Q9HSA8 - HALSA - GREMLIN Contacts

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Q9HSA8 - Bifunctional short chain isoprenyl diphosphate synthase

UniProt:	Q9HSA8	Sequences: MYTALSVGTAGAAAADALPAAIFGGSLTTVVGLLLLVLLAVVVYETVQIVDAYEKQALTVFGEYRGLLEPGINVIPPFVSRTYTFDMRTQTIDVPRQEAITRDNSPVTADAVVYIRVRDAKRAFLEVDDYKTAVSNLAQTTLRAVLGDMELDDTLNKRQEINSRIRTELDEPTDEWGIRVESVEVREVNPSQEVQQAMEQQTSAERRRRAMILEAQGERQSAIENAQGDKQSNIIRAQGEKQSQILEAQGDAISTVLRAKSAESMGERAIIEKGMETLEGIGEGESNTFVLPQEVTSLVGRYGKHLAGSDVGDGGSDLESMAFDEETRELIGLDNIDEILNQITEEADVDPADLEEKAEAVQRGEDAGLQDAGEVIEEMDAELDDGTEDTGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	392 (307)
Sequences:	1377 (798)
Seq/√Len:	45.5

ECOLI - HFLK HFLC QMCA
HALSA - Q9HSA8 Q9HHV6
SULSO - Q97WL9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_Y	67_L	7.953	1.00
60_V	80_S	7.443	1.00
302_Y	305_H	6.990	1.00
119_D	122_R	6.182	1.00
304_K	307_A	4.711	1.00
298_L	301_R	4.000	1.00
123_A	131_K	3.699	1.00
303_G	307_A	3.566	1.00
302_Y	307_A	3.484	1.00
288_T	291_L	3.327	1.00
243_S	247_E	3.326	1.00
297_S	301_R	3.249	1.00
46_T	74_V	3.062	1.00
49_I	72_I	2.851	1.00
287_N	291_L	2.642	1.00
297_S	300_G	2.612	1.00
60_V	65_R	2.523	1.00
50_V	56_Q	2.400	1.00
285_E	288_T	2.396	1.00
238_Q	242_Q	2.342	1.00
221_S	225_N	2.327	1.00
160_E	164_R	2.255	1.00
285_E	289_F	2.244	1.00
56_Q	82_T	2.196	1.00
65_R	80_S	2.152	1.00
33_L	37_V	2.128	1.00
259_A	263_E	2.035	0.99
66_G	80_S	1.964	0.99
241_K	245_I	1.953	0.99
30_V	34_L	1.878	0.99
225_N	229_D	1.839	0.99
253_I	257_L	1.826	0.99
189_N	195_Q	1.820	0.99
235_I	238_Q	1.815	0.99
112_V	186_R	1.762	0.98
167_T	171_E	1.749	0.98
300_G	303_G	1.711	0.98
137_L	169_L	1.686	0.98
42_V	46_T	1.686	0.98
307_A	310_D	1.662	0.98
133_A	137_L	1.658	0.98
246_L	249_Q	1.655	0.97
288_T	292_P	1.652	0.97
229_D	236_R	1.649	0.97
318_L	322_A	1.612	0.97
261_S	264_S	1.610	0.97
144_A	148_D	1.605	0.97
329_E	333_L	1.577	0.97
55_K	87_M	1.536	0.96
209_R	212_I	1.456	0.95
285_E	290_V	1.442	0.94
111_A	138_A	1.442	0.94
42_V	74_V	1.439	0.94
116_R	179_R	1.431	0.94
314_G	318_L	1.412	0.94
252_A	261_S	1.399	0.93
66_G	73_N	1.396	0.93
290_V	296_T	1.395	0.93
262_A	265_M	1.394	0.93
304_K	309_S	1.388	0.93
207_R	210_A	1.368	0.93
300_G	304_K	1.368	0.93
123_A	178_I	1.362	0.92
323_F	327_T	1.357	0.92
247_E	251_D	1.355	0.92
316_S	320_S	1.328	0.91
89_T	92_I	1.326	0.91
319_E	326_E	1.325	0.91
34_L	319_E	1.319	0.91
