GREMLIN Database
Q9HSA5 - Pyruvate kinase
UniProt: Q9HSA5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 579 (465)
Sequences: 4038 (2243)
Seq/√Len: 104.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_R56_Q4.3661.00
131_D141_T4.3381.00
214_A232_A4.3011.00
226_D261_Q4.0501.00
17_D52_A3.4661.00
225_L258_I3.3741.00
44_R48_E3.3551.00
78_D100_T3.1551.00
129_D141_T3.1461.00
197_L231_A3.0861.00
8_C28_M3.0711.00
65_L177_A2.9831.00
200_N212_I2.9231.00
271_T301_T2.8561.00
222_V254_I2.8321.00
196_V214_A2.8111.00
250_D329_E2.7761.00
62_A408_A2.7761.00
28_M31_A2.7641.00
129_D143_V2.6181.00
16_D19_S2.5951.00
132_R139_H2.5291.00
44_R180_L2.5281.00
19_S22_A2.5141.00
90_D139_H2.4831.00
76_P151_R2.4371.00
86_E89_S2.4141.00
90_D131_D2.3881.00
196_V212_I2.3041.00
91_V104_I2.3031.00
249_E325_R2.2721.00
42_A46_L2.2261.00
24_A61_L2.2021.00
230_D265_A2.1991.00
174_L185_V2.1781.00
15_N46_L2.1721.00
281_H314_D2.1361.00
370_S446_D2.1271.00
47_I180_L2.0951.00
398_T404_R2.0931.00
25_D57_T2.0851.00
213_V234_G2.0551.00
194_D198_A2.0511.00
246_C254_I2.0501.00
17_D49_T2.0061.00
304_V327_V1.9991.00
324_D328_R1.9891.00
78_D98_T1.9631.00
181_D402_D1.9631.00
201_R205_S1.9531.00
89_S101_P1.9361.00
121_L148_L1.9291.00
90_D141_T1.8911.00
103_R137_T1.8771.00
256_K299_D1.8671.00
178_A210_I1.8571.00
96_G136_D1.8211.00
211_P406_Q1.8131.00
115_P133_V1.8101.00
82_T147_S1.8091.00
51_R54_D1.8041.00
19_S317_T1.7911.00
193_A227_G1.7591.00
259_I271_T1.7441.00
93_F128_A1.7341.00
91_V140_A1.7301.00
373_V448_V1.7281.00
10_L20_V1.7221.00
33_I47_I1.7191.00
47_I63_V1.7191.00
194_D197_L1.7191.00
175_A206_H1.7151.00
85_I142_V1.7131.00
84_H147_S1.7051.00
112_A162_D1.7031.00
21_R25_D1.7031.00
363_L467_L1.7001.00
118_T127_E1.6981.00
225_L229_I1.6941.00
168_E172_R1.6931.00
7_V270_I1.6841.00
171_R175_A1.6841.00
29_T59_K1.6831.00
434_Q438_D1.6781.00
128_A140_A1.6661.00
235_V258_I1.6521.00
404_R417_Y1.6381.00
169_K173_D1.6331.00
17_D56_Q1.6181.00
83_I101_P1.6161.00
52_A56_Q1.5971.00
96_G103_R1.5971.00
41_A44_R1.5961.00
30_V64_M1.5841.00
219_A223_E1.5801.00
22_A25_D1.5741.00
89_S142_V1.5731.00
67_T71_E1.5731.00
257_R261_Q1.5661.00
92_A139_H1.5641.00
160_E220_G1.5581.00
24_A53_V1.5581.00
92_A137_T1.5571.00
7_V30_V1.5441.00
118_T129_D1.5301.00
171_R198_A1.5271.00
187_A199_V1.5231.00
318_R321_E1.5181.00
77_I150_S1.5151.00
114_E117_D1.4881.00
134_A137_T1.4871.00
213_V270_I1.4871.00
17_D53_V1.4781.00
