
117_L	121_G	0.895	0.98
46_T	49_Q	0.888	0.98
322_D	326_K	0.884	0.97
306_V	310_Q	0.881	0.97
257_R	264_H	0.880	0.97
49_Q	52_K	0.876	0.97
66_P	74_F	0.876	0.97
190_K	193_R	0.875	0.97
256_G	259_V	0.873	0.97
21_A	27_E	0.869	0.97
231_V	241_I	0.862	0.97
297_T	331_N	0.862	0.97
214_A	218_K	0.861	0.97
205_Q	209_E	0.858	0.97
106_C	109_H	0.857	0.97
11_V	15_S	0.854	0.97
226_I	229_Q	0.851	0.97
223_L	267_P	0.844	0.97
53_V	58_D	0.843	0.97
328_G	331_N	0.841	0.97
299_N	328_G	0.838	0.97
245_D	291_E	0.837	0.96
12_K	15_S	0.836	0.96
279_A	284_I	0.835	0.96
248_G	268_F	0.833	0.96
130_R	135_W	0.829	0.96
13_L	16_L	0.826	0.96
256_G	264_H	0.826	0.96
185_I	215_E	0.825	0.96
28_Y	31_F	0.823	0.96
125_D	140_V	0.822	0.96
155_L	241_I	0.821	0.96
304_E	310_Q	0.818	0.96
134_D	217_R	0.816	0.96
228_R	278_K	0.814	0.96
211_I	215_E	0.811	0.96
177_F	218_K	0.809	0.96
27_E	30_A	0.806	0.96
74_F	78_H	0.806	0.96
168_A	172_D	0.804	0.96
52_K	55_R	0.804	0.96
88_W	92_P	0.804	0.96
186_R	189_Y	0.804	0.96
29_E	56_Q	0.801	0.95
15_S	23_L	0.801	0.95
202_R	206_Q	0.797	0.95
174_T	177_F	0.794	0.95
25_A	55_R	0.792	0.95
118_V	121_G	0.789	0.95
327_N	331_N	0.789	0.95
12_K	16_L	0.788	0.95
189_Y	193_R	0.787	0.95
159_M	165_A	0.784	0.95
178_Y	181_E	0.783	0.95
296_K	304_E	0.782	0.95
293_D	297_T	0.782	0.95
33_T	48_Q	0.780	0.95
338_G	341_S	0.774	0.95
313_F	324_A	0.768	0.94
254_D	257_R	0.765	0.94
189_Y	208_V	0.764	0.94
55_R	59_P	0.761	0.94
29_E	32_Q	0.759	0.94
21_A	24_L	0.759	0.94
184_R	188_H	0.758	0.94
55_R	60_N	0.757	0.94
32_Q	35_V	0.752	0.94
89_V	95_D	0.752	0.94
189_Y	212_G	0.752	0.94
25_A	32_Q	0.751	0.94
14_H	17_T	0.746	0.93
246_L	291_E	0.746	0.93
200_K	203_Q	0.745	0.93
19_R	22_D	0.743	0.93
36_H	51_S	0.740	0.93
67_V	74_F	0.735	0.93
259_V	263_T	0.735	0.93
215_E	265_K	0.732	0.93
172_D	326_K	0.731	0.93
165_A	226_I	0.731	0.93
192_L	208_V	0.728	0.93
242_V	333_G	0.728	0.93
190_K	194_K	0.726	0.93
22_D	28_Y	0.722	0.92
99_G	102_N	0.721	0.92
255_K	259_V	0.720	0.92
245_D	272_L	0.717	0.92
304_E	316_P	0.717	0.92
153_D	239_A	0.713	0.92
175_T	178_Y	0.711	0.92
167_C	172_D	0.709	0.92
116_Q	119_R	0.708	0.92
150_E	153_D	0.707	0.92
13_L	22_D	0.706	0.91
171_S	229_Q	0.704	0.91
336_A	340_F	0.704	0.91
168_A	326_K	0.703	0.91
31_F	35_V	0.699	0.91
242_V	287_Q	0.698	0.91
