GREMLIN Database
Q9HSA8 - Bifunctional short chain isoprenyl diphosphate synthase
UniProt: Q9HSA8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (307)
Sequences: 1377 (798)
Seq/√Len: 45.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_Y67_L7.9531.00
60_V80_S7.4431.00
302_Y305_H6.9901.00
119_D122_R6.1821.00
304_K307_A4.7111.00
298_L301_R4.0001.00
123_A131_K3.6991.00
303_G307_A3.5661.00
302_Y307_A3.4841.00
288_T291_L3.3271.00
243_S247_E3.3261.00
297_S301_R3.2491.00
46_T74_V3.0621.00
49_I72_I2.8511.00
287_N291_L2.6421.00
297_S300_G2.6121.00
60_V65_R2.5231.00
50_V56_Q2.4001.00
285_E288_T2.3961.00
238_Q242_Q2.3421.00
221_S225_N2.3271.00
160_E164_R2.2551.00
285_E289_F2.2441.00
56_Q82_T2.1961.00
65_R80_S2.1521.00
33_L37_V2.1281.00
259_A263_E2.0350.99
66_G80_S1.9640.99
241_K245_I1.9530.99
30_V34_L1.8780.99
225_N229_D1.8390.99
253_I257_L1.8260.99
189_N195_Q1.8200.99
235_I238_Q1.8150.99
112_V186_R1.7620.98
167_T171_E1.7490.98
300_G303_G1.7110.98
137_L169_L1.6860.98
42_V46_T1.6860.98
307_A310_D1.6620.98
133_A137_L1.6580.98
246_L249_Q1.6550.97
288_T292_P1.6520.97
229_D236_R1.6490.97
318_L322_A1.6120.97
261_S264_S1.6100.97
144_A148_D1.6050.97
329_E333_L1.5770.97
55_K87_M1.5360.96
209_R212_I1.4560.95
285_E290_V1.4420.94
111_A138_A1.4420.94
42_V74_V1.4390.94
116_R179_R1.4310.94
314_G318_L1.4120.94
252_A261_S1.3990.93
66_G73_N1.3960.93
290_V296_T1.3950.93
262_A265_M1.3940.93
304_K309_S1.3880.93
207_R210_A1.3680.93
300_G304_K1.3680.93
123_A178_I1.3620.92
323_F327_T1.3570.92
247_E251_D1.3550.92
316_S320_S1.3280.91
89_T92_I1.3260.91
319_E326_E1.3250.91
34_L319_E1.3190.91
285_E291_L1.3170.91
284_G287_N1.3090.91
325_E330_L1.3050.91
256_V260_K1.2940.90
53_Y87_M1.2770.90
267_E271_I1.2760.90
118_R179_R1.2720.90
252_A256_V1.2540.89
85_F117_V1.2540.89
82_T117_V1.2480.89
324_D329_E1.2470.89
321_M328_R1.2470.89
90_Q93_D1.2460.89
75_I82_T1.2380.88
61_F65_R1.2290.88
112_V181_E1.2000.87
323_F326_E1.1990.87
48_Q68_L1.1950.86
34_L38_L1.1930.86
329_E332_G1.1870.86
31_V38_L1.1860.86
255_T261_S1.1860.86
302_Y306_L1.1810.86
53_Y195_Q1.1730.85
53_Y88_R1.1650.85
276_E279_E1.1640.85
327_T330_L1.1620.85
146_L154_T1.1610.85
32_G35_L1.1540.84
125_L144_A1.1540.84
322_A326_E1.1470.84
242_Q246_L1.1470.84
165_I169_L1.1450.84
324_D328_R1.1440.84
318_L329_E1.1320.83
292_P296_T1.1250.83
197_A232_S1.1230.83
59_T125_L1.1230.83
194_V250_G1.1130.82
206_R209_R1.1110.82
328_R331_I1.1040.82
231_Q234_I1.1030.82
241_K259_A1.1000.81
