GREMLIN Database
MFNA - L-tyrosine decarboxylase
UniProt: Q9HSA3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 355 (316)
Sequences: 35395 (23723)
Seq/√Len: 1334.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_N121_R3.3311.00
284_Y345_A3.3061.00
166_A176_L3.2841.00
284_Y341_R3.2521.00
288_E348_L3.2171.00
151_A183_G2.9291.00
161_P164_A2.9021.00
137_A168_I2.7251.00
59_L264_R2.6941.00
180_A204_M2.5431.00
103_A124_P2.5161.00
98_N119_E2.4631.00
98_N141_D2.3801.00
206_I220_G2.3701.00
137_A171_G2.3601.00
261_A264_R2.3261.00
169_A174_A2.3221.00
284_Y288_E2.2251.00
252_S255_G2.2101.00
147_V169_A2.1821.00
166_A170_A2.1371.00
295_D307_D2.1131.00
135_A138_D2.0961.00
26_P30_E2.0831.00
288_E345_A2.0031.00
288_E291_A1.9881.00
190_T193_D1.9641.00
163_P193_D1.9491.00
124_P135_A1.8931.00
109_F113_A1.8901.00
277_R281_N1.8801.00
346_A350_D1.8711.00
319_E350_D1.8531.00
280_G341_R1.8441.00
135_A139_L1.8421.00
333_V347_F1.8401.00
132_D135_A1.8401.00
33_Q37_A1.8281.00
163_P167_D1.8211.00
98_N143_D1.8071.00
65_G190_T1.7981.00
98_N144_T1.7921.00
149_G165_L1.7741.00
295_D309_P1.7201.00
126_D130_R1.7071.00
121_R139_L1.7061.00
75_A79_E1.7051.00
97_V143_D1.6931.00
178_V201_V1.6791.00
97_V145_A1.6771.00
297_V307_D1.6401.00
81_N108_S1.6381.00
133_V164_A1.6271.00
169_A176_L1.6231.00
59_L260_L1.6011.00
30_E34_A1.5831.00
285_L335_C1.5661.00
84_A203_T1.5581.00
168_I172_V1.5431.00
167_D171_G1.5421.00
283_E287_A1.5191.00
164_A167_D1.5191.00
29_R33_Q1.5191.00
170_A202_N1.5091.00
276_E280_G1.5001.00
34_A38_T1.4991.00
62_E267_W1.4731.00
133_V168_I1.4711.00
170_A200_P1.4551.00
315_A318_E1.4521.00
282_A286_A1.4431.00
279_Q283_E1.4411.00
74_A80_A1.4401.00
70_H225_D1.4391.00
137_A172_V1.4351.00
146_V177_H1.4081.00
109_F112_A1.4031.00
26_P37_A1.3861.00
201_V204_M1.3691.00
55_D260_L1.3631.00
149_G176_L1.3601.00
272_R276_E1.3541.00
286_A290_A1.3501.00
275_Y279_Q1.3491.00
81_N177_H1.3441.00
103_A122_L1.3401.00
112_A116_L1.3351.00
224_R227_E1.3331.00
208_P259_A1.3301.00
30_E33_Q1.3281.00
285_L344_L1.3241.00
55_D59_L1.3161.00
167_D200_P1.3161.00
341_R345_A1.3111.00
166_A200_P1.3101.00
140_V168_I1.3061.00
281_N341_R1.3031.00
237_P240_E1.2971.00
60_L220_G1.2851.00
305_A330_A1.2841.00
134_A138_D1.2781.00
111_K114_D1.2701.00
126_D132_D1.2651.00
184_G206_I1.2631.00
77_G181_A1.2561.00
315_A319_E1.2551.00
110_Q114_D1.2531.00
340_T343_M1.2501.00
168_I171_G1.2391.00
58_A68_S1.2161.00
288_E352_D1.2141.00
96_A145_A1.2041.00
213_Q336_M1.2041.00
56_A260_L1.2011.00
58_A62_E1.2001.00
203_T223_A1.1961.00
