GREMLIN Database
Q9HSC5 - Uncharacterized protein
UniProt: Q9HSC5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (231)
Sequences: 998 (800)
Seq/√Len: 52.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_T197_A5.5911.00
70_A76_A4.4981.00
46_A75_V3.6091.00
218_V221_G3.4991.00
196_Y207_T2.9111.00
21_P27_A2.6491.00
155_G168_T2.5471.00
58_A111_F2.5221.00
200_D203_Q2.4661.00
22_R162_G2.4391.00
15_D18_H2.4211.00
30_F209_G2.3871.00
2_K15_D2.3831.00
60_V125_T2.3811.00
45_L115_A2.3751.00
155_G170_L2.3661.00
60_V69_V2.3321.00
6_L13_L2.3161.00
57_S89_D2.2951.00
13_L45_L2.2871.00
62_R86_D2.2691.00
57_S72_D2.2321.00
167_I209_G2.1011.00
60_V128_Q2.0901.00
199_T205_L2.0741.00
88_A125_T2.0361.00
28_A75_V2.0321.00
6_L14_V2.0121.00
39_F44_H1.9691.00
87_A131_E1.9411.00
36_V68_I1.8620.99
20_L31_W1.8340.99
199_T219_N1.8270.99
204_R227_F1.7530.99
193_R198_H1.7420.99
21_P24_D1.6920.99
195_S198_H1.6570.98
171_P174_I1.6470.98
26_R156_T1.6370.98
223_G227_F1.6360.98
172_G208_V1.6220.98
23_Q220_R1.6210.98
196_Y217_A1.6020.98
155_G169_N1.6020.98
149_T152_G1.5920.98
67_A118_I1.5770.98
43_V115_A1.5610.98
6_L12_R1.5580.98
201_P220_R1.5560.98
190_T216_L1.5410.98
172_G212_G1.4840.97
114_A128_Q1.4800.97
52_V106_H1.4730.97
24_D27_A1.4590.97
3_G38_Y1.4590.97
28_A46_A1.4530.96
194_R198_H1.4340.96
30_F211_H1.4010.96
47_V52_V1.3840.95
196_Y215_E1.3830.95
41_P65_S1.3710.95
117_D123_V1.3680.95
95_I117_D1.3590.95
62_R87_A1.3490.95
81_R145_A1.3430.94
102_S106_H1.3400.94
53_G56_R1.3200.94
59_V138_Y1.3160.94
49_D52_V1.3090.94
44_H66_H1.2790.93
20_L28_A1.2780.93
61_V70_A1.2740.93
36_V66_H1.2690.93
147_A154_A1.2680.93
222_R225_D1.2610.92
52_V56_R1.2550.92
47_V56_R1.2510.92
190_T206_L1.2470.92
49_D56_R1.2440.92
60_V88_A1.2370.92
89_D130_P1.2190.91
61_V68_I1.2160.91
157_V222_R1.2070.91
39_F42_A1.2040.91
23_Q196_Y1.2030.90
160_V224_D1.2030.90
96_D114_A1.1910.90
216_L223_G1.1850.90
54_T195_S1.1630.89
184_E187_G1.1500.88
29_A78_P1.1430.88
216_L227_F1.1310.88
47_V106_H1.1190.87
49_D111_F1.1150.87
49_D109_D1.1100.87
2_K39_F1.1100.87
2_K215_E1.1060.86
206_L214_V1.1020.86
90_I96_D1.1010.86
24_D231_A1.0930.86
166_A233_D1.0890.85
61_V76_A1.0620.84
43_V69_V1.0520.83
34_E167_I1.0500.83
104_T210_S1.0410.83
193_R205_L1.0330.82
53_G106_H1.0320.82
51_G56_R1.0280.82
16_I44_H1.0240.82
52_V108_R1.0200.81
191_P203_Q1.0180.81
209_G215_E1.0180.81
76_A80_A1.0130.81
50_P108_R1.0120.81
157_V166_A1.0110.81
63_A66_H1.0080.81
56_R106_H1.0020.80