325_E328_R1.0980.81
195_Q199_E1.0980.81
97_Q139_Q1.0930.81
29_T33_L1.0880.81
301_R304_K1.0880.81
55_K70_P1.0820.80
53_Y116_R1.0820.80
305_H308_G1.0810.80
258_R281_I1.0730.80
129_D132_T1.0690.80
76_P80_S1.0680.80
45_E75_I1.0590.79
166_R185_V1.0570.79
321_M324_D1.0560.79
86_D199_E1.0540.79
220_Q223_I1.0530.79
314_G317_D1.0460.78
33_L318_L1.0460.78
330_L333_L1.0430.78
44_Y74_V1.0420.78
323_F328_R1.0400.78
35_L311_V1.0390.78
79_V242_Q1.0310.77
318_L323_F1.0250.77
205_E209_R1.0240.77
319_E322_A0.9960.75
39_L312_G0.9940.74
147_G228_G0.9930.74
124_F186_R0.9930.74
31_V34_L0.9890.74
42_V78_F0.9860.74
310_D313_D0.9850.74
320_S323_F0.9810.73
57_A124_F0.9790.73
52_A116_R0.9750.73
253_I256_V0.9730.73
300_G305_H0.9650.72
328_R332_G0.9650.72
195_Q203_S0.9610.72
315_G318_L0.9520.71
313_D316_S0.9500.71
280_G283_E0.9450.71
32_G36_L0.9430.70
102_R150_E0.9410.70
312_G322_A0.9370.70
28_T32_G0.9340.70
227_Q231_Q0.9290.69
322_A325_E0.9290.69
155_L198_M0.9190.68
311_V314_G0.9170.68
320_S324_D0.9170.68
316_S330_L0.9160.68
219_R227_Q0.9090.68
159_Q163_S0.9090.68
314_G319_E0.9050.67
260_K264_S0.9050.67
312_G320_S0.9010.67
239_G244_Q0.9000.67
138_A216_Q0.8980.67
310_D316_S0.8960.66
154_T161_I0.8880.66
322_A328_R0.8850.65
231_Q282_G0.8820.65
55_K69_E0.8820.65
112_V182_S0.8800.65
104_N206_R0.8790.65
315_G319_E0.8770.65
230_K234_I0.8760.65
285_E293_Q0.8720.64
325_E333_L0.8700.64
289_F292_P0.8690.64
324_D330_L0.8680.64
249_Q253_I0.8660.64
328_R333_L0.8600.63
161_I190_P0.8580.63
234_I238_Q0.8580.63
45_E212_I0.8570.63
198_M206_R0.8550.63
204_A226_A0.8540.63
86_D203_S0.8510.62
321_M331_I0.8480.62
303_G306_L0.8430.62
317_D323_F0.8430.62
317_D327_T0.8400.61
295_V301_R0.8390.61
36_L322_A0.8370.61
214_E218_E0.8350.61
156_N198_M0.8340.61
27_L32_G0.8330.61
162_N213_L0.8300.60
156_N215_A0.8270.60
116_R121_K0.8250.60
315_G320_S0.8230.60
316_S319_E0.8220.60
298_L303_G0.8180.59
29_T35_L0.8130.59
317_D329_E0.8130.59
86_D157_K0.8110.59
216_Q219_R0.8100.59
144_A168_E0.8070.58
273_K276_E0.8060.58
122_R126_E0.8050.58
267_E315_G0.8040.58
255_T262_A0.8010.58
134_V223_I0.8000.58
312_G318_L0.8000.58
292_P295_V0.7970.57
318_L321_M0.7970.57
202_T206_R0.7970.57
104_N151_L0.7950.57
90_Q115_I0.7890.57
125_L172_P0.7860.56
326_E329_E0.7840.56
254_S261_S0.7790.56
311_V320_S0.7780.56
48_Q188_V0.7780.56
325_E332_G0.7740.55
220_Q230_K0.7740.55
87_M215_A0.7720.55
36_L317_D0.7690.55
208_R212_I0.7680.55
93_D202_T0.7660.54
326_E330_L0.7660.54
325_E329_E0.7580.54
