Q9HSD1 - HALSA - GREMLIN Contacts

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Q9HSD1 - Uncharacterized protein

UniProt:	Q9HSD1	Sequences: MIERYPVDGATRAPHGTTNAYLVDGQARVLVDPAGRTAALDAAVSRGVDHIVVTHAHPDHVGAVDAYAAATDATVWAHAAFTARFERETGVAPDRVFRPGDAIGDTALTVTDTPGHAPDHVAVLATVDGECNAISGDLVFADSSVFVGAVDGDMRAYLASLRRLAAGAPARLQPGHGPTIEQPADRLHALYAHRRDRERRVLDAVAAGCETVDAILDAAYDKDLAGVRDLAGQTVRAHLDKLAREQRIDWNGSRATHQPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	260 (210)
Sequences:	8317 (6249)
Seq/√Len:	431.2

ECOLI - GLO2 YCBL
BACSU - YQJP PKSB YYBB YQGX YOBT YFLN YRKH
HALSA - Q9HSD1 Q9HRG5 Q9HNJ9 Q9HQ50 Q9HNJ2 Q9HSH2
SULSO - Q97VU4 Q97VU0 Q7LYK3 Q97UV2 Q97WC2 Q97U88 Q97YZ2 Q97UR2 Q97XZ1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
113_T	122_A	4.483	1.00
109_T	128_D	3.427	1.00
53_V	64_V	3.281	1.00
99_P	163_R	3.266	1.00
27_A	49_D	3.160	1.00
102_A	107_A	2.937	1.00
102_A	109_T	2.694	1.00
131_C	170_A	2.611	1.00
29_V	50_H	2.566	1.00
162_R	191_Y	2.530	1.00
50_H	76_W	2.474	1.00
74_T	95_R	2.414	1.00
165_A	188_H	2.265	1.00
110_V	121_V	2.251	1.00
52_V	123_V	2.231	1.00
108_L	125_A	2.230	1.00
165_A	191_Y	2.196	1.00
125_A	130_E	2.128	1.00
40_L	44_V	2.073	1.00
31_V	134_I	2.072	1.00
76_W	95_R	2.065	1.00
39_A	44_V	2.037	1.00
50_H	74_T	2.006	1.00
31_V	54_T	1.996	1.00
76_W	97_F	1.942	1.00
79_A	98_R	1.904	1.00
120_H	136_G	1.868	1.00
81_F	119_D	1.845	1.00
188_H	192_A	1.843	1.00
182_Q	185_D	1.800	1.00
27_A	47_G	1.714	1.00
132_N	173_Q	1.669	1.00
106_T	130_E	1.665	1.00
211_T	214_A	1.645	1.00
66_A	69_A	1.632	1.00
158_L	162_R	1.625	1.00
41_D	70_A	1.608	1.00
68_A	94_D	1.605	1.00
98_R	101_D	1.601	1.00
66_A	70_A	1.584	1.00
99_P	112_D	1.570	1.00
115_G	160_S	1.540	1.00
125_A	129_G	1.517	1.00
191_Y	195_R	1.509	1.00
113_T	160_S	1.504	1.00
78_H	112_D	1.502	1.00
110_V	123_V	1.490	1.00
54_T	136_G	1.476	1.00
153_D	156_A	1.474	1.00
39_A	43_A	1.446	1.00
51_I	73_A	1.434	1.00
188_H	191_Y	1.401	1.00
29_V	52_V	1.385	1.00
163_R	166_A	1.376	1.00
95_R	101_D	1.369	1.00
107_A	129_G	1.363	1.00
200_R	204_A	1.361	1.00
106_T	125_A	1.359	1.00
41_D	44_V	1.338	1.00
147_V	154_M	1.319	1.00
131_C	168_A	1.312	1.00
78_H	121_V	1.279	1.00
28_R	48_V	1.273	1.00
124_L	131_C	1.272	1.00
124_L	133_A	1.263	1.00
108_L	123_V	1.254	1.00
124_L	128_D	1.248	1.00
213_D	217_D	1.236	1.00
78_H	81_F	1.233	1.00
51_I	64_V	1.218	1.00
23_V	31_V	1.178	1.00
54_T	123_V	1.176	1.00
192_A	195_R	1.171	1.00
162_R	165_A	1.166	1.00
199_R	203_D	1.153	1.00
212_V	216_L	1.145	1.00
97_F	110_V	1.132	1.00
133_A	167_G	1.131	1.00
100_G	109_T	1.127	1.00
102_A	128_D	1.125	1.00
82_T	96_V	1.121	1.00
132_N	171_R	1.115	1.00
30_L	48_V	1.109	1.00
142_D	183_P	1.107	1.00
203_D	207_A	1.103	1.00
107_A	128_D	1.094	1.00
28_R	46_R	1.089	1.00
22_L	30_L	1.082	1.00
202_L	206_A	1.080	1.00
112_D	121_V	1.080	1.00