435_A438_D1.4751.00
81_G150_S1.4691.00
2_R324_D1.4661.00
31_A50_T1.4661.00
65_L182_V1.4541.00
45_E48_E1.4421.00
21_R57_T1.4351.00
95_E110_I1.4351.00
96_G137_T1.4211.00
407_L410_N1.4211.00
33_I50_T1.4171.00
315_N318_R1.4051.00
172_R175_A1.3981.00
248_M322_T1.3931.00
369_A449_V1.3931.00
110_I138_V1.3821.00
40_A176_L1.3791.00
63_V182_V1.3731.00
94_V103_R1.3500.99
280_V308_A1.3460.99
376_S396_C1.3450.99
45_E49_T1.3410.99
97_D109_S1.3330.99
134_A139_H1.3320.99
122_D125_R1.3150.99
38_G43_R1.3080.99
74_T126_I1.3040.99
435_A439_S1.3030.99
53_V57_T1.3030.99
19_S23_L1.2930.99
171_R202_V1.2910.99
44_R179_E1.2900.99
26_A321_E1.2820.99
39_D42_A1.2810.99
193_A231_A1.2680.99
117_D159_V1.2650.99
277_D281_H1.2580.99
437_V444_S1.2580.99
321_E325_R1.2550.99
74_T104_I1.2550.99
224_N227_G1.2540.99
209_D402_D1.2530.99
133_V138_V1.2520.99
251_V291_S1.2500.99
8_C31_A1.2390.99
75_A105_G1.2350.99
16_D49_T1.2300.99
261_Q265_A1.2250.99
297_V327_V1.2230.99
121_L128_A1.2130.99
48_E52_A1.2130.99
218_R221_A1.2050.99
23_L320_V1.2020.99
18_A21_R1.1970.99
175_A179_E1.1960.99
113_A138_V1.1950.99
94_V137_T1.1910.99
14_T19_S1.1870.99
355_A363_L1.1840.99
329_E332_G1.1830.99
4_A327_V1.1800.99
254_I258_I1.1800.99
21_R53_V1.1740.99
10_L46_L1.1730.98
178_A203_L1.1720.98
87_T145_G1.1720.98
33_I182_V1.1640.98
229_I261_Q1.1600.98
43_R46_L1.1430.98
178_A206_H1.1410.98
396_C407_L1.1410.98
293_V326_I1.1400.98
352_K447_T1.1360.98
10_L14_T1.1340.98
177_A182_V1.1340.98
15_N45_E1.1330.98
22_A321_E1.1330.98
49_T52_A1.1310.98
83_I148_L1.1270.98
156_V159_V1.1170.98
275_M293_V1.1150.98
24_A59_K1.1140.98
40_A173_D1.1050.98
259_I301_T1.1020.98
371_A395_V1.1010.98
47_I176_L1.0960.98
15_N49_T1.0880.98
424_D427_T1.0850.97
175_A205_S1.0850.97
17_D21_R1.0850.97
82_T149_G1.0690.97
14_T23_L1.0690.97
55_A401_H1.0670.97
197_L201_R1.0610.97
203_L208_A1.0610.97
363_L469_V1.0590.97
86_E145_G1.0530.97
131_D139_H1.0510.97
277_D280_V1.0460.97
193_A197_L1.0450.97
452_V466_T1.0440.97
33_I63_V1.0430.97
396_C413_V1.0410.97
253_M298_L1.0330.97
86_E101_P1.0330.97
127_E143_V1.0310.97
7_V303_G1.0290.97
68_Q71_E1.0290.97
35_A65_L1.0260.96
76_P150_S1.0220.96
374_V385_A1.0200.96
354_D387_K1.0160.96
142_V145_G1.0130.96
110_I133_V1.0120.96
277_D308_A1.0070.96
193_A224_N1.0050.96
179_E206_H1.0040.96
30_V303_G0.9990.96
10_L50_T0.9950.96
447_T471_V0.9930.96
93_F106_I0.9910.96
370_S443_A0.9890.96
383_R410_N0.9890.96
