Q9HS96 - HALSA - GREMLIN Contacts

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Q9HS96 - Uncharacterized protein

UniProt:	Q9HS96	Sequences: MTDRDAVPVASPGHEGRSDADGDAVEPVAVLVRLAERGEIEPWDIDIVAVTDKFLAALDEADLRTSGRALFYASVLLRMKSEAMLDDDDDEDADDGDDERAPWEPPGGDDAQPASDPVASLEAEMERRLDRKQARGSPQTLDELVRELREAERGSWWKESREYDTSDSPQGFRRGVNEMEYRSGDAGRMADEPTTAETLGNAHGEDIEATITDVRGALAAQYEAGRDEVLYAEIAAAGPSRVETFLAVLFLAHRGAVTLAQDELFGDLWVQATEEFPAQAATVPPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	286 (234)
Sequences:	230 (173)
Seq/√Len:	11.3

HALSA - Q9HS96

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_I	77_L	3.757	0.99
31_L	35_A	3.714	0.99
92_D	268_L	3.080	0.96
146_R	262_D	3.026	0.95
94_D	270_V	2.755	0.92
52_D	248_V	2.718	0.91
21_D	196_A	2.389	0.85
184_G	188_R	2.380	0.85
24_A	27_P	2.344	0.84
77_L	81_S	2.324	0.83
30_V	247_A	2.283	0.82
51_T	81_S	2.237	0.81
52_D	80_K	2.236	0.81
54_F	65_T	2.137	0.77
66_S	80_K	2.106	0.76
66_S	76_L	2.077	0.75
54_F	151_A	2.060	0.75
47_I	76_L	2.027	0.73
76_L	80_K	2.022	0.73
27_P	117_P	2.005	0.72
183_S	186_A	1.985	0.72
124_E	132_K	1.974	0.71
38_G	63_L	1.931	0.70
64_R	148_L	1.931	0.70
218_L	268_L	1.917	0.69
64_R	78_R	1.867	0.67
226_R	230_L	1.817	0.65
32_V	68_R	1.786	0.63
35_A	63_L	1.767	0.62
246_L	254_R	1.720	0.60
54_F	57_A	1.712	0.60
242_V	257_V	1.701	0.59
41_E	270_V	1.693	0.59
139_Q	143_E	1.685	0.59
186_A	190_A	1.679	0.58
47_I	66_S	1.679	0.58
26_E	62_D	1.638	0.56
93_A	96_G	1.600	0.54
63_L	127_R	1.599	0.54
73_A	141_L	1.577	0.53
32_V	64_R	1.550	0.52
92_D	220_A	1.550	0.52
52_D	76_L	1.509	0.50
105_P	216_G	1.509	0.50
65_T	149_R	1.506	0.50
101_A	268_L	1.504	0.50
84_M	247_A	1.499	0.50
58_L	114_A	1.495	0.49
35_A	52_D	1.493	0.49
114_A	220_A	1.488	0.49
86_D	97_D	1.475	0.48
71_F	75_V	1.462	0.48
38_G	127_R	1.452	0.47
62_D	198_T	1.435	0.46
55_L	76_L	1.422	0.46
147_E	245_F	1.417	0.46
96_G	270_V	1.411	0.45
87_D	189_M	1.402	0.45
206_D	209_A	1.401	0.45
33_R	37_R	1.400	0.45
213_D	270_V	1.400	0.45
50_V	69_A	1.400	0.45
35_A	76_L	1.382	0.44
105_P	114_A	1.380	0.44
69_A	245_F	1.356	0.43
54_F	181_Y	1.345	0.42
35_A	38_G	1.342	0.42
55_L	145_V	1.340	0.42
52_D	66_S	1.334	0.42
89_D	110_D	1.314	0.41
31_L	76_L	1.275	0.39
31_L	145_V	1.266	0.38
203_H	234_I	1.259	0.38
255_G	265_F	1.244	0.37
25_V	149_R	1.242	0.37
34_L	67_G	1.240	0.37
102_P	219_A	1.237	0.37
