Q9HSB2 - HALSA - GREMLIN Contacts

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Q9HSB2 - Uncharacterized protein

UniProt:	Q9HSB2	Sequences: MRVVSLAPSATAVVTALGASDRLVGTTTHCDAPDTPAVGGWLTPDYDRVVDLDPDVVLTSDALQAEIRDALRSRGFDVHHTAPATLDDVLASFADIGDAVGRPDAGDALAADCRRRLAGVRDATPADGPTVYCEEWADPPMAAGNWVPDAVDAAGGHYPFVDAGARSREIDAAAVRVAAPDHVVVHICGAGRQTDADPVTRWDLDAAVHVVDDSLLNQPSPRLIDGIELLAGQLHAT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	237 (227)
Sequences:	13861 (10799)
Seq/√Len:	716.7

ECOLI - BTUF FECB FHUD FEPB
BACSU - YVRC YHFQ YFIY YFMC YCLQ FEUA FHUD YXEB BTR
HALSA - Q9HSB2 BTUFA Q9HMF9 Q9HMG8 Q9HPB0
SULSO - Q980Z0 Q97ZU2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
90_L	114_R	4.050	1.00
97_G	106_G	4.029	1.00
94_A	107_D	3.935	1.00
102_R	105_A	3.534	1.00
116_R	228_E	3.070	1.00
98_D	103_P	3.000	1.00
5_S	11_T	2.917	1.00
94_A	110_A	2.719	1.00
105_A	108_A	2.647	1.00
48_R	51_D	2.527	1.00
118_A	122_D	2.500	1.00
151_V	156_G	2.490	1.00
107_D	111_A	2.438	1.00
111_A	115_R	2.422	1.00
130_T	157_H	2.307	1.00
197_D	200_T	2.256	1.00
174_A	177_V	2.237	1.00
148_P	152_D	2.144	1.00
114_R	118_A	2.137	1.00
19_A	100_V	2.029	1.00
68_R	72_R	1.969	1.00
4_V	49_V	1.935	1.00
70_A	73_S	1.926	1.00
13_V	93_F	1.890	1.00
14_V	100_V	1.875	1.00
108_A	112_D	1.871	1.00
3_V	100_V	1.871	1.00
119_G	123_A	1.857	1.00
182_H	209_H	1.827	1.00
19_A	102_R	1.808	1.00
20_S	23_L	1.798	1.00
115_R	119_G	1.786	1.00
58_L	96_I	1.714	1.00
88_D	91_A	1.692	1.00
104_D	108_A	1.671	1.00
118_A	121_R	1.667	1.00
182_H	207_A	1.661	1.00
128_G	157_H	1.631	1.00
112_D	116_R	1.621	1.00
25_G	52_L	1.589	1.00
44_P	49_V	1.575	1.00
69_D	73_S	1.557	1.00
19_A	23_L	1.556	1.00
65_A	69_D	1.550	1.00
116_R	225_D	1.523	1.00
90_L	110_A	1.509	1.00
45_D	48_R	1.507	1.00
79_H	99_A	1.482	1.00
91_A	94_A	1.470	1.00
105_A	109_L	1.461	1.00
27_T	30_C	1.445	1.00
198_P	201_R	1.445	1.00
24_V	52_L	1.425	1.00
79_H	95_D	1.420	1.00
5_S	14_V	1.419	1.00
91_A	95_D	1.409	1.00
197_D	201_R	1.400	1.00
50_V	74_R	1.392	1.00
131_V	156_G	1.379	1.00
130_T	181_D	1.359	1.00
94_A	114_R	1.358	1.00
69_D	72_R	1.351	1.00
122_D	125_P	1.347	1.00
17_L	102_R	1.346	1.00
36_P	48_R	1.340	1.00
111_A	114_R	1.329	1.00
95_D	98_D	1.326	1.00
15_T	20_S	1.318	1.00
174_A	178_A	1.310	1.00
14_V	19_A	1.309	1.00
159_P	178_A	1.309	1.00
103_P	107_D	1.306	1.00
131_V	151_V	1.299	1.00
4_V	52_L	1.294	1.00
120_V	227_I	1.261	1.00
64_Q	67_I	1.248	1.00
109_L	112_D	1.229	1.00
129_P	182_H	1.218	1.00
93_F	106_G	1.216	1.00
117_L	227_I	1.212	1.00
47_D	173_A	1.208	1.00
193_Q	196_A	1.207	1.00
110_A	114_R	1.205	1.00
104_D	107_D	1.204	1.00
14_V	23_L	1.199	1.00
14_V	58_L	1.188	1.00
192_R	195_D	1.173	1.00
116_R	119_G	1.168	1.00
4_V	25_G	1.165	1.00
115_R	118_A	1.152	1.00
121_R	153_A	1.151	1.00
2_R	24_V	1.151	1.00
119_G	122_D	1.146	1.00
183_V	202_W	1.136	1.00
160_F	178_A	1.135	1.00
159_P	162_D	1.134	1.00
116_R	120_V	1.132	1.00
57_V	76_F	1.131	1.00
15_T	23_L	1.126	1.00
129_P	207_A	1.123	1.00