22_A317_T0.9860.96
128_A142_V0.9840.96
156_V161_L0.9830.96
71_E218_R0.9830.96
226_D229_I0.9780.95
50_T63_V0.9770.95
49_T53_V0.9730.95
47_I182_V0.9710.95
283_R315_N0.9700.95
74_T149_G0.9690.95
100_T103_R0.9670.95
290_A326_I0.9660.95
48_E180_L0.9620.95
42_A45_E0.9620.95
99_A104_I0.9600.95
225_L261_Q0.9580.95
397_A418_A0.9500.95
200_N233_Q0.9490.95
171_R201_R0.9420.94
121_L140_A0.9390.94
118_T143_V0.9390.94
198_A201_R0.9370.94
87_T314_D0.9330.94
166_V171_R0.9320.94
108_T112_A0.9320.94
395_V436_A0.9310.94
68_Q169_K0.9290.94
106_I154_V0.9290.94
203_L210_I0.9250.94
452_V455_M0.9220.94
168_E171_R0.9220.94
122_D149_G0.9210.94
442_V472_A0.9190.94
182_V210_I0.9140.93
104_I148_L0.9130.93
358_R362_Y0.9090.93
122_D277_D0.9070.93
232_A235_V0.9070.93
44_R176_L0.9050.93
386_A410_N0.9050.93
26_A317_T0.9040.93
183_D405_R0.9030.93
90_D132_R0.9020.93
80_D150_S0.9010.93
222_V242_L0.9010.93
260_A264_D0.8980.93
20_V53_V0.8960.93
84_H145_G0.8950.93
77_I91_V0.8930.93
248_M290_A0.8930.93
204_E208_A0.8920.93
155_N245_E0.8910.93
26_A320_V0.8910.93
293_V304_V0.8910.93
53_V56_Q0.8890.92
191_R220_G0.8870.92
174_L199_V0.8810.92
276_L319_V0.8800.92
127_E284_R0.8790.92
229_I262_C0.8790.92
88_G141_T0.8760.92
455_M465_N0.8740.92
93_F140_A0.8740.92
229_I265_A0.8710.92
4_A297_V0.8670.91
14_T310_T0.8660.91
192_D195_D0.8640.91
68_Q173_D0.8620.91
77_I148_L0.8600.91
64_M186_A0.8550.91
357_A385_A0.8550.91
227_G230_D0.8530.91
36_S173_D0.8500.91
219_A250_D0.8500.91
196_V232_A0.8480.91
77_I81_G0.8460.90
174_L202_V0.8440.90
126_I148_L0.8420.90
40_A44_R0.8350.90
229_I258_I0.8320.90
176_L180_L0.8310.90
226_D265_A0.8290.90
315_N319_V0.8280.90
60_P404_R0.8260.89
113_A119_V0.8260.89
57_T60_P0.8260.89
54_D61_L0.8230.89
93_F104_I0.8230.89
60_P415_A0.8230.89
24_A57_T0.8220.89
178_A185_V0.8210.89
253_M330_V0.8190.89
398_T417_Y0.8180.89
131_D140_A0.8170.89
356_L451_L0.8150.89
433_V448_V0.8140.89
115_P132_R0.8130.89
259_I269_V0.8120.89
62_A184_Y0.8120.89
41_A45_E0.8110.89
115_P131_D0.8070.88
429_V450_V0.8050.88
16_D23_L0.8040.88
184_Y213_V0.8000.88
175_A202_V0.8000.88
317_T321_E0.7980.88
161_L164_D0.7950.88
20_V49_T0.7930.87
65_L71_E0.7930.87
71_E221_A0.7900.87
117_D130_V0.7890.87
67_T218_R0.7870.87
403_V407_L0.7870.87
71_E153_G0.7870.87
123_D153_G0.7850.87
213_V409_L0.7840.87
90_D102_D0.7820.87
374_V381_T0.7820.87
175_A178_A0.7820.87
123_D274_E0.7810.87
225_L257_R0.7780.86
358_R366_D0.7780.86
