GREMLIN Database
Q9HSA9 - Uncharacterized protein
UniProt: Q9HSA9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 203 (157)
Sequences: 241 (184)
Seq/√Len: 14.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_L84_V4.2251.00
121_I167_I4.0621.00
60_L96_Y3.7321.00
144_A150_G3.4180.99
57_F72_Q3.2180.99
42_R74_H3.1340.98
96_Y177_L2.6330.95
132_A143_P2.5860.94
152_E157_G2.3380.91
48_Y55_A2.1020.85
59_K63_D2.0840.85
90_G146_V2.0710.84
86_S93_K2.0700.84
187_A190_A1.9530.80
46_T49_L1.9470.80
87_V106_R1.9070.79
56_H113_R1.8240.76
186_A195_A1.8160.75
89_D94_R1.7690.73
186_A189_V1.7370.72
147_S153_L1.7150.71
51_R84_V1.6510.68
111_Y156_A1.5900.65
102_S106_R1.5830.64
48_Y116_T1.5830.64
135_V174_V1.5790.64
126_S137_D1.5560.63
69_G113_R1.5440.62
46_T83_V1.5200.61
73_H192_A1.5020.60
139_L146_V1.4990.60
124_L130_A1.4980.60
125_L138_A1.4860.59
185_D188_T1.4840.59
190_A193_S1.4510.57
55_A60_L1.4260.56
58_S158_V1.3990.55
59_K62_D1.3930.54
187_A194_E1.3870.54
53_P84_V1.3780.53
190_A194_E1.3590.52
84_V177_L1.3450.52
187_A193_S1.3210.50
66_L117_A1.3160.50
104_F169_E1.3050.49
49_L177_L1.3040.49
143_P147_S1.2950.49
67_G70_E1.2830.48
69_G105_E1.2620.47
135_V138_A1.2520.46
60_L140_D1.2510.46
94_R147_S1.2330.45
84_V107_R1.2290.45
102_S105_E1.2220.45
130_A136_A1.2130.44
133_G157_G1.2110.44
57_F69_G1.2040.44
165_Y169_E1.1960.43
42_R189_V1.1950.43
103_A107_R1.1670.42
72_Q114_R1.1660.42
49_L168_Q1.1620.42
79_C103_A1.1590.41
57_F124_L1.1460.41
40_D75_L1.1410.40
40_D124_L1.1400.40
45_I60_L1.1350.40
121_I189_V1.1170.39
42_R149_Y1.1000.38
64_L90_G1.0850.37
73_H101_F1.0660.36
160_S168_Q1.0660.36
186_A193_S1.0630.36
155_A164_G1.0610.36
75_L131_S1.0380.35
66_L71_T1.0370.35
118_R125_L1.0270.34
92_Y114_R1.0260.34
185_D191_F1.0260.34
155_A187_A1.0030.33
66_L119_G0.9980.33
52_T105_E0.9920.33
142_S145_T0.9890.33
84_V187_A0.9870.33
76_R145_T0.9710.32
56_H91_E0.9680.32
49_L133_G0.9670.32
150_G162_A0.9600.31
46_T96_Y0.9600.31
65_Q149_Y0.9580.31
121_I185_D0.9570.31
95_F119_G0.9520.31
84_V155_A0.9490.31
103_A144_A0.9460.31
77_R146_V0.9460.31
61_R75_L0.9320.30
65_Q76_R0.8950.28
79_C88_R0.8880.28
79_C86_S0.8880.28
184_F195_A0.8810.28
123_E135_V0.8770.27
56_H92_Y0.8750.27
114_R171_E0.8710.27
72_Q91_E0.8660.27
108_A112_L0.8630.27
89_D92_Y0.8610.27
56_H170_P0.8540.26
159_L184_F0.8460.26
158_V181_A0.8420.26
75_L113_R0.8420.26
159_L192_A0.8380.26
60_L126_S0.8380.26
50_A86_S0.8360.26
186_A190_A0.8360.26
57_F117_A0.8260.25
185_D192_A0.8190.25
55_A121_I0.8130.25
49_L151_A0.8120.25
149_Y194_E0.8120.25
170_P176_L0.8100.25
188_T191_F0.8090.24
57_F116_T0.7980.24
47_G158_V0.7970.24
103_A158_V0.7960.24
107_R135_V0.7950.24
133_G160_S0.7930.24
