GREMLIN Database
TRPA - Tryptophan synthase alpha chain
UniProt: Q9HSB9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (248)
Sequences: 3769 (2451)
Seq/√Len: 155.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_T29_A3.7351.00
24_D67_R3.2421.00
158_A197_A3.0581.00
103_Y115_A3.0501.00
63_N239_A2.8691.00
142_R169_T2.8251.00
31_A84_R2.5931.00
206_A227_G2.4281.00
21_V65_I2.3921.00
35_D86_D2.2831.00
18_S42_T2.2041.00
113_V141_C2.1891.00
115_A118_E2.1741.00
152_V161_R2.1631.00
36_A40_G2.1551.00
147_D169_T2.0761.00
74_T77_A2.0351.00
4_S7_A2.0141.00
110_A140_A1.9681.00
68_A73_M1.9461.00
114_S144_H1.9261.00
256_R260_A1.9221.00
34_I45_I1.9181.00
34_I85_I1.9111.00
39_D256_R1.8831.00
77_A80_D1.8731.00
83_A118_E1.8481.00
38_V89_V1.8451.00
17_V206_A1.8401.00
7_A11_D1.8331.00
40_G256_R1.8221.00
214_G218_R1.8221.00
76_D115_A1.8011.00
100_L126_V1.7781.00
49_L75_P1.7611.00
4_S8_A1.7461.00
15_A227_G1.7081.00
213_S216_Q1.6951.00
114_S118_E1.6901.00
38_V88_D1.6741.00
80_D83_A1.6461.00
95_T100_L1.6441.00
117_A144_H1.6361.00
176_G207_V1.6281.00
199_Q226_D1.6141.00
95_T99_L1.6051.00
196_A200_H1.5961.00
199_Q205_K1.5921.00
126_V137_L1.5921.00
162_E166_D1.5911.00
83_A115_A1.5821.00
174_V205_K1.5801.00
73_M77_A1.5731.00
19_Y65_I1.5571.00
34_I91_V1.5531.00
36_A39_D1.5161.00
33_Y238_V1.5141.00
207_V220_I1.5041.00
236_D240_D1.5021.00
111_A114_S1.4851.00
110_A143_A1.4751.00
115_A119_A1.4701.00
141_C148_L1.4241.00
111_A115_A1.4181.00
116_A146_L1.4121.00
44_V92_V1.3921.00
31_A35_D1.3851.00
156_T161_R1.3701.00
66_K70_D1.3681.00
73_M78_Y1.3591.00
97_Y129_L1.3481.00
206_A229_I1.3361.00
207_V225_A1.3241.00
138_R142_R1.3191.00
24_D239_A1.3051.00
242_V245_D1.3001.00
76_D103_Y1.2971.00
161_R198_L1.2921.00
32_E35_D1.2831.00
100_L112_F1.2831.00
6_L10_F1.2771.00
80_D84_R1.2761.00
36_A256_R1.2711.00
29_A32_E1.2691.00
97_Y105_D1.2641.00
211_V228_V1.2481.00
22_A47_L1.2411.00
20_V33_Y1.2331.00
116_A121_V1.2251.00
174_V194_A1.2241.00
27_P31_A1.2221.00
134_S150_F1.2211.00
79_L116_A1.2081.00
253_D257_D1.2021.00
33_Y255_L1.1881.00
211_V220_I1.1861.00
92_V149_V1.1841.00
113_V140_A1.1761.00
250_V254_R1.1681.00
139_E143_A1.1661.00
163_R166_D1.1551.00
212_S236_D1.1541.00
14_P222_A1.1301.00
168_T203_I1.1271.00
49_L93_C1.1251.00
236_D239_A1.1221.00
27_P77_A1.1221.00
255_L258_L1.1211.00
158_A200_H1.1141.00
45_I89_V1.1141.00
190_A193_D1.1000.99
94_M125_V1.0950.99
24_D235_V1.0930.99
172_V201_T1.0930.99
177_R184_R1.0910.99
192_P196_A1.0860.99
76_D111_A1.0850.99
36_A252_A1.0820.99
148_L169_T1.0790.99
63_N66_K1.0780.99
103_Y111_A1.0750.99
193_D196_A1.0750.99
97_Y137_L1.0590.99
38_V87_A1.0470.99
5_D9_A1.0470.99
