GREMLIN Database
TRPC - Indole-3-glycerol phosphate synthase
UniProt: Q9HSC1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (246)
Sequences: 3759 (2485)
Seq/√Len: 158.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_D168_R4.3221.00
97_T126_V3.5941.00
7_L137_F3.4091.00
9_S92_H3.3581.00
163_P196_A2.8911.00
195_G221_T2.8771.00
18_A119_T2.5691.00
208_V229_G2.5521.00
68_D71_E2.5331.00
57_T94_D2.5241.00
120_E144_D2.4671.00
244_T247_R2.4391.00
163_P200_E2.4071.00
77_V108_D2.3811.00
9_S91_H2.3641.00
104_R129_D2.3321.00
216_P220_R2.2371.00
146_L156_A2.1711.00
194_F227_A2.1261.00
123_L131_V2.0941.00
150_R175_D2.0521.00
50_I245_T1.9911.00
179_V207_L1.9821.00
219_A230_L1.9711.00
149_A156_A1.9261.00
192_D196_A1.9181.00
160_V166_L1.9011.00
34_S37_A1.8991.00
192_D195_G1.8951.00
141_D144_D1.8841.00
98_D101_R1.8331.00
34_S155_Q1.8231.00
136_R165_E1.8031.00
166_L201_A1.8011.00
140_D171_D1.7981.00
22_D121_P1.7741.00
63_T94_D1.6981.00
100_L111_V1.6791.00
198_A207_L1.6451.00
10_P13_S1.6441.00
201_A207_L1.6321.00
97_T113_R1.6271.00
13_S89_E1.5951.00
135_A169_A1.5911.00
214_A235_A1.5861.00
194_F209_A1.5861.00
146_L150_R1.5851.00
209_A222_M1.5771.00
17_A121_P1.5581.00
9_S12_Q1.5281.00
70_A103_I1.5181.00
183_D186_A1.5111.00
56_P99_A1.5101.00
40_H175_D1.5021.00
123_L145_M1.4901.00
221_T225_A1.4841.00
120_E148_A1.4681.00
133_L138_L1.4641.00
84_V107_V1.4451.00
83_A130_A1.4371.00
183_D188_T1.4351.00
61_T234_S1.4171.00
195_G225_A1.4131.00
143_G147_A1.4071.00
167_A200_E1.3811.00
149_A154_F1.3811.00
239_G244_T1.3761.00
48_T230_L1.3761.00
35_L39_L1.3631.00
147_A151_D1.3511.00
155_Q176_I1.3471.00
101_R126_V1.3451.00
148_A151_D1.3401.00
104_R111_V1.3331.00
135_A142_L1.3261.00
234_S238_D1.3241.00
39_L43_A1.3241.00
131_V149_A1.3171.00
146_L174_A1.2971.00
77_V109_V1.2961.00
157_L208_V1.2691.00
243_D247_R1.2661.00
190_D196_A1.2651.00
148_A152_R1.2551.00
146_L172_A1.2521.00
22_D25_T1.2301.00
54_V103_I1.2291.00
220_R224_A1.2181.00
70_A102_A1.2121.00
48_T219_A1.2021.00
11_V141_D1.2011.00
164_R167_A1.1791.00
74_R78_A1.1751.00
96_S99_A1.1711.00
213_I219_A1.1691.00
26_R30_V1.1681.00
166_L197_V1.1651.00
10_P89_E1.1631.00
242_R245_T1.1591.00
74_R106_A1.1561.00
69_P103_I1.1501.00
146_L173_D1.1471.00
77_V107_V1.1471.00
98_D102_A1.1411.00
7_L118_L1.1271.00
75_E79_G1.1251.00
7_L11_V1.1171.00
35_L43_A1.1091.00
67_G99_A1.1051.00
135_A168_R1.0991.00
166_L200_E1.0970.99
136_R185_T1.0960.99
35_L38_A1.0870.99
69_P73_A1.0830.99
52_A81_A1.0740.99
16_A19_R1.0470.99
16_A20_R1.0460.99
158_V174_A1.0280.99
38_A43_A1.0230.99
29_T32_A1.0180.99
56_P94_D1.0160.99
145_M148_A1.0100.99
162_S185_T1.0090.99
