GREMLIN Database
Q9HSD4 - Uncharacterized protein
UniProt: Q9HSD4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 384 (319)
Sequences: 4310 (2762)
Seq/√Len: 154.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_D225_K5.6621.00
247_G252_D4.4281.00
299_N327_N3.8181.00
279_A286_V3.6201.00
164_V271_L3.3541.00
272_L288_L3.0911.00
243_V275_I2.9911.00
242_V336_A2.9021.00
270_R274_C2.8271.00
228_R232_E2.8171.00
126_S137_V2.6851.00
307_R310_Q2.5661.00
182_V261_D2.5531.00
335_R338_G2.4791.00
270_R273_N2.4351.00
224_H274_C2.2601.00
231_V279_A2.2521.00
271_L275_I2.2401.00
276_E288_L2.2231.00
164_V222_R2.2191.00
224_H277_Y2.2141.00
289_V332_I2.2061.00
241_I279_A2.1911.00
293_D296_K2.1231.00
124_R142_K2.0821.00
256_G260_N2.0811.00
204_G208_V2.0531.00
227_A274_C2.0071.00
314_E321_D2.0031.00
243_V286_V1.9871.00
25_A29_E1.9831.00
311_G324_A1.9341.00
220_D270_R1.9251.00
294_T332_I1.9211.00
224_H227_A1.9171.00
224_H278_K1.8981.00
301_C318_C1.8721.00
257_R260_N1.8711.00
188_H204_G1.8671.00
276_E280_H1.8571.00
301_C315_C1.8211.00
313_F322_D1.8191.00
300_R320_L1.8131.00
239_A284_I1.8091.00
69_L72_D1.7921.00
223_L274_C1.7801.00
202_R205_Q1.7781.00
181_E218_K1.7761.00
315_C318_C1.7681.00
298_C315_C1.7461.00
199_A202_R1.7251.00
298_C301_C1.6591.00
298_C318_C1.6441.00
157_I165_A1.6251.00
296_K306_V1.5871.00
245_D288_L1.5731.00
223_L270_R1.5671.00
227_A277_Y1.5671.00
134_D213_D1.5611.00
191_Q195_S1.5531.00
26_R29_E1.5481.00
192_L205_Q1.5471.00
243_V288_L1.5451.00
243_V272_L1.5391.00
254_D264_H1.5391.00
167_C171_S1.5351.00
104_I137_V1.5081.00
192_L195_S1.5081.00
188_H211_I1.4711.00
244_G291_E1.4641.00
163_W166_T1.4451.00
13_L17_T1.4401.00
13_L73_V1.4361.00
195_S204_G1.4271.00
313_F320_L1.4231.00
227_A278_K1.4161.00
308_A311_G1.4061.00
307_R324_A1.4041.00
63_T73_V1.3891.00
303_C316_P1.3891.00
166_T326_K1.3821.00
60_N64_E1.3771.00
49_Q92_P1.3741.00
312_R321_D1.3711.00
213_D217_R1.3601.00
154_V333_G1.3531.00
132_D213_D1.3411.00
263_T268_F1.3331.00
65_Q71_N1.3291.00
89_V93_V1.3281.00
307_R311_G1.3131.00
151_Y239_A1.3051.00
330_L334_K1.2991.00
254_D260_N1.2881.00
276_E286_V1.2811.00
168_A329_A1.2701.00
231_V282_A1.2581.00
48_Q52_K1.2481.00
114_D117_L1.2391.00
26_R30_A1.2361.00
129_V138_H1.2311.00
188_H208_V1.2291.00
30_A33_T1.2251.00
65_Q70_R1.2231.00
24_L27_E1.2161.00
12_K28_Y1.2101.00
155_L167_C1.2051.00
49_Q53_V1.2031.00
58_D90_N1.1981.00
157_I167_C1.1971.00
156_A333_G1.1901.00
103_S111_P1.1741.00
247_G291_E1.1671.00
322_D330_L1.1621.00
14_H18_N1.1581.00
155_L168_A1.1551.00