204_A228_G0.7580.54
32_G298_L0.7560.53
284_G288_T0.7560.53
301_R305_H0.7560.53
320_S325_E0.7540.53
56_Q84_T0.7460.52
250_G268_R0.7460.52
43_V47_V0.7440.52
100_I137_L0.7440.52
316_S321_M0.7440.52
79_V310_D0.7430.52
313_D324_D0.7430.52
190_P199_E0.7430.52
183_V237_A0.7390.52
214_E228_G0.7370.52
232_S236_R0.7370.52
53_Y156_N0.7350.51
69_E73_N0.7350.51
40_A83_Y0.7350.51
287_N292_P0.7330.51
148_D215_A0.7270.51
39_L43_V0.7260.50
214_E269_A0.7230.50
164_R167_T0.7200.50
134_V146_L0.7170.50
146_L255_T0.7170.50
278_L281_I0.7160.49
38_L42_V0.7150.49
85_F124_F0.7140.49
321_M325_E0.7130.49
33_L39_L0.7130.49
37_V41_V0.7110.49
327_T332_G0.7110.49
322_A327_T0.7090.49
125_L188_V0.7090.49
104_N186_R0.7090.49
55_K120_A0.7080.49
217_G221_S0.7060.48
89_T185_V0.7050.48
313_D329_E0.7020.48
126_E245_I0.7010.48
38_L175_E0.7010.48
31_V117_V0.6990.48
94_V138_A0.6990.48
108_T170_D0.6980.48
285_E292_P0.6980.48
59_T120_A0.6970.48
114_Y194_V0.6970.48
35_L289_F0.6970.48
36_L81_R0.6930.47
291_L295_V0.6920.47
93_D97_Q0.6920.47
316_S323_F0.6890.47
110_D142_L0.6860.47
326_E332_G0.6840.46
178_I290_V0.6820.46
142_L187_E0.6810.46
107_V165_I0.6740.45
63_E233_N0.6710.45
311_V318_L0.6700.45
310_D327_T0.6660.45
50_V150_E0.6650.44
56_Q70_P0.6640.44
61_F92_I0.6610.44
159_Q229_D0.6590.44
202_T205_E0.6590.44
89_T93_D0.6580.44
33_L36_L0.6570.44
255_T259_A0.6560.44
322_A332_G0.6560.44
30_V38_L0.6540.43
325_E331_I0.6530.43
312_G317_D0.6510.43
125_L201_Q0.6510.43
309_S320_S0.6500.43
91_T188_V0.6470.43
255_T265_M0.6450.43
308_G311_V0.6430.42
114_Y176_W0.6430.42
101_T204_A0.6430.42
180_V209_R0.6410.42
46_T78_F0.6380.42
316_S332_G0.6360.42
100_I198_M0.6340.42
52_A80_S0.6320.41
327_T333_L0.6310.41
270_I301_R0.6300.41
98_E108_T0.6280.41
56_Q86_D0.6260.41
322_A330_L0.6260.41
255_T268_R0.6250.41
320_S327_T0.6220.40
106_P228_G0.6200.40
120_A179_R0.6180.40
59_T212_I0.6160.40
252_A259_A0.6160.40
312_G315_G0.6150.40
316_S327_T0.6140.40
262_A266_G0.6130.40
75_I80_S0.6110.39
211_M214_E0.6100.39
257_L260_K0.6080.39
170_D174_D0.6070.39
40_A44_Y0.6070.39
319_E328_R0.6040.39
312_G316_S0.6030.39
312_G323_F0.6000.38
326_E331_I0.6000.38
205_E220_Q0.5960.38
163_S167_T0.5930.38
138_A169_L0.5930.38
241_K250_G0.5930.38
137_L140_T0.5920.38
267_E306_L0.5920.38
217_G223_I0.5910.38
326_E333_L0.5910.38
312_G327_T0.5890.37
77_P93_D0.5860.37
184_E206_R0.5860.37
321_M327_T0.5860.37
77_P177_G0.5850.37
133_A176_W0.5840.37
321_M326_E0.5830.37
323_F331_I0.5830.37
239_G268_R0.5830.37
