GREMLIN Database
ADHS - 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
UniProt: Q9HSB8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (245)
Sequences: 1122 (652)
Seq/√Len: 41.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_M245_V4.5991.00
213_R217_D4.4431.00
20_L246_V4.2371.00
210_Q214_D4.0411.00
215_A220_A3.3221.00
132_A139_V3.2801.00
172_V196_I3.2381.00
143_A165_A3.0801.00
225_T242_I2.9271.00
129_A139_V2.9231.00
18_R221_A2.7531.00
106_A138_P2.6901.00
206_R210_Q2.5561.00
166_E192_A2.4351.00
159_G186_R2.3431.00
244_A248_D2.3401.00
97_E131_D2.2641.00
178_S183_S2.2611.00
53_A74_I2.1670.99
74_I140_L2.1380.99
52_D247_H2.1120.99
204_G207_E2.0970.99
223_V242_I2.0220.99
180_S183_S2.0150.99
58_P98_D1.9670.99
98_D130_A1.9440.99
177_Y184_F1.9380.99
108_S142_M1.9270.99
109_F125_L1.8990.99
100_V137_V1.8810.99
18_R216_M1.8760.99
155_A159_G1.8680.98
97_E134_R1.8590.98
21_T196_I1.8070.98
229_V242_I1.7960.98
76_H142_M1.7530.98
158_L178_S1.7370.98
212_I242_I1.7120.97
125_L141_A1.7060.97
203_A208_T1.6970.97
38_D41_A1.6460.97
94_G98_D1.6310.96
186_R189_D1.6100.96
76_H108_S1.6020.96
208_T238_M1.5990.96
97_E135_L1.5600.95
51_A239_T1.5540.95
163_R167_E1.5320.95
209_L245_V1.5310.95
76_H144_Y1.5200.95
95_T130_A1.5100.94
201_D205_D1.4930.94
13_I19_L1.4830.94
208_T225_T1.4620.93
145_A161_A1.4530.93
178_S184_F1.4440.93
75_V94_G1.4410.93
110_H142_M1.4310.93
78_N142_M1.4150.92
27_G167_E1.4090.92
76_H112_N1.4060.92
90_K142_M1.3980.92
107_V128_V1.3860.91
177_Y214_D1.3860.91
92_R128_V1.3820.91
79_A93_T1.3770.91
113_V164_L1.3580.90
115_S121_Q1.3460.90
202_P228_T1.3310.90
14_S19_L1.2930.88
207_E210_Q1.2920.88
197_I215_A1.2840.88
162_V175_T1.2770.88
76_H110_H1.2650.87
208_T212_I1.2580.87
234_T237_A1.2540.87
77_L128_V1.2410.86
90_K112_N1.2110.85
209_L241_A1.2090.84
56_T102_A1.2040.84
5_G9_R1.1970.84
61_A73_Y1.1880.83
147_G150_V1.1830.83
28_I79_A1.1810.83
213_R249_D1.1780.83
123_T127_D1.1720.83
90_K108_S1.1660.82
91_R132_A1.1370.81
233_A236_G1.1320.80
5_G31_G1.1260.80
112_N142_M1.0890.78
20_L223_V1.0890.78
6_K133_D1.0880.78
76_H160_H1.0850.77
28_I121_Q1.0830.77
108_S144_Y1.0790.77
145_A175_T1.0770.77
6_K171_D1.0720.77
110_H144_Y1.0690.76
92_R124_A1.0660.76
92_R125_L1.0640.76
182_E185_Q1.0610.76
11_N70_D1.0610.76
177_Y215_A1.0590.76
90_K110_H1.0570.76
112_N230_F1.0560.75
55_L142_M1.0550.75
62_P133_D1.0540.75
216_M220_A1.0460.75
41_A45_E1.0400.74
76_H90_K1.0320.74
78_N108_S1.0290.74
228_T231_Q1.0110.72
188_V218_A1.0090.72
91_R119_P1.0060.72
158_L175_T1.0060.72
131_D134_R1.0000.71
77_L107_V0.9970.71
140_L224_S0.9960.71
142_M198_A0.9960.71
162_V172_V0.9950.71
15_T52_D0.9920.71
78_N144_Y0.9910.71