285_E	291_L	1.317	0.91
284_G	287_N	1.309	0.91
325_E	330_L	1.305	0.91
256_V	260_K	1.294	0.90
53_Y	87_M	1.277	0.90
267_E	271_I	1.276	0.90
118_R	179_R	1.272	0.90
252_A	256_V	1.254	0.89
85_F	117_V	1.254	0.89
82_T	117_V	1.248	0.89
324_D	329_E	1.247	0.89
321_M	328_R	1.247	0.89
90_Q	93_D	1.246	0.89
75_I	82_T	1.238	0.88
61_F	65_R	1.229	0.88
112_V	181_E	1.200	0.87
323_F	326_E	1.199	0.87
48_Q	68_L	1.195	0.86
34_L	38_L	1.193	0.86
329_E	332_G	1.187	0.86
31_V	38_L	1.186	0.86
255_T	261_S	1.186	0.86
302_Y	306_L	1.181	0.86
53_Y	195_Q	1.173	0.85
53_Y	88_R	1.165	0.85
276_E	279_E	1.164	0.85
327_T	330_L	1.162	0.85
146_L	154_T	1.161	0.85
32_G	35_L	1.154	0.84
125_L	144_A	1.154	0.84
322_A	326_E	1.147	0.84
242_Q	246_L	1.147	0.84
165_I	169_L	1.145	0.84
324_D	328_R	1.144	0.84
318_L	329_E	1.132	0.83
292_P	296_T	1.125	0.83
197_A	232_S	1.123	0.83
59_T	125_L	1.123	0.83
194_V	250_G	1.113	0.82
206_R	209_R	1.111	0.82
328_R	331_I	1.104	0.82
231_Q	234_I	1.103	0.82
241_K	259_A	1.100	0.81
325_E	328_R	1.098	0.81
195_Q	199_E	1.098	0.81
97_Q	139_Q	1.093	0.81
29_T	33_L	1.088	0.81
301_R	304_K	1.088	0.81
55_K	70_P	1.082	0.80
53_Y	116_R	1.082	0.80
305_H	308_G	1.081	0.80
258_R	281_I	1.073	0.80
129_D	132_T	1.069	0.80
76_P	80_S	1.068	0.80
45_E	75_I	1.059	0.79
166_R	185_V	1.057	0.79
321_M	324_D	1.056	0.79
86_D	199_E	1.054	0.79
220_Q	223_I	1.053	0.79
314_G	317_D	1.046	0.78
33_L	318_L	1.046	0.78
330_L	333_L	1.043	0.78
44_Y	74_V	1.042	0.78
323_F	328_R	1.040	0.78
35_L	311_V	1.039	0.78
79_V	242_Q	1.031	0.77
318_L	323_F	1.025	0.77
205_E	209_R	1.024	0.77
319_E	322_A	0.996	0.75
39_L	312_G	0.994	0.74
147_G	228_G	0.993	0.74
124_F	186_R	0.993	0.74
31_V	34_L	0.989	0.74
42_V	78_F	0.986	0.74
310_D	313_D	0.985	0.74
320_S	323_F	0.981	0.73
57_A	124_F	0.979	0.73
52_A	116_R	0.975	0.73
253_I	256_V	0.973	0.73
300_G	305_H	0.965	0.72
328_R	332_G	0.965	0.72
195_Q	203_S	0.961	0.72
315_G	318_L	0.952	0.71
313_D	316_S	0.950	0.71
280_G	283_E	0.945	0.71
32_G	36_L	0.943	0.70
102_R	150_E	0.941	0.70
312_G	322_A	0.937	0.70
28_T	32_G	0.934	0.70
227_Q	231_Q	0.929	0.69
322_A	325_E	0.929	0.69
155_L	198_M	0.919	0.68
311_V	314_G	0.917	0.68
320_S	324_D	0.917	0.68
316_S	330_L	0.916	0.68
219_R	227_Q	0.909	0.68
159_Q	163_S	0.909	0.68
314_G	319_E	0.905	0.67
260_K	264_S	0.905	0.67
312_G	320_S	0.901	0.67
239_G	244_Q	0.900	0.67
138_A	216_Q	0.898	0.67
310_D	316_S	0.896	0.66
