GREMLIN Database
Q9HSD1 - Uncharacterized protein
UniProt: Q9HSD1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (210)
Sequences: 8317 (6249)
Seq/√Len: 431.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_T122_A4.4831.00
109_T128_D3.4271.00
53_V64_V3.2811.00
99_P163_R3.2661.00
27_A49_D3.1601.00
102_A107_A2.9371.00
102_A109_T2.6941.00
131_C170_A2.6111.00
29_V50_H2.5661.00
162_R191_Y2.5301.00
50_H76_W2.4741.00
74_T95_R2.4141.00
165_A188_H2.2651.00
110_V121_V2.2511.00
52_V123_V2.2311.00
108_L125_A2.2301.00
165_A191_Y2.1961.00
125_A130_E2.1281.00
40_L44_V2.0731.00
31_V134_I2.0721.00
76_W95_R2.0651.00
39_A44_V2.0371.00
50_H74_T2.0061.00
31_V54_T1.9961.00
76_W97_F1.9421.00
79_A98_R1.9041.00
120_H136_G1.8681.00
81_F119_D1.8451.00
188_H192_A1.8431.00
182_Q185_D1.8001.00
27_A47_G1.7141.00
132_N173_Q1.6691.00
106_T130_E1.6651.00
211_T214_A1.6451.00
66_A69_A1.6321.00
158_L162_R1.6251.00
41_D70_A1.6081.00
68_A94_D1.6051.00
98_R101_D1.6011.00
66_A70_A1.5841.00
99_P112_D1.5701.00
115_G160_S1.5401.00
125_A129_G1.5171.00
191_Y195_R1.5091.00
113_T160_S1.5041.00
78_H112_D1.5021.00
110_V123_V1.4901.00
54_T136_G1.4761.00
153_D156_A1.4741.00
39_A43_A1.4461.00
51_I73_A1.4341.00
188_H191_Y1.4011.00
29_V52_V1.3851.00
163_R166_A1.3761.00
95_R101_D1.3691.00
107_A129_G1.3631.00
200_R204_A1.3611.00
106_T125_A1.3591.00
41_D44_V1.3381.00
147_V154_M1.3191.00
131_C168_A1.3121.00
78_H121_V1.2791.00
28_R48_V1.2731.00
124_L131_C1.2721.00
124_L133_A1.2631.00
108_L123_V1.2541.00
124_L128_D1.2481.00
213_D217_D1.2361.00
78_H81_F1.2331.00
51_I64_V1.2181.00
23_V31_V1.1781.00
54_T123_V1.1761.00
192_A195_R1.1711.00
162_R165_A1.1661.00
199_R203_D1.1531.00
212_V216_L1.1451.00
97_F110_V1.1321.00
133_A167_G1.1311.00
100_G109_T1.1271.00
102_A128_D1.1251.00
82_T96_V1.1211.00
132_N171_R1.1151.00
30_L48_V1.1091.00
142_D183_P1.1071.00
203_D207_A1.1031.00
107_A128_D1.0941.00
28_R46_R1.0891.00
22_L30_L1.0821.00
202_L206_A1.0801.00
112_D121_V1.0801.00
124_L169_P1.0791.00
199_R202_L1.0721.00
38_A41_D1.0671.00
113_T120_H1.0641.00
77_A81_F1.0611.00
27_A50_H1.0521.00
64_V75_V1.0481.00
79_A96_V1.0481.00
40_L43_A1.0421.00
192_A196_D1.0371.00
135_S172_L1.0351.00
44_V70_A1.0251.00
109_T124_L1.0221.00
21_Y173_Q1.0141.00
162_R195_R1.0141.00
154_M157_Y1.0131.00
25_G105_D1.0031.00
158_L191_Y0.9971.00
14_P20_A0.9941.00
162_R166_A0.9881.00
68_A75_V0.9801.00
143_S146_F0.9761.00
49_D74_T0.9691.00
215_I219_A0.9661.00
161_L165_A0.9611.00
155_R159_A0.9571.00
26_Q46_R0.9571.00
180_I202_L0.9541.00
159_A162_R0.9531.00
159_A163_R0.9501.00
168_A184_A0.9501.00
210_E214_A0.9341.00
24_D28_R0.9291.00
120_H175_G0.9261.00
122_A133_A0.9151.00
30_L67_Y0.9131.00
136_G175_G0.9121.00
74_T94_D0.9111.00
48_V73_A0.9111.00
58_P62_G0.9101.00
21_Y134_I0.9081.00
109_T167_G0.9071.00
111_T124_L0.8971.00
122_A138_L0.8901.00
60_H137_D0.8871.00
103_I108_L0.8841.00
20_A34_A0.8801.00
30_L33_P0.8781.00
200_R203_D0.8751.00
122_A164_L0.8721.00
145_V148_G0.8711.00
65_D69_A0.8601.00
33_P51_I0.8601.00
156_A159_A0.8581.00
203_D206_A0.8531.00
124_L167_G0.8521.00
214_A218_A0.8511.00
125_A128_D0.8461.00
160_S163_R0.8361.00
210_E218_A0.8301.00
161_L164_L0.8301.00
186_R190_L0.8261.00
138_L164_L0.8241.00
77_A85_F0.8221.00
174_P177_G0.8151.00
198_E202_L0.8121.00
51_I67_Y0.8051.00
171_R181_E0.8031.00
197_R200_R0.8021.00
52_V108_L0.7931.00
186_R189_A0.7921.00
214_A217_D0.7901.00
106_T129_G0.7821.00
122_A160_S0.7801.00
39_A42_A0.7781.00
