GREMLIN Database
TRPB - Tryptophan synthase beta chain
UniProt: Q9HSC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (359)
Sequences: 5074 (2407)
Seq/√Len: 127.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_L396_V4.8451.00
273_D351_T4.5981.00
131_C138_C3.6301.00
38_Y211_D3.4321.00
141_Y184_D3.3631.00
235_V248_A3.2991.00
144_R168_T3.2831.00
69_H80_D3.2281.00
214_A218_E3.0901.00
359_A388_Q2.9391.00
199_V246_M2.9011.00
234_A275_L2.8551.00
144_R172_G2.6921.00
390_D393_G2.6861.00
139_E163_D2.6511.00
248_A398_N2.5641.00
76_R366_R2.5441.00
67_L396_V2.5371.00
59_S227_Q2.5051.00
113_R184_D2.4721.00
230_E394_P2.4661.00
139_E165_N2.4461.00
80_D228_L2.4101.00
220_L248_A2.3671.00
299_L345_V2.3331.00
65_T89_L2.1691.00
137_P163_D2.1681.00
234_A273_D2.1621.00
180_E183_R2.1471.00
277_V385_A2.1421.00
69_H74_S2.1301.00
221_R255_S2.1271.00
55_Q59_S2.0881.00
71_P75_Q2.0721.00
91_G129_M2.0511.00
106_A110_G2.0211.00
69_H82_Y1.9891.00
80_D394_P1.9891.00
235_V274_L1.9761.00
184_D188_N1.9381.00
379_T400_S1.9221.00
222_A226_E1.8911.00
145_T148_N1.8901.00
365_H414_S1.8561.00
217_S251_A1.8151.00
41_Y108_Y1.8141.00
353_T385_A1.7761.00
386_L397_V1.7611.00
152_P407_L1.7611.00
224_S228_L1.7481.00
341_L352_P1.7461.00
37_A40_R1.7451.00
158_R163_D1.7371.00
224_S396_V1.7291.00
148_N155_F1.7061.00
275_L351_T1.7061.00
233_A393_G1.6971.00
217_S248_A1.6881.00
248_A274_L1.6771.00
83_L367_L1.6631.00
364_F380_S1.6281.00
313_K346_D1.6281.00
224_S394_P1.5991.00
61_G89_L1.5951.00
304_E311_R1.5941.00
113_R137_P1.5911.00
72_T75_Q1.5691.00
64_P222_A1.5371.00
358_D362_A1.5261.00
73_L383_V1.5221.00
114_I118_T1.5101.00
313_K345_V1.5061.00
103_V195_V1.5041.00
188_N191_D1.4931.00
277_V353_T1.4881.00
39_E207_S1.4871.00
361_L377_L1.4871.00
107_K110_G1.4801.00
287_D301_T1.4751.00
298_S315_L1.4661.00
379_T399_V1.4401.00
61_G65_T1.4211.00
103_V114_I1.4181.00
129_M160_H1.4061.00
355_V384_A1.4001.00
35_T39_E1.3891.00
105_L110_G1.3781.00
148_N151_R1.3701.00
228_L394_P1.3691.00
183_R188_N1.3641.00
277_V355_V1.3601.00
168_T172_G1.3561.00
236_I386_L1.3481.00
343_H347_T1.3401.00
298_S301_T1.3391.00
171_S324_E1.3391.00
114_I131_C1.3381.00
366_R387_D1.3361.00
76_R370_D1.3361.00
307_L312_T1.3341.00
363_A384_A1.3291.00
385_A389_Y1.3281.00
127_T140_I1.3271.00
253_V350_I1.3241.00
234_A395_V1.3171.00
114_I117_E1.3151.00
276_A352_P1.3091.00
77_H387_D1.3081.00
383_V397_V1.3051.00
57_I61_G1.2991.00
47_D51_D1.2881.00
280_G356_D1.2871.00
147_V166_P1.2771.00
113_R118_T1.2751.00
236_I389_Y1.2741.00
54_R218_E1.2711.00
113_R117_E1.2661.00
115_V118_T1.2651.00
178_I200_V1.2591.00
73_L81_V1.2501.00
312_T342_A1.2180.99
295_N301_T1.2040.99
114_I119_G1.2020.99
144_R147_V1.1940.99
86_E400_S1.1840.99
36_D40_R1.1620.99
236_I275_L1.1530.99
151_R155_F1.1500.99
99_A130_A1.1490.99
38_Y42_V1.1490.99
105_L111_K1.1480.99
82_Y394_P1.1450.99
