Q9HS99 - HALSA - GREMLIN Contacts

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Q9HS99 - Uncharacterized protein

UniProt:	Q9HS99	Sequences: MTETRALLVDAFTDDSCAGNAAGVVPDAGGLTDDQMQAIAAELGASETAFLRPSDAADRRLRYFTPTTEVDLCGHATIASHAHLYDDGALAAGEHTLETNVGVLDIEVAEDGTVWMAQNPPTVREVELSYERVAEATGTEAAALRGASDDIPLAVADTGLPFLIVPITYLSDLGDADPDFDAVEALADDVGAAGVYMFSFDALDRASTAHGRAWVPGVGVDEDPVTGTASGAAGAYLARFGAFDGDAPDEMVFEQGHFVDRPGRVRVRVAGDAPMVGGRGVSTLDGTLAVPAETEEEILEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	301 (264)
Sequences:	4082 (3037)
Seq/√Len:	186.9

ECOLI - YDDE
BACSU - YFHB
HALSA - Q9HS99 Q9HHG6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
250_E	268_R	3.610	1.00
82_A	282_S	3.556	1.00
32_T	35_Q	3.322	1.00
225_V	263_G	3.080	1.00
176_A	197_M	3.054	1.00
169_Y	172_D	2.896	1.00
115_W	277_G	2.826	1.00
171_S	175_D	2.676	1.00
9_V	83_H	2.597	1.00
51_L	80_S	2.480	1.00
29_G	53_P	2.479	1.00
96_T	103_V	2.436	1.00
61_L	99_T	2.423	1.00
117_A	273_A	2.398	1.00
8_L	284_L	2.315	1.00
15_D	18_A	2.254	1.00
14_D	279_R	2.240	1.00
60_R	98_E	2.233	1.00
180_F	221_D	2.198	1.00
234_G	267_V	2.018	1.00
268_R	275_M	1.953	1.00
94_E	107_E	1.912	1.00
170_L	174_G	1.886	1.00
252_V	264_R	1.857	1.00
94_E	105_D	1.842	1.00
254_E	262_P	1.839	1.00
211_G	230_S	1.832	1.00
168_T	172_D	1.830	1.00
5_R	287_T	1.810	1.00
10_D	42_E	1.757	1.00
5_R	285_D	1.754	1.00
49_A	80_S	1.733	1.00
13_T	18_A	1.723	1.00
39_I	288_L	1.706	1.00
58_D	98_E	1.689	1.00
252_V	266_R	1.686	1.00
109_A	115_W	1.668	1.00
115_W	275_M	1.667	1.00
71_D	100_N	1.657	1.00
113_T	266_R	1.645	1.00
179_D	182_A	1.644	1.00
225_V	265_V	1.640	1.00
135_E	182_A	1.616	1.00
36_M	62_R	1.600	1.00
26_P	51_L	1.590	1.00
13_T	281_V	1.586	1.00
234_G	269_V	1.572	1.00
60_R	100_N	1.556	1.00
182_A	185_A	1.539	1.00
6_A	284_L	1.526	1.00
31_L	39_I	1.505	1.00
7_L	83_H	1.505	1.00
226_T	229_A	1.504	1.00
167_I	172_D	1.503	1.00
230_S	253_F	1.490	1.00
139_T	167_I	1.486	1.00
254_E	264_R	1.482	1.00
256_G	259_V	1.470	1.00
118_Q	231_G	1.456	1.00
54_S	98_E	1.454	1.00
106_I	114_V	1.439	1.00
40_A	48_T	1.416	1.00
33_D	36_M	1.409	1.00
170_L	201_D	1.402	1.00
31_L	35_Q	1.396	1.00
137_T	165_V	1.395	1.00
162_F	193_A	1.394	1.00
85_Y	108_V	1.340	1.00
72_L	228_T	1.340	1.00
253_F	265_V	1.337	1.00
61_L	80_S	1.334	1.00
270_A	275_M	1.331	1.00
8_L	45_A	1.331	1.00
167_I	173_L	1.327	1.00
35_Q	39_I	1.322	1.00
106_I	116_M	1.314	1.00
113_T	279_R	1.313	1.00
238_A	269_V	1.312	1.00
58_D	103_V	1.304	1.00
7_L	285_D	1.300	1.00
162_F	213_A	1.281	1.00
18_A	262_P	1.279	1.00
157_D	161_P	1.277	1.00
