GREMLIN Database
DHQS - 3-dehydroquinate synthase
UniProt: Q9HSB6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (303)
Sequences: 143 (90)
Seq/√Len: 5.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_E229_V4.4610.95
325_V339_L4.2720.93
326_E380_I3.4540.82
120_Y162_G3.2990.79
163_V172_A3.2520.78
171_T180_A3.2110.77
302_D306_R3.2100.77
215_I365_L3.1980.77
215_I307_T3.1460.75
213_A367_V2.6150.60
293_G387_Q2.5520.58
303_G325_V2.3810.53
159_L206_E2.3490.52
249_G262_Y2.1680.46
175_T296_D2.1570.46
319_K383_R2.1390.45
87_T325_V2.1260.45
142_T381_D2.1160.44
115_I183_V2.0610.42
360_S387_Q2.0540.42
270_V289_L2.0430.42
168_E243_V2.0270.41
299_Q323_F2.0220.41
128_A192_E2.0150.41
142_T347_V1.9420.39
217_T326_E1.9220.38
343_E376_F1.8270.35
342_A376_F1.8270.35
344_T376_F1.8270.35
141_W344_T1.8030.34
141_W343_E1.8030.34
141_W342_A1.8030.34
121_E138_G1.7850.34
151_A301_V1.7630.33
251_F347_V1.7620.33
187_S372_G1.7620.33
83_E99_D1.7380.33
310_A380_I1.6900.31
258_A274_A1.6810.31
114_R136_V1.6720.31
214_T284_G1.6560.30
216_T334_R1.6360.30
365_L368_F1.6310.30
195_R218_I1.5870.28
92_A368_F1.5850.28
218_I283_D1.5770.28
262_Y335_I1.5770.28
263_V342_A1.5720.28
263_V344_T1.5720.28
263_V343_E1.5720.28
117_D165_S1.5400.27
261_P274_A1.5300.27
148_N344_T1.5040.26
148_N343_E1.5040.26
148_N342_A1.5040.26
224_A252_F1.4970.26
339_L356_V1.4860.26
121_E263_V1.4810.26
177_D182_A1.4770.25
260_S376_F1.4740.25
206_E219_E1.4740.25
159_L304_D1.4660.25
249_G261_P1.4610.25
260_S343_E1.4480.25
260_S342_A1.4480.25
260_S344_T1.4480.25
169_A262_Y1.4380.25
165_S187_S1.4320.24
275_V373_G1.4310.24
176_L248_R1.4260.24
143_I148_N1.4250.24
254_H339_L1.4120.24
270_V312_V1.4100.24
341_N344_T1.4030.24
127_A347_V1.3960.24
343_E355_A1.3910.23
344_T355_A1.3910.23
342_A355_A1.3910.23
119_E360_S1.3860.23
238_D348_A1.3780.23
108_A115_I1.3770.23
229_V279_V1.3560.23
183_V247_S1.3530.23
111_A225_D1.3480.22
138_G263_V1.3320.22
109_D229_V1.3300.22
84_G90_L1.3250.22
200_R223_S1.3150.22
286_T291_E1.3090.22
140_D286_T1.3080.22
182_A223_S1.3000.21
195_R361_V1.3000.21
216_T279_V1.2920.21
255_A258_A1.2880.21
265_A384_I1.2800.21
243_V303_G1.2770.21
304_D331_D1.2580.20
156_E198_S1.2540.20
164_E202_A1.2420.20
213_A384_I1.2320.20
221_A311_V1.2300.20
141_W148_N1.2300.20
223_S338_L1.2270.20
128_A143_I1.2250.20
275_V317_I1.2230.20
198_S385_I1.2190.20
112_Y283_D1.2130.19
207_H294_S1.2070.19
141_W238_D1.2040.19
102_A214_T1.1860.19
293_G325_V1.1800.19
136_V322_M1.1720.19
