GREMLIN Database
Q9HSC8 - Uncharacterized protein
UniProt: Q9HSC8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (243)
Sequences: 12845 (11312)
Seq/√Len: 725.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_R151_R3.9071.00
12_A85_Q3.5641.00
13_R42_G2.9681.00
9_T43_T2.8171.00
96_A184_N2.6361.00
167_D171_R2.5901.00
4_S77_G2.4891.00
90_Q188_L2.4831.00
70_A74_A2.4691.00
27_A95_N2.4291.00
44_S48_R2.4061.00
18_D190_T2.3891.00
11_N40_V2.2671.00
62_R66_A2.2091.00
6_V71_G2.2061.00
3_L98_A2.2011.00
79_V101_I2.1071.00
66_A158_E2.0961.00
34_V47_V2.0291.00
42_G45_G1.9871.00
31_E54_D1.9851.00
89_I93_W1.9841.00
100_A180_A1.9801.00
18_D88_H1.9431.00
97_V144_A1.9041.00
35_A71_G1.8901.00
7_V32_V1.8841.00
100_A182_A1.8791.00
81_A94_T1.8671.00
17_L21_D1.8481.00
88_H188_L1.8471.00
68_R84_G1.8201.00
13_R46_T1.7971.00
4_S31_E1.7871.00
7_V19_A1.7801.00
28_P98_A1.7721.00
83_I89_I1.7621.00
81_A93_W1.7491.00
3_L94_T1.7031.00
93_W97_V1.6901.00
58_E70_A1.6881.00
59_L62_R1.6731.00
9_T34_V1.6711.00
81_A144_A1.6591.00
10_L61_E1.6511.00
36_N58_E1.6491.00
79_V144_A1.6471.00
95_N99_D1.5881.00
36_N57_L1.5711.00
31_E77_G1.5691.00
148_R152_A1.5641.00
17_L46_T1.5581.00
17_L49_D1.5371.00
3_L144_A1.5341.00
92_G96_A1.5281.00
19_A83_I1.5151.00
21_D25_A1.5001.00
65_N164_A1.4921.00
36_N39_S1.4881.00
113_H188_L1.4771.00
70_A73_A1.4691.00
75_T147_R1.4491.00
149_A177_R1.4411.00
72_I150_L1.4261.00
9_T12_A1.4201.00
68_R82_F1.4181.00
72_I82_F1.4111.00
64_L164_A1.3991.00
4_S75_T1.3941.00
64_L196_I1.3791.00
88_H190_T1.3741.00
157_D167_D1.3741.00
48_R57_L1.3731.00
106_D178_R1.3701.00
81_A89_I1.3601.00
152_A175_M1.3591.00
11_N39_S1.3571.00
105_A180_A1.3481.00
23_L83_I1.3461.00
149_A172_L1.3411.00
80_V147_R1.3331.00
54_D74_A1.3321.00
59_L70_A1.3041.00
101_I144_A1.2981.00
96_A99_D1.2881.00
7_V23_L1.2851.00
37_G61_E1.2851.00
9_T85_Q1.2841.00
143_V169_A1.2671.00
78_T146_T1.2431.00
59_L66_A1.2401.00
72_I80_V1.2371.00
98_A102_A1.2351.00
64_L68_R1.2341.00
148_R151_R1.1871.00
150_L168_A1.1841.00
93_W186_C1.1781.00
35_A67_A1.1721.00
12_A15_A1.1431.00
22_A89_I1.1261.00
115_T188_L1.1181.00
44_S57_L1.1181.00
73_A154_D1.1171.00
4_S33_V1.1161.00
192_A195_V1.1141.00
116_V120_V1.1101.00
45_G48_R1.1091.00
48_R58_E1.1021.00
97_V110_G1.0911.00
20_L32_V1.0881.00
44_S47_V1.0851.00
15_A190_T1.0851.00
8_P67_A1.0811.00
57_L70_A1.0721.00
36_N44_S1.0631.00
66_A70_A1.0561.00
68_R164_A1.0541.00
21_D24_A1.0441.00
58_E67_A1.0441.00
20_L34_V1.0431.00
37_G67_A1.0421.00
152_A177_R1.0391.00
88_H115_T1.0321.00
42_G46_T1.0271.00
31_E76_N1.0251.00
