GREMLIN Database
Q9HS99 - Uncharacterized protein
UniProt: Q9HS99 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (264)
Sequences: 4082 (3037)
Seq/√Len: 186.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
250_E268_R3.6101.00
82_A282_S3.5561.00
32_T35_Q3.3221.00
225_V263_G3.0801.00
176_A197_M3.0541.00
169_Y172_D2.8961.00
115_W277_G2.8261.00
171_S175_D2.6761.00
9_V83_H2.5971.00
51_L80_S2.4801.00
29_G53_P2.4791.00
96_T103_V2.4361.00
61_L99_T2.4231.00
117_A273_A2.3981.00
8_L284_L2.3151.00
15_D18_A2.2541.00
14_D279_R2.2401.00
60_R98_E2.2331.00
180_F221_D2.1981.00
234_G267_V2.0181.00
268_R275_M1.9531.00
94_E107_E1.9121.00
170_L174_G1.8861.00
252_V264_R1.8571.00
94_E105_D1.8421.00
254_E262_P1.8391.00
211_G230_S1.8321.00
168_T172_D1.8301.00
5_R287_T1.8101.00
10_D42_E1.7571.00
5_R285_D1.7541.00
49_A80_S1.7331.00
13_T18_A1.7231.00
39_I288_L1.7061.00
58_D98_E1.6891.00
252_V266_R1.6861.00
109_A115_W1.6681.00
115_W275_M1.6671.00
71_D100_N1.6571.00
113_T266_R1.6451.00
179_D182_A1.6441.00
225_V265_V1.6401.00
135_E182_A1.6161.00
36_M62_R1.6001.00
26_P51_L1.5901.00
13_T281_V1.5861.00
234_G269_V1.5721.00
60_R100_N1.5561.00
182_A185_A1.5391.00
6_A284_L1.5261.00
31_L39_I1.5051.00
7_L83_H1.5051.00
226_T229_A1.5041.00
167_I172_D1.5031.00
230_S253_F1.4901.00
139_T167_I1.4861.00
254_E264_R1.4821.00
256_G259_V1.4701.00
118_Q231_G1.4561.00
54_S98_E1.4541.00
106_I114_V1.4391.00
40_A48_T1.4161.00
33_D36_M1.4091.00
170_L201_D1.4021.00
31_L35_Q1.3961.00
137_T165_V1.3951.00
162_F193_A1.3941.00
85_Y108_V1.3401.00
72_L228_T1.3401.00
253_F265_V1.3371.00
61_L80_S1.3341.00
270_A275_M1.3311.00
8_L45_A1.3311.00
167_I173_L1.3271.00
35_Q39_I1.3221.00
106_I116_M1.3141.00
113_T279_R1.3131.00
238_A269_V1.3121.00
58_D103_V1.3041.00
7_L285_D1.3001.00
162_F213_A1.2811.00
18_A262_P1.2791.00
157_D161_P1.2771.00
22_A79_A1.2731.00
73_C76_A1.2721.00
98_E103_V1.2711.00
143_A168_T1.2491.00
111_D279_R1.2441.00
166_P198_F1.2431.00
170_L210_H1.2371.00
62_R69_E1.2341.00
196_Y230_S1.2311.00
265_V276_V1.2061.00
131_E135_E1.2021.00
170_L199_S1.2021.00
250_E266_R1.2001.00
117_A275_M1.1991.00
266_R277_G1.1941.00
54_S60_R1.1931.00
107_E275_M1.1861.00
209_A233_A1.1851.00
85_Y114_V1.1851.00
33_D37_Q1.1821.00
37_Q40_A1.1811.00
133_V163_L1.1781.00
6_A43_L1.1761.00
82_A86_D1.1631.00
23_G43_L1.1601.00
68_T218_V1.1461.00
25_V288_L1.1371.00
215_V220_V1.1331.00
164_I232_A1.1291.00
194_G213_A1.1261.00
7_L26_P1.1161.00
230_S265_V1.1141.00
46_S224_P1.1101.00
143_A175_D1.1091.00
166_P236_Y1.1011.00
216_P220_V1.0981.00
105_D117_A1.0971.00
30_G52_R1.0831.00
256_G262_P1.0791.00
178_P214_W1.0791.00
61_L97_L1.0751.00
131_E141_A1.0751.00
285_D289_A1.0691.00
136_A183_V1.0481.00
26_P83_H1.0431.00
37_Q41_A1.0401.00
63_Y76_A1.0371.00
47_E226_T1.0361.00
4_T25_V1.0341.00
143_A172_D1.0301.00