177_H205_A1.1901.00
287_A291_A1.1851.00
58_A61_G1.1831.00
346_A349_D1.1801.00
123_A139_L1.1801.00
287_A290_A1.1781.00
134_A137_A1.1761.00
260_L264_R1.1731.00
141_D172_V1.1621.00
69_P225_D1.1621.00
86_R239_L1.1581.00
31_A261_A1.1511.00
67_S225_D1.1501.00
215_P258_G1.1501.00
59_L267_W1.1381.00
100_V139_L1.1341.00
162_I178_V1.1291.00
321_W346_A1.1281.00
29_R37_A1.1281.00
88_A175_N1.1181.00
80_A205_A1.1151.00
149_G162_I1.1151.00
101_A122_L1.1091.00
286_A304_V1.1071.00
236_T240_E1.1071.00
270_G273_E1.1041.00
137_A141_D1.1031.00
51_E55_D1.0981.00
321_W347_F1.0951.00
32_A258_G1.0911.00
136_V165_L1.0871.00
152_G300_E1.0841.00
238_Y241_S1.0821.00
39_N48_A1.0801.00
137_A164_A1.0771.00
277_R280_G1.0761.00
59_L62_E1.0751.00
152_G183_G1.0721.00
24_P29_R1.0701.00
111_K115_V1.0631.00
202_N224_R1.0561.00
110_Q113_A1.0491.00
112_A115_V1.0491.00
31_A34_A1.0491.00
67_S192_H1.0411.00
300_E303_L1.0381.00
323_I333_V1.0361.00
136_V147_V1.0351.00
286_A296_V1.0301.00
147_V174_A1.0291.00
133_V137_A1.0291.00
273_E276_E1.0271.00
99_V113_A1.0251.00
281_N344_L1.0251.00
63_I184_G1.0131.00
323_I331_L1.0071.00
175_N203_T1.0051.00
52_R257_A1.0031.00
163_P199_A1.0011.00
314_Q318_E1.0001.00
270_G274_Q0.9981.00
39_N42_D0.9951.00
71_G222_L0.9941.00
183_G204_M0.9931.00
148_V177_H0.9911.00
239_L243_T0.9891.00
302_P305_A0.9871.00
100_V144_T0.9801.00
88_A203_T0.9751.00
191_D222_L0.9701.00
151_A204_M0.9681.00
342_E345_A0.9621.00
64_V206_I0.9601.00
159_V187_L0.9571.00
150_V154_T0.9551.00
65_G192_H0.9541.00
293_G309_P0.9511.00
211_M259_A0.9511.00
274_Q277_R0.9471.00
345_A349_D0.9451.00
141_D144_T0.9451.00
104_S160_D0.9331.00
188_P272_R0.9311.00
306_A333_V0.9311.00
310_D313_F0.9181.00
285_L347_F0.9181.00
273_E277_R0.9141.00
177_H203_T0.9141.00
282_A304_V0.9131.00
321_W350_D0.9061.00
126_D135_A0.9041.00
97_V119_E0.9031.00
32_A36_L0.9031.00
288_E349_D0.9011.00
274_Q337_P0.8991.00
119_E141_D0.8991.00
86_R115_V0.8961.00
225_D228_T0.8941.00
314_Q317_R0.8931.00
291_A352_D0.8901.00
244_Q248_G0.8881.00
274_Q278_T0.8871.00
170_A176_L0.8801.00
151_A199_A0.8761.00
335_C344_L0.8751.00
203_T227_E0.8751.00
67_S70_H0.8741.00
40_P43_P0.8731.00
166_A199_A0.8711.00
103_A125_T0.8641.00
339_V344_L0.8631.00
238_Y243_T0.8581.00
140_V172_V0.8561.00
307_D329_D0.8521.00
133_V136_V0.8461.00
289_L306_A0.8451.00
152_G301_L0.8441.00
53_E256_V0.8431.00
339_V343_M0.8431.00
110_Q122_L0.8401.00
48_A51_E0.8341.00
348_L352_D0.8341.00
297_V330_A0.8341.00
101_A113_A0.8331.00
342_E346_A0.8331.00
109_F116_L0.8231.00
54_R58_A0.8221.00
175_N227_E0.8181.00