225_R228_L1.1450.99
275_L385_A1.1320.99
280_G354_N1.1250.99
299_L352_P1.1250.99
82_Y228_L1.1220.99
37_A41_Y1.1220.99
106_A109_M1.1170.99
39_E43_L1.1090.99
91_G96_L1.1030.99
220_L252_F1.0950.99
32_E35_T1.0940.99
196_I200_V1.0900.99
249_F274_L1.0870.99
77_H386_L1.0830.99
73_L366_R1.0760.99
65_T93_A1.0700.99
72_T370_D1.0670.99
220_L398_N1.0600.99
234_A393_G1.0560.98
366_R370_D1.0540.98
409_T412_E1.0500.98
53_F57_I1.0440.98
196_I199_V1.0440.98
68_T85_R1.0430.98
103_V134_L1.0410.98
365_H369_R1.0390.98
144_R148_N1.0370.98
386_L395_V1.0340.98
275_L389_Y1.0300.98
56_R133_A1.0290.98
197_G201_G1.0290.98
295_N299_L1.0290.98
207_S211_D1.0260.98
80_D392_D1.0240.98
113_R139_E1.0240.98
152_P408_D1.0240.98
203_H207_S1.0210.98
364_F410_V1.0140.98
113_R119_G1.0130.98
42_V211_D1.0090.98
50_V53_F1.0080.98
210_R340_E1.0070.98
408_D412_E1.0060.98
32_E36_D1.0060.98
277_V354_N1.0010.98
82_Y224_S0.9990.98
183_R321_Q0.9940.98
200_V310_A0.9840.98
218_E251_A0.9810.98
361_L413_A0.9800.98
77_H366_R0.9800.98
363_A383_V0.9790.97
125_T156_R0.9750.97
409_T413_A0.9740.97
147_V158_R0.9730.97
178_I196_I0.9710.97
411_I415_A0.9710.97
362_A366_R0.9680.97
214_A251_A0.9680.97
356_D359_A0.9660.97
178_I182_M0.9660.97
155_F411_I0.9660.97
304_E313_K0.9660.97
220_L235_V0.9650.97
221_R225_R0.9640.97
48_G51_D0.9620.97
246_M341_L0.9600.97
225_R230_E0.9600.97
56_R100_L0.9570.97
156_R374_I0.9520.97
359_A384_A0.9520.97
383_V399_V0.9510.97
159_L365_H0.9510.97
367_L383_V0.9480.97
368_S375_P0.9470.97
114_I136_M0.9460.97
236_I277_V0.9460.97
144_R166_P0.9440.97
155_F158_R0.9330.97
38_Y212_F0.9300.97
283_R287_D0.9290.97
310_A314_L0.9250.96
183_R187_T0.9240.96
235_V252_F0.9240.96
312_T336_G0.9240.96
50_V54_R0.9230.96
255_S270_P0.9210.96
113_R116_A0.9200.96
151_R408_D0.9200.96
151_R158_R0.9180.96
384_A388_Q0.9140.96
368_S374_I0.9140.96
58_R226_E0.9130.96
112_D137_P0.9100.96
48_G52_D0.9090.96
253_V344_L0.9070.96
70_A73_L0.9070.96
234_A389_Y0.9060.96
195_V198_S0.9000.96
115_V184_D0.9000.96
231_L272_V0.8980.96
64_P223_Q0.8960.96
403_G406_D0.8950.96
194_Y197_G0.8940.96
52_D107_K0.8930.96
236_I385_A0.8920.96
54_R58_R0.8900.96
115_V119_G0.8850.95
68_T87_D0.8850.95
155_F407_L0.8830.95
235_V396_V0.8820.95
50_V57_I0.8800.95
408_D411_I0.8780.95
353_T388_Q0.8780.95
46_E108_Y0.8760.95
373_V399_V0.8750.95
249_F348_G0.8740.95
179_N183_R0.8730.95
103_V136_M0.8720.95
39_E42_V0.8710.95
375_P380_S0.8680.95
71_P133_A0.8620.95
105_L109_M0.8620.95
113_R192_T0.8610.95
198_S201_G0.8580.95
155_F414_S0.8560.95
107_K134_L0.8560.95
41_Y48_G0.8540.95
139_E184_D0.8480.94
106_A111_K0.8470.94
155_F159_L0.8440.94
193_H197_G0.8400.94
307_L322_I0.8390.94
350_I353_T0.8360.94
141_Y180_E0.8350.94
355_V385_A0.8320.94
375_P379_T0.8320.94
208_M212_F0.8260.93
178_I325_S0.8250.93
171_S176_E0.8230.93
156_R160_H0.8220.93
81_V395_V0.8190.93
74_S79_V0.8180.93
