GREMLIN Database
Q9HSB0 - Uncharacterized protein
UniProt: Q9HSB0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 80 (72)
Sequences: 142 (83)
Seq/√Len: 9.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_A72_S2.4510.82
41_L70_S2.3110.78
12_T20_S2.2220.75
16_H78_A1.8610.60
63_D78_A1.8080.58
13_P78_A1.7860.57
35_R76_K1.6120.49
7_A55_I1.6060.49
33_K69_Y1.5920.48
55_I64_V1.4780.43
48_V51_N1.4580.42
12_T21_Y1.4500.42
61_D77_V1.4450.42
57_D63_D1.4360.41
35_R68_G1.4360.41
52_M71_S1.4330.41
14_K47_E1.4160.40
23_Q61_D1.3960.40
20_S57_D1.3930.39
47_E71_S1.3760.39
51_N70_S1.3360.37
17_R66_R1.3250.37
17_R39_D1.3110.36
18_I48_V1.2540.34
48_V70_S1.2450.33
15_Q58_A1.2100.32
66_R71_S1.2080.32
32_F37_I1.1850.31
44_S61_D1.1790.31
30_T71_S1.1580.30
10_T39_D1.1370.29
23_Q62_L1.1350.29
9_R42_D1.1130.28
8_S27_D1.1080.28
33_K47_E1.1030.28
52_M57_D1.0990.28
38_G50_A1.0970.28
62_L76_K1.0650.26
33_K51_N1.0530.26
38_G72_S1.0520.26
15_Q51_N1.0410.26
9_R39_D1.0340.25
41_L48_V1.0150.25
34_S40_E1.0140.25
43_L57_D1.0120.25
20_S27_D1.0010.24
52_M64_V0.9970.24
32_F42_D0.9850.24
42_D72_S0.9730.23
41_L58_A0.9680.23
20_S63_D0.9650.23
39_D59_D0.9540.23
47_E51_N0.9460.22
36_L68_G0.9450.22
15_Q54_A0.9420.22
31_Y67_W0.9400.22
8_S16_H0.9130.21
68_G76_K0.9060.21
48_V72_S0.8890.21
9_R20_S0.8800.20
33_K40_E0.8780.20
13_P16_H0.8620.20
41_L51_N0.8440.19
15_Q47_E0.8400.19
17_R58_A0.8120.18
14_K61_D0.8120.18
8_S13_P0.8060.18
8_S20_S0.7670.17
11_L30_T0.7610.17
27_D77_V0.7540.17
38_G64_V0.7440.17
36_L51_N0.7400.17
22_L32_F0.7330.16
59_D64_V0.7290.16
21_Y63_D0.7110.16
21_Y77_V0.7100.16
47_E69_Y0.7070.16
14_K33_K0.6990.16
51_N69_Y0.6960.16
27_D78_A0.6830.15
10_T66_R0.6830.15
40_E69_Y0.6820.15
36_L70_S0.6800.15
26_A61_D0.6750.15
18_I72_S0.6700.15
9_R78_A0.6680.15
14_K69_Y0.6610.15
11_L35_R0.6550.15
7_A42_D0.6510.14
34_S62_L0.6500.14
37_I46_K0.6480.14
36_L48_V0.6460.14
56_E61_D0.6230.14
18_I51_N0.6190.14
17_R43_L0.6100.14
13_P26_A0.6080.14
30_T41_L0.5950.13
11_L48_V0.5930.13
9_R27_D0.5840.13
40_E76_K0.5750.13
10_T62_L0.5650.13
12_T19_L0.5630.13
33_K52_M0.5630.13
36_L71_S0.5410.12
10_T43_L0.5300.12
44_S63_D0.5090.12
35_R47_E0.5030.11
13_P63_D0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eyiA 1 0.775 90.3 0.855 Contact Map
1qgpA 1 0.9125 88.2 0.86 Contact Map
1qbjA 1 0.8125 85.8 0.865 Contact Map
4ou0A 1 0.8125 82.4 0.871 Contact Map
1oyiA 1 0.775 79.4 0.875 Contact Map
2lnbA 1 0.8875 76.5 0.878 Contact Map
1xmkA 1 0.8375 68.9 0.885 Contact Map
4ch7A 1 0.825 68.8 0.885 Contact Map
2pn6A 5 0.825 67 0.886 Contact Map
3lmmA 1 0.9 66.1 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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