22_A	79_A	1.273	1.00
73_C	76_A	1.272	1.00
98_E	103_V	1.271	1.00
143_A	168_T	1.249	1.00
111_D	279_R	1.244	1.00
166_P	198_F	1.243	1.00
170_L	210_H	1.237	1.00
62_R	69_E	1.234	1.00
196_Y	230_S	1.231	1.00
265_V	276_V	1.206	1.00
131_E	135_E	1.202	1.00
170_L	199_S	1.202	1.00
250_E	266_R	1.200	1.00
117_A	275_M	1.199	1.00
266_R	277_G	1.194	1.00
54_S	60_R	1.193	1.00
107_E	275_M	1.186	1.00
209_A	233_A	1.185	1.00
85_Y	114_V	1.185	1.00
33_D	37_Q	1.182	1.00
37_Q	40_A	1.181	1.00
133_V	163_L	1.178	1.00
6_A	43_L	1.176	1.00
82_A	86_D	1.163	1.00
23_G	43_L	1.160	1.00
68_T	218_V	1.146	1.00
25_V	288_L	1.137	1.00
215_V	220_V	1.133	1.00
164_I	232_A	1.129	1.00
194_G	213_A	1.126	1.00
7_L	26_P	1.116	1.00
230_S	265_V	1.114	1.00
46_S	224_P	1.110	1.00
143_A	175_D	1.109	1.00
166_P	236_Y	1.101	1.00
216_P	220_V	1.098	1.00
105_D	117_A	1.097	1.00
30_G	52_R	1.083	1.00
256_G	262_P	1.079	1.00
178_P	214_W	1.079	1.00
61_L	97_L	1.075	1.00
131_E	141_A	1.075	1.00
285_D	289_A	1.069	1.00
136_A	183_V	1.048	1.00
26_P	83_H	1.043	1.00
37_Q	41_A	1.040	1.00
63_Y	76_A	1.037	1.00
47_E	226_T	1.036	1.00
4_T	25_V	1.034	1.00
143_A	172_D	1.030	1.00
215_V	219_G	1.027	1.00
24_V	83_H	1.021	1.00
171_S	174_G	1.021	1.00
213_A	229_A	1.020	1.00
136_A	182_A	1.019	1.00
211_G	253_F	1.016	1.00
129_S	132_R	1.015	1.00
8_L	43_L	1.015	1.00
93_G	108_V	1.013	1.00
34_D	38_A	1.008	0.99
11_A	22_A	1.007	0.99
21_A	45_A	0.999	0.99
167_I	197_M	0.999	0.99
16_S	283_T	0.995	0.99
81_H	97_L	0.993	0.99
139_T	176_A	0.991	0.99
22_A	73_C	0.983	0.99
162_F	194_G	0.979	0.99
140_E	143_A	0.978	0.99
132_R	135_E	0.976	0.99
173_L	210_H	0.976	0.99
173_L	199_S	0.973	0.99
84_L	88_G	0.970	0.99
23_G	45_A	0.961	0.99
47_E	224_P	0.959	0.99
86_D	282_S	0.958	0.99
283_T	288_L	0.957	0.99
47_E	76_A	0.956	0.99
90_L	95_H	0.956	0.99
114_V	118_Q	0.945	0.99
6_A	286_G	0.945	0.99
11_A	79_A	0.944	0.99
226_T	255_Q	0.917	0.99
208_T	248_P	0.917	0.99
142_A	168_T	0.916	0.99
153_L	165_V	0.916	0.99
71_D	162_F	0.915	0.99
134_A	141_A	0.915	0.99
55_D	60_R	0.913	0.99
133_V	136_A	0.913	0.99
164_I	233_A	0.911	0.99
14_D	264_R	0.911	0.99
211_G	233_A	0.908	0.99
269_V	274_P	0.907	0.99
207_S	256_G	0.894	0.99
4_T	30_G	0.893	0.99
9_V	24_V	0.893	0.99
236_Y	240_F	0.891	0.99
51_L	84_L	0.889	0.99
107_E	115_W	0.881	0.99
9_V	280_G	0.879	0.99
52_R	60_R	0.876	0.99
216_P	219_G	0.875	0.99
72_L	101_V	0.873	0.99
70_V	76_A	0.870	0.99
164_I	236_Y	0.868	0.98
174_G	210_H	0.857	0.98
83_H	87_D	0.853	0.98
259_V	262_P	0.849	0.98
225_V	253_F	0.846	0.98
85_Y	95_H	0.844	0.98
49_A	61_L	0.842	0.98
