GREMLIN Database
NADM - Nicotinamide-nucleotide adenylyltransferase
UniProt: Q9HSC4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (165)
Sequences: 522 (411)
Seq/√Len: 32.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_E153_A6.1701.00
13_F57_I5.5601.00
13_F18_R4.6041.00
4_G28_V4.5411.00
25_A67_V3.2761.00
156_D159_E3.1051.00
30_E69_Y2.8411.00
55_M151_V2.5241.00
132_R136_D2.4170.99
34_G73_I2.3080.99
139_D142_S2.2810.99
6_Y20_V2.1860.99
104_I114_V2.1260.98
37_S75_D2.0890.98
35_I70_A2.0170.98
23_Q26_T1.9780.97
129_E133_R1.8920.97
3_R30_E1.8810.96
37_S82_W1.8420.96
13_F21_I1.7900.95
36_G75_D1.7650.95
3_R32_V1.6780.93
21_I31_L1.6280.92
48_F56_M1.6080.92
79_N103_V1.5720.91
42_H102_L1.5490.90
11_Q53_R1.5460.90
104_I108_N1.5260.90
61_L68_T1.5230.89
75_D82_W1.5230.89
100_N103_V1.4910.88
129_E132_R1.4810.88
18_R61_L1.4770.88
23_Q27_E1.4640.88
9_R17_H1.4580.87
133_R143_L1.4320.86
4_G101_P1.4310.86
146_D150_D1.4210.86
83_V102_L1.4200.86
54_I58_T1.4180.86
112_V164_V1.3410.82
9_R14_H1.3320.82
20_V126_E1.3080.81
63_E147_A1.3010.80
60_A147_A1.2390.77
28_V31_L1.2200.76
121_D124_V1.2030.75
55_M59_K1.2000.75
48_F157_G1.1970.74
44_A164_V1.1910.74
60_A148_V1.1780.73
22_E66_L1.1770.73
10_F14_H1.1760.73
134_M161_I1.1600.72
75_D102_L1.1560.72
152_V157_G1.1540.72
38_A50_A1.1460.71
14_H17_H1.1390.71
56_M148_V1.1260.70
22_E64_F1.1050.68
25_A66_L1.0990.68
49_T52_E1.0420.64
12_P16_G1.0340.63
50_A73_I1.0300.63
7_I75_D1.0280.63
159_E162_Q1.0240.62
8_G14_H1.0210.62
140_W149_A1.0170.62
32_V155_I1.0160.62
42_H109_E1.0150.62
59_K150_D1.0090.61
150_D154_E1.0070.61
8_G17_H1.0040.61
42_H52_E1.0030.61
29_D71_V1.0020.61
4_G31_L1.0010.61
83_V87_R0.9960.60
163_H166_D0.9830.59
51_G91_P0.9800.59
56_M152_V0.9800.59
134_M158_V0.9680.58
74_E85_H0.9610.57
76_L85_H0.9580.57
140_W144_V0.9550.57
140_W162_Q0.9430.56
33_V57_I0.9350.55
12_P17_H0.9340.55
41_S75_D0.9140.54
104_I164_V0.9080.53
141_E146_D0.9000.52
5_F34_G0.8980.52
56_M151_V0.8960.52
68_T95_V0.8930.52
87_R119_M0.8910.52
22_E26_T0.8850.51
21_I121_D0.8780.51
15_T31_L0.8740.50
136_D139_D0.8730.50
99_N103_V0.8690.50
149_A153_A0.8690.50
10_F17_H0.8650.50
27_E115_R0.8570.49
35_I50_A0.8540.49
67_V108_N0.8530.49
138_D142_S0.8530.49
48_F60_A0.8520.49
90_C120_Y0.8380.47
149_A156_D0.8360.47
81_V128_A0.8330.47
32_V164_V0.8320.47
67_V70_A0.8190.46
157_G160_R0.8180.46
27_E162_Q0.8150.45
26_T66_L0.8130.45
6_Y117_P0.8130.45
33_V68_T0.8060.45
4_G103_V0.8050.45
73_I89_M0.8020.44
25_A78_R0.7940.44
69_Y79_N0.7920.44
21_I33_V0.7890.43
31_L110_A0.7880.43
6_Y21_I0.7860.43
77_E117_P0.7860.43
39_G74_E0.7790.43
25_A70_A0.7790.43
68_T130_I0.7720.42
34_G71_V0.7660.42
7_I82_W0.7650.41
10_F46_N0.7630.41
64_F80_A0.7580.41
25_A82_W0.7560.41