124_L	169_P	1.079	1.00
199_R	202_L	1.072	1.00
38_A	41_D	1.067	1.00
113_T	120_H	1.064	1.00
77_A	81_F	1.061	1.00
27_A	50_H	1.052	1.00
64_V	75_V	1.048	1.00
79_A	96_V	1.048	1.00
40_L	43_A	1.042	1.00
192_A	196_D	1.037	1.00
135_S	172_L	1.035	1.00
44_V	70_A	1.025	1.00
109_T	124_L	1.022	1.00
21_Y	173_Q	1.014	1.00
162_R	195_R	1.014	1.00
154_M	157_Y	1.013	1.00
25_G	105_D	1.003	1.00
158_L	191_Y	0.997	1.00
14_P	20_A	0.994	1.00
162_R	166_A	0.988	1.00
68_A	75_V	0.980	1.00
143_S	146_F	0.976	1.00
49_D	74_T	0.969	1.00
215_I	219_A	0.966	1.00
161_L	165_A	0.961	1.00
155_R	159_A	0.957	1.00
26_Q	46_R	0.957	1.00
180_I	202_L	0.954	1.00
159_A	162_R	0.953	1.00
159_A	163_R	0.950	1.00
168_A	184_A	0.950	1.00
210_E	214_A	0.934	1.00
24_D	28_R	0.929	1.00
120_H	175_G	0.926	1.00
122_A	133_A	0.915	1.00
30_L	67_Y	0.913	1.00
136_G	175_G	0.912	1.00
74_T	94_D	0.911	1.00
48_V	73_A	0.911	1.00
58_P	62_G	0.910	1.00
21_Y	134_I	0.908	1.00
109_T	167_G	0.907	1.00
111_T	124_L	0.897	1.00
122_A	138_L	0.890	1.00
60_H	137_D	0.887	1.00
103_I	108_L	0.884	1.00
20_A	34_A	0.880	1.00
30_L	33_P	0.878	1.00
200_R	203_D	0.875	1.00
122_A	164_L	0.872	1.00
145_V	148_G	0.871	1.00
65_D	69_A	0.860	1.00
33_P	51_I	0.860	1.00
156_A	159_A	0.858	1.00
203_D	206_A	0.853	1.00
124_L	167_G	0.852	1.00
214_A	218_A	0.851	1.00
125_A	128_D	0.846	1.00
160_S	163_R	0.836	1.00
210_E	218_A	0.830	1.00
161_L	164_L	0.830	1.00
186_R	190_L	0.826	1.00
138_L	164_L	0.824	1.00
77_A	85_F	0.822	1.00
174_P	177_G	0.815	1.00
198_E	202_L	0.812	1.00
51_I	67_Y	0.805	1.00
171_R	181_E	0.803	1.00
197_R	200_R	0.802	1.00
52_V	108_L	0.793	1.00
186_R	189_A	0.792	1.00
214_A	217_D	0.790	1.00
106_T	129_G	0.782	1.00
122_A	160_S	0.780	1.00
39_A	42_A	0.778	1.00
158_L	165_A	0.775	1.00
154_M	158_L	0.769	1.00
80_A	83_A	0.764	1.00
26_Q	104_G	0.762	1.00
180_I	201_V	0.761	1.00
160_S	164_L	0.760	1.00
97_F	121_V	0.760	1.00
50_H	95_R	0.759	1.00
23_V	125_A	0.759	1.00
111_T	163_R	0.756	1.00
56_A	119_D	0.754	1.00
48_V	71_T	0.752	1.00
29_V	108_L	0.752	1.00
19_N	177_G	0.752	1.00
185_D	189_A	0.751	1.00
133_A	172_L	0.751	1.00
93_P	96_V	0.750	1.00
139_V	187_L	0.748	1.00
134_I	173_Q	0.744	1.00
97_F	101_D	0.739	1.00
111_T	122_A	0.738	1.00
207_A	210_E	0.738	1.00
191_Y	194_R	0.736	1.00
125_A	132_N	0.727	1.00
28_R	49_D	0.725	1.00
21_Y	175_G	0.721	1.00
143_S	148_G	0.719	1.00
152_G	155_R	0.716	1.00
81_F	84_R	0.715	1.00
118_P	156_A	0.711	1.00
52_V	121_V	0.710	1.00
24_D	46_R	0.704	1.00
138_L	160_S	0.702	1.00
48_V	67_Y	0.697	1.00
197_R	201_V	0.696	1.00
33_P	62_G	0.692	1.00
31_V	123_V	0.691	1.00
38_A	42_A	0.689	1.00
195_R	199_R	0.688	1.00
190_L	194_R	0.688	1.00
216_L	219_A	0.687	1.00
22_L	28_R	0.685	1.00
147_V	157_Y	0.684	1.00
65_D	68_A	0.678	1.00
32_D	55_H	0.678	1.00
169_P	217_D	0.677	1.00
77_A	93_P	0.675	1.00
210_E	215_I	0.674	1.00
222_K	226_G	0.659	1.00