64_L140_G1.0241.00
25_A91_P1.0191.00
92_G95_N1.0131.00
113_H185_A1.0041.00
58_E62_R1.0001.00
23_L32_V0.9901.00
115_T119_G0.9891.00
27_A92_G0.9811.00
97_V101_I0.9791.00
72_I75_T0.9691.00
12_A192_A0.9591.00
50_H53_V0.9501.00
140_G156_F0.9501.00
20_L24_A0.9481.00
106_D146_T0.9461.00
93_W110_G0.9451.00
32_V53_V0.9451.00
100_A104_G0.9411.00
67_A70_A0.9341.00
75_T80_V0.9331.00
69_N156_F0.9281.00
9_T16_L0.9281.00
9_T47_V0.9271.00
8_P85_Q0.9271.00
44_S55_T0.9171.00
56_L74_A0.9151.00
37_G63_N0.9151.00
5_V23_L0.9121.00
45_G49_D0.9111.00
62_R67_A0.8991.00
44_S58_E0.8941.00
5_V81_A0.8911.00
24_A50_H0.8891.00
110_G186_C0.8891.00
207_A211_K0.8811.00
101_I108_V0.8801.00
38_P59_L0.8751.00
22_A88_H0.8721.00
107_A179_V0.8701.00
112_V141_A0.8611.00
145_I169_A0.8581.00
64_L84_G0.8561.00
97_V108_V0.8561.00
103_D106_D0.8471.00
37_G62_R0.8451.00
57_L74_A0.8401.00
23_L89_I0.8391.00
168_A172_L0.8371.00
82_F156_F0.8371.00
79_V98_A0.8361.00
89_I94_T0.8361.00
65_N69_N0.8301.00
96_A182_A0.8261.00
100_A103_D0.8211.00
38_P57_L0.8181.00
69_N158_E0.8161.00
3_L81_A0.8151.00
8_P68_R0.8121.00
107_A172_L0.8091.00
149_A176_D0.8081.00
19_A87_T0.8041.00
111_P181_W0.8031.00
214_A218_R0.8001.00
83_I187_V0.7931.00
90_Q113_H0.7921.00
116_V119_G0.7921.00
107_A111_P0.7901.00
5_V94_T0.7901.00
16_L43_T0.7871.00
46_T49_D0.7841.00
19_A23_L0.7821.00
16_L85_Q0.7811.00
153_L175_M0.7781.00
150_L155_G0.7761.00
149_A152_A0.7721.00
28_P94_T0.7711.00
54_D76_N0.7711.00
33_V71_G0.7701.00
38_P61_E0.7691.00
104_G178_R0.7691.00
13_R17_L0.7661.00
40_V43_T0.7601.00
155_G168_A0.7521.00
78_T148_R0.7521.00
15_A192_A0.7481.00
24_A32_V0.7441.00
64_L67_A0.7421.00
132_G135_V0.7371.00
215_L218_R0.7321.00
78_T102_A0.7301.00
149_A153_L0.7291.00
96_A186_C0.7251.00
16_L47_V0.7251.00
146_T149_A0.7241.00
145_I150_L0.7231.00
140_G143_V0.7071.00
246_G250_R0.7071.00
141_A187_V0.7061.00
44_S56_L0.6961.00
16_L46_T0.6951.00
90_Q93_W0.6951.00
26_H95_N0.6951.00
53_V57_L0.6941.00
73_A155_G0.6901.00
153_L172_L0.6901.00
115_T190_T0.6851.00
211_K215_L0.6851.00
204_D207_A0.6781.00
33_V75_T0.6761.00
206_S210_L0.6751.00
24_A53_V0.6751.00
33_V74_A0.6751.00
247_A251_G0.6741.00
163_G166_R0.6651.00
35_A70_A0.6651.00
101_I146_T0.6641.00
19_A22_A0.6631.00
157_D160_L0.6621.00
96_A100_A0.6591.00
212_Y216_A0.6571.00
13_R16_L0.6561.00
47_V55_T0.6541.00
212_Y215_L0.6521.00
84_G164_A0.6511.00
211_K218_R0.6491.00
28_P95_N0.6451.00
69_N155_G0.6431.00
210_L214_A0.6431.00
62_R158_E0.6421.00
21_D50_H0.6411.00
172_L176_D0.6401.00
13_R85_Q0.6391.00
27_A30_A0.6381.00
24_A52_A0.6371.00