32_L70_A0.9970.80
47_V51_G0.9940.80
30_F167_I0.9940.80
47_V53_G0.9870.79
160_V166_A0.9870.79
60_V90_I0.9840.79
47_V107_G0.9780.79
56_R108_R0.9580.77
172_G176_A0.9490.77
205_L217_A0.9450.76
57_S132_Y0.9430.76
31_W159_A0.9410.76
30_F196_Y0.9390.76
50_P53_G0.9340.75
95_I128_Q0.9290.75
61_V80_A0.9230.75
68_I83_I0.9210.74
50_P71_P0.9070.73
123_V128_Q0.8980.72
53_G104_T0.8930.72
49_D105_F0.8890.72
51_G108_R0.8860.71
92_V95_I0.8850.71
56_R107_G0.8820.71
185_V235_V0.8810.71
58_A110_V0.8710.70
80_A84_A0.8680.70
195_S199_T0.8630.69
47_V108_R0.8590.69
9_T12_R0.8540.69
52_V107_G0.8510.68
2_K18_H0.8460.68
103_A194_R0.8440.68
81_R140_R0.8350.67
52_V104_T0.8310.67
53_G102_S0.8240.66
153_A169_N0.8210.66
94_E127_D0.8190.65
50_P107_G0.8180.65
27_A31_W0.8160.65
53_G108_R0.8100.65
49_D106_H0.8100.65
51_G54_T0.8030.64
5_V8_T0.8020.64
53_G71_P0.8010.64
139_E142_S0.7950.63
167_I215_E0.7930.63
182_T189_A0.7920.63
63_A83_I0.7880.62
92_V110_V0.7870.62
18_H28_A0.7840.62
105_F108_R0.7830.62
52_V109_D0.7820.62
87_A126_F0.7760.61
5_V115_A0.7750.61
52_V102_S0.7750.61
32_L46_A0.7750.61
204_R218_V0.7740.61
111_F115_A0.7730.61
208_V214_V0.7680.60
71_P107_G0.7630.60
8_T117_D0.7630.60
58_A90_I0.7580.59
84_A87_A0.7530.59
56_R109_D0.7500.59
5_V43_V0.7500.59
58_A69_V0.7490.58
56_R71_P0.7470.58
14_V39_F0.7410.58
166_A229_V0.7370.57
56_R105_F0.7350.57
51_G71_P0.7280.56
43_V183_V0.7280.56
124_D127_D0.7270.56
54_T102_S0.7270.56
20_L44_H0.7270.56
49_D108_R0.7270.56
13_L43_V0.7260.56
217_A229_V0.7230.56
43_V119_H0.7200.55
92_V97_V0.7180.55
223_G229_V0.7180.55
8_T119_H0.7130.55
52_V71_P0.7120.55
76_A118_I0.7070.54
207_T217_A0.7060.54
118_I129_Y0.7040.54
102_S108_R0.6980.53
50_P54_T0.6980.53
60_V129_Y0.6970.53
5_V11_A0.6960.53
64_G157_V0.6940.53
117_D211_H0.6930.53
50_P56_R0.6920.53
2_K14_V0.6890.52
54_T106_H0.6880.52
53_G107_G0.6870.52
146_P169_N0.6860.52
9_T13_L0.6850.52
69_V76_A0.6850.52
73_N109_D0.6810.51
165_N199_T0.6740.51
48_V140_R0.6720.50
57_S137_D0.6700.50
4_V7_Q0.6680.50
62_R126_F0.6660.50
218_V222_R0.6610.49
163_F213_N0.6560.49
56_R102_S0.6550.49
168_T235_V0.6550.49
192_V208_V0.6490.48
167_I207_T0.6460.48
27_A211_H0.6450.48
90_I117_D0.6400.47
2_K165_N0.6370.47
201_P204_R0.6350.47
6_L44_H0.6350.47
6_L192_V0.6340.46
230_S233_D0.6340.46
32_L104_T0.6340.46
60_V118_I0.6320.46
43_V60_V0.6320.46
11_A220_R0.6310.46
102_S210_S0.6300.46
5_V112_A0.6290.46
52_V105_F0.6290.46
60_V67_A0.6260.46
51_G106_H0.6250.45