20_V50_T0.7750.86
200_N204_E0.7730.86
298_L333_S0.7680.86
10_L33_I0.7650.85
360_A449_V0.7640.85
50_T54_D0.7600.85
383_R406_Q0.7590.85
77_I149_G0.7580.85
177_A185_V0.7560.85
199_V212_I0.7560.85
78_D101_P0.7560.85
402_D406_Q0.7550.85
77_I104_I0.7550.85
83_I104_I0.7550.85
87_T141_T0.7550.85
453_G460_G0.7530.85
92_A103_R0.7530.85
376_S382_A0.7500.84
30_V62_A0.7450.84
371_A442_V0.7440.84
93_F119_V0.7440.84
354_D384_K0.7430.84
7_V28_M0.7420.84
433_V470_H0.7410.84
401_H417_Y0.7400.84
362_Y366_D0.7400.84
116_G129_D0.7400.84
360_A364_A0.7390.83
382_A396_C0.7370.83
397_A436_A0.7370.83
52_A55_A0.7340.83
380_Y384_K0.7330.83
158_G219_A0.7330.83
364_A372_V0.7300.83
91_V100_T0.7290.83
122_D153_G0.7250.82
369_A469_V0.7220.82
40_A172_R0.7210.82
230_D267_V0.7210.82
429_V468_K0.7200.82
263_R302_D0.7190.82
24_A54_D0.7160.81
14_T317_T0.7140.81
114_E133_V0.7090.81
39_D151_R0.7050.80
225_L262_C0.7040.80
126_I142_V0.7030.80
377_E400_S0.7020.80
367_I447_T0.7020.80
329_E333_S0.7020.80
234_G268_P0.7000.80
126_I145_G0.6990.80
298_L330_V0.6980.80
35_A173_D0.6960.80
54_D57_T0.6950.80
21_R52_A0.6950.80
24_A50_T0.6940.79
436_A442_V0.6940.79
76_P98_T0.6940.79
225_L235_V0.6930.79
19_S49_T0.6920.79
184_Y410_N0.6920.79
356_L467_L0.6920.79
74_T77_I0.6900.79
353_T380_Y0.6890.79
74_T154_V0.6890.79
360_A451_L0.6890.79
10_L31_A0.6880.79
67_T187_A0.6880.79
68_Q308_A0.6870.79
62_A405_R0.6860.79
226_D257_R0.6840.78
178_A208_A0.6830.78
91_V99_A0.6830.78
157_P245_E0.6820.78
373_V442_V0.6790.78
122_D308_A0.6790.78
295_N299_D0.6780.78
216_I222_V0.6780.78
149_G312_V0.6770.78
275_M304_V0.6760.78
35_A43_R0.6750.78
247_P251_V0.6720.77
408_A415_A0.6700.77
77_I99_A0.6700.77
253_M333_S0.6700.77
236_M307_S0.6700.77
275_M323_M0.6670.77
400_S403_V0.6670.77
33_I43_R0.6650.76
433_V472_A0.6640.76
85_I126_I0.6640.76
256_K295_N0.6610.76
125_R282_A0.6590.76
22_A26_A0.6570.76
374_V382_A0.6560.76
163_V167_T0.6550.75
15_N20_V0.6550.75
353_T384_K0.6540.75
10_L49_T0.6540.75
404_R415_A0.6530.75
177_A181_D0.6520.75
89_S102_D0.6510.75
2_R29_T0.6510.75
92_A95_E0.6500.75
80_D83_I0.6490.75
401_H405_R0.6470.75
113_A130_V0.6460.74
87_T315_N0.6460.74
94_V110_I0.6460.74
360_A372_V0.6450.74
108_T191_R0.6440.74
297_V304_V0.6440.74
89_S128_A0.6440.74
460_G464_T0.6430.74
251_V290_A0.6430.74
92_A134_A0.6420.74
30_V408_A0.6420.74
351_A354_D0.6420.74
275_M307_S0.6410.74
15_N42_A0.6410.74
437_V442_V0.6400.74