218_R222_N0.6371.00
87_T189_R0.6331.00
79_V146_T0.6331.00
6_V35_A0.6291.00
72_I155_G0.6281.00
99_D103_D0.6271.00
234_L238_V0.6231.00
214_A217_Y0.6221.00
90_Q186_C0.6211.00
98_A144_A0.6181.00
26_H89_I0.6171.00
20_L23_L0.6141.00
192_A196_I0.6141.00
62_R70_A0.6131.00
13_R41_D0.6111.00
106_D177_R0.6101.00
217_Y221_K0.6091.00
138_F169_A0.6081.00
8_P37_G0.6071.00
114_R191_D0.6051.00
157_D171_R0.6051.00
109_T181_W0.6051.00
145_I172_L0.6021.00
209_G213_R0.6011.00
195_V198_R0.6001.00
182_A186_C0.5981.00
203_A207_A0.5961.00
37_G84_G0.5891.00
204_D208_R0.5891.00
7_V83_I0.5891.00
234_L237_A0.5881.00
218_R221_K0.5871.00
12_A64_L0.5871.00
151_R155_G0.5871.00
19_A86_D0.5871.00
80_V150_L0.5861.00
7_V34_V0.5851.00
10_L37_G0.5841.00
208_R212_Y0.5841.00
97_V182_A0.5751.00
109_T143_V0.5711.00
7_V85_Q0.5691.00
12_A43_T0.5671.00
82_F150_L0.5661.00
215_L219_L0.5651.00
221_K224_G0.5651.00
109_T112_V0.5651.00
176_D179_V0.5641.00
79_V102_A0.5641.00
67_A71_G0.5631.00
19_A89_I0.5601.00
71_G84_G0.5591.00
13_R43_T0.5591.00
56_L70_A0.5581.00
208_R216_A0.5571.00
11_N41_D0.5571.00
31_E75_T0.5551.00
113_H121_T0.5541.00
64_L82_F0.5511.00
134_D178_R0.5511.00
81_A97_V0.5491.00
99_D102_A0.5461.00
111_P116_V0.5461.00
208_R211_K0.5461.00
235_R239_G0.5451.00
8_P64_L0.5441.00
211_K214_A0.5431.00
3_L101_I0.5391.00
19_A88_H0.5381.00
27_A91_P0.5341.00
157_D168_A0.5341.00
166_R170_H0.5331.00
39_S43_T0.5331.00
6_V82_F0.5331.00
205_S208_R0.5321.00
111_P185_A0.5291.00
118_G121_T0.5281.00
20_L47_V0.5281.00
207_A210_L0.5241.00
139_D142_N0.5241.00
145_I168_A0.5211.00
151_R154_D0.5201.00
131_S135_V0.5201.00
105_A178_R0.5191.00
89_I187_V0.5181.00
3_L28_P0.5181.00
213_R217_Y0.5171.00
98_A101_I0.5131.00
226_T229_I0.5131.00
142_N187_V0.5131.00
3_L97_V0.5131.00
103_D180_A0.5131.00
104_G146_T0.5111.00
67_A84_G0.5091.00
117_E120_V0.5091.00
94_T144_A0.5081.00
72_I151_R0.5071.00
102_A146_T0.5040.99
182_A185_A0.5030.99
111_P183_P0.5030.99
141_A189_R0.5020.99
81_A142_N0.5010.99
9_T36_N0.5010.99
69_N73_A0.5000.99
85_Q189_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l7iA 4 0.0852 100 0.358 Contact Map
3bcvA 2 0.5475 100 0.37 Contact Map
2z86A 2 0.7836 100 0.39 Contact Map
2d7iA 1 0.9803 100 0.396 Contact Map
1xhbA 1 0.9344 100 0.398 Contact Map
1qg8A 1 0.6984 100 0.399 Contact Map
5ajoA 1 0.9639 100 0.402 Contact Map
4fixA 3 0.9803 100 0.439 Contact Map
3ckjA 2 0.8033 100 0.482 Contact Map
2bo4A 4 0.9607 100 0.484 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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