GREMLIN Database
Q9HSB2 - Uncharacterized protein
UniProt: Q9HSB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (227)
Sequences: 13861 (10799)
Seq/√Len: 716.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_L114_R4.0501.00
97_G106_G4.0291.00
94_A107_D3.9351.00
102_R105_A3.5341.00
116_R228_E3.0701.00
98_D103_P3.0001.00
5_S11_T2.9171.00
94_A110_A2.7191.00
105_A108_A2.6471.00
48_R51_D2.5271.00
118_A122_D2.5001.00
151_V156_G2.4901.00
107_D111_A2.4381.00
111_A115_R2.4221.00
130_T157_H2.3071.00
197_D200_T2.2561.00
174_A177_V2.2371.00
148_P152_D2.1441.00
114_R118_A2.1371.00
19_A100_V2.0291.00
68_R72_R1.9691.00
4_V49_V1.9351.00
70_A73_S1.9261.00
13_V93_F1.8901.00
14_V100_V1.8751.00
108_A112_D1.8711.00
3_V100_V1.8711.00
119_G123_A1.8571.00
182_H209_H1.8271.00
19_A102_R1.8081.00
20_S23_L1.7981.00
115_R119_G1.7861.00
58_L96_I1.7141.00
88_D91_A1.6921.00
104_D108_A1.6711.00
118_A121_R1.6671.00
182_H207_A1.6611.00
128_G157_H1.6311.00
112_D116_R1.6211.00
25_G52_L1.5891.00
44_P49_V1.5751.00
69_D73_S1.5571.00
19_A23_L1.5561.00
65_A69_D1.5501.00
116_R225_D1.5231.00
90_L110_A1.5091.00
45_D48_R1.5071.00
79_H99_A1.4821.00
91_A94_A1.4701.00
105_A109_L1.4611.00
27_T30_C1.4451.00
198_P201_R1.4451.00
24_V52_L1.4251.00
79_H95_D1.4201.00
5_S14_V1.4191.00
91_A95_D1.4091.00
197_D201_R1.4001.00
50_V74_R1.3921.00
131_V156_G1.3791.00
130_T181_D1.3591.00
94_A114_R1.3581.00
69_D72_R1.3511.00
122_D125_P1.3471.00
17_L102_R1.3461.00
36_P48_R1.3401.00
111_A114_R1.3291.00
95_D98_D1.3261.00
15_T20_S1.3181.00
174_A178_A1.3101.00
14_V19_A1.3091.00
159_P178_A1.3091.00
103_P107_D1.3061.00
131_V151_V1.2991.00
4_V52_L1.2941.00
120_V227_I1.2611.00
64_Q67_I1.2481.00
109_L112_D1.2291.00
129_P182_H1.2181.00
93_F106_G1.2161.00
117_L227_I1.2121.00
47_D173_A1.2081.00
193_Q196_A1.2071.00
110_A114_R1.2051.00
104_D107_D1.2041.00
14_V23_L1.1991.00
14_V58_L1.1881.00
192_R195_D1.1731.00
116_R119_G1.1681.00
4_V25_G1.1651.00
115_R118_A1.1521.00
121_R153_A1.1511.00
2_R24_V1.1511.00
119_G122_D1.1461.00
183_V202_W1.1361.00
160_F178_A1.1351.00
159_P162_D1.1341.00
116_R120_V1.1321.00
57_V76_F1.1311.00
15_T23_L1.1261.00
129_P207_A1.1231.00
46_Y70_A1.1181.00
67_I70_A1.1111.00
121_R125_P1.1021.00
184_V230_L1.0871.00
133_C151_V1.0811.00
112_D115_R1.0771.00
97_G110_A1.0761.00
81_T95_D1.0681.00
119_G228_E1.0621.00
56_V79_H1.0451.00
95_D99_A1.0291.00
117_L121_R1.0291.00
162_D178_A1.0291.00
16_A109_L1.0231.00
