GREMLIN Database
AROD - 3-dehydroquinate dehydratase
UniProt: Q9HSB4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (208)
Sequences: 1350 (1079)
Seq/√Len: 74.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_L116_V4.0771.00
200_A218_L3.3481.00
32_M53_A3.2951.00
121_D124_G3.2801.00
164_T176_T3.2661.00
78_A108_A3.0211.00
131_M147_L2.9201.00
151_P178_G2.7501.00
175_A197_L2.5231.00
128_L166_E2.5071.00
66_D69_D2.4681.00
199_Y208_T2.3721.00
165_H169_A2.3651.00
55_N64_A2.0641.00
120_H179_M2.0081.00
24_H49_L2.0071.00
52_L85_A1.9901.00
57_A70_R1.9791.00
53_A77_A1.8641.00
155_G165_H1.8591.00
214_A217_A1.8391.00
139_C167_Y1.8171.00
145_G172_M1.8091.00
128_L162_R1.8091.00
148_A177_M1.8091.00
85_A116_V1.7991.00
139_C172_M1.7961.00
179_M209_A1.7961.00
27_L197_L1.7491.00
28_V46_D1.7401.00
122_F179_M1.6991.00
131_M163_V1.6941.00
114_T143_D1.6591.00
122_F150_T1.6461.00
128_L159_D1.6461.00
90_R117_V1.6451.00
120_H209_A1.6441.00
209_A212_Q1.6431.00
217_A220_A1.6331.00
151_P157_A1.6291.00
157_A178_G1.6281.00
10_A13_G1.6221.00
181_D184_R1.6171.00
221_L224_D1.6070.99
164_T177_M1.5990.99
60_E91_S1.5900.99
119_A134_L1.5690.99
151_P182_L1.5330.99
75_A103_E1.5220.99
54_T120_H1.4980.99
190_T195_S1.4840.99
131_M149_V1.4700.99
132_A163_V1.4580.99
108_A113_T1.4560.99
135_L176_T1.4450.99
120_H212_Q1.4180.99
164_T174_V1.4050.99
120_H187_R1.3960.99
162_R166_E1.3820.98
25_V215_P1.3770.98
109_R143_D1.3630.98
160_V178_G1.3530.98
54_T87_D1.3440.98
149_V160_V1.3350.98
161_I193_Y1.3280.98
157_A186_T1.3180.98
53_A83_V1.3170.98
67_G93_L1.3150.98
87_D120_H1.3030.98
10_A15_L1.2780.97
77_A86_V1.2720.97
50_P144_V1.2720.97
68_G72_D1.2620.97
85_A144_V1.2530.97
24_H219_Q1.2400.97
75_A107_A1.2230.97
34_L63_A1.2180.97
132_A166_E1.2140.96
54_T89_E1.2130.96
160_V176_T1.2050.96
25_V49_L1.2010.96
190_T208_T1.1900.96
160_V186_T1.1800.96
158_L165_H1.1630.95
188_A221_L1.1630.95
15_L18_A1.1520.95
178_G186_T1.1520.95
85_A114_T1.1440.95
17_A42_L1.1420.95
54_T179_M1.1420.95
127_S130_A1.1180.94
65_A69_D1.1080.94
41_A46_D1.1070.94
148_A179_M1.1020.94
184_R188_A1.1020.94
67_G70_R1.0980.94
31_R54_T1.0880.94
108_A111_T1.0850.93
148_A209_A1.0800.93
105_L115_T1.0790.93
213_Y218_L1.0590.93
90_R138_A1.0450.92
187_R209_A1.0170.91
117_V138_A1.0100.91
25_V202_V1.0080.91
52_L81_D1.0020.90
143_D173_T0.9900.90
131_M135_L0.9730.89
38_P46_D0.9670.89
21_A49_L0.9640.89
155_G169_A0.9610.88
79_R107_A0.9600.88
70_R92_A0.9580.88
27_L50_P0.9570.88
74_L86_V0.9540.88
36_A46_D0.9520.88
50_P173_T0.9470.88
67_G71_I0.9370.87
150_T179_M0.9280.87
94_V137_E0.9240.86
87_D212_Q0.9200.86
20_A25_V0.9190.86
32_M74_L0.9100.86
179_M187_R0.9000.85
78_A111_T0.8990.85
119_A147_L0.8980.85
58_D63_A0.8910.84
25_V219_Q0.8860.84
132_A136_G0.8850.84
185_H189_V0.8820.84
87_D209_A0.8810.84
122_F210_P0.8780.84
220_A224_D0.8780.84
60_E119_A0.8760.83
89_E120_H0.8680.83
56_R89_E0.8640.83
69_D72_D0.8570.82
158_L192_L0.8550.82
164_T195_S0.8550.82
105_L117_V0.8520.82
91_S134_L0.8480.81
70_R74_L0.8460.81
179_M211_G0.8460.81
176_T193_Y0.8430.81
78_A88_I0.8360.80
30_F208_T0.8330.80
61_G89_E0.8290.80
31_R89_E0.8250.80
137_E155_G0.8240.79
122_F148_A0.8210.79
57_A60_E0.8210.79
139_C145_G0.8210.79
153_D182_L0.8150.79
36_A76_E0.8130.79
14_D30_F0.8130.79
72_D76_E0.8130.79
71_I100_D0.8120.78
11_S15_L0.8070.78
156_D159_D0.8060.78
125_T156_D0.8030.78
167_Y172_M0.7990.77
161_I164_T0.7960.77
122_F209_A0.7930.77
83_V113_T0.7930.77