154_T	161_I	0.888	0.66
322_A	328_R	0.885	0.65
231_Q	282_G	0.882	0.65
55_K	69_E	0.882	0.65
112_V	182_S	0.880	0.65
104_N	206_R	0.879	0.65
315_G	319_E	0.877	0.65
230_K	234_I	0.876	0.65
285_E	293_Q	0.872	0.64
325_E	333_L	0.870	0.64
289_F	292_P	0.869	0.64
324_D	330_L	0.868	0.64
249_Q	253_I	0.866	0.64
328_R	333_L	0.860	0.63
161_I	190_P	0.858	0.63
234_I	238_Q	0.858	0.63
45_E	212_I	0.857	0.63
198_M	206_R	0.855	0.63
204_A	226_A	0.854	0.63
86_D	203_S	0.851	0.62
321_M	331_I	0.848	0.62
303_G	306_L	0.843	0.62
317_D	323_F	0.843	0.62
317_D	327_T	0.840	0.61
295_V	301_R	0.839	0.61
36_L	322_A	0.837	0.61
214_E	218_E	0.835	0.61
156_N	198_M	0.834	0.61
27_L	32_G	0.833	0.61
162_N	213_L	0.830	0.60
156_N	215_A	0.827	0.60
116_R	121_K	0.825	0.60
315_G	320_S	0.823	0.60
316_S	319_E	0.822	0.60
298_L	303_G	0.818	0.59
29_T	35_L	0.813	0.59
317_D	329_E	0.813	0.59
86_D	157_K	0.811	0.59
216_Q	219_R	0.810	0.59
144_A	168_E	0.807	0.58
273_K	276_E	0.806	0.58
122_R	126_E	0.805	0.58
267_E	315_G	0.804	0.58
255_T	262_A	0.801	0.58
134_V	223_I	0.800	0.58
312_G	318_L	0.800	0.58
292_P	295_V	0.797	0.57
318_L	321_M	0.797	0.57
202_T	206_R	0.797	0.57
104_N	151_L	0.795	0.57
90_Q	115_I	0.789	0.57
125_L	172_P	0.786	0.56
326_E	329_E	0.784	0.56
254_S	261_S	0.779	0.56
311_V	320_S	0.778	0.56
48_Q	188_V	0.778	0.56
325_E	332_G	0.774	0.55
220_Q	230_K	0.774	0.55
87_M	215_A	0.772	0.55
36_L	317_D	0.769	0.55
208_R	212_I	0.768	0.55
93_D	202_T	0.766	0.54
326_E	330_L	0.766	0.54
325_E	329_E	0.758	0.54
204_A	228_G	0.758	0.54
32_G	298_L	0.756	0.53
284_G	288_T	0.756	0.53
301_R	305_H	0.756	0.53
320_S	325_E	0.754	0.53
56_Q	84_T	0.746	0.52
250_G	268_R	0.746	0.52
43_V	47_V	0.744	0.52
100_I	137_L	0.744	0.52
316_S	321_M	0.744	0.52
79_V	310_D	0.743	0.52
313_D	324_D	0.743	0.52
190_P	199_E	0.743	0.52
183_V	237_A	0.739	0.52
214_E	228_G	0.737	0.52
232_S	236_R	0.737	0.52
53_Y	156_N	0.735	0.51
69_E	73_N	0.735	0.51
40_A	83_Y	0.735	0.51
287_N	292_P	0.733	0.51
148_D	215_A	0.727	0.51
39_L	43_V	0.726	0.50
214_E	269_A	0.723	0.50
164_R	167_T	0.720	0.50
134_V	146_L	0.717	0.50
146_L	255_T	0.717	0.50
278_L	281_I	0.716	0.49
38_L	42_V	0.715	0.49
85_F	124_F	0.714	0.49
321_M	325_E	0.713	0.49
33_L	39_L	0.713	0.49
37_V	41_V	0.711	0.49
327_T	332_G	0.711	0.49
322_A	327_T	0.709	0.49
125_L	188_V	0.709	0.49
104_N	186_R	0.709	0.49
55_K	120_A	0.708	0.49
217_G	221_S	0.706	0.48
89_T	185_V	0.705	0.48