4_T	27_D	0.842	0.98
40_A	66_P	0.840	0.98
134_A	144_L	0.839	0.98
43_L	284_L	0.835	0.98
58_D	96_T	0.826	0.98
166_P	200_F	0.824	0.98
13_T	279_R	0.824	0.98
63_Y	73_C	0.822	0.98
200_F	209_A	0.819	0.98
49_A	76_A	0.818	0.98
35_Q	38_A	0.816	0.98
215_V	218_V	0.813	0.98
82_A	280_G	0.806	0.98
196_Y	229_A	0.803	0.97
51_L	88_G	0.803	0.97
57_A	103_V	0.800	0.97
11_A	63_Y	0.799	0.97
209_A	253_F	0.799	0.97
198_F	236_Y	0.797	0.97
10_D	17_C	0.793	0.97
109_A	113_T	0.790	0.97
54_S	57_A	0.790	0.97
143_A	166_P	0.787	0.97
25_V	43_L	0.787	0.97
268_R	277_G	0.786	0.97
36_M	64_F	0.785	0.97
201_D	204_D	0.785	0.97
9_V	282_S	0.784	0.97
72_L	104_L	0.780	0.97
173_L	176_A	0.777	0.97
137_T	197_M	0.776	0.97
132_R	182_A	0.769	0.97
166_P	240_F	0.768	0.97
187_A	217_G	0.765	0.97
96_T	105_D	0.764	0.97
17_C	42_E	0.763	0.97
133_V	165_V	0.762	0.97
259_V	263_G	0.759	0.96
5_R	87_D	0.757	0.96
99_T	116_M	0.757	0.96
215_V	221_D	0.750	0.96
30_G	33_D	0.747	0.96
78_I	228_T	0.746	0.96
70_V	160_L	0.744	0.96
38_A	41_A	0.743	0.96
208_T	251_M	0.737	0.96
22_A	76_A	0.731	0.96
87_D	285_D	0.728	0.96
174_G	256_G	0.726	0.95
63_Y	79_A	0.726	0.95
141_A	144_L	0.723	0.95
55_D	98_E	0.723	0.95
8_L	21_A	0.721	0.95
22_A	63_Y	0.720	0.95
57_A	98_E	0.717	0.95
207_S	254_E	0.717	0.95
196_Y	213_A	0.717	0.95
172_D	175_D	0.713	0.95
42_E	261_R	0.711	0.95
201_D	205_R	0.711	0.95
163_L	192_A	0.710	0.95
181_D	184_E	0.707	0.95
109_A	112_G	0.706	0.95
7_L	87_D	0.705	0.95
10_D	13_T	0.703	0.95
115_W	268_R	0.696	0.94
81_H	95_H	0.695	0.94
17_C	261_R	0.693	0.94
213_A	226_T	0.691	0.94
209_A	256_G	0.690	0.94
27_D	30_G	0.689	0.94
84_L	90_L	0.689	0.94
54_S	58_D	0.689	0.94
33_D	62_R	0.688	0.94
167_I	176_A	0.685	0.94
121_P	160_L	0.685	0.94
249_D	269_V	0.683	0.94
282_S	285_D	0.681	0.94
63_Y	70_V	0.680	0.94
126_V	163_L	0.669	0.93
209_A	247_A	0.668	0.93
132_R	185_A	0.667	0.93
123_V	235_A	0.662	0.93
139_T	172_D	0.662	0.93
183_V	195_V	0.661	0.93
63_Y	97_L	0.660	0.93
156_A	164_I	0.659	0.93
123_V	156_A	0.658	0.92
99_T	102_G	0.658	0.92
26_P	30_G	0.655	0.92
47_E	70_V	0.654	0.92
153_L	163_L	0.652	0.92
164_I	196_Y	0.649	0.92
14_D	18_A	0.649	0.92
113_T	277_G	0.649	0.92
180_F	216_P	0.648	0.92
121_P	161_P	0.646	0.92
118_Q	121_P	0.644	0.92
134_A	139_T	0.643	0.92
41_A	67_T	0.641	0.91
213_A	233_A	0.640	0.91
198_F	201_D	0.640	0.91
122_T	239_R	0.638	0.91
20_N	226_T	0.637	0.91
120_P	123_V	0.634	0.91
267_V	276_V	0.631	0.91
7_L	282_S	0.630	0.91
233_A	237_L	0.626	0.91
32_T	36_M	0.625	0.90
76_A	79_A	0.624	0.90
29_G	52_R	0.623	0.90
21_A	46_S	0.622	0.90