53_A74_L0.7910.77
23_E202_V0.7880.76
76_E79_R0.7870.76
20_A24_H0.7870.76
51_V167_Y0.7840.76
136_G139_C0.7840.76
75_A79_R0.7830.76
54_T187_R0.7730.75
10_A18_A0.7700.75
29_E33_D0.7690.75
148_A151_P0.7550.73
220_A223_A0.7500.73
38_P42_L0.7480.73
77_A82_C0.7470.72
107_A111_T0.7460.72
188_A213_Y0.7410.72
55_N73_A0.7360.71
124_G140_S0.7300.71
157_A182_L0.7180.69
144_V195_S0.7110.69
62_G89_E0.7110.69
94_V102_A0.7080.68
90_R137_E0.7030.68
22_P221_L0.7020.68
121_D179_M0.6950.67
134_L138_A0.6940.67
160_V177_M0.6890.66
103_E106_A0.6860.66
116_V175_A0.6840.66
148_A157_A0.6780.65
54_T209_A0.6740.65
164_T193_Y0.6730.64
37_D40_A0.6710.64
157_A163_V0.6700.64
42_L66_D0.6690.64
87_D179_M0.6670.64
77_A83_V0.6660.64
120_H146_K0.6630.63
121_D134_L0.6600.63
148_A190_T0.6590.63
31_R56_R0.6550.62
122_F212_Q0.6540.62
36_A72_D0.6520.62
147_L159_D0.6500.62
162_R165_H0.6410.61
189_V222_I0.6390.60
11_S41_A0.6360.60
179_M212_Q0.6360.60
149_V157_A0.6350.60
60_E208_T0.6340.60
151_P156_D0.6300.59
106_A116_V0.6300.59
187_R212_Q0.6270.59
179_M210_P0.6260.59
131_M159_D0.6260.59
133_D136_G0.6230.58
63_A186_T0.6220.58
122_F125_T0.6210.58
145_G175_A0.6200.58
191_P201_P0.6200.58
86_V153_D0.6190.58
183_G198_G0.6160.58
177_M190_T0.6080.57
129_S140_S0.6060.56
136_G170_A0.6060.56
215_P219_Q0.6040.56
24_H216_A0.6030.56
130_A133_D0.6030.56
201_P207_T0.6010.56
38_P45_Y0.6010.56
106_A110_S0.6000.56
181_D224_D0.5990.56
71_I75_A0.5980.55
204_D207_T0.5960.55
32_M55_N0.5940.55
55_N70_R0.5910.55
93_L100_D0.5910.55
175_A199_Y0.5890.54
75_A94_V0.5880.54
26_D219_Q0.5860.54
136_G140_S0.5850.54
74_L78_A0.5830.54
108_A115_T0.5820.53
50_P208_T0.5810.53
213_Y224_D0.5790.53
25_V34_L0.5780.53
118_S145_G0.5750.53
56_R61_G0.5740.52
13_G17_A0.5730.52
189_V192_L0.5720.52
133_D137_E0.5720.52
58_D217_A0.5690.52
164_T194_G0.5670.52
155_G219_Q0.5660.51
147_L200_A0.5660.51
142_G145_G0.5650.51
145_G174_V0.5620.51
75_A104_A0.5620.51
120_H211_G0.5610.51
116_V144_V0.5610.51
149_V178_G0.5600.51
67_G101_G0.5590.51
60_E88_I0.5590.51
55_N77_A0.5590.51
38_P43_D0.5550.50
39_L77_A0.5540.50
104_A108_A0.5540.50
174_V190_T0.5540.50
150_T178_G0.5530.50
28_V51_V0.5520.50
50_P190_T0.5510.50
30_F39_L0.5470.49
118_S146_K0.5460.49
57_A117_V0.5460.49
158_L161_I0.5440.49
125_T178_G0.5410.48
52_L138_A0.5350.48
125_T179_M0.5350.48
38_P77_A0.5340.47
14_D39_L0.5330.47
16_G203_A0.5330.47
27_L106_A0.5320.47
11_S14_D0.5320.47
121_D125_T0.5310.47
14_D45_Y0.5300.47
191_P222_I0.5300.47
120_H177_M0.5290.47
79_R111_T0.5280.47
58_D220_A0.5270.47
19_P22_P0.5270.47
43_D46_D0.5260.46
149_V164_T0.5230.46
86_V142_G0.5220.46
57_A61_G0.5190.46
200_A214_A0.5180.45
161_I190_T0.5160.45
135_L163_V0.5130.45
136_G155_G0.5130.45
194_G212_Q0.5120.45
61_G118_S0.5120.45
26_D60_E0.5110.45
12_T18_A0.5090.44
216_A221_L0.5070.44
157_A185_H0.5050.44
36_A95_D0.5040.44
188_A224_D0.5030.44
168_S174_V0.5010.43
147_L193_Y0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cnnA 2 0.9558 100 0.142 Contact Map
4h3dA 2 0.9735 100 0.151 Contact Map
4ph6A 2 0.9292 100 0.156 Contact Map
3l9cA 1 0.9336 100 0.195 Contact Map
1sflA 2 0.9646 100 0.196 Contact Map
2oczA 2 0.9159 100 0.203 Contact Map
2o7sA 2 0.9602 100 0.216 Contact Map
2egzA 1 0.9071 100 0.226 Contact Map
2yr1A 2 0.9646 100 0.237 Contact Map
2ox1A 2 0.8584 100 0.248 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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