TRPC - HALSA - GREMLIN Contacts

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TRPC - Indole-3-glycerol phosphate synthase

UniProt:	Q9HSC1	Sequences: MDDSSSLASPVQSILAAARRRDPPTRRCTVSARSLPAALHSAAADGRTPIIAEVKPTSPTTDTEHSGDPAELAREMVAGGAAAVSVLTEPHHFDGSTDALRAIRDAVDVPVLRKDFLLTEPQLDAVAADAVLLIARFLGDDLGDMLAAARDRGFQALVEVHSPRELARAVDADADIIGVNNRDLTALTVDLDTFGAVAPEAPADVTLVAESGIATPTDARTMRAAGADGLLVGSAIMDGPVRDTTRRLVTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	251 (246)
Sequences:	3759 (2485)
Seq/√Len:	158.4

ECOLI - TRPC
BACSU - TRPC
HALSA - TRPC
SULSO - TRPC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
140_D	168_R	4.322	1.00
97_T	126_V	3.594	1.00
7_L	137_F	3.409	1.00
9_S	92_H	3.358	1.00
163_P	196_A	2.891	1.00
195_G	221_T	2.877	1.00
18_A	119_T	2.569	1.00
208_V	229_G	2.552	1.00
68_D	71_E	2.533	1.00
57_T	94_D	2.524	1.00
120_E	144_D	2.467	1.00
244_T	247_R	2.439	1.00
163_P	200_E	2.407	1.00
77_V	108_D	2.381	1.00
9_S	91_H	2.364	1.00
104_R	129_D	2.332	1.00
216_P	220_R	2.237	1.00
146_L	156_A	2.171	1.00
194_F	227_A	2.126	1.00
123_L	131_V	2.094	1.00
150_R	175_D	2.052	1.00
50_I	245_T	1.991	1.00
179_V	207_L	1.982	1.00
219_A	230_L	1.971	1.00
149_A	156_A	1.926	1.00
192_D	196_A	1.918	1.00
160_V	166_L	1.901	1.00
34_S	37_A	1.899	1.00
192_D	195_G	1.895	1.00
141_D	144_D	1.884	1.00
98_D	101_R	1.833	1.00
34_S	155_Q	1.823	1.00
136_R	165_E	1.803	1.00
166_L	201_A	1.801	1.00
140_D	171_D	1.798	1.00
22_D	121_P	1.774	1.00
63_T	94_D	1.698	1.00
100_L	111_V	1.679	1.00
198_A	207_L	1.645	1.00
10_P	13_S	1.644	1.00
201_A	207_L	1.632	1.00
97_T	113_R	1.627	1.00
13_S	89_E	1.595	1.00
135_A	169_A	1.591	1.00
214_A	235_A	1.586	1.00
194_F	209_A	1.586	1.00
146_L	150_R	1.585	1.00
209_A	222_M	1.577	1.00
17_A	121_P	1.558	1.00
9_S	12_Q	1.528	1.00
70_A	103_I	1.518	1.00
183_D	186_A	1.511	1.00
56_P	99_A	1.510	1.00
40_H	175_D	1.502	1.00
123_L	145_M	1.490	1.00
221_T	225_A	1.484	1.00
120_E	148_A	1.468	1.00
133_L	138_L	1.464	1.00
84_V	107_V	1.445	1.00
83_A	130_A	1.437	1.00
183_D	188_T	1.435	1.00
61_T	234_S	1.417	1.00
195_G	225_A	1.413	1.00
143_G	147_A	1.407	1.00
167_A	200_E	1.381	1.00
149_A	154_F	1.381	1.00
239_G	244_T	1.376	1.00
48_T	230_L	1.376	1.00
35_L	39_L	1.363	1.00
147_A	151_D	1.351	1.00
155_Q	176_I	1.347	1.00
101_R	126_V	1.345	1.00
148_A	151_D	1.340	1.00
104_R	111_V	1.333	1.00
135_A	142_L	1.326	1.00
234_S	238_D	1.324	1.00