158_L165_A0.7751.00
154_M158_L0.7691.00
80_A83_A0.7641.00
26_Q104_G0.7621.00
180_I201_V0.7611.00
160_S164_L0.7601.00
97_F121_V0.7601.00
50_H95_R0.7591.00
23_V125_A0.7591.00
111_T163_R0.7561.00
56_A119_D0.7541.00
48_V71_T0.7521.00
29_V108_L0.7521.00
19_N177_G0.7521.00
185_D189_A0.7511.00
133_A172_L0.7511.00
93_P96_V0.7501.00
139_V187_L0.7481.00
134_I173_Q0.7441.00
97_F101_D0.7391.00
111_T122_A0.7381.00
207_A210_E0.7381.00
191_Y194_R0.7361.00
125_A132_N0.7271.00
28_R49_D0.7251.00
21_Y175_G0.7211.00
143_S148_G0.7191.00
152_G155_R0.7161.00
81_F84_R0.7151.00
118_P156_A0.7111.00
52_V121_V0.7101.00
24_D46_R0.7041.00
138_L160_S0.7021.00
48_V67_Y0.6971.00
197_R201_V0.6961.00
33_P62_G0.6921.00
31_V123_V0.6911.00
38_A42_A0.6891.00
195_R199_R0.6881.00
190_L194_R0.6881.00
216_L219_A0.6871.00
22_L28_R0.6851.00
147_V157_Y0.6841.00
65_D68_A0.6781.00
32_D55_H0.6781.00
169_P217_D0.6771.00
77_A93_P0.6751.00
210_E215_I0.6741.00
222_K226_G0.6591.00
79_A82_T0.6560.99
55_H137_D0.6530.99
189_A193_H0.6520.99
135_S175_G0.6470.99
122_A135_S0.6470.99
180_I186_R0.6450.99
193_H196_D0.6440.99
117_A120_H0.6400.99
36_R63_A0.6400.99
141_A197_R0.6400.99
154_M160_S0.6350.99
190_L193_H0.6350.99
128_D131_C0.6340.99
204_A209_C0.6300.99
20_A30_L0.6300.99
23_V29_V0.6290.99
125_A134_I0.6280.99
204_A218_A0.6240.99
22_L48_V0.6190.99
31_V52_V0.6140.99
33_P64_V0.6140.99
144_S147_V0.6130.99
115_G147_V0.6070.99
51_I75_V0.6060.99
63_A66_A0.6060.99
183_P186_R0.6050.99
25_G104_G0.6040.99
165_A184_A0.6040.99
28_R47_G0.5990.99
160_S165_A0.5980.99
91_V94_D0.5980.99
138_L157_Y0.5970.99
82_T94_D0.5970.99
27_A104_G0.5940.99
31_V108_L0.5940.99
61_V64_V0.5940.99
116_H137_D0.5930.99
143_S147_V0.5920.99
54_T57_H0.5900.99
45_S71_T0.5890.99
212_V215_I0.5890.99
222_K225_A0.5890.99
113_T138_L0.5860.99
26_Q47_G0.5840.99
187_L198_E0.5840.99
79_A83_A0.5830.99
56_A77_A0.5830.99
18_T175_G0.5830.99
158_L194_R0.5820.99
101_D110_V0.5770.99
158_L195_R0.5750.99
77_A82_T0.5730.99
57_H117_A0.5730.99
120_H138_L0.5700.99
35_G61_V0.5700.99
53_V61_V0.5700.99
115_G120_H0.5690.99
171_R179_T0.5680.99
142_D194_R0.5670.99
118_P151_D0.5640.98
144_S190_L0.5640.98
98_R112_D0.5610.98
124_L168_A0.5570.98
184_A188_H0.5550.98
37_T66_A0.5540.98
113_T136_G0.5530.98
97_F123_V0.5510.98
198_E201_V0.5440.98
82_T85_F0.5430.98
139_V172_L0.5400.98
189_A192_A0.5360.98
157_Y160_S0.5350.98
157_Y161_L0.5350.98
68_A72_D0.5340.98
221_D224_L0.5310.98
133_A164_L0.5300.98
135_S174_P0.5290.98
84_R87_R0.5290.98
201_V204_A0.5280.98
29_V48_V0.5280.98
148_G151_D0.5270.98
217_D225_A0.5260.98
38_A44_V0.5230.97
29_V49_D0.5200.97
81_F85_F0.5190.97
32_D137_D0.5190.97
23_V108_L0.5180.97
55_H60_H0.5180.97
100_G163_R0.5170.97
112_D163_R0.5150.97
201_V205_V0.5140.97
193_H197_R0.5130.97
61_V77_A0.5100.97
64_V68_A0.5060.97
80_A119_D0.5060.97
76_W101_D0.5050.97
210_E213_D0.5050.97
117_A138_L0.5040.97
56_A81_F0.5030.97
208_G211_T0.5010.97
148_G152_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.95 100 0.285 Contact Map
4ad9A 4 0.9769 100 0.315 Contact Map
2yheA 3 0.9846 100 0.404 Contact Map
4pdxA 2 0.9731 100 0.413 Contact Map
4nurA 2 0.9808 100 0.415 Contact Map
2cfuA 2 0.9731 100 0.419 Contact Map
2vw8A 2 0.9308 100 0.432 Contact Map
2p18A 1 0.9269 100 0.455 Contact Map
1xm8A 1 0.9346 100 0.457 Contact Map
4yslA 2 0.9692 100 0.458 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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