135_G139_E1.0420.99
117_A145_G1.0370.99
21_V64_A1.0320.99
113_V124_F1.0060.99
76_D80_D1.0050.99
112_F124_F1.0030.99
237_T254_R0.9960.99
31_A81_L0.9940.99
244_D250_V0.9870.99
35_D39_D0.9860.99
4_S44_V0.9820.99
215_E219_E0.9770.99
27_P73_M0.9770.99
241_G251_V0.9710.99
60_T183_A0.9610.99
18_S234_Y0.9590.99
184_R216_Q0.9580.99
60_T236_D0.9560.99
47_L82_V0.9470.98
217_A228_V0.9450.98
183_A236_D0.9450.98
131_V167_L0.9430.98
110_A114_S0.9410.98
233_A237_T0.9410.98
155_T178_V0.9380.98
5_D8_A0.9370.98
83_A119_A0.9340.98
7_A10_F0.9330.98
113_V137_L0.9310.98
8_A15_A0.9290.98
241_G244_D0.9270.98
79_L115_A0.9250.98
237_T241_G0.9250.98
82_V91_V0.9120.98
194_A197_A0.9100.98
17_V44_V0.9050.98
67_R239_A0.9050.98
222_A228_V0.9000.98
240_D254_R0.8970.98
67_R70_D0.8940.98
35_D38_V0.8920.98
113_V146_L0.8900.98
26_T71_A0.8880.98
158_A162_E0.8860.98
16_L234_Y0.8860.98
87_A91_V0.8840.98
22_A81_L0.8700.97
31_A34_I0.8650.97
18_S37_L0.8630.97
151_V175_Q0.8620.97
251_V254_R0.8610.97
19_Y48_G0.8600.97
22_A78_Y0.8580.97
241_G254_R0.8580.97
110_A144_H0.8560.97
237_T240_D0.8560.97
172_V198_L0.8550.97
152_V168_T0.8540.97
163_R167_L0.8510.97
38_V45_I0.8480.97
30_T81_L0.8430.97
92_V123_G0.8420.97
6_L9_A0.8410.97
251_V258_L0.8370.97
174_V198_L0.8320.96
27_P30_T0.8320.96
114_S117_A0.8250.96
212_S216_Q0.8240.96
257_D260_A0.8180.96
254_R257_D0.8120.96
134_S138_R0.8070.96
136_P140_A0.8040.96
31_A86_D0.8040.96
34_I89_V0.8020.96
34_I47_L0.7960.95
135_G167_L0.7960.95
252_A256_R0.7950.95
150_F168_T0.7920.95
61_I235_V0.7850.95
192_P219_E0.7850.95
140_A144_H0.7830.95
27_P80_D0.7790.95
174_V224_G0.7790.95
237_T258_L0.7760.95
105_D140_A0.7690.94
152_V198_L0.7640.94
150_F164_M0.7570.94
234_Y259_A0.7530.94
218_R223_S0.7530.94
29_A33_Y0.7510.94
127_P229_I0.7510.94
150_F167_L0.7500.94
82_V121_V0.7500.94
27_P81_L0.7480.94
35_D87_A0.7470.94
39_D86_D0.7460.94
192_P223_S0.7450.94
136_P139_E0.7400.93
165_L203_I0.7400.93
51_F55_V0.7390.93
211_V217_A0.7380.93
27_P71_A0.7380.93
124_F148_L0.7320.93
76_D79_L0.7320.93
62_Q90_P0.7320.93
183_A187_V0.7310.93
91_V121_V0.7280.93
153_A156_T0.7280.93
56_A209_F0.7240.93
131_V163_R0.7220.92
33_Y252_A0.7210.92
16_L259_A0.7200.92
91_V122_S0.7120.92
195_L205_K0.7040.91
152_V156_T0.7030.91
131_V150_F0.7020.91
220_I228_V0.6960.91
215_E218_R0.6950.91
30_T47_L0.6950.91
85_I91_V0.6940.91
113_V144_H0.6890.91
183_A212_S0.6880.91
169_T203_I0.6870.90
18_S44_V0.6850.90
252_A255_L0.6840.90
59_T63_N0.6830.90
165_L172_V0.6810.90
14_P228_V0.6800.90
234_Y255_L0.6780.90
132_D160_R0.6750.90
250_V253_D0.6740.90
161_R165_L0.6690.89
19_Y64_A0.6680.89
150_F172_V0.6680.89
214_G217_A0.6670.89
37_L255_L0.6660.89
184_R212_S0.6640.89