36_M	52_R	0.621	0.90
134_A	140_E	0.621	0.90
47_E	66_P	0.621	0.90
180_F	183_V	0.620	0.90
178_P	183_V	0.619	0.90
160_L	232_A	0.618	0.90
161_P	193_A	0.617	0.90
120_P	274_P	0.611	0.89
67_T	219_G	0.610	0.89
154_A	240_F	0.606	0.89
5_R	286_G	0.605	0.89
5_R	23_G	0.604	0.89
170_L	173_L	0.604	0.89
84_L	95_H	0.602	0.89
116_M	120_P	0.601	0.89
11_A	76_A	0.599	0.89
130_Y	134_A	0.596	0.88
116_M	119_N	0.596	0.88
170_L	254_E	0.596	0.88
225_V	230_S	0.595	0.88
198_F	237_L	0.591	0.88
157_D	160_L	0.586	0.87
18_A	38_A	0.584	0.87
71_D	160_L	0.583	0.87
193_A	197_M	0.582	0.87
41_A	260_D	0.580	0.87
25_V	48_T	0.580	0.87
238_A	251_M	0.577	0.87
20_N	227_G	0.575	0.86
121_P	158_T	0.573	0.86
109_A	268_R	0.572	0.86
6_A	283_T	0.572	0.86
213_A	232_A	0.571	0.86
136_A	186_L	0.568	0.86
234_G	276_V	0.567	0.86
115_W	118_Q	0.564	0.85
196_Y	211_G	0.564	0.85
184_E	217_G	0.563	0.85
75_H	227_G	0.560	0.85
81_H	106_I	0.552	0.84
251_M	267_V	0.551	0.84
129_S	134_A	0.550	0.84
137_T	195_V	0.549	0.84
33_D	100_N	0.547	0.84
105_D	108_V	0.546	0.84
77_T	102_G	0.545	0.83
118_Q	158_T	0.543	0.83
225_V	259_V	0.542	0.83
88_G	92_A	0.542	0.83
22_A	61_L	0.541	0.83
196_Y	233_A	0.541	0.83
28_A	52_R	0.540	0.83
49_A	73_C	0.539	0.83
192_A	217_G	0.538	0.83
44_G	261_R	0.538	0.83
121_P	159_G	0.536	0.82
162_F	229_A	0.536	0.82
208_T	254_E	0.536	0.82
76_A	223_D	0.535	0.82
46_S	66_P	0.535	0.82
207_S	264_R	0.533	0.82
22_A	280_G	0.533	0.82
184_E	221_D	0.533	0.82
161_P	232_A	0.531	0.82
63_Y	228_T	0.531	0.82
224_P	263_G	0.530	0.82
43_L	283_T	0.529	0.82
67_T	220_V	0.526	0.81
11_A	49_A	0.523	0.81
9_V	82_A	0.520	0.80
116_M	122_T	0.520	0.80
65_T	70_V	0.519	0.80
11_A	73_C	0.518	0.80
199_S	210_H	0.518	0.80
10_D	15_D	0.515	0.80
65_T	220_V	0.514	0.80
201_D	210_H	0.510	0.79
204_D	207_S	0.507	0.79
27_D	31_L	0.505	0.79
125_E	135_E	0.504	0.78
17_C	283_T	0.504	0.78
284_L	288_L	0.503	0.78
121_P	231_G	0.502	0.78
101_V	104_L	0.502	0.78
36_M	50_F	0.501	0.78
63_Y	72_L	0.501	0.78
139_T	143_A	0.501	0.78
25_V	39_I	0.500	0.78
136_A	195_V	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ednA	2	0.9535	100	0.279	Contact Map
1ym5A	2	0.9269	100	0.296	Contact Map
1qyaA	2	0.9402	100	0.302	Contact Map
1s7jA	1	0.8638	100	0.305	Contact Map
1xubA	2	0.8904	100	0.311	Contact Map
4dunA	2	0.8571	100	0.32	Contact Map
1u0kA	2	0.9136	100	0.332	Contact Map
4jbdA	2	0.8704	100	0.427	Contact Map
3ejxA	5	0.8837	100	0.437	Contact Map
4juuA	2	0.9003	100	0.439	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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