129_L	160_S	1.226	0.37
51_T	250_F	1.224	0.36
27_P	54_F	1.214	0.36
47_I	69_A	1.210	0.36
45_I	117_P	1.207	0.36
42_P	261_Q	1.205	0.36
43_W	261_Q	1.205	0.36
82_E	86_D	1.205	0.36
52_D	121_L	1.204	0.36
94_D	97_D	1.196	0.35
72_Y	130_D	1.178	0.34
184_G	187_G	1.174	0.34
29_A	78_R	1.172	0.34
196_A	245_F	1.170	0.34
202_A	205_E	1.164	0.34
54_F	212_T	1.163	0.34
79_M	130_D	1.163	0.34
41_E	73_A	1.152	0.33
52_D	63_L	1.152	0.33
50_V	74_S	1.151	0.33
72_Y	189_M	1.135	0.33
95_D	105_P	1.120	0.32
151_A	214_V	1.118	0.32
63_L	128_R	1.118	0.32
54_F	193_P	1.108	0.31
68_R	250_F	1.103	0.31
34_L	272_A	1.102	0.31
47_I	81_S	1.097	0.31
153_R	267_D	1.095	0.31
49_A	271_Q	1.088	0.31
140_T	249_L	1.086	0.30
197_E	207_I	1.085	0.30
100_R	114_A	1.079	0.30
101_A	104_E	1.077	0.30
28_V	265_F	1.074	0.30
93_A	209_A	1.069	0.30
35_A	74_S	1.065	0.30
91_E	129_L	1.056	0.29
50_V	76_L	1.054	0.29
48_V	74_S	1.052	0.29
71_F	145_V	1.038	0.29
62_D	94_D	1.036	0.28
22_G	125_M	1.028	0.28
207_I	218_L	1.027	0.28
38_G	128_R	1.023	0.28
182_R	186_A	1.020	0.28
58_L	132_K	1.015	0.28
94_D	229_V	1.005	0.27
31_L	50_V	1.002	0.27
53_K	264_L	1.001	0.27
103_W	213_D	0.995	0.27
45_I	79_M	0.991	0.27
119_A	132_K	0.990	0.27
49_A	95_D	0.986	0.26
31_L	140_T	0.976	0.26
89_D	112_Q	0.970	0.26
144_L	251_L	0.963	0.26
97_D	236_A	0.962	0.26
69_A	80_K	0.960	0.26
95_D	100_R	0.956	0.25
259_L	268_L	0.940	0.25
143_E	195_T	0.935	0.25
102_P	164_D	0.935	0.25
30_V	148_L	0.932	0.24
89_D	219_A	0.931	0.24
52_D	127_R	0.928	0.24
69_A	76_L	0.927	0.24
76_L	148_L	0.925	0.24
95_D	212_T	0.925	0.24
27_P	132_K	0.924	0.24
57_A	247_A	0.922	0.24
79_M	147_E	0.921	0.24
103_W	161_R	0.911	0.24
240_S	256_A	0.909	0.24
76_L	145_V	0.907	0.24
90_D	268_L	0.907	0.24
139_Q	251_L	0.907	0.24
41_E	239_P	0.899	0.23
63_L	141_L	0.898	0.23
241_R	262_D	0.892	0.23
252_A	256_A	0.890	0.23
147_E	264_L	0.886	0.23
47_I	74_S	0.884	0.23
255_G	270_V	0.881	0.23
46_D	50_V	0.878	0.23
100_R	267_D	0.877	0.23
46_D	203_H	0.865	0.22
205_E	209_A	0.863	0.22
63_L	68_R	0.860	0.22
48_V	244_T	0.855	0.22
79_M	118_V	0.855	0.22
126_E	263_E	0.850	0.22
182_R	187_G	0.839	0.21
51_T	64_R	0.839	0.21
21_D	101_A	0.839	0.21
217_A	221_Q	0.835	0.21
118_V	241_R	0.835	0.21
95_D	197_E	0.831	0.21
41_E	104_E	0.831	0.21
35_A	152_E	0.830	0.21
93_A	146_R	0.830	0.21
80_K	148_L	0.830	0.21
44_D	259_L	0.828	0.21