300_V310_A1.1710.19
281_T358_D1.1690.19
111_A167_A1.1650.19
207_H387_Q1.1590.18
298_V312_V1.1560.18
110_T366_H1.1500.18
341_N376_F1.1440.18
148_N265_A1.1430.18
338_L373_G1.1420.18
141_W263_V1.1400.18
113_V168_E1.1370.18
180_A261_P1.1300.18
275_V356_V1.1300.18
192_E325_V1.1290.18
234_L275_V1.1220.18
120_Y187_S1.1170.18
120_Y346_K1.1050.17
218_I331_D1.1040.17
136_V364_D1.1040.17
254_H356_V1.1000.17
103_L116_R1.0990.17
170_E302_D1.0980.17
199_V335_I1.0920.17
128_A134_T1.0910.17
100_L159_L1.0760.17
115_I307_T1.0760.17
279_V368_F1.0750.17
136_V192_E1.0750.17
246_M346_K1.0680.17
281_T331_D1.0670.17
215_I308_R1.0660.17
173_F183_V1.0590.16
141_W260_S1.0590.16
290_A373_G1.0550.16
172_A296_D1.0550.16
208_L261_P1.0550.16
321_P386_E1.0440.16
142_T215_I1.0350.16
150_I163_V1.0310.16
255_A262_Y1.0260.16
281_T287_K1.0260.16
143_I265_A1.0250.16
86_G90_L1.0250.16
214_T364_D1.0230.16
238_D257_T1.0190.16
198_S233_S1.0170.16
106_G214_T1.0170.16
126_A218_I1.0130.16
263_V376_F1.0120.16
160_V235_L1.0060.16
249_G379_A1.0040.16
93_D102_A1.0010.15
152_R252_F1.0000.15
174_E296_D0.9860.15
258_A346_K0.9800.15
137_V235_L0.9800.15
258_A349_T0.9800.15
155_E229_V0.9770.15
146_L150_I0.9760.15
143_I157_T0.9760.15
213_A265_A0.9750.15
148_N161_A0.9740.15
84_G87_T0.9720.15
132_D328_E0.9710.15
141_W376_F0.9700.15
304_D335_I0.9640.15
171_T196_T0.9630.15
309_S387_Q0.9630.15
117_D180_A0.9620.15
248_R373_G0.9610.15
113_V167_A0.9600.15
327_A367_V0.9580.15
251_F319_K0.9560.15
208_L274_A0.9540.15
345_I376_F0.9520.15
95_S166_A0.9520.15
277_A337_T0.9440.15
168_E289_L0.9420.14
139_D387_Q0.9410.14
126_A294_S0.9380.14
164_E334_R0.9260.14
154_G284_G0.9220.14
171_T247_S0.9130.14
168_E173_F0.9120.14
174_E277_A0.9110.14
260_S355_A0.9080.14
160_V229_V0.9080.14
142_T307_T0.9050.14
83_E86_G0.9040.14
229_V234_L0.9020.14
104_R209_A0.8930.14
263_V341_N0.8920.14
130_V207_H0.8920.14
234_L303_G0.8850.14
138_G376_F0.8850.14
125_Q300_V0.8810.14
200_R299_Q0.8810.14
260_S263_V0.8800.13
352_G368_F0.8780.13
102_A236_A0.8780.13
108_A114_R0.8780.13
142_T238_D0.8770.13
333_D369_L0.8660.13
232_G252_F0.8660.13
91_P315_A0.8560.13
142_T365_L0.8560.13
131_A250_L0.8530.13
91_P168_E0.8510.13
206_E368_F0.8490.13
102_A156_E0.8480.13
148_N348_A0.8440.13
259_Q379_A0.8410.13
113_V184_L0.8350.13
254_H344_T0.8320.13
254_H343_E0.8320.13
254_H342_A0.8320.13
216_T326_E0.8230.13
111_A302_D0.8230.13
148_N259_Q0.8230.13
140_D291_E0.8220.13
157_T265_A0.8210.13
165_S322_M0.8180.13