52_T88_R0.7930.24
82_G100_R0.7810.23
120_M159_L0.7750.23
188_T192_A0.7700.23
72_Q139_L0.7700.23
156_A189_V0.7570.22
74_H95_F0.7450.22
150_G169_E0.7390.22
45_I116_T0.7380.22
84_V189_V0.7370.22
91_E136_A0.7340.22
45_I126_S0.7320.21
146_V156_A0.7280.21
178_V184_F0.7250.21
189_V195_A0.7240.21
132_A144_A0.7240.21
95_F153_L0.7220.21
57_F145_T0.7100.21
185_D193_S0.7080.21
149_Y152_E0.7030.20
125_L148_K0.6960.20
66_L123_E0.6950.20
46_T152_E0.6940.20
82_G151_A0.6840.20
159_L164_G0.6750.19
85_E192_A0.6750.19
144_A147_S0.6750.19
67_G95_F0.6740.19
46_T160_S0.6740.19
46_T148_K0.6660.19
98_A101_F0.6660.19
71_T134_A0.6630.19
85_E96_Y0.6600.19
111_Y158_V0.6580.19
123_E127_N0.6560.19
82_G146_V0.6540.19
91_E129_D0.6540.19
132_A147_S0.6510.19
91_E143_P0.6460.18
94_R182_D0.6460.18
85_E101_F0.6440.18
61_R147_S0.6380.18
64_L141_V0.6320.18
109_L128_P0.6310.18
142_S164_G0.6290.18
94_R110_G0.6280.18
159_L181_A0.6260.18
107_R155_A0.6230.18
39_S43_D0.6190.18
73_H194_E0.6190.18
116_T176_L0.6160.17
51_R134_A0.6160.17
65_Q190_A0.6150.17
85_E106_R0.6110.17
91_E114_R0.6080.17
149_Y164_G0.6030.17
57_F139_L0.6020.17
131_S158_V0.5970.17
80_A133_G0.5940.17
142_S165_Y0.5930.17
57_F102_S0.5910.17
181_A184_F0.5910.17
47_G101_F0.5900.17
89_D147_S0.5880.17
154_E158_V0.5860.17
142_S180_Y0.5800.16
53_P121_I0.5790.16
54_G74_H0.5750.16
105_E115_E0.5750.16
112_L122_R0.5720.16
139_L153_L0.5710.16
144_A174_V0.5700.16
59_K154_E0.5690.16
57_F142_S0.5680.16
105_E195_A0.5680.16
139_L154_E0.5660.16
83_V143_P0.5640.16
62_D118_R0.5630.16
73_H93_K0.5580.16
38_G58_S0.5570.16
53_P184_F0.5570.16
55_A64_L0.5500.15
98_A151_A0.5400.15
175_V194_E0.5380.15
43_D138_A0.5360.15
182_D186_A0.5350.15
111_Y114_R0.5350.15
102_S128_P0.5330.15
182_D187_A0.5300.15
122_R138_A0.5260.15
150_G159_L0.5260.15
45_I75_L0.5230.15
177_L188_T0.5200.15
62_D154_E0.5180.15
38_G152_E0.5180.15
56_H132_A0.5180.15
134_A156_A0.5160.14
94_R190_A0.5160.14
95_F143_P0.5150.14
44_A88_R0.5100.14
59_K163_D0.5100.14
169_E173_L0.5090.14
70_E141_V0.5080.14
46_T97_P0.5080.14
102_S193_S0.5060.14
135_V151_A0.5060.14
83_V158_V0.5040.14
188_T194_E0.5030.14
118_R122_R0.5000.14
73_H141_V0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qlzA 2 0.7094 99.7 0.733 Contact Map
1p4xA 1 0.9458 99.3 0.798 Contact Map
3f6oA 2 0.4631 98.8 0.837 Contact Map
4g6qA 4 0.5172 98.7 0.844 Contact Map
2zkzA 2 0.4236 98.7 0.845 Contact Map
2p4wA 2 0.5025 98.7 0.846 Contact Map
2oqgA 4 0.5271 98.7 0.846 Contact Map
1q1hA 1 0.3793 98.6 0.848 Contact Map
1u2wA 2 0.5222 98.6 0.848 Contact Map
4ch7A 1 0.7537 98.6 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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