39_L	43_A	1.324	1.00
131_V	149_A	1.317	1.00
146_L	174_A	1.297	1.00
77_V	109_V	1.296	1.00
157_L	208_V	1.269	1.00
243_D	247_R	1.266	1.00
190_D	196_A	1.265	1.00
148_A	152_R	1.255	1.00
146_L	172_A	1.252	1.00
22_D	25_T	1.230	1.00
54_V	103_I	1.229	1.00
220_R	224_A	1.218	1.00
70_A	102_A	1.212	1.00
48_T	219_A	1.202	1.00
11_V	141_D	1.201	1.00
164_R	167_A	1.179	1.00
74_R	78_A	1.175	1.00
96_S	99_A	1.171	1.00
213_I	219_A	1.169	1.00
26_R	30_V	1.168	1.00
166_L	197_V	1.165	1.00
10_P	89_E	1.163	1.00
242_R	245_T	1.159	1.00
74_R	106_A	1.156	1.00
69_P	103_I	1.150	1.00
146_L	173_D	1.147	1.00
77_V	107_V	1.147	1.00
98_D	102_A	1.141	1.00
7_L	118_L	1.127	1.00
75_E	79_G	1.125	1.00
7_L	11_V	1.117	1.00
35_L	43_A	1.109	1.00
67_G	99_A	1.105	1.00
135_A	168_R	1.099	1.00
166_L	200_E	1.097	0.99
136_R	185_T	1.096	0.99
35_L	38_A	1.087	0.99
69_P	73_A	1.083	0.99
52_A	81_A	1.074	0.99
16_A	19_R	1.047	0.99
16_A	20_R	1.046	0.99
158_V	174_A	1.028	0.99
38_A	43_A	1.023	0.99
29_T	32_A	1.018	0.99
56_P	94_D	1.016	0.99
145_M	148_A	1.010	0.99
162_S	185_T	1.009	0.99
192_D	221_T	1.008	0.99
150_R	156_A	1.001	0.99
17_A	97_T	0.998	0.99
198_A	227_A	0.991	0.99
8_A	11_V	0.986	0.99
216_P	223_R	0.986	0.99
187_L	234_S	0.985	0.99
90_P	96_S	0.985	0.99
70_A	106_A	0.984	0.99
214_A	218_D	0.983	0.99
215_T	218_D	0.978	0.99
56_P	67_G	0.972	0.99
170_V	205_V	0.968	0.99
174_A	177_I	0.967	0.99
219_A	232_V	0.961	0.99
217_T	220_R	0.958	0.99
12_Q	15_L	0.944	0.98
73_A	107_V	0.943	0.98
222_M	227_A	0.933	0.98
181_N	194_F	0.933	0.98
120_E	141_D	0.931	0.98
193_T	196_A	0.929	0.98
183_D	193_T	0.927	0.98
218_D	221_T	0.925	0.98
169_A	174_A	0.923	0.98
75_E	242_R	0.921	0.98
13_S	90_P	0.905	0.98
122_Q	145_M	0.905	0.98
5_S	91_H	0.903	0.98
123_L	148_A	0.902	0.98
99_A	102_A	0.902	0.98
181_N	209_A	0.899	0.98
10_P	90_P	0.893	0.98
60_T	87_L	0.888	0.98
61_T	238_D	0.888	0.98
117_L	145_M	0.887	0.98
213_I	222_M	0.884	0.98
157_L	178_G	0.877	0.98
150_R	155_Q	0.877	0.98
6_S	10_P	0.870	0.97
5_S	9_S	0.867	0.97
56_P	63_T	0.860	0.97
72_L	237_M	0.860	0.97
176_I	206_T	0.858	0.97
33_R	38_A	0.848	0.97
167_A	170_V	0.845	0.97
26_R	29_T	0.844	0.97
9_S	13_S	0.842	0.97
5_S	92_H	0.839	0.97
36_P	175_D	0.839	0.97
144_D	148_A	0.838	0.97
14_I	17_A	0.833	0.97
178_G	210_E	0.830	0.97
4_S	8_A	0.828	0.97
194_F	207_L	0.828	0.97
181_N	222_M	0.827	0.97
37_A	41_S	0.826	0.96
51_I	208_V	0.826	0.96
18_A	121_P	0.825	0.96
