Q9HSA9 - HALSA - GREMLIN Contacts

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Q9HSA9 - Uncharacterized protein

UniProt:	Q9HSA9	Sequences: MGVDEDKRATLRRFAAVGAAGPLARLAGGDSDDDGASGSDVRDAITGYLARTPGAHFSKLRDDLQLGTGETQHHLRRLCADGVVESVRDGEYKRFYPAGRFSAFERRALGYLRRETARGMIRELLSNPDASAGAVADALDVSPATVSKYGAELEAAGVLSRADGYEIQEPETLVVLLVRYADSFDAATVAFASEAASMVSYDP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	203 (157)
Sequences:	241 (184)
Seq/√Len:	14.7

HALSA - Q9HSA9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
49_L	84_V	4.225	1.00
121_I	167_I	4.062	1.00
60_L	96_Y	3.732	1.00
144_A	150_G	3.418	0.99
57_F	72_Q	3.218	0.99
42_R	74_H	3.134	0.98
96_Y	177_L	2.633	0.95
132_A	143_P	2.586	0.94
152_E	157_G	2.338	0.91
48_Y	55_A	2.102	0.85
59_K	63_D	2.084	0.85
90_G	146_V	2.071	0.84
86_S	93_K	2.070	0.84
187_A	190_A	1.953	0.80
46_T	49_L	1.947	0.80
87_V	106_R	1.907	0.79
56_H	113_R	1.824	0.76
186_A	195_A	1.816	0.75
89_D	94_R	1.769	0.73
186_A	189_V	1.737	0.72
147_S	153_L	1.715	0.71
51_R	84_V	1.651	0.68
111_Y	156_A	1.590	0.65
102_S	106_R	1.583	0.64
48_Y	116_T	1.583	0.64
135_V	174_V	1.579	0.64
126_S	137_D	1.556	0.63
69_G	113_R	1.544	0.62
46_T	83_V	1.520	0.61
73_H	192_A	1.502	0.60
139_L	146_V	1.499	0.60
124_L	130_A	1.498	0.60
125_L	138_A	1.486	0.59
185_D	188_T	1.484	0.59
190_A	193_S	1.451	0.57
55_A	60_L	1.426	0.56
58_S	158_V	1.399	0.55
59_K	62_D	1.393	0.54
187_A	194_E	1.387	0.54
53_P	84_V	1.378	0.53
190_A	194_E	1.359	0.52
84_V	177_L	1.345	0.52
187_A	193_S	1.321	0.50
66_L	117_A	1.316	0.50
104_F	169_E	1.305	0.49
49_L	177_L	1.304	0.49
143_P	147_S	1.295	0.49
67_G	70_E	1.283	0.48
69_G	105_E	1.262	0.47
135_V	138_A	1.252	0.46
60_L	140_D	1.251	0.46
94_R	147_S	1.233	0.45
84_V	107_R	1.229	0.45
102_S	105_E	1.222	0.45
130_A	136_A	1.213	0.44
133_G	157_G	1.211	0.44
57_F	69_G	1.204	0.44
165_Y	169_E	1.196	0.43
42_R	189_V	1.195	0.43
103_A	107_R	1.167	0.42
72_Q	114_R	1.166	0.42
49_L	168_Q	1.162	0.42
79_C	103_A	1.159	0.41
57_F	124_L	1.146	0.41
40_D	75_L	1.141	0.40
40_D	124_L	1.140	0.40
45_I	60_L	1.135	0.40
121_I	189_V	1.117	0.39
42_R	149_Y	1.100	0.38
64_L	90_G	1.085	0.37
73_H	101_F	1.066	0.36
160_S	168_Q	1.066	0.36
186_A	193_S	1.063	0.36
155_A	164_G	1.061	0.36
75_L	131_S	1.038	0.35
66_L	71_T	1.037	0.35
118_R	125_L	1.027	0.34
92_Y	114_R	1.026	0.34
185_D	191_F	1.026	0.34
155_A	187_A	1.003	0.33
66_L	119_G	0.998	0.33
52_T	105_E	0.992	0.33
142_S	145_T	0.989	0.33
84_V	187_A	0.987	0.33
76_R	145_T	0.971	0.32
56_H	91_E	0.968	0.32
49_L	133_G	0.967	0.32
150_G	162_A	0.960	0.31
46_T	96_Y	0.960	0.31
65_Q	149_Y	0.958	0.31
121_I	185_D	0.957	0.31
95_F	119_G	0.952	0.31
84_V	155_A	0.949	0.31
103_A	144_A	0.946	0.31
77_R	146_V	0.946	0.31
61_R	75_L	0.932	0.30
65_Q	76_R	0.895	0.28
79_C	88_R	0.888	0.28
79_C	86_S	0.888	0.28
184_F	195_A	0.881	0.28
123_E	135_V	0.877	0.27
56_H	92_Y	0.875	0.27
114_R	171_E	0.871	0.27
72_Q	91_E	0.866	0.27
108_A	112_L	0.863	0.27
89_D	92_Y	0.861	0.27
56_H	170_P	0.854	0.26
159_L	184_F	0.846	0.26
158_V	181_A	0.842	0.26
75_L	113_R	0.842	0.26
159_L	192_A	0.838	0.26
60_L	126_S	0.838	0.26
50_A	86_S	0.836	0.26
186_A	190_A	0.836	0.26
57_F	117_A	0.826	0.25
185_D	192_A	0.819	0.25
55_A	121_I	0.813	0.25
49_L	151_A	0.812	0.25
