GREMLIN Database
Q9HSA2 - Zinc metalloproteinase homolog
UniProt: Q9HSA2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (401)
Sequences: 1241 (973)
Seq/√Len: 48.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_L132_F5.6561.00
362_V409_L5.2941.00
372_A406_I4.7941.00
122_A139_P4.6291.00
25_L389_H4.2061.00
199_M246_F4.0861.00
193_L197_V4.0221.00
212_G268_E3.4391.00
144_R148_L3.2151.00
216_A272_Q3.1521.00
46_G49_D3.0261.00
125_T137_Q2.9991.00
164_V179_A2.9601.00
270_E377_A2.9151.00
216_A268_E2.8971.00
276_A361_A2.8001.00
47_V51_G2.7831.00
194_V199_M2.7811.00
203_Y235_N2.7061.00
199_M205_F2.7061.00
211_G214_R2.6381.00
286_H356_E2.5851.00
206_D209_D2.5391.00
140_A144_R2.4541.00
184_G295_T2.4371.00
163_A182_I2.3971.00
194_V246_F2.3901.00
359_A408_Y2.3391.00
284_N356_E2.2781.00
205_F234_M2.2511.00
290_T353_N2.2441.00
355_R401_P2.2161.00
214_R218_E2.1641.00
70_V120_F2.1331.00
70_V116_A2.1111.00
393_E397_Y2.1071.00
270_E373_D2.0771.00
289_Q356_E2.0741.00
352_A356_E2.0571.00
88_V324_P2.0431.00
269_T370_P2.0391.00
122_A142_F2.0271.00
21_S25_L2.0010.99
303_F307_R1.9920.99
210_E214_R1.9660.99
397_Y401_P1.9570.99
179_A302_L1.9380.99
145_D239_R1.9360.99
103_V107_V1.9240.99
39_A42_A1.9140.99
74_A116_A1.9020.99
30_A57_H1.8970.99
221_F228_C1.8930.99
49_D380_S1.8440.99
368_G409_L1.8390.99
224_A360_F1.8110.99
95_V100_L1.7840.99
51_G55_A1.7810.99
385_N388_P1.7730.99
147_L151_G1.7670.99
175_W344_P1.7530.99
91_V108_G1.7520.99
246_F255_R1.7440.99
393_E401_P1.7390.99
246_F257_V1.7320.98
186_F190_T1.7240.98
130_S135_N1.7180.98
139_P142_F1.7170.98
130_S136_E1.7140.98
236_A240_S1.7060.98
139_P143_A1.7040.98
289_Q353_N1.6940.98
67_R120_F1.6720.98
137_Q141_L1.6570.98
372_A410_T1.6090.98
393_E404_E1.6060.98
353_N356_E1.6030.97
235_N238_S1.5860.97
233_V263_I1.5820.97
123_V127_G1.5790.97
52_E123_V1.5510.97
177_V181_G1.5180.97
111_V115_V1.5150.96
265_Q381_Q1.5110.96
59_L128_V1.5110.96
160_L182_I1.5020.96
392_Y396_H1.4980.96
373_D377_A1.4840.96
401_P404_E1.4780.96
49_D52_E1.4710.96
129_E242_H1.4700.96
95_V101_A1.4640.96
217_I272_Q1.4590.96
66_L69_V1.4550.96
171_L178_A1.4520.95
27_V61_T1.4370.95
205_F255_R1.4300.95
16_T69_V1.4020.95
136_E241_G1.3990.94
129_E240_S1.3920.94
77_G81_T1.3910.94
70_V74_A1.3710.94
243_S265_Q1.3660.94
152_L157_V1.3630.94
359_A363_D1.3630.94
72_A76_L1.3620.94
203_Y234_M1.3500.93
134_F242_H1.3480.93
146_A149_S1.3460.93
22_L395_F1.3450.93
234_M246_F1.3320.93
91_V104_A1.3310.93
182_I186_F1.3100.92
212_G215_D1.2990.92
205_F246_F1.2970.92
14_G18_L1.2880.92
40_W410_T1.2800.91