232_E	240_V	0.696	0.91
29_E	33_T	0.695	0.91
65_Q	69_L	0.695	0.91
16_L	19_R	0.695	0.91
293_D	335_R	0.694	0.91
13_L	63_T	0.694	0.91
287_Q	336_A	0.693	0.91
178_Y	182_V	0.692	0.91
174_T	266_M	0.691	0.91
158_D	295_S	0.685	0.90
60_N	63_T	0.685	0.90
152_D	239_A	0.684	0.90
241_I	275_I	0.679	0.90
63_T	67_V	0.679	0.90
275_I	286_V	0.678	0.90
240_V	287_Q	0.676	0.90
277_Y	281_D	0.675	0.90
17_T	20_K	0.674	0.89
46_T	51_S	0.674	0.89
189_Y	192_L	0.673	0.89
62_G	74_F	0.670	0.89
90_N	94_Y	0.670	0.89
74_F	77_S	0.669	0.89
165_A	271_L	0.666	0.89
162_R	311_G	0.663	0.89
155_L	169_F	0.662	0.89
164_V	266_M	0.662	0.89
16_L	22_D	0.662	0.89
52_K	56_Q	0.661	0.89
186_R	194_K	0.659	0.88
186_R	191_Q	0.658	0.88
212_G	219_V	0.658	0.88
188_H	195_S	0.658	0.88
296_K	307_R	0.654	0.88
337_L	341_S	0.654	0.88
24_L	29_E	0.653	0.88
297_T	305_G	0.653	0.88
130_R	136_Y	0.648	0.88
91_V	94_Y	0.646	0.87
193_R	208_V	0.646	0.87
326_K	329_A	0.644	0.87
161_A	253_N	0.643	0.87
25_A	33_T	0.641	0.87
179_G	262_K	0.640	0.87
252_D	291_E	0.640	0.87
179_G	182_V	0.636	0.87
272_L	276_E	0.635	0.86
248_G	263_T	0.634	0.86
156_A	329_A	0.633	0.86
91_V	106_C	0.632	0.86
106_C	126_S	0.630	0.86
300_R	330_L	0.629	0.86
313_F	316_P	0.628	0.86
269_A	273_N	0.628	0.86
128_L	137_V	0.624	0.86
201_P	208_V	0.621	0.85
15_S	21_A	0.619	0.85
48_Q	93_V	0.618	0.85
90_N	125_D	0.617	0.85
185_I	193_R	0.614	0.85
105_W	111_P	0.614	0.85
14_H	20_K	0.613	0.85
117_L	120_E	0.612	0.84
162_R	166_T	0.611	0.84
193_R	197_G	0.610	0.84
93_V	122_D	0.609	0.84
51_S	54_Q	0.608	0.84
12_K	22_D	0.606	0.84
181_E	211_I	0.604	0.84
109_H	112_R	0.603	0.84
303_C	313_F	0.601	0.83
306_V	313_F	0.601	0.83
124_R	140_V	0.599	0.83
153_D	169_F	0.599	0.83
53_V	90_N	0.597	0.83
193_R	204_G	0.595	0.83
297_T	313_F	0.595	0.83
290_N	293_D	0.594	0.83
253_N	263_T	0.594	0.83
103_S	106_C	0.594	0.83
332_I	335_R	0.588	0.82
185_I	189_Y	0.587	0.82
217_R	220_D	0.587	0.82
201_P	204_G	0.587	0.82
322_D	327_N	0.586	0.82
59_P	62_G	0.584	0.82
164_V	223_L	0.580	0.81
51_S	59_P	0.580	0.81
158_D	325_D	0.576	0.81
129_V	140_V	0.575	0.81
164_V	227_A	0.575	0.81
323_N	328_G	0.575	0.81
196_I	201_P	0.574	0.80
44_S	48_Q	0.573	0.80
49_Q	55_R	0.572	0.80
260_N	264_H	0.572	0.80
232_E	237_R	0.570	0.80
32_Q	52_K	0.570	0.80