192_D221_T1.0080.99
150_R156_A1.0010.99
17_A97_T0.9980.99
198_A227_A0.9910.99
8_A11_V0.9860.99
216_P223_R0.9860.99
187_L234_S0.9850.99
90_P96_S0.9850.99
70_A106_A0.9840.99
214_A218_D0.9830.99
215_T218_D0.9780.99
56_P67_G0.9720.99
170_V205_V0.9680.99
174_A177_I0.9670.99
219_A232_V0.9610.99
217_T220_R0.9580.99
12_Q15_L0.9440.98
73_A107_V0.9430.98
222_M227_A0.9330.98
181_N194_F0.9330.98
120_E141_D0.9310.98
193_T196_A0.9290.98
183_D193_T0.9270.98
218_D221_T0.9250.98
169_A174_A0.9230.98
75_E242_R0.9210.98
13_S90_P0.9050.98
122_Q145_M0.9050.98
5_S91_H0.9030.98
123_L148_A0.9020.98
99_A102_A0.9020.98
181_N209_A0.8990.98
10_P90_P0.8930.98
60_T87_L0.8880.98
61_T238_D0.8880.98
117_L145_M0.8870.98
213_I222_M0.8840.98
157_L178_G0.8770.98
150_R155_Q0.8770.98
6_S10_P0.8700.97
5_S9_S0.8670.97
56_P63_T0.8600.97
72_L237_M0.8600.97
176_I206_T0.8580.97
33_R38_A0.8480.97
167_A170_V0.8450.97
26_R29_T0.8440.97
9_S13_S0.8420.97
5_S92_H0.8390.97
36_P175_D0.8390.97
144_D148_A0.8380.97
14_I17_A0.8330.97
178_G210_E0.8300.97
4_S8_A0.8280.97
194_F207_L0.8280.97
181_N222_M0.8270.97
37_A41_S0.8260.96
51_I208_V0.8260.96
18_A121_P0.8250.96
14_I118_L0.8250.96
209_A227_A0.8160.96
36_P40_H0.8160.96
195_G227_A0.8160.96
213_I232_V0.8160.96
11_V118_L0.8150.96
181_N193_T0.8090.96
13_S91_H0.8050.96
50_I230_L0.8010.96
114_K211_S0.7970.96
54_V67_G0.7930.96
86_V111_V0.7910.95
32_A124_D0.7880.95
67_G72_L0.7830.95
70_A74_R0.7830.95
206_T229_G0.7820.95
67_G94_D0.7790.95
99_A103_I0.7740.95
79_G245_T0.7720.95
170_V202_P0.7710.95
123_L154_F0.7710.95
235_A244_T0.7650.95
101_R105_D0.7640.95
63_T67_G0.7530.94
135_A158_V0.7520.94
232_V248_L0.7510.94
15_L18_A0.7500.94
222_M230_L0.7480.94
64_E242_R0.7480.94
8_A12_Q0.7470.94
38_A155_Q0.7470.94
117_L123_L0.7450.94
21_R25_T0.7440.94
124_D154_F0.7430.94
201_A205_V0.7390.94
103_I107_V0.7390.94
162_S165_E0.7340.93
143_G171_D0.7270.93
136_R161_H0.7250.93
37_A43_A0.7230.93
71_E75_E0.7220.93
161_H210_E0.7190.93
49_P82_A0.7160.92
72_L242_R0.7150.92
103_I111_V0.7140.92
83_A176_I0.7120.92
54_V73_A0.7100.92
116_F211_S0.7100.92
13_S17_A0.7050.92
163_P167_A0.7030.92
170_V201_A0.6990.92
117_L122_Q0.6980.91
88_T113_R0.6960.91
239_G247_R0.6950.91
130_A156_A0.6950.91
189_V209_A0.6930.91
89_E92_H0.6910.91
174_A205_V0.6900.91
244_T248_L0.6890.91
189_V212_G0.6870.91
27_R30_V0.6840.91
64_E72_L0.6780.90
133_L142_L0.6780.90
21_R125_A0.6740.90
90_P97_T0.6730.90
144_D147_A0.6720.90
221_T224_A0.6670.90
43_A229_G0.6660.89
10_P14_I0.6580.89
40_H44_A0.6570.89
211_S231_L0.6570.89
120_E145_M0.6560.89
167_A171_D0.6540.89
177_I205_V0.6510.88
245_T249_V0.6500.88
37_A40_H0.6460.88
140_D143_G0.6430.88