246_L252_A0.5810.37
41_V171_E0.5810.37
321_M330_L0.5800.36
32_G39_L0.5790.36
38_L47_V0.5770.36
313_D325_E0.5750.36
121_K161_I0.5740.36
32_G40_A0.5730.36
281_I286_S0.5720.36
105_S269_A0.5710.36
70_P312_G0.5690.36
32_G41_V0.5680.35
162_N185_V0.5670.35
309_S313_D0.5670.35
121_K145_V0.5670.35
47_V72_I0.5660.35
29_T46_T0.5620.35
222_A233_N0.5610.35
310_D318_L0.5610.35
42_V75_I0.5600.35
260_K280_G0.5600.35
314_G326_E0.5600.35
35_L167_T0.5590.35
255_T273_K0.5590.35
306_L309_S0.5570.34
50_V111_A0.5560.34
159_Q199_E0.5550.34
151_L216_Q0.5530.34
102_R219_R0.5520.34
319_E329_E0.5520.34
239_G254_S0.5510.34
42_V240_E0.5500.34
137_L172_P0.5490.34
35_L325_E0.5490.34
237_A245_I0.5490.34
195_Q208_R0.5480.34
39_L330_L0.5460.33
314_G327_T0.5450.33
134_V178_I0.5450.33
104_N152_D0.5440.33
36_L39_L0.5430.33
41_V318_L0.5430.33
216_Q227_Q0.5400.33
138_A206_R0.5400.33
317_D320_S0.5390.33
228_G274_G0.5370.33
36_L328_R0.5370.33
104_N198_M0.5370.33
265_M269_A0.5360.33
318_L324_D0.5360.33
106_P144_A0.5350.33
134_V169_L0.5340.32
205_E213_L0.5330.32
153_D211_M0.5330.32
140_T184_E0.5330.32
268_R304_K0.5320.32
319_E324_D0.5320.32
324_D333_L0.5320.32
59_T81_R0.5320.32
317_D326_E0.5310.32
266_G270_I0.5310.32
324_D332_G0.5280.32
297_S304_K0.5270.32
94_V135_S0.5270.32
175_E326_E0.5260.32
33_L38_L0.5240.32
102_R178_I0.5230.31
172_P176_W0.5220.31
312_G326_E0.5220.31
34_L37_V0.5220.31
189_N192_Q0.5210.31
130_Y178_I0.5200.31
95_P110_D0.5200.31
171_E174_D0.5200.31
35_L316_S0.5190.31
155_L188_V0.5180.31
88_R93_D0.5170.31
148_D153_D0.5160.31
36_L163_S0.5150.31
48_Q82_T0.5140.31
144_A203_S0.5140.31
158_R199_E0.5140.31
99_A272_E0.5120.31
89_T111_A0.5100.30
144_A169_L0.5100.30
176_W184_E0.5100.30
168_E172_P0.5100.30
255_T269_A0.5090.30
45_E74_V0.5080.30
250_G255_T0.5060.30
255_T258_R0.5060.30
147_G177_G0.5040.30
66_G171_E0.5040.30
266_G272_E0.5020.30
91_T185_V0.5020.30
285_E294_E0.5020.30
302_Y310_D0.5010.30
47_V82_T0.5010.30
42_V218_E0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bk6A 3 0.4337 100 0.629 Contact Map
4fvgA 2 0.2781 100 0.691 Contact Map
1winA 1 0.3418 100 0.7 Contact Map
2rpbA 1 0.2883 99.9 0.746 Contact Map
2zuoA 7 0.7372 93.3 0.939 Contact Map
2kogA 1 0.1199 43.5 0.962 Contact Map
3fymA 1 0.0255 32.4 0.965 Contact Map
3hd7A 1 0.1199 17.7 0.969 Contact Map
2m8rA 1 0.1173 15.7 0.97 Contact Map
2acmB 1 0.1046 14.7 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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