GREMLIN Database
Q9HSC6 - Uncharacterized protein
UniProt: Q9HSC6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 201 (191)
Sequences: 2526 (1708)
Seq/√Len: 123.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_A150_A3.7121.00
20_A136_R3.5011.00
48_S104_V3.3361.00
30_L134_L3.2551.00
31_G66_V3.2161.00
7_V65_G3.1511.00
156_V177_V3.0571.00
184_L188_F2.9081.00
153_G178_T2.8291.00
40_A52_M2.7751.00
33_L133_L2.6991.00
95_A179_L2.4681.00
179_L183_L2.4631.00
92_V179_L2.4601.00
102_A154_S2.3281.00
94_L123_G2.2181.00
106_V115_V2.1731.00
48_S108_A2.1051.00
22_F134_L2.0671.00
120_T151_I2.0341.00
87_D186_I2.0251.00
88_V183_L2.0141.00
184_L190_W1.9831.00
145_L149_C1.9101.00
16_K134_L1.9091.00
172_A176_G1.8371.00
36_L62_A1.7361.00
94_L150_A1.7321.00
160_A165_L1.7261.00
35_A62_A1.6671.00
2_N58_D1.6341.00
159_V163_S1.5741.00
102_A158_W1.5741.00
136_R142_T1.5541.00
46_V110_V1.5501.00
9_F93_G1.5361.00
32_V62_A1.5101.00
149_C181_V1.4981.00
102_A115_V1.4841.00
11_T69_A1.4831.00
116_V158_W1.4761.00
110_V114_G1.4501.00
105_G118_L1.4501.00
115_V158_W1.4261.00
56_T60_G1.4181.00
31_G62_A1.4171.00
5_G9_F1.4131.00
24_V70_V1.3951.00
152_A181_V1.3701.00
133_L141_L1.3521.00
28_A63_L1.3491.00
185_A190_W1.3491.00
45_L53_L1.3481.00
21_D194_T1.3301.00
176_G180_A1.3111.00
41_T121_T1.2921.00
116_V155_T1.2881.00
118_L122_T1.2791.00
60_G64_A1.2681.00
124_V140_V1.2471.00
104_V108_A1.2461.00
171_A175_A1.2400.99
37_G129_V1.2380.99
160_A170_A1.2330.99
25_L147_A1.2160.99
76_V81_L1.2110.99
47_G50_P1.2110.99
41_T125_G1.2100.99
95_A175_A1.1960.99
40_A125_G1.1740.99
95_A99_A1.1690.99
33_L129_V1.1680.99
170_A174_G1.1640.99
112_P158_W1.1560.99
128_L140_V1.1480.99
27_V70_V1.1410.99
7_V61_F1.1230.99
155_T159_V1.1190.99
65_G69_A1.1130.99
91_A183_L1.1080.99
99_A178_T1.1060.99
46_V108_A1.1010.99
91_A179_L1.0770.99
32_V59_V1.0760.99
112_P116_V1.0760.99
98_A102_A1.0750.99
52_M114_G1.0710.98
98_A178_T1.0480.98
28_A66_V1.0420.98
159_V162_A1.0360.98
95_A153_G1.0350.98
47_G51_A1.0330.98
63_L67_V1.0240.98
98_A154_S1.0230.98
102_A119_G1.0190.98
14_S27_V1.0170.98
52_M125_G1.0170.98
6_L9_F1.0140.98
181_V190_W0.9950.98
102_A157_L0.9920.97
149_C153_G0.9900.97
87_D91_A0.9890.97
29_V141_L0.9840.97
29_V147_A0.9800.97
148_T192_L0.9730.97
18_I27_V0.9720.97
12_V89_P0.9600.97
185_A189_E0.9520.97
143_E191_A0.9440.97
166_G169_I0.9370.96
41_T129_V0.9270.96
3_A61_F0.9250.96
6_L10_A0.9230.96
103_L107_G0.9170.96
6_L36_L0.9150.96
152_A177_V0.9140.96
93_G97_F0.9120.96
183_L187_R0.9060.96
96_A175_A0.9060.96
99_A174_G0.8970.95
9_F12_V0.8860.95
138_P141_L0.8860.95
153_G174_G0.8750.95
96_A100_S0.8630.94
157_L174_G0.8580.94
191_A194_T0.8570.94
119_G174_G0.8450.94
123_G178_T0.8440.94
7_V11_T0.8420.94
177_V181_V0.8390.94
11_T89_P0.8370.93
25_L124_V0.8360.93
44_V49_V0.8320.93
120_T124_V0.8300.93
8_A93_G0.8280.93
17_A27_V0.8250.93
2_N16_K0.8170.93
5_G97_F0.8100.92
95_A178_T0.8100.92
114_G118_L0.8030.92
92_V96_A0.8020.92
86_V89_P0.7960.92
40_A51_A0.7900.91
145_L192_L0.7900.91
99_A160_A0.7850.91
68_V159_V0.7830.91
48_S51_A0.7810.91
165_L170_A0.7800.91
116_V151_I0.7670.90
156_V160_A0.7660.90