79_A	82_T	0.656	0.99
55_H	137_D	0.653	0.99
189_A	193_H	0.652	0.99
135_S	175_G	0.647	0.99
122_A	135_S	0.647	0.99
180_I	186_R	0.645	0.99
193_H	196_D	0.644	0.99
117_A	120_H	0.640	0.99
36_R	63_A	0.640	0.99
141_A	197_R	0.640	0.99
154_M	160_S	0.635	0.99
190_L	193_H	0.635	0.99
128_D	131_C	0.634	0.99
204_A	209_C	0.630	0.99
20_A	30_L	0.630	0.99
23_V	29_V	0.629	0.99
125_A	134_I	0.628	0.99
204_A	218_A	0.624	0.99
22_L	48_V	0.619	0.99
31_V	52_V	0.614	0.99
33_P	64_V	0.614	0.99
144_S	147_V	0.613	0.99
115_G	147_V	0.607	0.99
51_I	75_V	0.606	0.99
63_A	66_A	0.606	0.99
183_P	186_R	0.605	0.99
25_G	104_G	0.604	0.99
165_A	184_A	0.604	0.99
28_R	47_G	0.599	0.99
160_S	165_A	0.598	0.99
91_V	94_D	0.598	0.99
138_L	157_Y	0.597	0.99
82_T	94_D	0.597	0.99
27_A	104_G	0.594	0.99
31_V	108_L	0.594	0.99
61_V	64_V	0.594	0.99
116_H	137_D	0.593	0.99
143_S	147_V	0.592	0.99
54_T	57_H	0.590	0.99
45_S	71_T	0.589	0.99
212_V	215_I	0.589	0.99
222_K	225_A	0.589	0.99
113_T	138_L	0.586	0.99
26_Q	47_G	0.584	0.99
187_L	198_E	0.584	0.99
79_A	83_A	0.583	0.99
56_A	77_A	0.583	0.99
18_T	175_G	0.583	0.99
158_L	194_R	0.582	0.99
101_D	110_V	0.577	0.99
158_L	195_R	0.575	0.99
77_A	82_T	0.573	0.99
57_H	117_A	0.573	0.99
120_H	138_L	0.570	0.99
35_G	61_V	0.570	0.99
53_V	61_V	0.570	0.99
115_G	120_H	0.569	0.99
171_R	179_T	0.568	0.99
142_D	194_R	0.567	0.99
118_P	151_D	0.564	0.98
144_S	190_L	0.564	0.98
98_R	112_D	0.561	0.98
124_L	168_A	0.557	0.98
184_A	188_H	0.555	0.98
37_T	66_A	0.554	0.98
113_T	136_G	0.553	0.98
97_F	123_V	0.551	0.98
198_E	201_V	0.544	0.98
82_T	85_F	0.543	0.98
139_V	172_L	0.540	0.98
189_A	192_A	0.536	0.98
157_Y	160_S	0.535	0.98
157_Y	161_L	0.535	0.98
68_A	72_D	0.534	0.98
221_D	224_L	0.531	0.98
133_A	164_L	0.530	0.98
135_S	174_P	0.529	0.98
84_R	87_R	0.529	0.98
201_V	204_A	0.528	0.98
29_V	48_V	0.528	0.98
148_G	151_D	0.527	0.98
217_D	225_A	0.526	0.98
38_A	44_V	0.523	0.97
29_V	49_D	0.520	0.97
81_F	85_F	0.519	0.97
32_D	137_D	0.519	0.97
23_V	108_L	0.518	0.97
55_H	60_H	0.518	0.97
100_G	163_R	0.517	0.97
112_D	163_R	0.515	0.97
201_V	205_V	0.514	0.97
193_H	197_R	0.513	0.97
61_V	77_A	0.510	0.97
64_V	68_A	0.506	0.97
80_A	119_D	0.506	0.97
76_W	101_D	0.505	0.97
210_E	213_D	0.505	0.97
117_A	138_L	0.504	0.97
56_A	81_F	0.503	0.97
208_G	211_T	0.501	0.97
148_G	152_G	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zo4A	1	0.95	100	0.285	Contact Map
4ad9A	4	0.9769	100	0.315	Contact Map
2yheA	3	0.9846	100	0.404	Contact Map
4pdxA	2	0.9731	100	0.413	Contact Map
4nurA	2	0.9808	100	0.415	Contact Map
2cfuA	2	0.9731	100	0.419	Contact Map
2vw8A	2	0.9308	100	0.432	Contact Map
2p18A	1	0.9269	100	0.455	Contact Map
1xm8A	1	0.9346	100	0.457	Contact Map
4yslA	2	0.9692	100	0.458	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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