14_I	118_L	0.825	0.96
209_A	227_A	0.816	0.96
36_P	40_H	0.816	0.96
195_G	227_A	0.816	0.96
213_I	232_V	0.816	0.96
11_V	118_L	0.815	0.96
181_N	193_T	0.809	0.96
13_S	91_H	0.805	0.96
50_I	230_L	0.801	0.96
114_K	211_S	0.797	0.96
54_V	67_G	0.793	0.96
86_V	111_V	0.791	0.95
32_A	124_D	0.788	0.95
67_G	72_L	0.783	0.95
70_A	74_R	0.783	0.95
206_T	229_G	0.782	0.95
67_G	94_D	0.779	0.95
99_A	103_I	0.774	0.95
79_G	245_T	0.772	0.95
170_V	202_P	0.771	0.95
123_L	154_F	0.771	0.95
235_A	244_T	0.765	0.95
101_R	105_D	0.764	0.95
63_T	67_G	0.753	0.94
135_A	158_V	0.752	0.94
232_V	248_L	0.751	0.94
15_L	18_A	0.750	0.94
222_M	230_L	0.748	0.94
64_E	242_R	0.748	0.94
8_A	12_Q	0.747	0.94
38_A	155_Q	0.747	0.94
117_L	123_L	0.745	0.94
21_R	25_T	0.744	0.94
124_D	154_F	0.743	0.94
201_A	205_V	0.739	0.94
103_I	107_V	0.739	0.94
162_S	165_E	0.734	0.93
143_G	171_D	0.727	0.93
136_R	161_H	0.725	0.93
37_A	43_A	0.723	0.93
71_E	75_E	0.722	0.93
161_H	210_E	0.719	0.93
49_P	82_A	0.716	0.92
72_L	242_R	0.715	0.92
103_I	111_V	0.714	0.92
83_A	176_I	0.712	0.92
54_V	73_A	0.710	0.92
116_F	211_S	0.710	0.92
13_S	17_A	0.705	0.92
163_P	167_A	0.703	0.92
170_V	201_A	0.699	0.92
117_L	122_Q	0.698	0.91
88_T	113_R	0.696	0.91
239_G	247_R	0.695	0.91
130_A	156_A	0.695	0.91
189_V	209_A	0.693	0.91
89_E	92_H	0.691	0.91
174_A	205_V	0.690	0.91
244_T	248_L	0.689	0.91
189_V	212_G	0.687	0.91
27_R	30_V	0.684	0.91
64_E	72_L	0.678	0.90
133_L	142_L	0.678	0.90
21_R	125_A	0.674	0.90
90_P	97_T	0.673	0.90
144_D	147_A	0.672	0.90
221_T	224_A	0.667	0.90
43_A	229_G	0.666	0.89
10_P	14_I	0.658	0.89
40_H	44_A	0.657	0.89
211_S	231_L	0.657	0.89
120_E	145_M	0.656	0.89
167_A	171_D	0.654	0.89
177_I	205_V	0.651	0.88
245_T	249_V	0.650	0.88
37_A	40_H	0.646	0.88
140_D	143_G	0.643	0.88
175_D	204_D	0.637	0.87
179_V	194_F	0.635	0.87
37_A	155_Q	0.635	0.87
117_L	133_L	0.634	0.87
61_T	214_A	0.633	0.87
36_P	155_Q	0.632	0.87
158_V	169_A	0.631	0.87
181_N	191_L	0.630	0.87
165_E	168_R	0.629	0.87
133_L	145_M	0.629	0.87
84_V	103_I	0.627	0.86
68_D	102_A	0.626	0.86
89_E	187_L	0.625	0.86
80_G	109_V	0.624	0.86
142_L	158_V	0.622	0.86
5_S	8_A	0.621	0.86
243_D	246_R	0.620	0.86
21_R	121_P	0.617	0.86
103_I	106_A	0.617	0.86
83_A	155_Q	0.617	0.86
87_L	231_L	0.613	0.85
60_T	178_G	0.610	0.85
135_A	165_E	0.607	0.85
196_A	200_E	0.607	0.85
64_E	67_G	0.605	0.85
73_A	103_I	0.600	0.84
45_D	82_A	0.600	0.84