216_I225_L0.6400.74
312_V319_V0.6390.74
192_D224_N0.6370.73
112_A191_R0.6350.73
450_V470_H0.6350.73
243_G284_R0.6340.73
363_L367_I0.6330.73
297_V330_V0.6320.73
381_T453_G0.6320.73
110_I136_D0.6310.73
37_H241_D0.6290.72
38_G42_A0.6290.72
6_I323_M0.6290.72
91_V142_V0.6270.72
377_E420_V0.6270.72
253_M329_E0.6260.72
91_V105_G0.6260.72
310_T323_M0.6250.72
298_L334_A0.6250.72
80_D101_P0.6250.72
263_R271_T0.6240.72
324_D327_V0.6240.72
385_A451_L0.6230.72
165_V190_V0.6220.72
457_E460_G0.6210.71
85_I89_S0.6210.71
421_A427_T0.6190.71
93_F121_L0.6190.71
75_A107_S0.6180.71
166_V202_V0.6160.71
6_I320_V0.6160.71
202_V205_S0.6160.71
361_R390_P0.6160.71
394_V413_V0.6160.71
68_Q221_A0.6150.71
91_V101_P0.6150.71
126_I146_G0.6130.70
2_R6_I0.6120.70
43_R177_A0.6120.70
339_R342_Q0.6110.70
352_K374_V0.6100.70
268_P409_L0.6080.70
54_D60_P0.6070.70
322_T326_I0.6070.70
10_L15_N0.6070.70
433_V442_V0.6050.70
257_R333_S0.6050.70
434_Q437_V0.6050.70
97_D105_G0.6030.69
202_V206_H0.6030.69
25_D56_Q0.6030.69
90_D129_D0.6030.69
68_Q218_R0.6030.69
77_I126_I0.6030.69
364_A369_A0.6030.69
451_L464_T0.6020.69
297_V354_D0.6010.69
184_Y409_L0.6010.69
198_A202_V0.6010.69
310_T319_V0.6010.69
375_A428_V0.5990.69
72_V154_V0.5970.68
47_I50_T0.5970.68
211_P383_R0.5950.68
449_V469_V0.5940.68
190_V196_V0.5940.68
193_A216_I0.5940.68
50_T61_L0.5930.68
377_E399_P0.5920.68
106_I138_V0.5910.68
276_L322_T0.5880.67
221_A229_I0.5870.67
148_L151_R0.5870.67
111_A162_D0.5860.67
23_L317_T0.5850.67
92_A136_D0.5850.67
54_D59_K0.5830.67
16_D20_V0.5820.67
303_G409_L0.5800.66
25_D59_K0.5790.66
185_V208_A0.5790.66
20_V23_L0.5780.66
216_I234_G0.5770.66
181_D210_I0.5770.66
397_A416_N0.5760.66
74_T93_F0.5760.66
449_V467_L0.5750.66
185_V203_L0.5740.65
122_D191_R0.5740.65
31_A54_D0.5740.65
254_I257_R0.5720.65
360_A369_A0.5720.65
389_R411_W0.5710.65
365_R391_S0.5710.65
82_T150_S0.5700.65
72_V169_K0.5700.65
373_V397_A0.5700.65
233_Q267_V0.5680.65
74_T148_L0.5680.65
65_L176_L0.5670.65
261_Q264_D0.5670.65
35_A182_V0.5670.65
34_N37_H0.5670.65
18_A49_T0.5660.64
465_N468_K0.5660.64
6_I324_D0.5650.64
99_A105_G0.5650.64
266_G387_K0.5650.64
121_L126_I0.5640.64
443_A446_D0.5640.64
39_D76_P0.5640.64
201_R204_E0.5630.64
83_I100_T0.5630.64
106_I156_V0.5630.64
351_A384_K0.5620.64
48_E179_E0.5620.64
203_L211_P0.5620.64
24_A83_I0.5610.64
334_A339_R0.5610.64
187_A190_V0.5610.64
184_Y211_P0.5610.64
14_T312_V0.5600.64
266_G390_P0.5590.63