165_L169_I0.7640.90
145_L181_V0.7630.90
62_A66_V0.7600.90
4_V190_W0.7570.89
103_L157_L0.7520.89
53_L114_G0.7490.89
36_L59_V0.7440.89
137_V140_V0.7410.88
25_L29_V0.7390.88
115_V119_G0.7360.88
128_L133_L0.7350.88
40_A45_L0.7350.88
22_F137_V0.7280.88
11_T65_G0.7240.87
66_V70_V0.7140.87
120_T147_A0.7110.86
20_A102_A0.7070.86
128_L141_L0.6970.85
82_A85_V0.6960.85
64_A68_V0.6960.85
46_V105_G0.6820.84
16_K20_A0.6820.84
99_A157_L0.6780.84
97_F123_G0.6760.83
70_V195_V0.6710.83
23_D138_P0.6700.83
102_A178_T0.6690.83
110_V115_V0.6680.83
169_I173_A0.6640.82
18_I195_V0.6600.82
4_V8_A0.6580.82
156_V174_G0.6510.81
137_V142_T0.6490.81
161_T170_A0.6480.81
18_I73_A0.6470.81
95_A119_G0.6460.81
49_V53_L0.6460.81
14_S69_A0.6460.81
9_F13_G0.6450.81
62_A70_V0.6450.81
24_V187_R0.6410.80
100_S122_T0.6360.80
160_A174_G0.6350.79
55_S59_V0.6350.79
30_L129_V0.6330.79
158_W161_T0.6300.79
183_L186_I0.6240.78
59_V113_F0.6220.78
161_T167_A0.6180.78
46_V49_V0.6180.78
23_D146_Y0.6160.77
14_S66_V0.6120.77
60_G113_F0.6120.77
151_I154_S0.6120.77
157_L161_T0.6120.77
135_Q184_L0.6120.77
45_L121_T0.6120.77
62_A65_G0.6120.77
32_V36_L0.6090.77
71_V75_R0.6070.76
25_L151_I0.6030.76
128_L139_F0.6020.76
152_A183_L0.6000.76
13_G140_V0.6000.76
18_I69_A0.6000.76
3_A57_T0.6000.76
100_S174_G0.5990.75
156_V173_A0.5990.75
94_L178_T0.5960.75
30_L135_Q0.5960.75
173_A177_V0.5910.74
40_A44_V0.5910.74
3_A7_V0.5880.74
128_L169_I0.5880.74
162_A176_G0.5860.74
52_M157_L0.5820.73
34_T37_G0.5800.73
19_D22_F0.5790.73
143_E178_T0.5790.73
26_G30_L0.5750.72
36_L149_C0.5740.72
56_T111_S0.5740.72
149_C185_A0.5700.72
8_A61_F0.5680.72
2_N11_T0.5670.71
59_V117_V0.5620.71
2_N9_F0.5610.71
111_S118_L0.5610.71
106_V161_T0.5600.70
12_V93_G0.5590.70
41_T45_L0.5590.70
33_L37_G0.5580.70
25_L143_E0.5560.70
124_V147_A0.5550.70
111_S114_G0.5530.70
170_A178_T0.5520.69
144_D189_E0.5500.69
4_V32_V0.5500.69
13_G151_I0.5500.69
121_T129_V0.5500.69
32_V35_A0.5490.69
169_I172_A0.5490.69
41_T140_V0.5470.69
142_T186_I0.5450.68
95_A115_V0.5450.68
2_N100_S0.5410.68
95_A186_I0.5400.68
3_A152_A0.5390.68
98_A153_G0.5380.67
30_L122_T0.5320.67
63_L113_F0.5300.66
97_F182_R0.5300.66
7_V31_G0.5270.66
63_L66_V0.5260.66
43_D104_V0.5250.66
88_V186_I0.5240.65
119_G149_C0.5230.65
64_A173_A0.5220.65
22_F26_G0.5200.65
27_V66_V0.5200.65
29_V117_V0.5190.65
86_V148_T0.5190.65
14_S31_G0.5180.65
2_N96_A0.5170.64
6_L143_E0.5170.64
88_V92_V0.5160.64
91_A115_V0.5140.64
99_A171_A0.5130.64
41_T72_V0.5120.64
102_A150_A0.5100.63
17_A30_L0.5090.63
22_F141_L0.5080.63
53_L111_S0.5060.63
15_L77_G0.5050.63
162_A166_G0.5010.62
46_V104_V0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f2bA 4 0.3881 15.2 0.954 Contact Map
3llqA 3 0.3881 5.8 0.962 Contact Map
2o9gA 3 0.3881 4.8 0.963 Contact Map
3cn5A 3 0.398 2.7 0.968 Contact Map
3fewX 1 0.2587 1.9 0.97 Contact Map
4p02B 1 0.3632 1.9 0.97 Contact Map
2l9uA 2 0.199 1.5 0.972 Contact Map
2mawA 1 0.3234 1.5 0.972 Contact Map
3gd8A 4 0.3682 1.4 0.972 Contact Map
3uhmA 1 0.2935 1.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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