313_D	329_E	0.702	0.48
126_E	245_I	0.701	0.48
38_L	175_E	0.701	0.48
31_V	117_V	0.699	0.48
94_V	138_A	0.699	0.48
108_T	170_D	0.698	0.48
285_E	292_P	0.698	0.48
59_T	120_A	0.697	0.48
114_Y	194_V	0.697	0.48
35_L	289_F	0.697	0.48
36_L	81_R	0.693	0.47
291_L	295_V	0.692	0.47
93_D	97_Q	0.692	0.47
316_S	323_F	0.689	0.47
110_D	142_L	0.686	0.47
326_E	332_G	0.684	0.46
178_I	290_V	0.682	0.46
142_L	187_E	0.681	0.46
107_V	165_I	0.674	0.45
63_E	233_N	0.671	0.45
311_V	318_L	0.670	0.45
310_D	327_T	0.666	0.45
50_V	150_E	0.665	0.44
56_Q	70_P	0.664	0.44
61_F	92_I	0.661	0.44
159_Q	229_D	0.659	0.44
202_T	205_E	0.659	0.44
89_T	93_D	0.658	0.44
33_L	36_L	0.657	0.44
255_T	259_A	0.656	0.44
322_A	332_G	0.656	0.44
30_V	38_L	0.654	0.43
325_E	331_I	0.653	0.43
312_G	317_D	0.651	0.43
125_L	201_Q	0.651	0.43
309_S	320_S	0.650	0.43
91_T	188_V	0.647	0.43
255_T	265_M	0.645	0.43
308_G	311_V	0.643	0.42
114_Y	176_W	0.643	0.42
101_T	204_A	0.643	0.42
180_V	209_R	0.641	0.42
46_T	78_F	0.638	0.42
316_S	332_G	0.636	0.42
100_I	198_M	0.634	0.42
52_A	80_S	0.632	0.41
327_T	333_L	0.631	0.41
270_I	301_R	0.630	0.41
98_E	108_T	0.628	0.41
56_Q	86_D	0.626	0.41
322_A	330_L	0.626	0.41
255_T	268_R	0.625	0.41
320_S	327_T	0.622	0.40
106_P	228_G	0.620	0.40
120_A	179_R	0.618	0.40
59_T	212_I	0.616	0.40
252_A	259_A	0.616	0.40
312_G	315_G	0.615	0.40
316_S	327_T	0.614	0.40
262_A	266_G	0.613	0.40
75_I	80_S	0.611	0.39
211_M	214_E	0.610	0.39
257_L	260_K	0.608	0.39
170_D	174_D	0.607	0.39
40_A	44_Y	0.607	0.39
319_E	328_R	0.604	0.39
312_G	316_S	0.603	0.39
312_G	323_F	0.600	0.38
326_E	331_I	0.600	0.38
205_E	220_Q	0.596	0.38
163_S	167_T	0.593	0.38
138_A	169_L	0.593	0.38
241_K	250_G	0.593	0.38
137_L	140_T	0.592	0.38
267_E	306_L	0.592	0.38
217_G	223_I	0.591	0.38
326_E	333_L	0.591	0.38
312_G	327_T	0.589	0.37
77_P	93_D	0.586	0.37
184_E	206_R	0.586	0.37
321_M	327_T	0.586	0.37
77_P	177_G	0.585	0.37
133_A	176_W	0.584	0.37
321_M	326_E	0.583	0.37
323_F	331_I	0.583	0.37
239_G	268_R	0.583	0.37
246_L	252_A	0.581	0.37
41_V	171_E	0.581	0.37
321_M	330_L	0.580	0.36
32_G	39_L	0.579	0.36
38_L	47_V	0.577	0.36
313_D	325_E	0.575	0.36
121_K	161_I	0.574	0.36
32_G	40_A	0.573	0.36
281_I	286_S	0.572	0.36
105_S	269_A	0.571	0.36
70_P	312_G	0.569	0.36
32_G	41_V	0.568	0.35
162_N	185_V	0.567	0.35
309_S	313_D	0.567	0.35
121_K	145_V	0.567	0.35
47_V	72_I	0.566	0.35
29_T	46_T	0.562	0.35
222_A	233_N	0.561	0.35