56_R134_L0.8180.93
116_A119_G0.8160.93
169_V180_E0.8060.93
380_S383_V0.8030.92
194_Y198_S0.7990.92
235_V251_A0.7990.92
41_Y46_E0.7950.92
328_V361_L0.7910.92
103_V130_A0.7890.92
231_L255_S0.7850.92
79_V386_L0.7820.91
127_T131_C0.7810.91
283_R286_V0.7810.91
224_S230_E0.7770.91
130_A195_V0.7760.91
148_N412_E0.7670.91
111_K193_H0.7640.91
176_E179_N0.7630.90
193_H198_S0.7630.90
195_V199_V0.7630.90
216_I244_N0.7600.90
273_D393_G0.7590.90
295_N298_S0.7530.90
31_V35_T0.7510.90
402_R406_D0.7510.90
296_S299_L0.7480.90
145_T172_G0.7430.89
295_N300_S0.7410.89
251_A254_G0.7410.89
94_H244_N0.7370.89
367_L399_V0.7360.89
382_A397_V0.7300.88
232_P396_V0.7300.88
298_S304_E0.7270.88
108_Y111_K0.7270.88
217_S252_F0.7260.88
210_R250_G0.7260.88
67_L227_Q0.7250.88
154_V164_V0.7230.88
311_R314_L0.7230.88
87_D400_S0.7220.88
225_R231_L0.7220.88
275_L353_T0.7220.88
239_A276_A0.7220.88
246_M250_G0.7200.88
234_A351_T0.7180.88
33_E37_A0.7180.88
42_V207_S0.7140.87
314_L322_I0.7110.87
402_R405_K0.7080.87
239_A337_V0.7070.87
218_E222_A0.7060.87
112_D191_D0.7030.87
171_S179_N0.7010.86
276_A341_L0.7000.86
301_T305_G0.6980.86
96_L129_M0.6960.86
194_Y201_G0.6950.86
234_A390_D0.6880.85
306_V311_R0.6870.85
248_A251_A0.6840.85
178_I198_S0.6840.85
86_E379_T0.6830.85
407_L411_I0.6810.85
187_T190_A0.6800.85
79_V393_G0.6780.84
67_L224_S0.6780.84
281_G324_E0.6770.84
239_A298_S0.6760.84
250_G340_E0.6740.84
255_S272_V0.6730.84
106_A193_H0.6720.84
284_L295_N0.6720.84
83_L399_V0.6720.84
73_L76_R0.6710.84
198_S310_A0.6710.84
51_D55_Q0.6700.84
383_V386_L0.6680.84
54_R222_A0.6660.83
68_T71_P0.6660.83
282_S326_H0.6660.83
85_R88_L0.6650.83
233_A394_P0.6600.83
282_S286_V0.6600.83
284_L337_V0.6590.83
145_T171_S0.6570.83
157_M162_A0.6560.82
307_L314_L0.6560.82
184_D187_T0.6550.82
106_A114_I0.6540.82
394_P398_N0.6540.82
224_S227_Q0.6530.82
211_D214_A0.6480.82
221_R231_L0.6460.82
195_V201_G0.6460.82
34_L254_G0.6460.82
298_S302_G0.6450.81
192_T197_G0.6440.81
36_D39_E0.6440.81
315_L323_V0.6430.81
231_L252_F0.6430.81
42_V50_V0.6420.81
179_N182_M0.6420.81
176_E180_E0.6420.81
145_T324_E0.6410.81
254_G270_P0.6380.81
154_V158_R0.6370.81
105_L108_Y0.6360.81
196_I201_G0.6340.80
89_L96_L0.6330.80
303_T316_Q0.6320.80
194_Y199_V0.6300.80
216_I398_N0.6300.80
81_V386_L0.6290.80
272_V349_R0.6290.80
298_S310_A0.6280.80
78_G391_G0.6260.79
280_G286_V0.6240.79
193_H196_I0.6230.79
282_S325_S0.6210.79
359_A362_A0.6210.79
307_L310_A0.6200.79
379_T382_A0.6200.79
156_R407_L0.6190.79
316_Q321_Q0.6160.78
221_R254_G0.6160.78
225_R229_G0.6140.78
38_Y207_S0.6140.78
55_Q58_R0.6130.78
154_V166_P0.6130.78
211_D250_G0.6110.78
41_Y50_V0.6110.78
248_A396_V0.6060.77
355_V388_Q0.6040.77
385_A388_Q0.6040.77
295_N303_T0.6030.77
79_V395_V0.6010.77
298_S303_T0.6010.77
40_R43_L0.5980.76
115_V193_H0.5980.76
342_A345_V0.5970.76
221_R251_A0.5970.76
364_F377_L0.5950.76