217_A222_A0.6600.89
23_G73_M0.6590.89
49_L78_Y0.6580.88
105_D136_P0.6570.88
47_L91_V0.6570.88
105_D137_L0.6540.88
28_A84_R0.6510.88
92_V151_V0.6500.88
97_Y101_F0.6470.88
51_F97_Y0.6460.88
9_A12_D0.6420.87
140_A143_A0.6400.87
230_V233_A0.6370.87
37_L259_A0.6350.87
117_A146_L0.6340.87
184_R187_V0.6340.87
48_G227_G0.6330.87
233_A236_D0.6320.86
208_G231_G0.6290.86
162_E200_H0.6290.86
83_A166_D0.6280.86
37_L42_T0.6280.86
193_D200_H0.6270.86
93_C121_V0.6250.86
85_I89_V0.6210.85
8_A13_G0.6200.85
63_N67_R0.6150.85
158_A161_R0.6150.85
195_L224_G0.6130.85
19_Y258_L0.6130.85
234_Y237_T0.6120.85
231_G235_V0.6120.85
30_T38_V0.6110.85
78_Y82_V0.6080.84
197_A200_H0.6080.84
104_G110_A0.6070.84
124_F141_C0.6050.84
125_V171_F0.5990.83
162_E165_L0.5990.83
252_A259_A0.5980.83
124_F146_L0.5960.83
81_L84_R0.5940.83
10_F13_G0.5930.83
201_T204_P0.5910.83
31_A85_I0.5910.83
192_P224_G0.5910.83
58_G209_F0.5880.82
105_D113_V0.5860.82
241_G245_D0.5860.82
82_V93_C0.5840.82
165_L201_T0.5820.82
198_L201_T0.5810.81
189_A193_D0.5800.81
147_D170_G0.5800.81
220_I224_G0.5780.81
94_M229_I0.5770.81
8_A11_D0.5760.81
15_A43_D0.5760.81
153_A175_Q0.5660.80
22_A82_V0.5560.79
49_L95_T0.5550.78
9_A13_G0.5540.78
218_R222_A0.5510.78
57_E125_V0.5500.78
34_I38_V0.5500.78
51_F177_R0.5490.78
34_I87_A0.5480.78
181_T209_F0.5470.77
51_F98_N0.5450.77
193_D197_A0.5440.77
127_P174_V0.5430.77
187_V191_T0.5340.76
93_C116_A0.5340.76
44_V206_A0.5320.76
70_D200_H0.5310.75
38_V86_D0.5250.75
28_A31_A0.5240.74
5_D15_A0.5240.74
131_V164_M0.5240.74
44_V89_V0.5220.74
242_V251_V0.5220.74
156_T160_R0.5220.74
245_D252_A0.5210.74
27_P84_R0.5190.74
130_P133_E0.5190.74
20_V34_I0.5180.74
38_V85_I0.5180.74
220_I223_S0.5170.73
5_D13_G0.5170.73
58_G181_T0.5160.73
132_D163_R0.5160.73
49_L112_F0.5160.73
126_V141_C0.5160.73
230_V258_L0.5130.73
186_E189_A0.5120.73
182_G209_F0.5110.73
4_S86_D0.5100.72
254_R258_L0.5100.72
137_L148_L0.5090.72
152_V191_T0.5090.72
235_V239_A0.5090.72
15_A206_A0.5090.72
53_E176_G0.5060.72
51_F149_V0.5050.72
238_V241_G0.5030.71
25_P33_Y0.5020.71
69_L99_L0.5010.71
41_G89_V0.5010.71
241_G250_V0.5010.71
27_P68_A0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ujpA 1 0.8514 100 0.434 Contact Map
3thaA 2 0.8949 100 0.463 Contact Map
2ekcA 1 0.913 100 0.496 Contact Map
3vndA 3 0.9094 100 0.497 Contact Map
4ht3A 1 0.9457 100 0.499 Contact Map
3navA 2 0.9167 100 0.506 Contact Map
1rd5A 6 0.9239 100 0.526 Contact Map
1geqA 1 0.8768 100 0.546 Contact Map
3cu2A 2 0.779 100 0.631 Contact Map
2f6uA 2 0.6884 100 0.665 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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