161_A266_M1.1461.00
11_V14_H1.1391.00
100_R103_S1.1371.00
191_Q194_K1.1331.00
228_R282_A1.1301.00
89_V92_P1.1131.00
242_V332_I1.1100.99
289_V335_R1.1080.99
91_V95_D1.1050.99
181_E215_E1.1050.99
47_D50_A1.1040.99
185_I208_V1.1020.99
53_V56_Q1.1000.99
192_L204_G1.0990.99
159_M268_F1.0950.99
274_C277_Y1.0910.99
106_C128_L1.0910.99
11_V31_F1.0780.99
25_A56_Q1.0770.99
66_P73_V1.0720.99
166_T172_D1.0700.99
16_L20_K1.0680.99
90_N93_V1.0670.99
248_G269_A1.0650.99
223_L271_L1.0630.99
61_P65_Q1.0610.99
154_V240_V1.0540.99
278_K281_D1.0430.99
310_Q313_F1.0350.99
304_E313_F1.0330.99
187_E191_Q1.0320.99
289_V336_A1.0300.99
294_T335_R1.0230.99
227_A271_L1.0190.99
223_L227_A1.0190.99
63_T66_P1.0170.99
154_V337_L1.0140.99
216_A220_D1.0120.99
73_V76_V1.0090.99
299_N330_L1.0090.99
32_Q36_H1.0050.99
33_T36_H1.0030.99
25_A28_Y1.0020.99
227_A275_I0.9940.99
92_P95_D0.9920.99
220_D274_C0.9900.99
64_E68_V0.9880.99
201_P205_Q0.9870.99
104_I126_S0.9830.99
43_Y51_S0.9790.99
159_M272_L0.9760.99
326_K330_L0.9760.99
127_E138_H0.9720.99
232_E282_A0.9700.99
186_R190_K0.9650.99
15_S19_R0.9630.99
240_V285_D0.9610.99
230_I241_I0.9610.99
49_Q93_V0.9590.99
185_I212_G0.9530.98
311_G323_N0.9450.98
65_Q68_V0.9420.98
310_Q324_A0.9410.98
231_V284_I0.9410.98
98_R101_G0.9410.98
188_H191_Q0.9370.98
222_R226_I0.9350.98
154_V242_V0.9340.98
207_V210_R0.9310.98
172_D323_N0.9270.98
297_T335_R0.9260.98
98_R105_W0.9200.98
23_L28_Y0.9180.98
59_P63_T0.9170.98
312_R322_D0.9160.98
163_W172_D0.9160.98
163_W173_R0.9120.98
299_N320_L0.9110.98
291_E294_T0.9100.98
296_K305_G0.9100.98
32_Q55_R0.9100.98
308_A324_A0.9080.98
273_N276_E0.9080.98
161_A262_K0.9070.98
335_R339_K0.9060.98
29_E55_R0.9040.98
304_E307_R0.9040.98
299_N322_D0.9040.98
303_C317_E0.9030.98
117_L121_G0.8950.98
46_T49_Q0.8880.98
322_D326_K0.8840.97
306_V310_Q0.8810.97
257_R264_H0.8800.97
49_Q52_K0.8760.97
66_P74_F0.8760.97
190_K193_R0.8750.97
256_G259_V0.8730.97
21_A27_E0.8690.97
231_V241_I0.8620.97
297_T331_N0.8620.97
214_A218_K0.8610.97
205_Q209_E0.8580.97
106_C109_H0.8570.97
11_V15_S0.8540.97
226_I229_Q0.8510.97
223_L267_P0.8440.97
53_V58_D0.8430.97
328_G331_N0.8410.97
299_N328_G0.8380.97
245_D291_E0.8370.96
12_K15_S0.8360.96
279_A284_I0.8350.96
248_G268_F0.8330.96
130_R135_W0.8290.96
13_L16_L0.8260.96
256_G264_H0.8260.96
185_I215_E0.8250.96
28_Y31_F0.8230.96
125_D140_V0.8220.96
155_L241_I0.8210.96
304_E310_Q0.8180.96
134_D217_R0.8160.96
228_R278_K0.8140.96
211_I215_E0.8110.96
177_F218_K0.8090.96
27_E30_A0.8060.96
74_F78_H0.8060.96