310_D	318_L	0.561	0.35
42_V	75_I	0.560	0.35
260_K	280_G	0.560	0.35
314_G	326_E	0.560	0.35
35_L	167_T	0.559	0.35
255_T	273_K	0.559	0.35
306_L	309_S	0.557	0.34
50_V	111_A	0.556	0.34
159_Q	199_E	0.555	0.34
151_L	216_Q	0.553	0.34
102_R	219_R	0.552	0.34
319_E	329_E	0.552	0.34
239_G	254_S	0.551	0.34
42_V	240_E	0.550	0.34
137_L	172_P	0.549	0.34
35_L	325_E	0.549	0.34
237_A	245_I	0.549	0.34
195_Q	208_R	0.548	0.34
39_L	330_L	0.546	0.33
314_G	327_T	0.545	0.33
134_V	178_I	0.545	0.33
104_N	152_D	0.544	0.33
36_L	39_L	0.543	0.33
41_V	318_L	0.543	0.33
216_Q	227_Q	0.540	0.33
138_A	206_R	0.540	0.33
317_D	320_S	0.539	0.33
228_G	274_G	0.537	0.33
36_L	328_R	0.537	0.33
104_N	198_M	0.537	0.33
265_M	269_A	0.536	0.33
318_L	324_D	0.536	0.33
106_P	144_A	0.535	0.33
134_V	169_L	0.534	0.32
205_E	213_L	0.533	0.32
153_D	211_M	0.533	0.32
140_T	184_E	0.533	0.32
268_R	304_K	0.532	0.32
319_E	324_D	0.532	0.32
324_D	333_L	0.532	0.32
59_T	81_R	0.532	0.32
317_D	326_E	0.531	0.32
266_G	270_I	0.531	0.32
324_D	332_G	0.528	0.32
297_S	304_K	0.527	0.32
94_V	135_S	0.527	0.32
175_E	326_E	0.526	0.32
33_L	38_L	0.524	0.32
102_R	178_I	0.523	0.31
172_P	176_W	0.522	0.31
312_G	326_E	0.522	0.31
34_L	37_V	0.522	0.31
189_N	192_Q	0.521	0.31
130_Y	178_I	0.520	0.31
95_P	110_D	0.520	0.31
171_E	174_D	0.520	0.31
35_L	316_S	0.519	0.31
155_L	188_V	0.518	0.31
88_R	93_D	0.517	0.31
148_D	153_D	0.516	0.31
36_L	163_S	0.515	0.31
48_Q	82_T	0.514	0.31
144_A	203_S	0.514	0.31
158_R	199_E	0.514	0.31
99_A	272_E	0.512	0.31
89_T	111_A	0.510	0.30
144_A	169_L	0.510	0.30
176_W	184_E	0.510	0.30
168_E	172_P	0.510	0.30
255_T	269_A	0.509	0.30
45_E	74_V	0.508	0.30
250_G	255_T	0.506	0.30
255_T	258_R	0.506	0.30
147_G	177_G	0.504	0.30
66_G	171_E	0.504	0.30
266_G	272_E	0.502	0.30
91_T	185_V	0.502	0.30
285_E	294_E	0.502	0.30
302_Y	310_D	0.501	0.30
47_V	82_T	0.501	0.30
42_V	218_E	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bk6A	3	0.4337	100	0.629	Contact Map
4fvgA	2	0.2781	100	0.691	Contact Map
1winA	1	0.3418	100	0.7	Contact Map
2rpbA	1	0.2883	99.9	0.746	Contact Map
2zuoA	7	0.7372	93.3	0.939	Contact Map
2kogA	1	0.1199	43.5	0.962	Contact Map
3fymA	1	0.0255	32.4	0.965	Contact Map
3hd7A	1	0.1199	17.7	0.969	Contact Map
2m8rA	1	0.1173	15.7	0.97	Contact Map
2acmB	1	0.1046	14.7	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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