GREMLIN Database
Q9HS98 - Purine phosphoribosyltransferase
UniProt: Q9HS98 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 230 (173)
Sequences: 292 (190)
Seq/√Len: 14.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_A141_Y4.0031.00
18_I129_L3.1990.98
26_S116_V2.7720.96
132_L157_N2.6430.95
125_R140_D2.6290.95
95_D122_N2.5250.93
102_I128_T2.4000.91
108_S128_T2.3710.91
39_V54_C2.2170.88
95_D123_A2.2160.88
171_A175_D2.1840.87
108_S157_N2.1710.87
151_W156_W2.1370.86
98_I105_T2.1070.85
103_A131_L2.0670.84
158_F165_I2.0470.83
68_E160_E2.0350.83
57_L98_I2.0280.82
102_I130_Q1.8860.78
133_Q145_R1.8860.78
46_G155_P1.7880.74
71_V75_E1.7130.70
52_C154_Y1.6970.69
37_D97_L1.6890.69
14_N17_Y1.6810.69
28_Q143_G1.6780.69
53_L65_L1.6630.68
19_Y154_Y1.6430.67
61_D84_Y1.6340.66
99_I108_S1.6110.65
153_V158_F1.5990.65
21_L132_L1.5840.64
29_V53_L1.5470.62
98_I164_D1.5360.61
25_V108_S1.5330.61
138_E153_V1.5200.61
69_H161_D1.5130.60
98_I116_V1.5030.60
117_Q120_D1.5020.60
98_I109_I1.5010.60
77_S102_I1.4930.59
42_L62_L1.4920.59
98_I120_D1.4850.59
47_W108_S1.4590.57
94_K121_A1.4030.54
50_G54_C1.3790.53
102_I152_I1.3680.52
113_H117_Q1.3680.52
101_D106_G1.3460.51
98_I143_G1.3420.51
151_W155_P1.3390.51
130_Q154_Y1.3350.51
14_N122_N1.3310.50
39_V50_G1.3220.50
107_G111_H1.3200.50
75_E78_A1.2870.48
172_T175_D1.2770.47
50_G70_Y1.2610.46
66_K135_S1.2590.46
39_V112_A1.2580.46
131_L139_P1.2500.46
128_T164_D1.2410.45
46_G55_D1.2330.45
80_P115_Y1.2250.44
20_G24_D1.1870.42
129_L168_G1.1770.42
29_V42_L1.1750.42
15_W19_Y1.1710.42
108_S132_L1.1700.42
43_A64_S1.1660.41
26_S122_N1.1470.40
106_G127_A1.1440.40
73_T157_N1.1340.40
15_W155_P1.1260.39
92_E120_D1.1180.39
18_I153_V1.1170.39
26_S93_D1.1110.38
47_W54_C1.1060.38
53_L99_I1.1050.38
40_V98_I1.1030.38
23_R82_V1.1000.38
22_C69_H1.0800.37
47_W91_V1.0790.37
38_V91_V1.0530.35
13_T70_Y1.0530.35
89_G98_I1.0520.35
40_V91_V1.0450.35
54_C62_L1.0360.35
70_Y80_P1.0340.34
102_I157_N1.0240.34
79_E98_I1.0180.34
51_R55_D0.9900.32
41_A60_N0.9880.32
141_Y166_I0.9690.31
28_Q142_V0.9640.31
92_E113_H0.9570.31
130_Q157_N0.9530.31
100_D151_W0.9480.30
43_A65_L0.9400.30
42_L64_S0.9380.30
67_M107_G0.9350.30
32_A125_R0.9210.29
130_Q165_I0.9130.29
93_D141_Y0.9090.29
46_G95_D0.9060.28
4_L175_D0.9030.28
50_G149_W0.8960.28
132_L152_I0.8950.28
92_E138_E0.8870.28
110_E124_V0.8820.27
20_G105_T0.8770.27
55_D149_W0.8750.27
153_V164_D0.8730.27
61_D94_K0.8690.27
139_P155_P0.8610.26
69_H156_W0.8610.26
171_A176_G0.8570.26
120_D136_A0.8560.26
99_I111_H0.8560.26
113_H137_F0.8480.26
14_N38_V0.8460.26
44_R149_W0.8430.26
36_P65_L0.8370.25
73_T108_S0.8360.25
64_S154_Y0.8320.25
100_D168_G0.8310.25
102_I132_L0.8290.25
103_A117_Q0.8290.25
12_I26_S0.8210.25
109_I128_T0.8170.25
41_A85_P0.8170.25
157_N163_I0.8140.24
45_G70_Y0.8130.24
151_W168_G0.8110.24
66_K84_Y0.8100.24
110_E118_D0.8080.24
17_Y50_G0.8000.24
58_G163_I0.7950.24