75_E	241_V	0.599	0.84
67_G	237_M	0.597	0.84
150_R	173_D	0.594	0.83
18_A	23_P	0.594	0.83
73_A	106_A	0.592	0.83
166_L	207_L	0.592	0.83
26_R	32_A	0.592	0.83
132_L	231_L	0.589	0.83
57_T	63_T	0.588	0.83
130_A	155_Q	0.587	0.83
138_L	141_D	0.584	0.82
114_K	132_L	0.579	0.82
207_L	227_A	0.577	0.82
86_V	103_I	0.576	0.82
43_A	176_I	0.575	0.81
54_V	72_L	0.573	0.81
33_R	129_D	0.571	0.81
197_V	201_A	0.571	0.81
235_A	239_G	0.570	0.81
141_D	145_M	0.569	0.81
12_Q	16_A	0.569	0.81
39_L	229_G	0.569	0.81
73_A	84_V	0.569	0.81
75_E	78_A	0.567	0.81
24_P	27_R	0.567	0.81
14_I	89_E	0.566	0.80
160_V	193_T	0.565	0.80
43_A	228_D	0.565	0.80
58_S	62_D	0.564	0.80
191_L	213_I	0.564	0.80
34_S	38_A	0.561	0.80
31_S	35_L	0.554	0.79
17_A	21_R	0.553	0.79
27_R	31_S	0.552	0.79
81_A	245_T	0.550	0.79
87_L	211_S	0.550	0.79
232_V	235_A	0.547	0.78
118_L	137_F	0.545	0.78
170_V	177_I	0.542	0.77
191_L	194_F	0.542	0.77
132_L	211_S	0.540	0.77
48_T	249_V	0.539	0.77
39_L	49_P	0.538	0.77
86_V	100_L	0.538	0.77
134_I	184_L	0.538	0.77
50_I	242_R	0.535	0.77
157_L	176_I	0.535	0.77
193_T	197_V	0.534	0.76
10_P	118_L	0.531	0.76
186_A	189_V	0.530	0.76
37_A	129_D	0.530	0.76
164_R	168_R	0.530	0.76
197_V	200_E	0.529	0.76
89_E	94_D	0.527	0.76
89_E	118_L	0.526	0.75
87_L	184_L	0.526	0.75
38_A	83_A	0.526	0.75
76_M	84_V	0.525	0.75
99_A	237_M	0.524	0.75
23_P	121_P	0.524	0.75
173_D	205_V	0.523	0.75
4_S	7_L	0.521	0.75
102_A	106_A	0.521	0.75
139_G	168_R	0.519	0.74
49_P	229_G	0.516	0.74
81_A	84_V	0.515	0.74
41_S	45_D	0.512	0.73
28_C	31_S	0.512	0.73
215_T	235_A	0.509	0.73
162_S	197_V	0.508	0.73
30_V	33_R	0.508	0.73
179_V	227_A	0.507	0.73
88_T	100_L	0.507	0.73
113_R	126_V	0.507	0.73
34_S	43_A	0.507	0.73
50_I	249_V	0.505	0.72
166_L	198_A	0.504	0.72
191_L	218_D	0.504	0.72
123_L	149_A	0.504	0.72
69_P	99_A	0.502	0.72
39_L	83_A	0.502	0.72
33_R	37_A	0.501	0.72
39_L	176_I	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1piiA	1	0.9841	100	0.321	Contact Map
3tsmA	2	1	100	0.364	Contact Map
1i4nA	1	0.9641	100	0.368	Contact Map
4a29A	1	0.9681	100	0.376	Contact Map
3qjaA	1	0.9522	100	0.394	Contact Map
1vc4A	2	0.9761	100	0.402	Contact Map
1hg3A	3	0.7888	100	0.661	Contact Map
1w0mA	3	0.7809	99.9	0.696	Contact Map
2yzrA	5	0.8088	99.9	0.711	Contact Map
1jvnA	1	0.9323	99.9	0.719	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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