67_L228_L0.5940.76
377_L410_V0.5940.76
107_K112_D0.5940.76
77_H370_D0.5920.76
129_M133_A0.5900.75
97_N215_I0.5890.75
361_L410_V0.5890.75
155_F408_D0.5850.75
218_E250_G0.5840.75
142_M157_M0.5800.74
106_A136_M0.5800.74
179_N321_Q0.5790.74
304_E346_D0.5790.74
107_K136_M0.5770.74
166_P169_V0.5770.74
113_R141_Y0.5750.74
91_G160_H0.5750.74
34_L196_I0.5730.73
74_S80_D0.5720.73
221_R252_F0.5710.73
71_P74_S0.5700.73
375_P399_V0.5700.73
337_V345_V0.5690.73
364_F375_P0.5690.73
312_T318_E0.5690.73
336_G339_P0.5680.73
186_A193_H0.5680.73
379_T386_L0.5650.72
35_T208_M0.5650.72
196_I310_A0.5640.72
35_T207_S0.5630.72
107_K111_K0.5630.72
300_S354_N0.5630.72
185_W188_N0.5620.72
301_T304_E0.5620.72
127_T195_V0.5610.72
369_R414_S0.5600.72
180_E184_D0.5590.71
310_A321_Q0.5590.71
299_L302_G0.5540.71
237_A244_N0.5530.71
36_D41_Y0.5500.70
231_L270_P0.5500.70
159_L368_S0.5490.70
149_R330_A0.5490.70
70_A74_S0.5490.70
97_N213_Q0.5490.70
96_L133_A0.5480.70
191_D197_G0.5460.70
253_V274_L0.5450.70
360_A380_S0.5450.70
375_P383_V0.5440.69
284_L297_A0.5430.69
222_A225_R0.5430.69
147_V167_V0.5430.69
66_P88_L0.5420.69
214_A250_G0.5400.69
200_V312_T0.5390.69
131_C137_P0.5390.69
356_D388_Q0.5380.69
33_E36_D0.5360.68
191_D198_S0.5350.68
329_S332_L0.5340.68
103_V127_T0.5340.68
362_A387_D0.5330.68
31_V34_L0.5320.68
209_V213_Q0.5320.68
304_E342_A0.5310.68
297_A302_G0.5300.67
55_Q71_P0.5300.67
63_R97_N0.5300.67
213_Q379_T0.5290.67
53_F215_I0.5280.67
188_N192_T0.5280.67
40_R48_G0.5270.67
199_V248_A0.5240.67
245_T349_R0.5240.67
56_R59_S0.5240.67
367_L375_P0.5240.67
308_H335_A0.5240.67
42_V47_D0.5230.66
47_D50_V0.5220.66
147_V168_T0.5210.66
140_I196_I0.5200.66
332_L378_E0.5200.66
69_H228_L0.5200.66
103_V137_P0.5190.66
220_L251_A0.5190.66
87_D379_T0.5180.66
43_L47_D0.5180.66
127_T138_C0.5170.66
281_G357_D0.5170.66
32_E39_E0.5170.66
79_V392_D0.5170.66
61_G96_L0.5170.66
147_V413_A0.5160.65
310_A319_T0.5140.65
140_I178_I0.5130.65
178_I195_V0.5130.65
58_R64_P0.5130.65
89_L409_T0.5120.65
178_I310_A0.5120.65
332_L381_H0.5110.65
298_S336_G0.5110.65
163_D166_P0.5110.65
345_V349_R0.5090.64
182_M195_V0.5090.64
83_L383_V0.5080.64
124_G157_M0.5080.64
73_L79_V0.5080.64
275_L350_I0.5080.64
117_E241_G0.5040.64
192_T198_S0.5030.63
60_F100_L0.5030.63
169_V176_E0.5020.63
284_L287_D0.5020.63
252_F255_S0.5010.63
89_L129_M0.5010.63
296_S301_T0.5000.63
279_A322_I0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o2eA 2 0.7233 100 0.333 Contact Map
1x1qA 2 0.8884 100 0.334 Contact Map
4negA 2 0.7442 100 0.341 Contact Map
4ht3B 2 0.893 100 0.355 Contact Map
1v8zA 2 0.8791 100 0.372 Contact Map
1tdjA 2 0.7767 100 0.377 Contact Map
3ss7X 1 0.8488 100 0.379 Contact Map
2gn0A 2 0.7465 100 0.398 Contact Map
1v71A 2 0.7256 100 0.402 Contact Map
3iauA 1 0.8233 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0122 seconds.