Q9HSC8 - HALSA - GREMLIN Contacts

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Q9HSC8 - Uncharacterized protein

UniProt:	Q9HSC8	Sequences: MDLSVVVPTLNARDALLDALDALAAHAPAAEVVVANGPSVDGTSGTVRDHDAVDTLLELSERNLNAARNAGIAATNGTVVAFIGQDTHIQPGWTNAVADAIADGADAVTGPVHRTVEGGVTTESVDEATVSGRDVTFFDGANVAITRRALRALDGFDEALQTGAARDAAHRLAGMDRRVAWAPNACVLRTDADDVIHRLPEDADSSARGLKYRALAYRLTKNYGATAAITARVLRHAVGDAASVGGAVLRGDADLSTWVGAGLAVLPGLWRGSQAGLSARVADRTTTRNPNGVSTRMDRVHARHD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	305 (243)
Sequences:	12845 (11312)
Seq/√Len:	725.7

ECOLI - YIBD WCAE WCAA GTRB WBBL ARNC YAIP PGAC
BACSU - GGAA CGED YFNE GGAB EPSH EPSE EPSJ YWDF SPSA YKCC TUAG CSBB YKOT TAGF YDAM
HALSA - Q9HSC8 Q9HQP4 Q9HQP8 Q9HQP3 Q9HNK3 Q9HR08 Q9HQQ6
SULSO - Q7LXF7 Q97TZ0 Q97X05 Q97YG5 Q97YN4 Q97TY0 Q7LXG6 Q97WK7 Q97YM4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
147_R	151_R	3.907	1.00
12_A	85_Q	3.564	1.00
13_R	42_G	2.968	1.00
9_T	43_T	2.817	1.00
96_A	184_N	2.636	1.00
167_D	171_R	2.590	1.00
4_S	77_G	2.489	1.00
90_Q	188_L	2.483	1.00
70_A	74_A	2.469	1.00
27_A	95_N	2.429	1.00
44_S	48_R	2.406	1.00
18_D	190_T	2.389	1.00
11_N	40_V	2.267	1.00
62_R	66_A	2.209	1.00
6_V	71_G	2.206	1.00
3_L	98_A	2.201	1.00
79_V	101_I	2.107	1.00
66_A	158_E	2.096	1.00
34_V	47_V	2.029	1.00
42_G	45_G	1.987	1.00
31_E	54_D	1.985	1.00
89_I	93_W	1.984	1.00
100_A	180_A	1.980	1.00
18_D	88_H	1.943	1.00
97_V	144_A	1.904	1.00
35_A	71_G	1.890	1.00
7_V	32_V	1.884	1.00
100_A	182_A	1.879	1.00
81_A	94_T	1.867	1.00
17_L	21_D	1.848	1.00
88_H	188_L	1.847	1.00
68_R	84_G	1.820	1.00
13_R	46_T	1.797	1.00
4_S	31_E	1.787	1.00
7_V	19_A	1.780	1.00
28_P	98_A	1.772	1.00
83_I	89_I	1.762	1.00
81_A	93_W	1.749	1.00
3_L	94_T	1.703	1.00
93_W	97_V	1.690	1.00
58_E	70_A	1.688	1.00
59_L	62_R	1.673	1.00
9_T	34_V	1.671	1.00
81_A	144_A	1.659	1.00
10_L	61_E	1.651	1.00
36_N	58_E	1.649	1.00
79_V	144_A	1.647	1.00
95_N	99_D	1.588	1.00
36_N	57_L	1.571	1.00
31_E	77_G	1.569	1.00
148_R	152_A	1.564	1.00
17_L	46_T	1.558	1.00
17_L	49_D	1.537	1.00
3_L	144_A	1.534	1.00
92_G	96_A	1.528	1.00
19_A	83_I	1.515	1.00
21_D	25_A	1.500	1.00
65_N	164_A	1.492	1.00
36_N	39_S	1.488	1.00
113_H	188_L	1.477	1.00
70_A	73_A	1.469	1.00
75_T	147_R	1.449	1.00
149_A	177_R	1.441	1.00
72_I	150_L	1.426	1.00
9_T	12_A	1.420	1.00
68_R	82_F	1.418	1.00
72_I	82_F	1.411	1.00
64_L	164_A	1.399	1.00