46_Y	70_A	1.118	1.00
67_I	70_A	1.111	1.00
121_R	125_P	1.102	1.00
184_V	230_L	1.087	1.00
133_C	151_V	1.081	1.00
112_D	115_R	1.077	1.00
97_G	110_A	1.076	1.00
81_T	95_D	1.068	1.00
119_G	228_E	1.062	1.00
56_V	79_H	1.045	1.00
95_D	99_A	1.029	1.00
117_L	121_R	1.029	1.00
162_D	178_A	1.029	1.00
16_A	109_L	1.023	1.00
36_P	39_G	1.022	1.00
157_H	161_V	1.019	1.00
17_L	109_L	1.018	1.00
149_D	153_A	1.013	1.00
26_T	37_A	1.001	1.00
92_S	95_D	0.993	1.00
149_D	152_D	0.988	1.00
94_A	98_D	0.983	1.00
50_V	76_F	0.971	1.00
59_T	80_H	0.970	1.00
132_Y	142_A	0.960	1.00
136_W	139_P	0.942	1.00
194_T	200_T	0.938	1.00
84_A	87_D	0.932	1.00
133_C	186_H	0.928	1.00
13_V	96_I	0.922	1.00
196_A	200_T	0.908	1.00
28_T	37_A	0.907	1.00
12_A	222_R	0.897	1.00
214_S	218_Q	0.894	1.00
160_F	174_A	0.892	1.00
2_R	53_D	0.884	1.00
132_Y	180_P	0.883	1.00
135_E	139_P	0.880	1.00
129_P	156_G	0.879	1.00
185_V	210_V	0.875	1.00
61_D	82_A	0.873	1.00
203_D	208_V	0.872	1.00
96_I	100_V	0.872	1.00
5_S	23_L	0.862	1.00
94_A	97_G	0.861	1.00
158_Y	162_D	0.856	1.00
109_L	113_C	0.856	1.00
113_C	153_A	0.855	1.00
160_F	163_A	0.853	1.00
192_R	196_A	0.851	1.00
113_C	117_L	0.850	1.00
5_S	10_A	0.847	1.00
75_G	78_V	0.847	1.00
10_A	58_L	0.846	1.00
133_C	147_V	0.841	1.00
184_V	209_H	0.839	1.00
85_T	88_D	0.839	1.00
215_L	229_L	0.839	1.00
117_L	153_A	0.838	1.00
145_N	148_P	0.836	1.00
23_L	35_T	0.831	1.00
120_V	124_T	0.831	1.00
194_T	198_P	0.824	1.00
58_L	99_A	0.823	1.00
225_D	229_L	0.817	1.00
176_R	180_P	0.814	1.00
212_D	215_L	0.809	1.00
3_V	56_V	0.805	1.00
140_P	144_G	0.802	1.00
185_V	208_V	0.800	1.00
96_I	99_A	0.797	1.00
107_D	110_A	0.794	1.00
57_V	74_R	0.792	1.00
87_D	91_A	0.791	1.00
120_V	224_I	0.787	1.00
90_L	113_C	0.783	1.00
17_L	100_V	0.777	1.00
130_T	159_P	0.772	1.00
222_R	225_D	0.770	1.00
171_D	174_A	0.769	1.00
66_E	69_D	0.769	1.00
129_P	133_C	0.769	1.00
90_L	94_A	0.768	1.00
90_L	117_L	0.767	1.00
106_G	110_A	0.765	1.00
89_V	113_C	0.761	1.00
17_L	105_A	0.758	1.00
116_R	224_I	0.753	1.00
7_A	60_S	0.752	1.00
194_T	197_D	0.752	1.00
57_V	78_V	0.750	1.00
108_A	111_A	0.749	1.00
150_A	227_I	0.747	1.00
212_D	229_L	0.746	1.00
81_T	92_S	0.745	1.00
26_T	35_T	0.743	1.00
146_W	149_D	0.730	1.00
56_V	99_A	0.730	1.00
113_C	224_I	0.729	1.00
134_E	183_V	0.728	1.00
3_V	14_V	0.727	1.00
202_W	206_A	0.727	1.00
87_D	90_L	0.722	1.00
12_A	220_S	0.717	1.00
188_C	213_D	0.716	1.00
126_A	129_P	0.716	1.00
148_P	158_Y	0.715	1.00
100_V	103_P	0.710	1.00
132_Y	175_V	0.706	1.00
170_I	178_A	0.703	1.00
72_R	78_V	0.700	1.00
93_F	109_L	0.691	1.00
89_V	93_F	0.691	1.00
49_V	71_L	0.690	1.00
110_A	113_C	0.689	1.00
32_A	222_R	0.687	1.00
139_P	169_E	0.687	1.00
142_A	160_F	0.687	1.00
219_P	222_R	0.682	1.00
10_A	13_V	0.681	1.00
35_T	39_G	0.679	1.00
18_G	102_R	0.679	1.00
195_D	198_P	0.675	1.00
57_V	71_L	0.671	1.00
87_D	114_R	0.670	1.00
14_V	96_I	0.665	1.00
17_L	93_F	0.665	1.00
158_Y	161_V	0.665	1.00
46_Y	74_R	0.664	1.00
6_L	57_V	0.664	1.00
17_L	106_G	0.663	1.00