367_G370_P1.2780.91
400_P405_R1.2750.91
98_D169_A1.2700.91
56_Y129_E1.2670.91
277_H281_H1.2550.91
75_V333_V1.2530.90
220_V279_L1.2520.90
273_A371_L1.2450.90
59_L131_A1.2380.90
180_T299_G1.2370.90
215_D218_E1.2290.90
315_Y327_G1.2190.89
90_F108_G1.2180.89
285_G288_W1.2180.89
187_L190_T1.2120.89
208_V233_V1.2000.88
88_V92_Y1.1960.88
78_V83_A1.1940.88
87_A112_A1.1850.88
360_F392_Y1.1830.88
266_M377_A1.1800.88
45_I386_P1.1780.87
78_V116_A1.1760.87
218_E231_V1.1680.87
121_D146_A1.1680.87
152_L197_V1.1660.87
146_A150_A1.1640.87
131_A204_D1.1600.87
88_V326_A1.1580.87
143_A147_L1.1500.86
41_L402_V1.1430.86
31_E58_R1.1420.86
355_R408_Y1.1400.86
9_L13_A1.1380.86
91_V101_A1.1380.86
362_V368_G1.1340.85
243_S393_E1.1300.85
21_S389_H1.1260.85
79_L82_G1.1260.85
73_G147_L1.1190.85
243_S381_Q1.1190.85
94_T97_S1.1190.85
184_G291_I1.1130.84
145_D260_D1.1130.84
385_N389_H1.1080.84
209_D214_R1.1070.84
63_V67_R1.1010.84
52_E136_E1.0930.83
23_A61_T1.0840.83
389_H393_E1.0830.83
18_L395_F1.0820.83
107_V158_A1.0820.83
277_H354_E1.0810.83
145_D244_N1.0800.82
252_A401_P1.0780.82
162_G166_V1.0740.82
13_A17_L1.0620.81
234_M259_F1.0600.81
388_P397_Y1.0490.81
345_L349_L1.0410.80
99_V162_G1.0390.80
226_F247_F1.0330.80
145_D202_F1.0320.79
92_Y101_A1.0270.79
99_V155_V1.0260.79
251_G255_R1.0170.78
126_F138_S1.0150.78
237_S260_D1.0140.78
187_L191_Q1.0120.78
40_W407_R1.0090.78
281_H354_E1.0070.78
308_L314_L1.0070.78
170_A181_G1.0060.78
172_P308_L1.0030.77
185_V189_A0.9980.77
102_G165_L0.9960.77
245_A399_H0.9940.77
379_T402_V0.9930.77
171_L174_W0.9920.77
23_A64_S0.9900.77
23_A396_H0.9860.76
274_V399_H0.9780.76
274_V374_A0.9750.75
141_L144_R0.9740.75
195_P205_F0.9690.75
263_I271_L0.9670.75
390_P394_A0.9640.75
234_M272_Q0.9640.75
258_L263_I0.9600.74
181_G185_V0.9580.74
375_L402_V0.9560.74
60_G124_E0.9550.74
134_F239_R0.9520.74
195_P248_T0.9490.73
16_T20_A0.9470.73
103_V158_A0.9450.73
76_L360_F0.9440.73
176_F282_W0.9430.73
126_F135_N0.9370.72
105_L339_S0.9360.72
182_I246_F0.9340.72
399_H405_R0.9280.72
127_G130_S0.9280.72
297_Q339_S0.9250.72
21_S28_R0.9240.71
350_W398_Q0.9240.71
26_N385_N0.9210.71
20_A65_Q0.9170.71
196_R253_T0.9160.71
14_G31_E0.9140.71
78_V109_A0.9140.71
73_G304_V0.9110.70
200_P255_R0.9080.70
239_R259_F0.9080.70
17_L321_P0.9060.70
48_D52_E0.9040.70
304_V345_L0.8930.69
202_F260_D0.8920.69
268_E272_Q0.8870.68
167_A182_I0.8830.68
259_F262_L0.8820.68
26_N389_H0.8810.68
244_N261_T0.8810.68
126_F240_S0.8790.68
157_V161_G0.8770.67
218_E222_D0.8740.67
235_N239_R0.8680.67
14_G345_L0.8610.66