4_S	75_T	1.394	1.00
64_L	196_I	1.379	1.00
88_H	190_T	1.374	1.00
157_D	167_D	1.374	1.00
48_R	57_L	1.373	1.00
106_D	178_R	1.370	1.00
81_A	89_I	1.360	1.00
152_A	175_M	1.359	1.00
11_N	39_S	1.357	1.00
105_A	180_A	1.348	1.00
23_L	83_I	1.346	1.00
149_A	172_L	1.341	1.00
80_V	147_R	1.333	1.00
54_D	74_A	1.332	1.00
59_L	70_A	1.304	1.00
101_I	144_A	1.298	1.00
96_A	99_D	1.288	1.00
7_V	23_L	1.285	1.00
37_G	61_E	1.285	1.00
9_T	85_Q	1.284	1.00
143_V	169_A	1.267	1.00
78_T	146_T	1.243	1.00
59_L	66_A	1.240	1.00
72_I	80_V	1.237	1.00
98_A	102_A	1.235	1.00
64_L	68_R	1.234	1.00
148_R	151_R	1.187	1.00
150_L	168_A	1.184	1.00
93_W	186_C	1.178	1.00
35_A	67_A	1.172	1.00
12_A	15_A	1.143	1.00
22_A	89_I	1.126	1.00
115_T	188_L	1.118	1.00
44_S	57_L	1.118	1.00
73_A	154_D	1.117	1.00
4_S	33_V	1.116	1.00
192_A	195_V	1.114	1.00
116_V	120_V	1.110	1.00
45_G	48_R	1.109	1.00
48_R	58_E	1.102	1.00
97_V	110_G	1.091	1.00
20_L	32_V	1.088	1.00
44_S	47_V	1.085	1.00
15_A	190_T	1.085	1.00
8_P	67_A	1.081	1.00
57_L	70_A	1.072	1.00
36_N	44_S	1.063	1.00
66_A	70_A	1.056	1.00
68_R	164_A	1.054	1.00
21_D	24_A	1.044	1.00
58_E	67_A	1.044	1.00
20_L	34_V	1.043	1.00
37_G	67_A	1.042	1.00
152_A	177_R	1.039	1.00
88_H	115_T	1.032	1.00
42_G	46_T	1.027	1.00
31_E	76_N	1.025	1.00
64_L	140_G	1.024	1.00
25_A	91_P	1.019	1.00
92_G	95_N	1.013	1.00
113_H	185_A	1.004	1.00
58_E	62_R	1.000	1.00
23_L	32_V	0.990	1.00
115_T	119_G	0.989	1.00
27_A	92_G	0.981	1.00
97_V	101_I	0.979	1.00
72_I	75_T	0.969	1.00
12_A	192_A	0.959	1.00
50_H	53_V	0.950	1.00
140_G	156_F	0.950	1.00
20_L	24_A	0.948	1.00
106_D	146_T	0.946	1.00
93_W	110_G	0.945	1.00
32_V	53_V	0.945	1.00
100_A	104_G	0.941	1.00
67_A	70_A	0.934	1.00
75_T	80_V	0.933	1.00
69_N	156_F	0.928	1.00
9_T	16_L	0.928	1.00
9_T	47_V	0.927	1.00
8_P	85_Q	0.927	1.00
44_S	55_T	0.917	1.00
56_L	74_A	0.915	1.00
37_G	63_N	0.915	1.00
5_V	23_L	0.912	1.00
45_G	49_D	0.911	1.00
62_R	67_A	0.899	1.00
44_S	58_E	0.894	1.00
5_V	81_A	0.891	1.00
24_A	50_H	0.889	1.00
110_G	186_C	0.889	1.00
207_A	211_K	0.881	1.00
101_I	108_V	0.880	1.00
38_P	59_L	0.875	1.00
22_A	88_H	0.872	1.00
107_A	179_V	0.870	1.00
112_V	141_A	0.861	1.00
145_I	169_A	0.858	1.00
64_L	84_G	0.856	1.00
97_V	108_V	0.856	1.00
103_D	106_D	0.847	1.00
37_G	62_R	0.845	1.00
57_L	74_A	0.840	1.00
23_L	89_I	0.839	1.00
168_A	172_L	0.837	1.00
82_F	156_F	0.837	1.00
79_V	98_A	0.836	1.00
89_I	94_T	0.836	1.00