168_A172_D0.8040.96
52_K55_R0.8040.96
88_W92_P0.8040.96
186_R189_Y0.8040.96
29_E56_Q0.8010.95
15_S23_L0.8010.95
202_R206_Q0.7970.95
174_T177_F0.7940.95
25_A55_R0.7920.95
118_V121_G0.7890.95
327_N331_N0.7890.95
12_K16_L0.7880.95
189_Y193_R0.7870.95
159_M165_A0.7840.95
178_Y181_E0.7830.95
296_K304_E0.7820.95
293_D297_T0.7820.95
33_T48_Q0.7800.95
338_G341_S0.7740.95
313_F324_A0.7680.94
254_D257_R0.7650.94
189_Y208_V0.7640.94
55_R59_P0.7610.94
29_E32_Q0.7590.94
21_A24_L0.7590.94
184_R188_H0.7580.94
55_R60_N0.7570.94
32_Q35_V0.7520.94
89_V95_D0.7520.94
189_Y212_G0.7520.94
25_A32_Q0.7510.94
14_H17_T0.7460.93
246_L291_E0.7460.93
200_K203_Q0.7450.93
19_R22_D0.7430.93
36_H51_S0.7400.93
67_V74_F0.7350.93
259_V263_T0.7350.93
215_E265_K0.7320.93
172_D326_K0.7310.93
165_A226_I0.7310.93
192_L208_V0.7280.93
242_V333_G0.7280.93
190_K194_K0.7260.93
22_D28_Y0.7220.92
99_G102_N0.7210.92
255_K259_V0.7200.92
245_D272_L0.7170.92
304_E316_P0.7170.92
153_D239_A0.7130.92
175_T178_Y0.7110.92
167_C172_D0.7090.92
116_Q119_R0.7080.92
150_E153_D0.7070.92
13_L22_D0.7060.91
171_S229_Q0.7040.91
336_A340_F0.7040.91
168_A326_K0.7030.91
31_F35_V0.6990.91
242_V287_Q0.6980.91
232_E240_V0.6960.91
29_E33_T0.6950.91
65_Q69_L0.6950.91
16_L19_R0.6950.91
293_D335_R0.6940.91
13_L63_T0.6940.91
287_Q336_A0.6930.91
178_Y182_V0.6920.91
174_T266_M0.6910.91
158_D295_S0.6850.90
60_N63_T0.6850.90
152_D239_A0.6840.90
241_I275_I0.6790.90
63_T67_V0.6790.90
275_I286_V0.6780.90
240_V287_Q0.6760.90
277_Y281_D0.6750.90
17_T20_K0.6740.89
46_T51_S0.6740.89
189_Y192_L0.6730.89
62_G74_F0.6700.89
90_N94_Y0.6700.89
74_F77_S0.6690.89
165_A271_L0.6660.89
162_R311_G0.6630.89
155_L169_F0.6620.89
164_V266_M0.6620.89
16_L22_D0.6620.89
52_K56_Q0.6610.89
186_R194_K0.6590.88
186_R191_Q0.6580.88
212_G219_V0.6580.88
188_H195_S0.6580.88
296_K307_R0.6540.88
337_L341_S0.6540.88
24_L29_E0.6530.88
297_T305_G0.6530.88
130_R136_Y0.6480.88
91_V94_Y0.6460.87
193_R208_V0.6460.87
326_K329_A0.6440.87
161_A253_N0.6430.87
25_A33_T0.6410.87
179_G262_K0.6400.87
252_D291_E0.6400.87
179_G182_V0.6360.87
272_L276_E0.6350.86
248_G263_T0.6340.86
156_A329_A0.6330.86
91_V106_C0.6320.86
106_C126_S0.6300.86
300_R330_L0.6290.86
313_F316_P0.6280.86
269_A273_N0.6280.86
128_L137_V0.6240.86
201_P208_V0.6210.85
15_S21_A0.6190.85
48_Q93_V0.6180.85
90_N125_D0.6170.85
185_I193_R0.6140.85
105_W111_P0.6140.85
14_H20_K0.6130.85
117_L120_E0.6120.84
162_R166_T0.6110.84
193_R197_G0.6100.84
93_V122_D0.6090.84
51_S54_Q0.6080.84
12_K22_D0.6060.84
181_E211_I0.6040.84