145_D203_Y0.8610.66
392_Y397_Y0.8480.65
43_T163_A0.8470.65
177_V299_G0.8470.65
332_G335_L0.8470.65
371_L375_L0.8450.64
50_P383_L0.8420.64
194_V257_V0.8400.64
184_G299_G0.8390.64
24_A28_R0.8390.64
19_F396_H0.8370.64
240_S275_L0.8360.64
211_G215_D0.8320.63
23_A283_K0.8280.63
213_L217_I0.8260.63
257_V261_T0.8230.62
52_E204_D0.8200.62
236_A239_R0.8190.62
358_D405_R0.8180.62
18_L27_V0.8180.62
122_A143_A0.8170.62
234_M257_V0.8160.62
214_R287_I0.8130.61
379_T386_P0.8120.61
199_M248_T0.8100.61
85_G404_E0.8080.61
293_A349_L0.8040.61
253_T344_P0.8030.61
163_A186_F0.8020.60
145_D261_T0.8020.60
315_Y330_L0.8000.60
29_Y32_R0.7980.60
354_E357_A0.7900.59
203_Y246_F0.7900.59
202_F239_R0.7890.59
111_V296_L0.7870.59
247_F261_T0.7870.59
327_G330_L0.7850.59
393_E409_L0.7820.58
232_Y255_R0.7820.58
138_S141_L0.7820.58
176_F303_F0.7800.58
54_L58_R0.7780.58
107_V154_G0.7760.58
199_M234_M0.7740.58
304_V331_A0.7740.58
375_L382_N0.7730.58
228_C282_W0.7730.58
134_F202_F0.7710.57
187_L360_F0.7680.57
273_A375_L0.7650.57
45_I197_V0.7650.57
123_V254_K0.7640.57
263_I268_E0.7630.57
13_A18_L0.7620.57
107_V150_A0.7620.57
107_V181_G0.7610.56
112_A186_F0.7610.56
70_V209_D0.7600.56
132_F221_F0.7580.56
355_R404_E0.7580.56
244_N382_N0.7570.56
389_H394_A0.7550.56
145_D237_S0.7510.55
319_G330_L0.7480.55
176_F388_P0.7450.55
50_P54_L0.7440.55
22_L25_L0.7430.55
221_F279_L0.7410.54
299_G302_L0.7410.54
155_V407_R0.7410.54
97_S100_L0.7360.54
154_G158_A0.7320.54
46_G51_G0.7260.53
243_S282_W0.7240.53
152_L184_G0.7240.53
392_Y404_E0.7230.53
213_L263_I0.7230.53
7_V335_L0.7230.53
216_A219_D0.7200.52
10_A13_A0.7200.52
128_V270_E0.7200.52
203_Y239_R0.7200.52
302_L312_G0.7170.52
406_I410_T0.7170.52
128_V274_V0.7160.52
8_F184_G0.7150.52
258_L271_L0.7140.52
73_G115_V0.7130.52
282_W285_G0.7110.51
174_W177_V0.7100.51
23_A26_N0.7090.51
50_P386_P0.7090.51
270_E383_L0.7090.51
114_Q146_A0.7070.51
140_A155_V0.7070.51
218_E228_C0.7070.51
320_V330_L0.7060.51
397_Y404_E0.7030.51
129_E134_F0.7030.51
245_A260_D0.6990.50
245_A274_V0.6980.50
342_T346_Q0.6950.50
254_K282_W0.6950.50
103_V301_V0.6940.50
259_F375_L0.6930.50
127_G131_A0.6900.49
183_V302_L0.6880.49
239_R375_L0.6880.49
93_D108_G0.6870.49
155_V159_V0.6870.49
252_A255_R0.6860.49
242_H393_E0.6860.49
256_V360_F0.6830.49
267_G377_A0.6810.48
166_V170_A0.6810.48
312_G316_G0.6800.48
304_V334_W0.6790.48
217_I258_L0.6770.48
354_E399_H0.6760.48
149_S288_W0.6730.48
156_F349_L0.6720.47
134_F259_F0.6710.47
247_F282_W0.6700.47
226_F279_L0.6690.47
335_L339_S0.6680.47
129_E135_N0.6680.47