95_D141_Y0.7940.24
150_A177_P0.7920.24
60_N82_V0.7910.24
87_P99_I0.7890.23
13_T130_Q0.7840.23
41_A129_L0.7800.23
56_F121_A0.7790.23
34_F141_Y0.7650.23
76_K143_G0.7620.22
67_M117_Q0.7580.22
35_E137_F0.7570.22
69_H149_W0.7570.22
163_I169_V0.7550.22
107_G171_A0.7540.22
19_Y56_F0.7480.22
104_D123_A0.7410.22
109_I153_V0.7400.22
99_I109_I0.7390.22
25_V154_Y0.7390.22
107_G119_R0.7350.21
138_E142_V0.7270.21
73_T165_I0.7270.21
73_T128_T0.7250.21
99_I112_A0.7220.21
78_A141_Y0.7210.21
78_A117_Q0.7180.21
157_N165_I0.7180.21
129_L143_G0.7180.21
18_I165_I0.7160.21
71_V173_D0.7120.21
73_T164_D0.7100.20
67_M99_I0.7070.20
27_D108_S0.7050.20
89_G107_G0.6970.20
102_I150_A0.6830.20
110_E125_R0.6830.20
89_G109_I0.6780.19
157_N164_D0.6770.19
125_R174_D0.6750.19
170_M178_Y0.6740.19
64_S151_W0.6740.19
116_V132_L0.6710.19
87_P174_D0.6710.19
46_G139_P0.6700.19
93_D171_A0.6680.19
27_D60_N0.6650.19
53_L78_A0.6610.19
44_R156_W0.6600.19
34_F40_V0.6600.19
58_G126_T0.6590.19
69_H76_K0.6580.19
64_S69_H0.6570.19
9_N125_R0.6530.19
29_V40_V0.6490.18
80_P107_G0.6480.18
158_F162_M0.6460.18
102_I146_L0.6450.18
78_A122_N0.6420.18
51_R151_W0.6370.18
4_L172_T0.6320.18
147_D158_F0.6320.18
38_V96_V0.6290.18
151_W157_N0.6250.18
92_E119_R0.6230.18
41_A154_Y0.6170.17
21_L70_Y0.6130.17
13_T152_I0.6120.17
116_V124_V0.6110.17
63_T70_Y0.6100.17
100_D162_M0.6010.17
70_Y132_L0.5950.17
9_N154_Y0.5910.17
40_V47_W0.5910.17
48_F52_C0.5900.16
51_R172_T0.5900.16
55_D161_D0.5870.16
22_C34_F0.5850.16
28_Q168_G0.5840.16
5_P141_Y0.5790.16
124_V138_E0.5750.16
18_I169_V0.5740.16
34_F121_A0.5740.16
42_L132_L0.5740.16
41_A112_A0.5730.16
130_Q141_Y0.5730.16
131_L145_R0.5730.16
47_W52_C0.5710.16
114_E177_P0.5710.16
114_E146_L0.5690.16
101_D104_D0.5670.16
43_A63_T0.5660.16
32_A152_I0.5630.16
51_R149_W0.5620.16
128_T154_Y0.5580.16
27_D82_V0.5550.15
82_V174_D0.5550.15
163_I167_A0.5510.15
12_I146_L0.5500.15
39_V127_A0.5500.15
24_D92_E0.5500.15
40_V121_A0.5500.15
38_V65_L0.5480.15
77_S123_A0.5420.15
70_Y105_T0.5370.15
42_L154_Y0.5350.15
121_A166_I0.5340.15
17_Y102_I0.5330.15
52_C151_W0.5320.15
66_K73_T0.5310.15
103_A109_I0.5300.15
48_F105_T0.5290.15
13_T132_L0.5200.14
21_L145_R0.5200.14
153_V162_M0.5180.14
121_A124_V0.5130.14
13_T168_G0.5110.14
153_V157_N0.5100.14
8_F172_T0.5090.14
101_D108_S0.5080.14
29_V93_D0.5070.14
31_A141_Y0.5030.14
151_W158_F0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4trbA 2 0.9 100 0.477 Contact Map
5bqpA 3 0.7435 100 0.531 Contact Map
3ozfA 4 0.7783 100 0.554 Contact Map
4qyiA 3 0.7217 100 0.557 Contact Map
1fsgA 4 0.7739 100 0.56 Contact Map
4qriA 2 0.6739 100 0.563 Contact Map
2jbhA 4 0.7739 100 0.565 Contact Map
4raoA 4 0.7478 100 0.565 Contact Map
4rqaA 3 0.7261 100 0.572 Contact Map
2gebA 3 0.7565 100 0.575 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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