GREMLIN Database
Q9HSD0 - Uncharacterized protein
UniProt: Q9HSD0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 89 (74)
Sequences: 179 (83)
Seq/√Len: 9.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_K37_E3.2500.95
19_R22_L3.0870.93
34_K38_I3.0190.92
52_L82_K2.7760.89
73_S76_S2.1460.71
29_A32_V1.8360.59
22_L70_L1.8190.58
32_V35_V1.7890.57
64_R77_F1.7520.55
35_V80_A1.7010.53
25_L63_N1.6670.51
45_G82_K1.6060.48
71_V86_Y1.5410.45
29_A42_L1.5260.45
76_S84_V1.5080.44
59_R80_A1.4630.42
58_V61_A1.4010.39
44_Q80_A1.4010.39
54_P74_R1.3870.39
40_S55_D1.3870.39
54_P84_V1.3740.38
41_P51_S1.3410.37
33_A82_K1.3400.37
46_E52_L1.3280.36
33_A73_S1.3070.35
19_R70_L1.2590.33
42_L69_H1.2330.32
39_D64_R1.1730.30
50_E70_L1.1420.29
20_S39_D1.1360.29
60_Y74_R1.1340.29
50_E60_Y1.0720.26
52_L71_V1.0690.26
14_D17_E1.0490.26
30_K43_S1.0300.25
55_D62_L1.0300.25
71_V83_Q1.0230.25
20_S86_Y1.0140.24
66_D73_S0.9900.24
54_P87_L0.9880.24
20_S47_L0.9870.23
50_E73_S0.9800.23
41_P62_L0.9550.22
35_V40_S0.9510.22
75_Y83_Q0.9440.22
27_P30_K0.9020.21
41_P46_E0.9000.21
47_L62_L0.8890.20
22_L41_P0.8800.20
22_L67_E0.8780.20
28_S36_L0.8730.20
27_P36_L0.8730.20
20_S72_D0.8680.20
50_E87_L0.8540.19
25_L74_R0.8460.19
59_R85_Y0.8310.19
45_G84_V0.8210.19
48_A80_A0.8180.18
24_E50_E0.8020.18
48_A76_S0.8000.18
24_E69_H0.7980.18
51_S78_E0.7900.18
43_S55_D0.7890.18
66_D71_V0.7880.18
55_D60_Y0.7840.18
45_G86_Y0.7830.18
63_N76_S0.7650.17
61_A80_A0.7480.17
51_S77_F0.7480.17
31_L38_I0.7420.16
60_Y64_R0.7410.16
23_Q69_H0.7250.16
24_E41_P0.7250.16
42_L77_F0.6940.15
47_L52_L0.6880.15
45_G54_P0.6840.15
35_V62_L0.6740.15
39_D84_V0.6610.15
33_A83_Q0.6600.15
68_Q74_R0.6550.14
41_P70_L0.6510.14
20_S60_Y0.6480.14
21_R70_L0.6320.14
23_Q64_R0.6270.14
76_S80_A0.6200.14
54_P66_D0.6090.13
19_R46_E0.6050.13
46_E50_E0.5980.13
30_K59_R0.5970.13
72_D78_E0.5960.13
51_S84_V0.5940.13
29_A68_Q0.5890.13
49_D63_N0.5880.13
15_D69_H0.5870.13
30_K36_L0.5770.13
15_D43_S0.5610.12
32_V80_A0.5590.12
39_D87_L0.5510.12
21_R69_H0.5490.12
45_G48_A0.5490.12
19_R40_S0.5470.12
31_L44_Q0.5440.12
61_A77_F0.5430.12
32_V61_A0.5240.12
63_N74_R0.5230.12
19_R33_A0.5180.12
42_L49_D0.5150.12
66_D70_L0.5050.11
82_K87_L0.5020.11
31_L48_A0.5020.11
44_Q58_V0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dk5A 1 0.9213 98.5 0.72 Contact Map
2mlgA 1 0.7528 98.2 0.744 Contact Map
3s2wA 3 0.9213 98 0.756 Contact Map
2hztA 2 0.8202 98 0.758 Contact Map
4a5nA 2 0.8315 97.9 0.76 Contact Map
4rbrA 2 0.9438 97.9 0.761 Contact Map
1hsjA 2 1 97.9 0.762 Contact Map
2p4wA 2 0.8427 97.9 0.763 Contact Map
2nyxA 2 0.9326 97.9 0.763 Contact Map
3nqoA 2 0.9888 97.9 0.764 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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