81_N205_A0.8151.00
54_R57_V0.8141.00
316_L323_I0.8131.00
238_Y242_D0.8121.00
147_V165_L0.8101.00
286_A300_E0.8081.00
169_A173_D0.8061.00
208_P218_A0.8061.00
140_V144_T0.8011.00
59_L63_I0.8011.00
104_S108_S0.7981.00
44_E48_A0.7951.00
109_F115_V0.7931.00
64_V222_L0.7911.00
140_V174_A0.7901.00
164_A168_I0.7841.00
55_D264_R0.7821.00
89_R118_V0.7811.00
121_R141_D0.7801.00
189_F192_H0.7801.00
88_A92_A0.7781.00
115_V239_L0.7781.00
56_A59_L0.7771.00
223_A228_T0.7761.00
25_H265_A0.7691.00
237_P241_S0.7641.00
221_F224_R0.7641.00
109_F148_V0.7641.00
150_V153_T0.7611.00
184_G211_M0.7591.00
239_L242_D0.7591.00
285_L333_V0.7581.00
27_A265_A0.7571.00
124_P139_L0.7561.00
280_G284_Y0.7561.00
29_R36_L0.7531.00
240_E243_T0.7511.00
61_G66_L0.7511.00
285_L304_V0.7401.00
294_Y308_M0.7371.00
300_E305_A0.7341.00
200_P224_R0.7341.00
151_A189_F0.7301.00
101_A105_A0.7291.00
72_Y83_Q0.7281.00
26_P29_R0.7261.00
183_G187_L0.7241.00
285_L348_L0.7201.00
86_R90_N0.7191.00
163_P200_P0.7191.00
99_V146_V0.7171.00
113_A120_L0.7161.00
336_M339_V0.7131.00
180_A183_G0.7131.00
55_D58_A0.7121.00
63_I263_L0.7101.00
213_Q337_P0.7011.00
45_T322_R0.6981.00
214_A217_P0.6921.00
180_A184_G0.6921.00
347_F351_V0.6921.00
101_A120_L0.6911.00
102_P105_A0.6901.00
130_R160_D0.6901.00
66_L70_H0.6891.00
208_P214_A0.6851.00
236_T239_L0.6841.00
121_R144_T0.6811.00
269_D273_E0.6801.00
188_P275_Y0.6791.00
169_A172_V0.6781.00
184_G189_F0.6771.00
237_P243_T0.6761.00
300_E304_V0.6751.00
25_H28_A0.6741.00
218_A255_G0.6741.00
175_N202_N0.6731.00
77_G81_N0.6691.00
285_L289_L0.6691.00
285_L288_E0.6681.00
260_L263_L0.6671.00
61_G68_S0.6651.00
52_R55_D0.6651.00
59_L263_L0.6651.00
151_A162_I0.6611.00
84_A177_H0.6601.00
44_E317_R0.6601.00
261_A265_A0.6601.00
176_L201_V0.6581.00
297_V305_A0.6571.00
210_K332_R0.6561.00
39_N43_P0.6541.00
317_R322_R0.6541.00
284_Y344_L0.6541.00
101_A148_V0.6531.00
64_V191_D0.6521.00
284_Y287_A0.6511.00
166_A201_V0.6511.00
27_A30_E0.6511.00
286_A299_P0.6501.00
185_F188_P0.6491.00
278_T302_P0.6481.00
324_S327_A0.6481.00
253_G257_A0.6461.00
62_E65_G0.6461.00
266_L270_G0.6401.00
237_P242_D0.6341.00
262_S265_A0.6331.00
211_M263_L0.6301.00
56_A256_V0.6271.00
167_D170_A0.6261.00
66_L204_M0.6251.00
193_D199_A0.6221.00
88_A146_V0.6211.00
100_V123_A0.6201.00
345_A348_L0.6181.00
34_A39_N0.6181.00
84_A221_F0.6161.00
66_L222_L0.6151.00
244_Q247_L0.6151.00
253_G256_V0.6151.00
347_F350_D0.6151.00
100_V121_R0.6151.00
290_A296_V0.6151.00
114_D122_L0.6141.00
50_A54_R0.6121.00
111_K116_L0.6101.00
142_G172_V0.6091.00