175_D204_D0.6370.87
179_V194_F0.6350.87
37_A155_Q0.6350.87
117_L133_L0.6340.87
61_T214_A0.6330.87
36_P155_Q0.6320.87
158_V169_A0.6310.87
181_N191_L0.6300.87
165_E168_R0.6290.87
133_L145_M0.6290.87
84_V103_I0.6270.86
68_D102_A0.6260.86
89_E187_L0.6250.86
80_G109_V0.6240.86
142_L158_V0.6220.86
5_S8_A0.6210.86
243_D246_R0.6200.86
21_R121_P0.6170.86
103_I106_A0.6170.86
83_A155_Q0.6170.86
87_L231_L0.6130.85
60_T178_G0.6100.85
135_A165_E0.6070.85
196_A200_E0.6070.85
64_E67_G0.6050.85
73_A103_I0.6000.84
45_D82_A0.6000.84
75_E241_V0.5990.84
67_G237_M0.5970.84
150_R173_D0.5940.83
18_A23_P0.5940.83
73_A106_A0.5920.83
166_L207_L0.5920.83
26_R32_A0.5920.83
132_L231_L0.5890.83
57_T63_T0.5880.83
130_A155_Q0.5870.83
138_L141_D0.5840.82
114_K132_L0.5790.82
207_L227_A0.5770.82
86_V103_I0.5760.82
43_A176_I0.5750.81
54_V72_L0.5730.81
33_R129_D0.5710.81
197_V201_A0.5710.81
235_A239_G0.5700.81
141_D145_M0.5690.81
12_Q16_A0.5690.81
39_L229_G0.5690.81
73_A84_V0.5690.81
75_E78_A0.5670.81
24_P27_R0.5670.81
14_I89_E0.5660.80
160_V193_T0.5650.80
43_A228_D0.5650.80
58_S62_D0.5640.80
191_L213_I0.5640.80
34_S38_A0.5610.80
31_S35_L0.5540.79
17_A21_R0.5530.79
27_R31_S0.5520.79
81_A245_T0.5500.79
87_L211_S0.5500.79
232_V235_A0.5470.78
118_L137_F0.5450.78
170_V177_I0.5420.77
191_L194_F0.5420.77
132_L211_S0.5400.77
48_T249_V0.5390.77
39_L49_P0.5380.77
86_V100_L0.5380.77
134_I184_L0.5380.77
50_I242_R0.5350.77
157_L176_I0.5350.77
193_T197_V0.5340.76
10_P118_L0.5310.76
186_A189_V0.5300.76
37_A129_D0.5300.76
164_R168_R0.5300.76
197_V200_E0.5290.76
89_E94_D0.5270.76
89_E118_L0.5260.75
87_L184_L0.5260.75
38_A83_A0.5260.75
76_M84_V0.5250.75
99_A237_M0.5240.75
23_P121_P0.5240.75
173_D205_V0.5230.75
4_S7_L0.5210.75
102_A106_A0.5210.75
139_G168_R0.5190.74
49_P229_G0.5160.74
81_A84_V0.5150.74
41_S45_D0.5120.73
28_C31_S0.5120.73
215_T235_A0.5090.73
162_S197_V0.5080.73
30_V33_R0.5080.73
179_V227_A0.5070.73
88_T100_L0.5070.73
113_R126_V0.5070.73
34_S43_A0.5070.73
50_I249_V0.5050.72
166_L198_A0.5040.72
191_L218_D0.5040.72
123_L149_A0.5040.72
69_P99_A0.5020.72
39_L83_A0.5020.72
33_R37_A0.5010.72
39_L176_I0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1piiA 1 0.9841 100 0.321 Contact Map
3tsmA 2 1 100 0.364 Contact Map
1i4nA 1 0.9641 100 0.368 Contact Map
4a29A 1 0.9681 100 0.376 Contact Map
3qjaA 1 0.9522 100 0.394 Contact Map
1vc4A 2 0.9761 100 0.402 Contact Map
1hg3A 3 0.7888 100 0.661 Contact Map
1w0mA 3 0.7809 99.9 0.696 Contact Map
2yzrA 5 0.8088 99.9 0.711 Contact Map
1jvnA 1 0.9323 99.9 0.719 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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