46_Y	67_I	0.662	1.00
18_G	105_A	0.659	1.00
81_T	96_I	0.657	1.00
186_H	211_V	0.656	1.00
10_A	96_I	0.649	1.00
39_G	44_P	0.643	1.00
93_F	110_A	0.642	1.00
226_G	229_L	0.642	1.00
16_A	93_F	0.640	1.00
94_A	103_P	0.637	1.00
203_D	206_A	0.637	1.00
156_G	182_H	0.634	1.00
223_L	226_G	0.632	1.00
58_L	81_T	0.631	1.00
11_T	15_T	0.627	1.00
129_P	181_D	0.618	1.00
36_P	40_G	0.618	1.00
220_S	226_G	0.615	1.00
4_V	24_V	0.615	1.00
224_I	228_E	0.610	1.00
121_R	154_A	0.610	1.00
31_D	218_Q	0.608	1.00
54_P	57_V	0.608	1.00
40_G	43_T	0.607	1.00
141_M	144_G	0.606	1.00
117_L	120_V	0.606	1.00
5_S	26_T	0.604	1.00
17_L	97_G	0.602	1.00
219_P	226_G	0.601	1.00
121_R	124_T	0.600	1.00
123_A	228_E	0.594	1.00
6_L	38_V	0.594	1.00
20_S	34_D	0.593	1.00
11_T	30_C	0.592	1.00
131_V	134_E	0.591	1.00
89_V	223_L	0.591	1.00
59_T	68_R	0.588	1.00
120_V	154_A	0.587	1.00
44_P	67_I	0.585	1.00
76_F	81_T	0.583	1.00
132_Y	159_P	0.583	1.00
211_V	216_L	0.583	1.00
84_A	88_D	0.582	1.00
148_P	161_V	0.582	1.00
154_A	227_I	0.581	1.00
51_D	177_V	0.580	1.00
150_A	230_L	0.572	1.00
160_F	170_I	0.568	1.00
68_R	80_H	0.568	1.00
170_I	175_V	0.565	1.00
70_A	74_R	0.563	1.00
10_A	81_T	0.561	1.00
130_T	134_E	0.559	1.00
135_E	138_D	0.558	1.00
5_S	8_P	0.555	1.00
48_R	52_L	0.553	1.00
215_L	218_Q	0.552	1.00
214_S	217_N	0.548	1.00
120_V	123_A	0.548	1.00
217_N	220_S	0.548	1.00
47_D	50_V	0.547	1.00
71_L	78_V	0.546	1.00
4_V	38_V	0.546	1.00
179_A	204_L	0.545	1.00
142_A	170_I	0.543	1.00
113_C	116_R	0.542	1.00
8_P	11_T	0.541	1.00
187_I	210_V	0.541	1.00
38_V	52_L	0.538	1.00
58_L	79_H	0.537	1.00
65_A	68_R	0.536	1.00
13_V	16_A	0.534	1.00
28_T	32_A	0.533	1.00
11_T	26_T	0.533	1.00
90_L	153_A	0.533	1.00
140_P	143_A	0.532	1.00
97_G	102_R	0.532	1.00
8_P	29_H	0.530	1.00
46_Y	49_V	0.530	1.00
111_A	119_G	0.530	1.00
224_I	227_I	0.529	1.00
20_S	35_T	0.528	1.00
83_P	88_D	0.527	1.00
114_R	117_L	0.527	1.00
68_R	71_L	0.526	1.00
131_V	184_V	0.525	1.00
7_A	10_A	0.523	1.00
128_G	131_V	0.517	1.00
130_T	182_H	0.516	1.00
215_L	225_D	0.516	1.00
47_D	51_D	0.516	1.00
146_W	219_P	0.516	1.00
41_W	59_T	0.515	1.00
26_T	30_C	0.514	1.00
76_F	79_H	0.513	1.00
86_L	149_D	0.513	1.00
193_Q	197_D	0.511	1.00
150_A	223_L	0.511	1.00
220_S	225_D	0.510	1.00
117_L	224_I	0.510	1.00
132_Y	183_V	0.508	0.99
47_D	171_D	0.507	0.99
72_R	77_D	0.507	0.99
8_P	32_A	0.507	0.99
219_P	224_I	0.505	0.99
17_L	96_I	0.505	0.99
86_L	89_V	0.501	0.99
103_P	106_G	0.501	0.99
50_V	173_A	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4m7oA	1	0.9873	100	0.224	Contact Map
3md9A	1	0.9873	100	0.225	Contact Map
4hn9A	1	0.9958	100	0.229	Contact Map
2r79A	5	0.9916	100	0.23	Contact Map
2r7aA	2	0.9916	100	0.233	Contact Map
2q8pA	1	0.9873	100	0.238	Contact Map
4pagA	2	0.9958	100	0.246	Contact Map
4mlzA	1	0.9831	100	0.247	Contact Map
3pshA	1	1	100	0.252	Contact Map
4ovkA	1	0.9916	100	0.255	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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