77_G205_A0.6081.00
289_L294_Y0.6081.00
264_R267_W0.6081.00
128_D298_D0.6071.00
74_A83_Q0.6071.00
276_E279_Q0.6051.00
102_P149_G0.6031.00
113_A116_L0.6021.00
119_E143_D0.5991.00
31_A35_F0.5971.00
98_N142_G0.5971.00
136_V140_V0.5961.00
166_A178_V0.5941.00
35_F52_R0.5931.00
82_L86_R0.5911.00
181_A207_D0.5901.00
266_L271_Y0.5901.00
271_Y275_Y0.5891.00
133_V165_L0.5881.00
34_A37_A0.5861.00
190_T199_A0.5861.00
38_T42_D0.5851.00
151_A178_V0.5851.00
64_V184_G0.5851.00
60_L263_L0.5841.00
301_L305_A0.5841.00
27_A31_A0.5821.00
309_P312_E0.5821.00
284_Y348_L0.5811.00
136_V168_I0.5771.00
259_A262_S0.5761.00
301_L304_V0.5761.00
289_L348_L0.5731.00
26_P33_Q0.5721.00
90_N115_V0.5721.00
263_L267_W0.5721.00
109_F114_D0.5711.00
302_P307_D0.5701.00
255_G258_G0.5691.00
272_R275_Y0.5691.00
37_A40_P0.5681.00
83_Q87_A0.5671.00
303_L334_V0.5661.00
292_R352_D0.5651.00
258_G262_S0.5631.00
250_T253_G0.5611.00
92_A96_A0.5591.00
123_A135_A0.5581.00
349_D352_D0.5581.00
280_G283_E0.5571.00
236_T241_S0.5571.00
33_Q36_L0.5571.00
37_A42_D0.5531.00
166_A169_A0.5511.00
264_R268_P0.5501.00
281_N285_L0.5491.00
38_T43_P0.5481.00
277_R341_R0.5481.00
182_W185_F0.5471.00
24_P28_A0.5471.00
149_G178_V0.5471.00
278_T335_C0.5451.00
52_R260_L0.5431.00
262_S266_L0.5431.00
110_Q116_L0.5421.00
203_T221_F0.5411.00
213_Q216_V0.5411.00
259_A263_L0.5401.00
27_A261_A0.5391.00
60_L73_I0.5381.00
275_Y278_T0.5381.00
218_A256_V0.5371.00
151_A159_V0.5351.00
104_S107_F0.5351.00
288_E344_L0.5351.00
32_A35_F0.5341.00
289_L351_V0.5341.00
70_H192_H0.5311.00
220_G223_A0.5301.00
307_D330_A0.5291.00
82_L115_V0.5291.00
189_F204_M0.5281.00
70_H224_R0.5281.00
307_D311_A0.5261.00
85_V109_F0.5231.00
308_M311_A0.5221.00
107_F111_K0.5201.00
130_R298_D0.5181.00
150_V160_D0.5181.00
279_Q282_A0.5141.00
137_A140_V0.5131.00
89_R146_V0.5131.00
302_P308_M0.5121.00
81_N148_V0.5101.00
110_Q115_V0.5081.00
162_I166_A0.5081.00
146_V175_N0.5031.00
104_S125_T0.5031.00
28_A262_S0.5031.00
223_A226_P0.5021.00
165_L176_L0.5021.00
113_A118_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e9kA 2 0.9775 100 0.354 Contact Map
3f9tA 2 0.9972 100 0.367 Contact Map
4ritB 2 0.9775 100 0.367 Contact Map
3vp6A 2 0.9972 100 0.38 Contact Map
2jisA 2 0.9972 100 0.381 Contact Map
1js3A 2 0.9662 100 0.382 Contact Map
4e1oA 2 0.9972 100 0.389 Contact Map
3k40A 2 0.9408 100 0.389 Contact Map
2qmaA 2 0.9465 100 0.39 Contact Map
1kmjA 2 0.9803 100 0.394 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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