148_N263_V0.8180.13
185_L347_V0.8160.13
141_W253_V0.8120.12
250_L317_I0.8080.12
231_T274_A0.8070.12
110_T185_L0.8040.12
105_R219_E0.8030.12
311_V372_G0.8010.12
174_E341_N0.8000.12
156_E215_I0.7990.12
186_D346_K0.7990.12
91_P95_S0.7910.12
159_L352_G0.7910.12
146_L231_T0.7910.12
93_D106_G0.7890.12
259_Q263_V0.7870.12
247_S373_G0.7870.12
250_L280_R0.7850.12
157_T300_V0.7850.12
92_A303_G0.7790.12
252_F322_M0.7760.12
136_V165_S0.7730.12
91_P113_V0.7720.12
156_E352_G0.7710.12
190_P380_I0.7700.12
170_E293_G0.7700.12
127_A142_T0.7690.12
259_Q264_A0.7670.12
201_D204_D0.7670.12
208_L355_A0.7650.12
148_N260_S0.7640.12
143_I255_A0.7600.12
224_A299_Q0.7560.12
154_G217_T0.7550.12
250_L336_E0.7540.12
95_S214_T0.7470.12
250_L265_A0.7450.12
98_A129_E0.7440.12
158_T303_G0.7430.12
349_T355_A0.7420.12
138_G343_E0.7400.11
138_G344_T0.7400.11
138_G342_A0.7400.11
287_K347_V0.7390.11
255_A349_T0.7370.11
152_R380_I0.7360.11
225_D370_Q0.7360.11
97_S206_E0.7340.11
254_H325_V0.7330.11
96_G188_D0.7320.11
374_R382_E0.7310.11
94_F99_D0.7300.11
379_A384_I0.7280.11
234_L261_P0.7270.11
149_L253_V0.7250.11
251_F327_A0.7250.11
180_A255_A0.7240.11
128_A183_V0.7190.11
223_S246_M0.7190.11
99_D296_D0.7180.11
238_D326_E0.7150.11
216_T381_D0.7110.11
192_E233_S0.7100.11
232_G255_A0.7090.11
349_T357_T0.7080.11
182_A382_E0.7070.11
154_G209_A0.7060.11
356_V373_G0.7010.11
94_F368_F0.6990.11
170_E209_A0.6960.11
207_H219_E0.6940.11
170_E173_F0.6930.11
123_F162_G0.6920.11
160_V262_Y0.6910.11
246_M284_G0.6910.11
106_G132_D0.6900.11
121_E141_W0.6900.11
199_V380_I0.6880.11
165_S358_D0.6850.11
152_R157_T0.6800.11
227_V275_V0.6780.11
193_I215_I0.6760.11
209_A229_V0.6750.11
125_Q299_Q0.6730.11
93_D123_F0.6730.11
112_Y137_V0.6720.11
215_I251_F0.6710.11
106_G380_I0.6690.11
148_N376_F0.6690.11
348_A384_I0.6680.11
235_L287_K0.6650.11
150_I363_D0.6650.11
274_A331_D0.6640.11
113_V124_A0.6610.10
121_E376_F0.6590.10
252_F368_F0.6580.10
198_S334_R0.6540.10
120_Y261_P0.6510.10
223_S315_A0.6460.10
217_T243_V0.6450.10
170_E306_R0.6440.10
168_E365_L0.6440.10
121_E341_N0.6410.10
215_I311_V0.6410.10
99_D112_Y0.6400.10
329_T369_L0.6400.10
257_T323_F0.6400.10
118_E323_F0.6390.10
351_N359_L0.6370.10
217_T247_S0.6360.10
111_A116_R0.6340.10
213_A310_A0.6320.10
243_V301_V0.6310.10
159_L219_E0.6310.10
224_A322_M0.6300.10
132_D198_S0.6250.10
134_T304_D0.6250.10
236_A302_D0.6250.10
87_T90_L0.6230.10
227_V317_I0.6230.10
134_T380_I0.6220.10
163_V282_P0.6210.10
373_G379_A0.6210.10