22_E63_E0.7560.41
66_L130_I0.7550.41
24_I90_C0.7530.41
96_A107_F0.7510.40
18_R22_E0.7480.40
52_E145_P0.7420.40
18_R66_L0.7360.39
90_C163_H0.7340.39
73_I123_D0.7330.39
50_A72_P0.7330.39
144_V148_V0.7290.39
9_R16_G0.7250.38
29_D140_W0.7230.38
22_E67_V0.7220.38
65_N142_S0.7190.38
48_F148_V0.7170.38
43_S59_K0.7150.38
42_H75_D0.7100.37
70_A108_N0.7080.37
60_A145_P0.7060.37
57_I84_S0.6990.36
43_S75_D0.6960.36
159_E165_A0.6920.36
87_R112_V0.6860.35
154_E157_G0.6840.35
104_I120_Y0.6800.35
162_Q166_D0.6790.35
152_V158_V0.6790.35
60_A73_I0.6790.35
66_L125_L0.6750.35
105_R163_H0.6730.34
108_N132_R0.6720.34
108_N111_A0.6680.34
15_T95_V0.6660.34
64_F70_A0.6630.34
7_I36_G0.6630.34
16_G36_G0.6550.33
94_E100_N0.6550.33
83_V112_V0.6540.33
55_M152_V0.6530.33
30_E51_G0.6510.33
60_A153_A0.6480.33
22_E31_L0.6470.32
91_P160_R0.6430.32
4_G44_A0.6420.32
15_T145_P0.6420.32
109_E140_W0.6380.32
133_R138_D0.6350.32
58_T66_L0.6300.31
83_V107_F0.6270.31
41_S78_R0.6250.31
11_Q17_H0.6240.31
87_R116_Q0.6240.31
42_H107_F0.6190.30
77_E126_E0.6170.30
26_T64_F0.6160.30
110_A114_V0.6110.30
3_R127_G0.6100.30
3_R103_V0.6080.30
119_M127_G0.6080.30
125_L143_L0.6050.30
107_F111_A0.6010.29
104_I113_E0.5990.29
82_W127_G0.5980.29
4_G97_Y0.5980.29
13_F60_A0.5960.29
42_H101_P0.5940.29
91_P94_E0.5910.29
136_D153_A0.5890.28
134_M155_I0.5870.28
40_D43_S0.5850.28
41_S102_L0.5840.28
40_D46_N0.5840.28
135_A165_A0.5810.28
156_D161_I0.5790.28
86_V98_S0.5790.28
30_E54_I0.5790.28
87_R110_A0.5780.28
35_I150_D0.5740.27
11_Q14_H0.5720.27
7_I37_S0.5720.27
95_V115_R0.5680.27
25_A104_I0.5640.27
46_N131_R0.5640.27
3_R100_N0.5620.27
33_V81_V0.5620.27
148_V151_V0.5580.26
45_R87_R0.5570.26
65_N116_Q0.5560.26
67_V77_E0.5550.26
48_F112_V0.5540.26
36_G73_I0.5500.26
36_G43_S0.5500.26
135_A161_I0.5480.26
108_N113_E0.5470.26
49_T145_P0.5450.26
42_H91_P0.5430.25
16_G70_A0.5420.25
137_G158_V0.5400.25
110_A113_E0.5380.25
10_F13_F0.5350.25
49_T122_R0.5330.25
76_L87_R0.5310.25
153_A158_V0.5280.25
35_I66_L0.5280.25
77_E108_N0.5270.24
29_D142_S0.5200.24
102_L119_M0.5180.24
108_N117_P0.5180.24
19_R166_D0.5160.24
107_F114_V0.5130.24
7_I34_G0.5100.23
54_I77_E0.5100.23
39_G144_V0.5070.23
100_N160_R0.5060.23
15_T59_K0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ej2A 5 0.9209 100 0.524 Contact Map
1f9aA 5 0.9266 100 0.531 Contact Map
2qjtB 2 1 100 0.553 Contact Map
2qjoA 3 0.9887 100 0.565 Contact Map
3nv7A 4 0.8192 99.9 0.651 Contact Map
4natA 5 0.8136 99.9 0.652 Contact Map
4f3rA 5 0.774 99.8 0.653 Contact Map
1qjcA 4 0.8249 99.8 0.655 Contact Map
3nd5A 5 0.791 99.8 0.655 Contact Map
1o6bA 5 0.8588 99.8 0.656 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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