215_V219_G1.0271.00
24_V83_H1.0211.00
171_S174_G1.0211.00
213_A229_A1.0201.00
136_A182_A1.0191.00
211_G253_F1.0161.00
129_S132_R1.0151.00
8_L43_L1.0151.00
93_G108_V1.0131.00
34_D38_A1.0080.99
11_A22_A1.0070.99
21_A45_A0.9990.99
167_I197_M0.9990.99
16_S283_T0.9950.99
81_H97_L0.9930.99
139_T176_A0.9910.99
22_A73_C0.9830.99
162_F194_G0.9790.99
140_E143_A0.9780.99
132_R135_E0.9760.99
173_L210_H0.9760.99
173_L199_S0.9730.99
84_L88_G0.9700.99
23_G45_A0.9610.99
47_E224_P0.9590.99
86_D282_S0.9580.99
283_T288_L0.9570.99
47_E76_A0.9560.99
90_L95_H0.9560.99
114_V118_Q0.9450.99
6_A286_G0.9450.99
11_A79_A0.9440.99
226_T255_Q0.9170.99
208_T248_P0.9170.99
142_A168_T0.9160.99
153_L165_V0.9160.99
71_D162_F0.9150.99
134_A141_A0.9150.99
55_D60_R0.9130.99
133_V136_A0.9130.99
164_I233_A0.9110.99
14_D264_R0.9110.99
211_G233_A0.9080.99
269_V274_P0.9070.99
207_S256_G0.8940.99
4_T30_G0.8930.99
9_V24_V0.8930.99
236_Y240_F0.8910.99
51_L84_L0.8890.99
107_E115_W0.8810.99
9_V280_G0.8790.99
52_R60_R0.8760.99
216_P219_G0.8750.99
72_L101_V0.8730.99
70_V76_A0.8700.99
164_I236_Y0.8680.98
174_G210_H0.8570.98
83_H87_D0.8530.98
259_V262_P0.8490.98
225_V253_F0.8460.98
85_Y95_H0.8440.98
49_A61_L0.8420.98
4_T27_D0.8420.98
40_A66_P0.8400.98
134_A144_L0.8390.98
43_L284_L0.8350.98
58_D96_T0.8260.98
166_P200_F0.8240.98
13_T279_R0.8240.98
63_Y73_C0.8220.98
200_F209_A0.8190.98
49_A76_A0.8180.98
35_Q38_A0.8160.98
215_V218_V0.8130.98
82_A280_G0.8060.98
196_Y229_A0.8030.97
51_L88_G0.8030.97
57_A103_V0.8000.97
11_A63_Y0.7990.97
209_A253_F0.7990.97
198_F236_Y0.7970.97
10_D17_C0.7930.97
109_A113_T0.7900.97
54_S57_A0.7900.97
143_A166_P0.7870.97
25_V43_L0.7870.97
268_R277_G0.7860.97
36_M64_F0.7850.97
201_D204_D0.7850.97
9_V282_S0.7840.97
72_L104_L0.7800.97
173_L176_A0.7770.97
137_T197_M0.7760.97
132_R182_A0.7690.97
166_P240_F0.7680.97
187_A217_G0.7650.97
96_T105_D0.7640.97
17_C42_E0.7630.97
133_V165_V0.7620.97
259_V263_G0.7590.96
5_R87_D0.7570.96
99_T116_M0.7570.96
215_V221_D0.7500.96
30_G33_D0.7470.96
78_I228_T0.7460.96
70_V160_L0.7440.96
38_A41_A0.7430.96
208_T251_M0.7370.96
22_A76_A0.7310.96
87_D285_D0.7280.96
174_G256_G0.7260.95
63_Y79_A0.7260.95
141_A144_L0.7230.95
55_D98_E0.7230.95
8_L21_A0.7210.95
22_A63_Y0.7200.95
57_A98_E0.7170.95
207_S254_E0.7170.95
196_Y213_A0.7170.95
172_D175_D0.7130.95
42_E261_R0.7110.95
201_D205_R0.7110.95
163_L192_A0.7100.95
181_D184_E0.7070.95
109_A112_G0.7060.95
7_L87_D0.7050.95
10_D13_T0.7030.95
115_W268_R0.6960.94
81_H95_H0.6950.94
17_C261_R0.6930.94
213_A226_T0.6910.94
209_A256_G0.6900.94
27_D30_G0.6890.94
84_L90_L0.6890.94
54_S58_D0.6890.94
33_D62_R0.6880.94
167_I176_A0.6850.94
121_P160_L0.6850.94
249_D269_V0.6830.94
282_S285_D0.6810.94
63_Y70_V0.6800.94
126_V163_L0.6690.93
209_A247_A0.6680.93
132_R185_A0.6670.93
123_V235_A0.6620.93