65_N	69_N	0.830	1.00
96_A	182_A	0.826	1.00
100_A	103_D	0.821	1.00
38_P	57_L	0.818	1.00
69_N	158_E	0.816	1.00
3_L	81_A	0.815	1.00
8_P	68_R	0.812	1.00
107_A	172_L	0.809	1.00
149_A	176_D	0.808	1.00
19_A	87_T	0.804	1.00
111_P	181_W	0.803	1.00
214_A	218_R	0.800	1.00
83_I	187_V	0.793	1.00
90_Q	113_H	0.792	1.00
116_V	119_G	0.792	1.00
107_A	111_P	0.790	1.00
5_V	94_T	0.790	1.00
16_L	43_T	0.787	1.00
46_T	49_D	0.784	1.00
19_A	23_L	0.782	1.00
16_L	85_Q	0.781	1.00
153_L	175_M	0.778	1.00
150_L	155_G	0.776	1.00
149_A	152_A	0.772	1.00
28_P	94_T	0.771	1.00
54_D	76_N	0.771	1.00
33_V	71_G	0.770	1.00
38_P	61_E	0.769	1.00
104_G	178_R	0.769	1.00
13_R	17_L	0.766	1.00
40_V	43_T	0.760	1.00
155_G	168_A	0.752	1.00
78_T	148_R	0.752	1.00
15_A	192_A	0.748	1.00
24_A	32_V	0.744	1.00
64_L	67_A	0.742	1.00
132_G	135_V	0.737	1.00
215_L	218_R	0.732	1.00
78_T	102_A	0.730	1.00
149_A	153_L	0.729	1.00
96_A	186_C	0.725	1.00
16_L	47_V	0.725	1.00
146_T	149_A	0.724	1.00
145_I	150_L	0.723	1.00
140_G	143_V	0.707	1.00
246_G	250_R	0.707	1.00
141_A	187_V	0.706	1.00
44_S	56_L	0.696	1.00
16_L	46_T	0.695	1.00
90_Q	93_W	0.695	1.00
26_H	95_N	0.695	1.00
53_V	57_L	0.694	1.00
73_A	155_G	0.690	1.00
153_L	172_L	0.690	1.00
115_T	190_T	0.685	1.00
211_K	215_L	0.685	1.00
204_D	207_A	0.678	1.00
33_V	75_T	0.676	1.00
206_S	210_L	0.675	1.00
24_A	53_V	0.675	1.00
33_V	74_A	0.675	1.00
247_A	251_G	0.674	1.00
163_G	166_R	0.665	1.00
35_A	70_A	0.665	1.00
101_I	146_T	0.664	1.00
19_A	22_A	0.663	1.00
157_D	160_L	0.662	1.00
96_A	100_A	0.659	1.00
212_Y	216_A	0.657	1.00
13_R	16_L	0.656	1.00
47_V	55_T	0.654	1.00
212_Y	215_L	0.652	1.00
84_G	164_A	0.651	1.00
211_K	218_R	0.649	1.00
28_P	95_N	0.645	1.00
69_N	155_G	0.643	1.00
210_L	214_A	0.643	1.00
62_R	158_E	0.642	1.00
21_D	50_H	0.641	1.00
172_L	176_D	0.640	1.00
13_R	85_Q	0.639	1.00
27_A	30_A	0.638	1.00
24_A	52_A	0.637	1.00
218_R	222_N	0.637	1.00
87_T	189_R	0.633	1.00
79_V	146_T	0.633	1.00
6_V	35_A	0.629	1.00
72_I	155_G	0.628	1.00
99_D	103_D	0.627	1.00
234_L	238_V	0.623	1.00
214_A	217_Y	0.622	1.00
90_Q	186_C	0.621	1.00
98_A	144_A	0.618	1.00
26_H	89_I	0.617	1.00
20_L	23_L	0.614	1.00
192_A	196_I	0.614	1.00
62_R	70_A	0.613	1.00
13_R	41_D	0.611	1.00
106_D	177_R	0.610	1.00
217_Y	221_K	0.609	1.00
138_F	169_A	0.608	1.00
8_P	37_G	0.607	1.00
114_R	191_D	0.605	1.00
157_D	171_R	0.605	1.00
109_T	181_W	0.605	1.00
145_I	172_L	0.602	1.00