111_V150_A0.6680.47
92_Y97_S0.6620.46
254_K392_Y0.6610.46
314_L318_F0.6600.46
403_P407_R0.6600.46
243_S404_E0.6590.46
45_I256_V0.6590.46
290_T294_A0.6570.46
145_D257_V0.6560.46
354_E358_D0.6520.45
19_F189_A0.6520.45
213_L272_Q0.6520.45
343_A350_W0.6490.45
347_N383_L0.6490.45
375_L409_L0.6480.45
82_G326_A0.6480.45
145_D236_A0.6470.45
175_W297_Q0.6460.45
12_V72_A0.6440.45
11_L18_L0.6430.45
274_V385_N0.6430.45
247_F262_L0.6420.44
66_L345_L0.6410.44
124_E309_L0.6400.44
7_V14_G0.6390.44
288_W292_G0.6380.44
228_C236_A0.6360.44
164_V212_G0.6340.44
85_G320_V0.6340.44
238_S377_A0.6340.44
277_H399_H0.6330.44
216_A269_T0.6330.44
60_G136_E0.6330.44
244_N278_E0.6310.43
377_A386_P0.6300.43
357_A405_R0.6290.43
51_G151_G0.6290.43
281_H358_D0.6290.43
164_V302_L0.6280.43
402_V406_I0.6270.43
182_I404_E0.6260.43
240_S247_F0.6250.43
17_L36_E0.6250.43
30_A53_L0.6240.43
266_M381_Q0.6230.43
199_M203_Y0.6230.43
195_P253_T0.6220.42
155_V171_L0.6220.42
266_M274_V0.6220.42
66_L93_D0.6220.42
263_I279_L0.6210.42
284_N288_W0.6210.42
50_P208_V0.6200.42
211_G263_I0.6200.42
133_G239_R0.6190.42
220_V256_V0.6190.42
349_L352_A0.6190.42
148_L202_F0.6190.42
43_T47_V0.6180.42
247_F259_F0.6180.42
52_E63_V0.6170.42
9_L28_R0.6160.42
335_L338_L0.6150.42
103_V165_L0.6140.42
136_E231_V0.6120.41
358_D400_P0.6120.41
207_P378_L0.6070.41
145_D148_L0.6040.41
114_Q150_A0.6040.41
256_V284_N0.6040.41
126_F129_E0.6030.41
376_G406_I0.6020.40
63_V128_V0.6020.40
141_L148_L0.6010.40
128_V294_A0.6010.40
217_I229_E0.5980.40
246_F261_T0.5950.40
10_A28_R0.5940.40
109_A276_A0.5940.40
290_T350_W0.5920.40
244_N361_A0.5920.40
26_N392_Y0.5910.39
159_V162_G0.5910.39
203_Y236_A0.5910.39
244_N399_H0.5900.39
194_V203_Y0.5900.39
135_N138_S0.5890.39
16_T72_A0.5890.39
111_V114_Q0.5870.39
37_R47_V0.5870.39
378_L383_L0.5860.39
286_H353_N0.5850.39
174_W185_V0.5850.39
164_V327_G0.5850.39
40_W406_I0.5840.39
307_R314_L0.5820.39
245_A262_L0.5820.39
312_G323_Q0.5810.38
121_D320_V0.5810.38
102_G337_P0.5810.38
124_E204_D0.5800.38
110_T161_G0.5790.38
239_R244_N0.5790.38
255_R261_T0.5780.38
175_W195_P0.5770.38
248_T287_I0.5770.38
17_L67_R0.5760.38
289_Q349_L0.5760.38
244_N378_L0.5750.38
167_A176_F0.5750.38
103_V141_L0.5750.38
17_L369_E0.5750.38
184_G193_L0.5750.38
205_F239_R0.5740.38
62_A69_V0.5730.38
7_V293_A0.5730.38
118_V309_L0.5730.38
13_A76_L0.5710.38
115_V360_F0.5690.37
40_W131_A0.5690.37
110_T296_L0.5680.37
252_A318_F0.5680.37
124_E264_D0.5680.37
219_D300_V0.5670.37
296_L300_V0.5670.37
135_N145_D0.5670.37
184_G189_A0.5650.37