110_I135_G0.5580.63
236_M305_M0.5560.63
91_V103_R0.5560.63
252_P411_W0.5550.63
23_L28_M0.5550.63
165_V191_R0.5550.63
421_A428_V0.5550.63
166_V174_L0.5540.63
111_A133_V0.5540.63
371_A393_P0.5540.63
71_E163_V0.5520.62
189_F241_D0.5520.62
236_M272_A0.5510.62
235_V265_A0.5490.62
403_V453_G0.5480.62
10_L28_M0.5460.62
270_I305_M0.5450.62
194_D201_R0.5430.61
396_C415_A0.5430.61
367_I449_V0.5430.61
83_I89_S0.5430.61
229_I267_V0.5420.61
425_A452_V0.5420.61
204_E209_D0.5420.61
155_N167_T0.5400.61
216_I258_I0.5400.61
111_A136_D0.5390.61
91_V149_G0.5390.61
384_K429_V0.5390.61
253_M290_A0.5380.61
174_L207_G0.5380.61
367_I469_V0.5370.60
117_D158_G0.5360.60
39_D172_R0.5360.60
322_T325_R0.5350.60
153_G244_V0.5350.60
425_A466_T0.5350.60
98_T103_R0.5350.60
120_L186_A0.5340.60
336_Y340_Q0.5340.60
382_A415_A0.5330.60
174_L208_A0.5320.60
47_I51_R0.5320.60
199_V202_V0.5320.60
190_V214_A0.5320.60
77_I82_T0.5310.60
14_T311_A0.5310.60
67_T153_G0.5300.59
386_A394_V0.5280.59
44_R47_I0.5270.59
189_F245_E0.5260.59
89_S145_G0.5260.59
248_M291_S0.5240.59
271_T300_G0.5240.59
395_V441_V0.5240.59
85_I91_V0.5230.58
275_M301_T0.5230.58
95_E135_G0.5230.58
189_F236_M0.5220.58
399_P417_Y0.5220.58
236_M275_M0.5210.58
363_L449_V0.5200.58
263_R387_K0.5190.58
166_V199_V0.5190.58
192_D227_G0.5180.58
194_D227_G0.5170.58
263_R299_D0.5160.57
22_A101_P0.5160.57
85_I121_L0.5150.57
46_L49_T0.5140.57
2_R291_S0.5140.57
187_A212_I0.5130.57
110_I113_A0.5110.57
48_E51_R0.5110.57
202_V207_G0.5110.57
364_A449_V0.5100.57
15_N18_A0.5100.57
294_A298_L0.5090.56
411_W452_V0.5090.56
257_R260_A0.5080.56
454_M468_K0.5080.56
414_H441_V0.5080.56
174_L182_V0.5070.56
64_M409_L0.5060.56
234_G409_L0.5060.56
107_S150_S0.5060.56
238_A272_A0.5050.56
453_G464_T0.5040.56
270_I409_L0.5030.55
36_S65_L0.5030.55
268_P302_D0.5020.55
163_V190_V0.5010.55
149_G152_K0.5010.55
147_S281_H0.5000.55
123_D241_D0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e28A 3 0.9914 100 0.175 Contact Map
3t05A 3 0.9896 100 0.178 Contact Map
3gr4A 4 0.8117 100 0.283 Contact Map
1a3wA 3 0.8066 100 0.285 Contact Map
3gg8A 3 0.8083 100 0.286 Contact Map
1e0tA 3 0.7617 100 0.289 Contact Map
3khdA 3 0.81 100 0.29 Contact Map
4kctB 3 0.81 100 0.305 Contact Map
4drsA 3 0.7945 100 0.316 Contact Map
3qtgA 3 0.7634 100 0.324 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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