209_G	213_R	0.601	1.00
195_V	198_R	0.600	1.00
182_A	186_C	0.598	1.00
203_A	207_A	0.596	1.00
37_G	84_G	0.589	1.00
204_D	208_R	0.589	1.00
7_V	83_I	0.589	1.00
234_L	237_A	0.588	1.00
218_R	221_K	0.587	1.00
12_A	64_L	0.587	1.00
151_R	155_G	0.587	1.00
19_A	86_D	0.587	1.00
80_V	150_L	0.586	1.00
7_V	34_V	0.585	1.00
10_L	37_G	0.584	1.00
208_R	212_Y	0.584	1.00
97_V	182_A	0.575	1.00
109_T	143_V	0.571	1.00
7_V	85_Q	0.569	1.00
12_A	43_T	0.567	1.00
82_F	150_L	0.566	1.00
215_L	219_L	0.565	1.00
221_K	224_G	0.565	1.00
109_T	112_V	0.565	1.00
176_D	179_V	0.564	1.00
79_V	102_A	0.564	1.00
67_A	71_G	0.563	1.00
19_A	89_I	0.560	1.00
71_G	84_G	0.559	1.00
13_R	43_T	0.559	1.00
56_L	70_A	0.558	1.00
208_R	216_A	0.557	1.00
11_N	41_D	0.557	1.00
31_E	75_T	0.555	1.00
113_H	121_T	0.554	1.00
64_L	82_F	0.551	1.00
134_D	178_R	0.551	1.00
81_A	97_V	0.549	1.00
99_D	102_A	0.546	1.00
111_P	116_V	0.546	1.00
208_R	211_K	0.546	1.00
235_R	239_G	0.545	1.00
8_P	64_L	0.544	1.00
211_K	214_A	0.543	1.00
3_L	101_I	0.539	1.00
19_A	88_H	0.538	1.00
27_A	91_P	0.534	1.00
157_D	168_A	0.534	1.00
166_R	170_H	0.533	1.00
39_S	43_T	0.533	1.00
6_V	82_F	0.533	1.00
205_S	208_R	0.532	1.00
111_P	185_A	0.529	1.00
118_G	121_T	0.528	1.00
20_L	47_V	0.528	1.00
207_A	210_L	0.524	1.00
139_D	142_N	0.524	1.00
145_I	168_A	0.521	1.00
151_R	154_D	0.520	1.00
131_S	135_V	0.520	1.00
105_A	178_R	0.519	1.00
89_I	187_V	0.518	1.00
3_L	28_P	0.518	1.00
213_R	217_Y	0.517	1.00
98_A	101_I	0.513	1.00
226_T	229_I	0.513	1.00
142_N	187_V	0.513	1.00
3_L	97_V	0.513	1.00
103_D	180_A	0.513	1.00
104_G	146_T	0.511	1.00
67_A	84_G	0.509	1.00
117_E	120_V	0.509	1.00
94_T	144_A	0.508	1.00
72_I	151_R	0.507	1.00
102_A	146_T	0.504	0.99
182_A	185_A	0.503	0.99
111_P	183_P	0.503	0.99
141_A	189_R	0.502	0.99
81_A	142_N	0.501	0.99
9_T	36_N	0.501	0.99
69_N	73_A	0.500	0.99
85_Q	189_R	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l7iA	4	0.0852	100	0.358	Contact Map
3bcvA	2	0.5475	100	0.37	Contact Map
2z86A	2	0.7836	100	0.39	Contact Map
2d7iA	1	0.9803	100	0.396	Contact Map
1xhbA	1	0.9344	100	0.398	Contact Map
1qg8A	1	0.6984	100	0.399	Contact Map
5ajoA	1	0.9639	100	0.402	Contact Map
4fixA	3	0.9803	100	0.439	Contact Map
3ckjA	2	0.8033	100	0.482	Contact Map
2bo4A	4	0.9607	100	0.484	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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