36_P39_G1.0221.00
157_H161_V1.0191.00
17_L109_L1.0181.00
149_D153_A1.0131.00
26_T37_A1.0011.00
92_S95_D0.9931.00
149_D152_D0.9881.00
94_A98_D0.9831.00
50_V76_F0.9711.00
59_T80_H0.9701.00
132_Y142_A0.9601.00
136_W139_P0.9421.00
194_T200_T0.9381.00
84_A87_D0.9321.00
133_C186_H0.9281.00
13_V96_I0.9221.00
196_A200_T0.9081.00
28_T37_A0.9071.00
12_A222_R0.8971.00
214_S218_Q0.8941.00
160_F174_A0.8921.00
2_R53_D0.8841.00
132_Y180_P0.8831.00
135_E139_P0.8801.00
129_P156_G0.8791.00
185_V210_V0.8751.00
61_D82_A0.8731.00
203_D208_V0.8721.00
96_I100_V0.8721.00
5_S23_L0.8621.00
94_A97_G0.8611.00
158_Y162_D0.8561.00
109_L113_C0.8561.00
113_C153_A0.8551.00
160_F163_A0.8531.00
192_R196_A0.8511.00
113_C117_L0.8501.00
5_S10_A0.8471.00
75_G78_V0.8471.00
10_A58_L0.8461.00
133_C147_V0.8411.00
184_V209_H0.8391.00
85_T88_D0.8391.00
215_L229_L0.8391.00
117_L153_A0.8381.00
145_N148_P0.8361.00
23_L35_T0.8311.00
120_V124_T0.8311.00
194_T198_P0.8241.00
58_L99_A0.8231.00
225_D229_L0.8171.00
176_R180_P0.8141.00
212_D215_L0.8091.00
3_V56_V0.8051.00
140_P144_G0.8021.00
185_V208_V0.8001.00
96_I99_A0.7971.00
107_D110_A0.7941.00
57_V74_R0.7921.00
87_D91_A0.7911.00
120_V224_I0.7871.00
90_L113_C0.7831.00
17_L100_V0.7771.00
130_T159_P0.7721.00
222_R225_D0.7701.00
171_D174_A0.7691.00
66_E69_D0.7691.00
129_P133_C0.7691.00
90_L94_A0.7681.00
90_L117_L0.7671.00
106_G110_A0.7651.00
89_V113_C0.7611.00
17_L105_A0.7581.00
116_R224_I0.7531.00
7_A60_S0.7521.00
194_T197_D0.7521.00
57_V78_V0.7501.00
108_A111_A0.7491.00
150_A227_I0.7471.00
212_D229_L0.7461.00
81_T92_S0.7451.00
26_T35_T0.7431.00
146_W149_D0.7301.00
56_V99_A0.7301.00
113_C224_I0.7291.00
134_E183_V0.7281.00
3_V14_V0.7271.00
202_W206_A0.7271.00
87_D90_L0.7221.00
12_A220_S0.7171.00
188_C213_D0.7161.00
126_A129_P0.7161.00
148_P158_Y0.7151.00
100_V103_P0.7101.00
132_Y175_V0.7061.00
170_I178_A0.7031.00
72_R78_V0.7001.00
93_F109_L0.6911.00
89_V93_F0.6911.00
49_V71_L0.6901.00
110_A113_C0.6891.00
32_A222_R0.6871.00
139_P169_E0.6871.00
142_A160_F0.6871.00
219_P222_R0.6821.00
10_A13_V0.6811.00
35_T39_G0.6791.00
18_G102_R0.6791.00
195_D198_P0.6751.00
57_V71_L0.6711.00
87_D114_R0.6701.00
14_V96_I0.6651.00
17_L93_F0.6651.00
158_Y161_V0.6651.00
46_Y74_R0.6641.00
6_L57_V0.6641.00
17_L106_G0.6631.00
46_Y67_I0.6621.00
18_G105_A0.6591.00
81_T96_I0.6571.00
186_H211_V0.6561.00
10_A96_I0.6491.00
39_G44_P0.6431.00
93_F110_A0.6421.00
226_G229_L0.6421.00
16_A93_F0.6401.00