54_Q	58_D	0.570	0.80
80_E	83_V	0.569	0.80
219_V	265_K	0.568	0.80
254_D	258_Y	0.565	0.79
195_S	200_K	0.564	0.79
122_D	142_K	0.564	0.79
193_R	212_G	0.563	0.79
25_A	30_A	0.563	0.79
252_D	263_T	0.562	0.79
256_G	263_T	0.561	0.79
189_Y	261_D	0.560	0.79
274_C	278_K	0.560	0.79
300_R	322_D	0.560	0.79
188_H	207_V	0.557	0.78
12_K	18_N	0.557	0.78
162_R	323_N	0.556	0.78
259_V	262_K	0.556	0.78
47_D	92_P	0.554	0.78
292_Y	296_K	0.554	0.78
159_M	248_G	0.553	0.78
291_E	335_R	0.553	0.78
220_D	224_H	0.552	0.78
31_F	39_D	0.550	0.78
334_K	339_K	0.549	0.78
50_A	89_V	0.549	0.78
198_K	201_P	0.547	0.77
279_A	282_A	0.545	0.77
105_W	109_H	0.545	0.77
12_K	19_R	0.544	0.77
14_H	19_R	0.543	0.77
18_N	21_A	0.543	0.77
330_L	333_G	0.543	0.77
136_Y	213_D	0.543	0.77
121_G	141_V	0.542	0.77
90_N	95_D	0.541	0.76
33_T	55_R	0.540	0.76
205_Q	208_V	0.540	0.76
334_K	337_L	0.539	0.76
19_R	23_L	0.537	0.76
73_V	77_S	0.537	0.76
316_P	324_A	0.536	0.76
167_C	170_L	0.535	0.76
215_E	219_V	0.535	0.76
75_D	78_H	0.534	0.76
76_V	82_T	0.534	0.76
184_R	191_Q	0.530	0.75
295_S	307_R	0.530	0.75
186_R	193_R	0.529	0.75
252_D	259_V	0.528	0.75
49_Q	95_D	0.527	0.75
33_T	37_D	0.525	0.74
78_H	81_D	0.524	0.74
66_P	71_N	0.524	0.74
166_T	176_T	0.523	0.74
177_F	181_E	0.522	0.74
145_V	280_H	0.521	0.74
191_Q	204_G	0.521	0.74
104_I	107_P	0.520	0.74
95_D	107_P	0.519	0.74
97_E	107_P	0.514	0.73
255_K	258_Y	0.513	0.73
293_D	313_F	0.511	0.72
35_V	39_D	0.509	0.72
294_T	331_N	0.508	0.72
14_H	21_A	0.508	0.72
49_Q	54_Q	0.506	0.72
63_T	74_F	0.506	0.72
262_K	266_M	0.505	0.71
225_K	228_R	0.502	0.71
251_K	269_A	0.502	0.71
24_L	28_Y	0.501	0.71
156_A	168_A	0.501	0.71
43_Y	50_A	0.500	0.71
108_A	112_R	0.500	0.71
231_V	286_V	0.500	0.71
48_Q	51_S	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nu0A	1	0.3385	95.4	0.925	Contact Map
1vhxA	2	0.3568	95	0.927	Contact Map
1iv0A	1	0.2526	93.9	0.931	Contact Map
1twfI	1	0.2422	87.8	0.941	Contact Map
1qypA	1	0.1146	86.5	0.942	Contact Map
1ffkW	1	0.1849	84.1	0.944	Contact Map
4aybP	1	0.1068	83.3	0.944	Contact Map
3h0gI	1	0.2344	82.7	0.945	Contact Map
2k4xA	1	0.1406	82.5	0.945	Contact Map
4c2mI	1	0.2474	79.4	0.946	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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