40_E44_R0.9850.70
212_I225_T0.9800.70
29_T108_S0.9800.70
108_S112_N0.9760.69
19_L196_I0.9750.69
77_L96_V0.9740.69
90_K160_H0.9730.69
29_T76_H0.9710.69
117_H121_Q0.9660.69
75_V104_A0.9610.68
145_A224_S0.9490.67
120_D123_T0.9480.67
177_Y220_A0.9410.67
105_D138_P0.9410.67
36_L163_R0.9370.66
45_E236_G0.9350.66
107_V171_D0.9330.66
78_N110_H0.9310.66
20_L239_T0.9310.66
135_L139_V0.9260.65
78_N111_I0.9220.65
13_I53_A0.9210.65
46_V49_N0.9150.64
144_Y198_A0.9100.64
10_L190_A0.9100.64
179_G183_S0.9060.64
57_Q76_H0.9030.63
55_L108_S0.9000.63
44_R245_V0.8980.63
141_A165_A0.8970.63
15_T66_P0.8960.63
203_A211_G0.8940.63
86_D115_S0.8910.62
5_G10_L0.8900.62
27_G163_R0.8840.62
22_I46_V0.8810.61
236_G245_V0.8770.61
18_R249_D0.8640.60
29_T142_M0.8610.60
21_T53_A0.8520.59
151_D161_A0.8490.59
57_Q142_M0.8460.58
241_A244_A0.8440.58
18_R126_A0.8410.58
112_N160_H0.8400.58
53_A105_D0.8400.58
111_I212_I0.8360.57
89_D117_H0.8350.57
184_F187_V0.8340.57
21_T74_I0.8330.57
81_T118_E0.8200.56
235_P247_H0.8200.56
10_L14_S0.8190.56
240_A245_V0.8130.55
113_V143_A0.8000.54
153_H201_D0.7990.54
151_D154_D0.7990.54
9_R138_P0.7970.54
20_L243_S0.7950.54
165_A173_I0.7940.54
12_R53_A0.7920.53
142_M160_H0.7880.53
48_A236_G0.7870.53
10_L134_R0.7830.52
112_N121_Q0.7670.51
116_D148_P0.7660.51
74_I150_V0.7650.51
118_E122_I0.7640.51
30_L115_S0.7630.51
19_L52_D0.7600.50
14_S172_V0.7580.50
158_L187_V0.7560.50
159_G190_A0.7540.50
58_P94_G0.7530.50
101_R134_R0.7480.49
39_I43_I0.7410.49
96_V137_V0.7370.48
152_E157_N0.7360.48
178_S187_V0.7350.48
49_N239_T0.7330.48
109_F129_A0.7330.48
75_V205_D0.7320.48
94_G130_A0.7290.47
24_M39_I0.7280.47
162_V187_V0.7270.47
141_A170_A0.7230.47
185_Q189_D0.7180.46
6_K9_R0.7120.46
61_A75_V0.7100.46
105_D179_G0.7090.46
29_T90_K0.7090.46
11_N66_P0.7070.45
44_R48_A0.7070.45
13_I140_L0.7020.45
29_T112_N0.7000.45
10_L13_I0.6990.45
197_I211_G0.6980.45
32_A230_F0.6880.44
57_Q144_Y0.6880.44
209_L238_M0.6860.43
90_K230_F0.6840.43
217_D245_V0.6810.43
96_V107_V0.6810.43
106_A164_L0.6810.43
110_H160_H0.6780.43
112_N144_Y0.6750.42
29_T110_H0.6730.42
96_V128_V0.6720.42
76_H198_A0.6680.42
152_E176_A0.6670.42
175_T187_V0.6660.42
47_T61_A0.6660.42
14_S234_T0.6640.41
127_D240_A0.6610.41
10_L19_L0.6550.41
28_I78_N0.6540.41
26_H33_I0.6530.40
78_N90_K0.6530.40
57_Q108_S0.6520.40
203_A207_E0.6510.40
179_G182_E0.6510.40
209_L228_T0.6500.40
196_I242_I0.6480.40
106_A217_D0.6480.40
210_Q236_G0.6480.40
43_I56_T0.6470.40
23_P142_M0.6470.40
165_A169_G0.6450.40
110_H170_A0.6400.39
8_A61_A0.6400.39
152_E230_F0.6390.39
27_G32_A0.6390.39
35_G163_R0.6380.39
6_K13_I0.6370.39
46_V239_T0.6370.39
37_V186_R0.6370.39