166_A283_D0.6190.10
259_Q265_A0.6170.10
270_V339_L0.6150.10
105_R127_A0.6140.10
153_I257_T0.6110.10
85_D91_P0.6100.10
131_A265_A0.6100.10
102_A126_A0.6100.10
163_V178_I0.6090.10
152_R257_T0.6090.10
112_Y296_D0.6070.10
235_L345_I0.6070.10
134_T238_D0.6010.10
102_A202_A0.6000.10
143_I171_T0.6000.10
136_V178_I0.5950.10
175_T263_V0.5940.10
173_F385_I0.5940.10
102_A130_V0.5910.10
168_E270_V0.5900.10
141_W254_H0.5900.10
106_G130_V0.5870.10
231_T300_V0.5840.10
185_L243_V0.5840.10
229_V289_L0.5820.10
173_F229_V0.5800.10
115_I229_V0.5800.10
115_I264_A0.5790.10
234_L315_A0.5780.09
317_I338_L0.5770.09
162_G166_A0.5750.09
243_V311_V0.5740.09
97_S387_Q0.5680.09
95_S104_R0.5670.09
171_T380_I0.5670.09
191_D378_E0.5670.09
130_V215_I0.5660.09
307_T338_L0.5660.09
215_I294_S0.5650.09
162_G187_S0.5610.09
120_Y186_D0.5610.09
153_I224_A0.5600.09
275_V282_P0.5590.09
165_S327_A0.5580.09
227_V370_Q0.5570.09
296_D341_N0.5530.09
220_E257_T0.5520.09
141_W355_A0.5520.09
187_S387_Q0.5490.09
133_H247_S0.5480.09
170_E360_S0.5460.09
189_D279_V0.5460.09
134_T208_L0.5460.09
235_L259_Q0.5450.09
174_E336_E0.5400.09
177_D311_V0.5400.09
219_E279_V0.5390.09
137_V277_A0.5380.09
173_F349_T0.5380.09
355_A376_F0.5380.09
163_V231_T0.5360.09
94_F167_A0.5360.09
204_D215_I0.5350.09
199_V352_G0.5350.09
169_A359_L0.5320.09
161_A227_V0.5310.09
222_G273_G0.5300.09
189_D218_I0.5290.09
150_I178_I0.5290.09
96_G364_D0.5290.09
296_D363_D0.5290.09
202_A371_D0.5280.09
171_T175_T0.5270.09
121_E343_E0.5250.09
121_E342_A0.5250.09
121_E344_T0.5250.09
217_T334_R0.5190.09
211_S351_N0.5190.09
153_I384_I0.5180.09
98_A103_L0.5170.09
205_R309_S0.5170.09
156_E206_E0.5160.09
84_G97_S0.5150.09
173_F209_A0.5150.09
165_S380_I0.5120.09
263_V355_A0.5110.09
292_L366_H0.5110.09
217_T306_R0.5090.09
148_N213_A0.5070.09
249_G263_V0.5060.09
255_A323_F0.5060.09
234_L319_K0.5040.09
162_G186_D0.5020.09
153_I182_A0.5020.09
172_A263_V0.5010.09
198_S331_D0.5000.09
130_V387_Q0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1at0A 2 0.2868 96.5 0.959 Contact Map
2imzA 2 0.2429 95.6 0.962 Contact Map
2in0A 1 0.2791 95.6 0.962 Contact Map
2lwyA 1 0.2739 94.5 0.964 Contact Map
1dfaA 1 0.2713 94.2 0.965 Contact Map
4kl5A 2 0.292 94.2 0.965 Contact Map
3nzmA 1 0.2972 94.2 0.965 Contact Map
2w6rA 1 0.4315 94.1 0.965 Contact Map
1am2A 2 0.2687 93.6 0.966 Contact Map
4o1rA 2 0.2868 93.5 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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