94_A103_P0.6371.00
203_D206_A0.6371.00
156_G182_H0.6341.00
223_L226_G0.6321.00
58_L81_T0.6311.00
11_T15_T0.6271.00
129_P181_D0.6181.00
36_P40_G0.6181.00
220_S226_G0.6151.00
4_V24_V0.6151.00
224_I228_E0.6101.00
121_R154_A0.6101.00
31_D218_Q0.6081.00
54_P57_V0.6081.00
40_G43_T0.6071.00
141_M144_G0.6061.00
117_L120_V0.6061.00
5_S26_T0.6041.00
17_L97_G0.6021.00
219_P226_G0.6011.00
121_R124_T0.6001.00
123_A228_E0.5941.00
6_L38_V0.5941.00
20_S34_D0.5931.00
11_T30_C0.5921.00
131_V134_E0.5911.00
89_V223_L0.5911.00
59_T68_R0.5881.00
120_V154_A0.5871.00
44_P67_I0.5851.00
76_F81_T0.5831.00
132_Y159_P0.5831.00
211_V216_L0.5831.00
84_A88_D0.5821.00
148_P161_V0.5821.00
154_A227_I0.5811.00
51_D177_V0.5801.00
150_A230_L0.5721.00
160_F170_I0.5681.00
68_R80_H0.5681.00
170_I175_V0.5651.00
70_A74_R0.5631.00
10_A81_T0.5611.00
130_T134_E0.5591.00
135_E138_D0.5581.00
5_S8_P0.5551.00
48_R52_L0.5531.00
215_L218_Q0.5521.00
214_S217_N0.5481.00
120_V123_A0.5481.00
217_N220_S0.5481.00
47_D50_V0.5471.00
71_L78_V0.5461.00
4_V38_V0.5461.00
179_A204_L0.5451.00
142_A170_I0.5431.00
113_C116_R0.5421.00
8_P11_T0.5411.00
187_I210_V0.5411.00
38_V52_L0.5381.00
58_L79_H0.5371.00
65_A68_R0.5361.00
13_V16_A0.5341.00
28_T32_A0.5331.00
11_T26_T0.5331.00
90_L153_A0.5331.00
140_P143_A0.5321.00
97_G102_R0.5321.00
8_P29_H0.5301.00
46_Y49_V0.5301.00
111_A119_G0.5301.00
224_I227_I0.5291.00
20_S35_T0.5281.00
83_P88_D0.5271.00
114_R117_L0.5271.00
68_R71_L0.5261.00
131_V184_V0.5251.00
7_A10_A0.5231.00
128_G131_V0.5171.00
130_T182_H0.5161.00
215_L225_D0.5161.00
47_D51_D0.5161.00
146_W219_P0.5161.00
41_W59_T0.5151.00
26_T30_C0.5141.00
76_F79_H0.5131.00
86_L149_D0.5131.00
193_Q197_D0.5111.00
150_A223_L0.5111.00
220_S225_D0.5101.00
117_L224_I0.5101.00
132_Y183_V0.5080.99
47_D171_D0.5070.99
72_R77_D0.5070.99
8_P32_A0.5070.99
219_P224_I0.5050.99
17_L96_I0.5050.99
86_L89_V0.5010.99
103_P106_G0.5010.99
50_V173_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m7oA 1 0.9873 100 0.224 Contact Map
3md9A 1 0.9873 100 0.225 Contact Map
4hn9A 1 0.9958 100 0.229 Contact Map
2r79A 5 0.9916 100 0.23 Contact Map
2r7aA 2 0.9916 100 0.233 Contact Map
2q8pA 1 0.9873 100 0.238 Contact Map
4pagA 2 0.9958 100 0.246 Contact Map
4mlzA 1 0.9831 100 0.247 Contact Map
3pshA 1 1 100 0.252 Contact Map
4ovkA 1 0.9916 100 0.255 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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