21_T212_I0.6350.39
114_G147_G0.6340.39
62_P193_K0.6340.39
78_N198_A0.6340.39
110_H121_Q0.6320.39
98_D101_R0.6300.38
43_I102_A0.6270.38
41_A44_R0.6270.38
174_K227_R0.6250.38
23_P76_H0.6230.38
196_I221_A0.6220.38
115_S175_T0.6210.38
56_T61_A0.6210.38
113_V161_A0.6200.38
154_D157_N0.6170.37
107_V132_A0.6150.37
123_T233_A0.6140.37
13_I74_I0.6130.37
176_A198_A0.6110.37
153_H175_T0.6110.37
209_L229_V0.6100.37
73_Y104_A0.6100.37
111_I141_A0.6100.37
184_F220_A0.6060.36
206_R209_L0.6060.36
72_G105_D0.6060.36
9_R12_R0.6050.36
130_A133_D0.6050.36
115_S146_R0.6010.36
113_V192_A0.6000.36
184_F197_I0.5980.36
177_Y197_I0.5980.36
204_G233_A0.5970.36
23_P80_S0.5970.36
111_I131_D0.5960.35
80_S230_F0.5940.35
63_R191_T0.5930.35
209_L249_D0.5880.35
207_E214_D0.5880.35
29_T35_G0.5790.34
115_S224_S0.5790.34
180_S214_D0.5760.34
10_L127_D0.5750.34
166_E193_K0.5730.33
138_P230_F0.5730.33
196_I224_S0.5710.33
91_R123_T0.5710.33
209_L232_H0.5680.33
80_S90_K0.5680.33
79_A112_N0.5660.33
121_Q144_Y0.5640.33
100_V131_D0.5630.33
105_D171_D0.5620.33
27_G231_Q0.5590.32
110_H230_F0.5580.32
150_V158_L0.5580.32
48_A69_G0.5560.32
34_D238_M0.5560.32
184_F188_V0.5560.32
125_L140_L0.5530.32
43_I64_V0.5500.32
151_D157_N0.5500.32
216_M246_V0.5490.32
76_H121_Q0.5490.32
130_A134_R0.5460.31
23_P90_K0.5430.31
200_G227_R0.5430.31
188_V225_T0.5420.31
39_I206_R0.5370.31
166_E173_I0.5370.31
66_P69_G0.5360.30
143_A225_T0.5360.30
144_Y160_H0.5320.30
58_P126_A0.5320.30
57_Q90_K0.5310.30
161_A176_A0.5310.30
137_V186_R0.5300.30
32_A73_Y0.5300.30
96_V135_L0.5300.30
22_I51_A0.5290.30
199_G227_R0.5280.30
47_T60_I0.5280.30
29_T144_Y0.5270.30
72_G108_S0.5220.29
73_Y106_A0.5200.29
172_V242_I0.5180.29
142_M230_F0.5180.29
188_V191_T0.5150.29
95_T218_A0.5150.29
50_G72_G0.5140.29
214_D240_A0.5130.29
58_P108_S0.5130.29
233_A237_A0.5120.29
207_E211_G0.5110.29
204_G249_D0.5100.28
56_T152_E0.5090.28
48_A210_Q0.5090.28
30_L112_N0.5070.28
24_M54_V0.5060.28
210_Q213_R0.5050.28
109_F124_A0.5050.28
162_V202_P0.5050.28
42_T133_D0.5040.28
214_D220_A0.5040.28
11_N68_K0.5020.28
213_R216_M0.5020.28
175_T184_F0.5020.28
32_A187_V0.5000.28
43_I131_D0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fokA 3 0.9019 100 0.34 Contact Map
3iv3A 2 0.9698 100 0.397 Contact Map
4mozA 5 1 100 0.401 Contact Map
1to3A 2 0.9547 100 0.433 Contact Map
3glcA 6 0.9547 100 0.479 Contact Map
1w8sA 4 0.917 100 0.523 Contact Map
2qjgA 6 0.9849 100 0.547 Contact Map
3oa3A 2 0.8302 100 0.656 Contact Map
3r12A 2 0.8302 100 0.661 Contact Map
3ndoA 2 0.7962 100 0.667 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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