109_H112_R0.6030.84
303_C313_F0.6010.83
306_V313_F0.6010.83
124_R140_V0.5990.83
153_D169_F0.5990.83
53_V90_N0.5970.83
193_R204_G0.5950.83
297_T313_F0.5950.83
290_N293_D0.5940.83
253_N263_T0.5940.83
103_S106_C0.5940.83
332_I335_R0.5880.82
185_I189_Y0.5870.82
217_R220_D0.5870.82
201_P204_G0.5870.82
322_D327_N0.5860.82
59_P62_G0.5840.82
164_V223_L0.5800.81
51_S59_P0.5800.81
158_D325_D0.5760.81
129_V140_V0.5750.81
164_V227_A0.5750.81
323_N328_G0.5750.81
196_I201_P0.5740.80
44_S48_Q0.5730.80
49_Q55_R0.5720.80
260_N264_H0.5720.80
232_E237_R0.5700.80
32_Q52_K0.5700.80
54_Q58_D0.5700.80
80_E83_V0.5690.80
219_V265_K0.5680.80
254_D258_Y0.5650.79
195_S200_K0.5640.79
122_D142_K0.5640.79
193_R212_G0.5630.79
25_A30_A0.5630.79
252_D263_T0.5620.79
256_G263_T0.5610.79
189_Y261_D0.5600.79
274_C278_K0.5600.79
300_R322_D0.5600.79
188_H207_V0.5570.78
12_K18_N0.5570.78
162_R323_N0.5560.78
259_V262_K0.5560.78
47_D92_P0.5540.78
292_Y296_K0.5540.78
159_M248_G0.5530.78
291_E335_R0.5530.78
220_D224_H0.5520.78
31_F39_D0.5500.78
334_K339_K0.5490.78
50_A89_V0.5490.78
198_K201_P0.5470.77
279_A282_A0.5450.77
105_W109_H0.5450.77
12_K19_R0.5440.77
14_H19_R0.5430.77
18_N21_A0.5430.77
330_L333_G0.5430.77
136_Y213_D0.5430.77
121_G141_V0.5420.77
90_N95_D0.5410.76
33_T55_R0.5400.76
205_Q208_V0.5400.76
334_K337_L0.5390.76
19_R23_L0.5370.76
73_V77_S0.5370.76
316_P324_A0.5360.76
167_C170_L0.5350.76
215_E219_V0.5350.76
75_D78_H0.5340.76
76_V82_T0.5340.76
184_R191_Q0.5300.75
295_S307_R0.5300.75
186_R193_R0.5290.75
252_D259_V0.5280.75
49_Q95_D0.5270.75
33_T37_D0.5250.74
78_H81_D0.5240.74
66_P71_N0.5240.74
166_T176_T0.5230.74
177_F181_E0.5220.74
145_V280_H0.5210.74
191_Q204_G0.5210.74
104_I107_P0.5200.74
95_D107_P0.5190.74
97_E107_P0.5140.73
255_K258_Y0.5130.73
293_D313_F0.5110.72
35_V39_D0.5090.72
294_T331_N0.5080.72
14_H21_A0.5080.72
49_Q54_Q0.5060.72
63_T74_F0.5060.72
262_K266_M0.5050.71
225_K228_R0.5020.71
251_K269_A0.5020.71
24_L28_Y0.5010.71
156_A168_A0.5010.71
43_Y50_A0.5000.71
108_A112_R0.5000.71
231_V286_V0.5000.71
48_Q51_S0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3385 95.4 0.925 Contact Map
1vhxA 2 0.3568 95 0.927 Contact Map
1iv0A 1 0.2526 93.9 0.931 Contact Map
1twfI 1 0.2422 87.8 0.941 Contact Map
1qypA 1 0.1146 86.5 0.942 Contact Map
1ffkW 1 0.1849 84.1 0.944 Contact Map
4aybP 1 0.1068 83.3 0.944 Contact Map
3h0gI 1 0.2344 82.7 0.945 Contact Map
2k4xA 1 0.1406 82.5 0.945 Contact Map
4c2mI 1 0.2474 79.4 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.