64_G86_D0.6230.45
56_R111_F0.6220.45
146_P174_I0.6200.45
39_F169_N0.6200.45
92_V96_D0.6180.45
206_L216_L0.6120.44
53_G105_F0.6120.44
64_G84_A0.6110.44
31_W211_H0.6110.44
2_K78_P0.6110.44
125_T129_Y0.6090.44
33_R213_N0.6070.44
38_Y104_T0.6070.44
71_P210_S0.6060.44
36_V39_F0.6050.43
187_G190_T0.6000.43
112_A116_A0.5990.43
62_R67_A0.5990.43
172_G214_V0.5980.43
20_L25_V0.5980.43
79_A83_I0.5980.43
25_V28_A0.5950.42
67_A237_V0.5940.42
166_A204_R0.5920.42
47_V109_D0.5920.42
91_D130_P0.5890.42
133_E137_D0.5890.42
4_V210_S0.5890.42
34_E159_A0.5880.42
144_P183_V0.5830.41
114_A117_D0.5830.41
185_V227_F0.5790.41
16_I40_P0.5760.40
49_D53_G0.5750.40
118_I125_T0.5740.40
79_A82_R0.5740.40
36_V41_P0.5730.40
29_A158_I0.5710.40
158_I215_E0.5710.40
51_G107_G0.5710.40
189_A199_T0.5700.40
2_K6_L0.5700.40
199_T207_T0.5640.39
62_R65_S0.5630.39
106_H110_V0.5610.39
4_V108_R0.5600.39
159_A223_G0.5600.39
157_V193_R0.5600.39
47_V50_P0.5580.39
185_V206_L0.5580.39
16_I210_S0.5560.38
50_P106_H0.5560.38
110_V132_Y0.5560.38
128_Q173_E0.5540.38
75_V223_G0.5530.38
41_P148_V0.5530.38
2_K169_N0.5520.38
153_A170_L0.5520.38
117_D122_G0.5450.37
68_I127_D0.5450.37
50_P104_T0.5410.37
38_Y97_V0.5410.37
90_I111_F0.5380.37
52_V111_F0.5380.37
44_H206_L0.5370.37
116_A210_S0.5350.36
3_G44_H0.5340.36
154_A234_E0.5340.36
196_Y219_N0.5330.36
50_P105_F0.5330.36
78_P158_I0.5320.36
36_V79_A0.5310.36
90_I237_V0.5300.36
192_V214_V0.5300.36
165_N215_E0.5300.36
17_A20_L0.5280.36
160_V231_A0.5260.35
39_F165_N0.5220.35
39_F215_E0.5210.35
25_V141_V0.5210.35
126_F150_D0.5210.35
18_H169_N0.5200.35
89_D132_Y0.5200.35
118_I121_R0.5160.35
27_A196_Y0.5160.35
66_H78_P0.5140.34
132_Y137_D0.5140.34
107_G164_G0.5140.34
42_A129_Y0.5100.34
47_V71_P0.5060.34
68_I125_T0.5050.33
23_Q34_E0.5040.33
77_V83_I0.5040.33
108_R113_P0.5040.33
95_I123_V0.5040.33
4_V51_G0.5040.33
133_E138_Y0.5040.33
39_F66_H0.5020.33
159_A167_I0.5010.33
64_G208_V0.5010.33
165_N212_G0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q6kA 5 0.9456 100 0.09 Contact Map
2zbvA 3 0.9833 100 0.091 Contact Map
2wr8A 3 0.9707 100 0.095 Contact Map
2cw5A 3 0.9498 100 0.116 Contact Map
2f4nA 4 0.8619 100 0.122 Contact Map
1rqpA 4 0.9874 100 0.127 Contact Map
4c92E 1 0.3054 13.8 0.967 Contact Map
3i18A 1 0.1381 11.3 0.968 Contact Map
3q3wA 1 0.5105 10.4 0.969 Contact Map
1ljoA 3 0.2929 10.3 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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