321_P349_L0.5650.37
119_P200_P0.5650.37
285_G360_F0.5650.37
49_D383_L0.5620.37
278_E399_H0.5610.37
96_G108_G0.5610.37
173_E310_D0.5600.36
279_L282_W0.5600.36
391_Y406_I0.5600.36
388_P401_P0.5600.36
25_L385_N0.5600.36
355_R398_Q0.5580.36
330_L337_P0.5570.36
221_F227_A0.5560.36
153_A183_V0.5560.36
222_D360_F0.5550.36
140_A167_A0.5550.36
240_S286_H0.5540.36
132_F181_G0.5530.36
243_S382_N0.5510.36
241_G271_L0.5510.36
236_A259_F0.5500.36
48_D89_A0.5480.35
133_G261_T0.5480.35
125_T180_T0.5460.35
26_N128_V0.5450.35
60_G370_P0.5450.35
199_M339_S0.5450.35
213_L268_E0.5440.35
236_A257_V0.5440.35
70_V96_G0.5430.35
79_L83_A0.5430.35
104_A111_V0.5420.35
72_A80_Y0.5420.35
63_V70_V0.5410.35
11_L15_T0.5400.35
8_F30_A0.5400.35
175_W221_F0.5390.35
24_A349_L0.5390.35
24_A65_Q0.5370.34
219_D222_D0.5370.34
242_H361_A0.5360.34
141_L239_R0.5360.34
91_V99_V0.5360.34
205_F263_I0.5340.34
378_L382_N0.5340.34
377_A381_Q0.5340.34
239_R261_T0.5330.34
7_V21_S0.5330.34
292_G321_P0.5310.34
53_L190_T0.5310.34
219_D363_D0.5310.34
175_W305_A0.5300.34
8_F11_L0.5300.34
86_A90_F0.5280.34
10_A99_V0.5280.34
237_S245_A0.5280.34
111_V250_F0.5270.33
36_E89_A0.5270.33
286_H360_F0.5260.33
200_P260_D0.5260.33
50_P385_N0.5260.33
225_G274_V0.5250.33
305_A331_A0.5250.33
38_S41_L0.5240.33
181_G264_D0.5230.33
197_V294_A0.5220.33
300_V373_D0.5210.33
315_Y320_V0.5210.33
168_V325_A0.5210.33
31_E69_V0.5200.33
142_F360_F0.5200.33
22_L392_Y0.5200.33
202_F236_A0.5190.33
76_L80_Y0.5190.33
89_A121_D0.5180.33
374_A381_Q0.5160.32
15_T26_N0.5160.32
18_L349_L0.5150.32
221_F256_V0.5140.32
168_V175_W0.5130.32
307_R394_A0.5130.32
224_A279_L0.5130.32
203_Y347_N0.5120.32
340_R344_P0.5120.32
165_L304_V0.5120.32
135_N240_S0.5110.32
119_P205_F0.5110.32
271_L343_A0.5100.32
200_P261_T0.5090.32
236_A371_L0.5080.32
156_F189_A0.5080.32
66_L120_F0.5070.32
369_E410_T0.5070.32
76_L90_F0.5060.32
183_V298_A0.5050.31
28_R115_V0.5050.31
284_N360_F0.5040.31
239_R246_F0.5040.31
195_P257_V0.5030.31
54_L385_N0.5020.31
176_F344_P0.5010.31
206_D233_V0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw6A 2 0.9556 100 0.195 Contact Map
4il3A 1 0.9533 100 0.198 Contact Map
3c37A 1 0.4743 100 0.721 Contact Map
3cqbA 4 0.2313 99.8 0.829 Contact Map
4qhjA 2 0.229 97.4 0.929 Contact Map
4jiuA 1 0.236 95.9 0.94 Contact Map
3dteA 2 0.3551 95.3 0.943 Contact Map
4jixA 2 0.2523 94.3 0.946 Contact Map
2kw0A 1 0.1636 36.1 0.969 Contact Map
4o66A 2 0.1636 35.8 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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