149_Y	194_E	0.812	0.25
170_P	176_L	0.810	0.25
188_T	191_F	0.809	0.24
57_F	116_T	0.798	0.24
47_G	158_V	0.797	0.24
103_A	158_V	0.796	0.24
107_R	135_V	0.795	0.24
133_G	160_S	0.793	0.24
52_T	88_R	0.793	0.24
82_G	100_R	0.781	0.23
120_M	159_L	0.775	0.23
188_T	192_A	0.770	0.23
72_Q	139_L	0.770	0.23
156_A	189_V	0.757	0.22
74_H	95_F	0.745	0.22
150_G	169_E	0.739	0.22
45_I	116_T	0.738	0.22
84_V	189_V	0.737	0.22
91_E	136_A	0.734	0.22
45_I	126_S	0.732	0.21
146_V	156_A	0.728	0.21
178_V	184_F	0.725	0.21
189_V	195_A	0.724	0.21
132_A	144_A	0.724	0.21
95_F	153_L	0.722	0.21
57_F	145_T	0.710	0.21
185_D	193_S	0.708	0.21
149_Y	152_E	0.703	0.20
125_L	148_K	0.696	0.20
66_L	123_E	0.695	0.20
46_T	152_E	0.694	0.20
82_G	151_A	0.684	0.20
159_L	164_G	0.675	0.19
85_E	192_A	0.675	0.19
144_A	147_S	0.675	0.19
67_G	95_F	0.674	0.19
46_T	160_S	0.674	0.19
46_T	148_K	0.666	0.19
98_A	101_F	0.666	0.19
71_T	134_A	0.663	0.19
85_E	96_Y	0.660	0.19
111_Y	158_V	0.658	0.19
123_E	127_N	0.656	0.19
82_G	146_V	0.654	0.19
91_E	129_D	0.654	0.19
132_A	147_S	0.651	0.19
91_E	143_P	0.646	0.18
94_R	182_D	0.646	0.18
85_E	101_F	0.644	0.18
61_R	147_S	0.638	0.18
64_L	141_V	0.632	0.18
109_L	128_P	0.631	0.18
142_S	164_G	0.629	0.18
94_R	110_G	0.628	0.18
159_L	181_A	0.626	0.18
107_R	155_A	0.623	0.18
39_S	43_D	0.619	0.18
73_H	194_E	0.619	0.18
116_T	176_L	0.616	0.17
51_R	134_A	0.616	0.17
65_Q	190_A	0.615	0.17
85_E	106_R	0.611	0.17
91_E	114_R	0.608	0.17
149_Y	164_G	0.603	0.17
57_F	139_L	0.602	0.17
131_S	158_V	0.597	0.17
80_A	133_G	0.594	0.17
142_S	165_Y	0.593	0.17
57_F	102_S	0.591	0.17
181_A	184_F	0.591	0.17
47_G	101_F	0.590	0.17
89_D	147_S	0.588	0.17
154_E	158_V	0.586	0.17
142_S	180_Y	0.580	0.16
53_P	121_I	0.579	0.16
54_G	74_H	0.575	0.16
105_E	115_E	0.575	0.16
112_L	122_R	0.572	0.16
139_L	153_L	0.571	0.16
144_A	174_V	0.570	0.16
59_K	154_E	0.569	0.16
57_F	142_S	0.568	0.16
105_E	195_A	0.568	0.16
139_L	154_E	0.566	0.16
83_V	143_P	0.564	0.16
62_D	118_R	0.563	0.16
73_H	93_K	0.558	0.16
38_G	58_S	0.557	0.16
53_P	184_F	0.557	0.16
55_A	64_L	0.550	0.15
98_A	151_A	0.540	0.15
175_V	194_E	0.538	0.15
43_D	138_A	0.536	0.15
182_D	186_A	0.535	0.15
111_Y	114_R	0.535	0.15
102_S	128_P	0.533	0.15
182_D	187_A	0.530	0.15
122_R	138_A	0.526	0.15
150_G	159_L	0.526	0.15
45_I	75_L	0.523	0.15
177_L	188_T	0.520	0.15
62_D	154_E	0.518	0.15
38_G	152_E	0.518	0.15
56_H	132_A	0.518	0.15
134_A	156_A	0.516	0.14
94_R	190_A	0.516	0.14
95_F	143_P	0.515	0.14
44_A	88_R	0.510	0.14
59_K	163_D	0.510	0.14
169_E	173_L	0.509	0.14
70_E	141_V	0.508	0.14
46_T	97_P	0.508	0.14
102_S	193_S	0.506	0.14
135_V	151_A	0.506	0.14
83_V	158_V	0.504	0.14
188_T	194_E	0.503	0.14
118_R	122_R	0.500	0.14
73_H	141_V	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qlzA	2	0.7094	99.7	0.733	Contact Map
1p4xA	1	0.9458	99.3	0.798	Contact Map
3f6oA	2	0.4631	98.8	0.837	Contact Map
4g6qA	4	0.5172	98.7	0.844	Contact Map
2zkzA	2	0.4236	98.7	0.845	Contact Map
2p4wA	2	0.5025	98.7	0.846	Contact Map
2oqgA	4	0.5271	98.7	0.846	Contact Map
1q1hA	1	0.3793	98.6	0.848	Contact Map
1u2wA	2	0.5222	98.6	0.848	Contact Map
4ch7A	1	0.7537	98.6	0.85	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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