139_T172_D0.6620.93
183_V195_V0.6610.93
63_Y97_L0.6600.93
156_A164_I0.6590.93
123_V156_A0.6580.92
99_T102_G0.6580.92
26_P30_G0.6550.92
47_E70_V0.6540.92
153_L163_L0.6520.92
164_I196_Y0.6490.92
14_D18_A0.6490.92
113_T277_G0.6490.92
180_F216_P0.6480.92
121_P161_P0.6460.92
118_Q121_P0.6440.92
134_A139_T0.6430.92
41_A67_T0.6410.91
213_A233_A0.6400.91
198_F201_D0.6400.91
122_T239_R0.6380.91
20_N226_T0.6370.91
120_P123_V0.6340.91
267_V276_V0.6310.91
7_L282_S0.6300.91
233_A237_L0.6260.91
32_T36_M0.6250.90
76_A79_A0.6240.90
29_G52_R0.6230.90
21_A46_S0.6220.90
36_M52_R0.6210.90
134_A140_E0.6210.90
47_E66_P0.6210.90
180_F183_V0.6200.90
178_P183_V0.6190.90
160_L232_A0.6180.90
161_P193_A0.6170.90
120_P274_P0.6110.89
67_T219_G0.6100.89
154_A240_F0.6060.89
5_R286_G0.6050.89
5_R23_G0.6040.89
170_L173_L0.6040.89
84_L95_H0.6020.89
116_M120_P0.6010.89
11_A76_A0.5990.89
130_Y134_A0.5960.88
116_M119_N0.5960.88
170_L254_E0.5960.88
225_V230_S0.5950.88
198_F237_L0.5910.88
157_D160_L0.5860.87
18_A38_A0.5840.87
71_D160_L0.5830.87
193_A197_M0.5820.87
41_A260_D0.5800.87
25_V48_T0.5800.87
238_A251_M0.5770.87
20_N227_G0.5750.86
121_P158_T0.5730.86
109_A268_R0.5720.86
6_A283_T0.5720.86
213_A232_A0.5710.86
136_A186_L0.5680.86
234_G276_V0.5670.86
115_W118_Q0.5640.85
196_Y211_G0.5640.85
184_E217_G0.5630.85
75_H227_G0.5600.85
81_H106_I0.5520.84
251_M267_V0.5510.84
129_S134_A0.5500.84
137_T195_V0.5490.84
33_D100_N0.5470.84
105_D108_V0.5460.84
77_T102_G0.5450.83
118_Q158_T0.5430.83
225_V259_V0.5420.83
88_G92_A0.5420.83
22_A61_L0.5410.83
196_Y233_A0.5410.83
28_A52_R0.5400.83
49_A73_C0.5390.83
192_A217_G0.5380.83
44_G261_R0.5380.83
121_P159_G0.5360.82
162_F229_A0.5360.82
208_T254_E0.5360.82
76_A223_D0.5350.82
46_S66_P0.5350.82
207_S264_R0.5330.82
22_A280_G0.5330.82
184_E221_D0.5330.82
161_P232_A0.5310.82
63_Y228_T0.5310.82
224_P263_G0.5300.82
43_L283_T0.5290.82
67_T220_V0.5260.81
11_A49_A0.5230.81
9_V82_A0.5200.80
116_M122_T0.5200.80
65_T70_V0.5190.80
11_A73_C0.5180.80
199_S210_H0.5180.80
10_D15_D0.5150.80
65_T220_V0.5140.80
201_D210_H0.5100.79
204_D207_S0.5070.79
27_D31_L0.5050.79
125_E135_E0.5040.78
17_C283_T0.5040.78
284_L288_L0.5030.78
121_P231_G0.5020.78
101_V104_L0.5020.78
36_M50_F0.5010.78
63_Y72_L0.5010.78
139_T143_A0.5010.78
25_V39_I0.5000.78
136_A195_V0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ednA 2 0.9535 100 0.279 Contact Map
1ym5A 2 0.9269 100 0.296 Contact Map
1qyaA 2 0.9402 100 0.302 Contact Map
1s7jA 1 0.8638 100 0.305 Contact Map
1xubA 2 0.8904 100 0.311 Contact Map
4dunA 2 0.8571 100 0.32 Contact Map
1u0kA 2 0.9136 100 0.332 Contact Map
4jbdA 2 0.8704 100 0.427 Contact Map
3ejxA 5 0.8837 100 0.437 Contact Map
4juuA 2 0.9003 100 0.439 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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