133_Q	245_F	0.827	0.21
40_I	267_D	0.820	0.21
112_Q	274_E	0.816	0.21
93_A	204_G	0.814	0.20
104_E	114_A	0.807	0.20
29_A	79_M	0.801	0.20
182_R	188_R	0.799	0.20
218_L	251_L	0.794	0.20
54_F	63_L	0.787	0.20
35_A	248_V	0.787	0.20
137_S	147_E	0.782	0.19
48_V	151_A	0.781	0.19
46_D	250_F	0.780	0.19
47_I	80_K	0.778	0.19
208_E	211_I	0.776	0.19
104_E	259_L	0.773	0.19
55_L	80_K	0.771	0.19
159_E	262_D	0.770	0.19
54_F	216_G	0.769	0.19
55_L	248_V	0.768	0.19
185_D	220_A	0.765	0.19
133_Q	247_A	0.763	0.19
125_M	196_A	0.761	0.19
104_E	260_A	0.759	0.19
25_V	60_E	0.759	0.19
86_D	96_G	0.752	0.19
70_L	268_L	0.750	0.19
124_E	129_L	0.750	0.19
198_T	265_F	0.750	0.19
46_D	78_R	0.749	0.19
38_G	80_K	0.741	0.18
49_A	223_E	0.737	0.18
191_D	220_A	0.736	0.18
141_L	259_L	0.732	0.18
161_R	230_L	0.732	0.18
197_E	214_V	0.731	0.18
74_S	80_K	0.728	0.18
62_D	115_S	0.726	0.18
40_I	80_K	0.726	0.18
42_P	144_L	0.725	0.18
43_W	144_L	0.725	0.18
144_L	261_Q	0.725	0.18
41_E	247_A	0.721	0.18
24_A	268_L	0.719	0.18
136_G	269_W	0.715	0.18
129_L	163_Y	0.715	0.18
251_L	261_Q	0.714	0.17
43_W	251_L	0.714	0.17
42_P	251_L	0.714	0.17
39_E	66_S	0.714	0.17
127_R	241_R	0.713	0.17
139_Q	192_E	0.713	0.17
62_D	135_R	0.711	0.17
117_P	124_E	0.708	0.17
96_G	219_A	0.704	0.17
35_A	148_L	0.703	0.17
102_P	105_P	0.701	0.17
58_L	128_R	0.700	0.17
31_L	55_L	0.699	0.17
263_E	267_D	0.699	0.17
96_G	260_A	0.697	0.17
122_E	128_R	0.691	0.17
35_A	40_I	0.690	0.17
75_V	264_L	0.686	0.17
184_G	266_G	0.686	0.17
210_T	247_A	0.680	0.17
36_E	270_V	0.680	0.17
66_S	74_S	0.680	0.17
72_Y	154_G	0.678	0.17
134_A	254_R	0.678	0.17
127_R	248_V	0.675	0.16
68_R	264_L	0.669	0.16
40_I	66_S	0.668	0.16
240_S	243_E	0.667	0.16
32_V	63_L	0.666	0.16
164_D	266_G	0.666	0.16
201_N	207_I	0.665	0.16
105_P	164_D	0.665	0.16
31_L	152_E	0.663	0.16
24_A	117_P	0.660	0.16
105_P	219_A	0.658	0.16
105_P	112_Q	0.654	0.16
31_L	63_L	0.654	0.16
81_S	221_Q	0.652	0.16
244_T	248_V	0.652	0.16
208_E	263_E	0.650	0.16
30_V	271_Q	0.646	0.16
41_E	251_L	0.631	0.15
34_L	37_R	0.629	0.15
117_P	198_T	0.629	0.15
96_G	232_A	0.629	0.15
30_V	149_R	0.626	0.15
242_V	272_A	0.625	0.15
28_V	77_L	0.625	0.15
250_F	266_G	0.624	0.15
71_F	76_L	0.623	0.15
227_D	233_E	0.621	0.15
184_G	256_A	0.618	0.15
143_E	256_A	0.615	0.15
58_L	264_L	0.614	0.15
114_A	232_A	0.610	0.15
45_I	71_F	0.609	0.15
29_A	67_G	0.605	0.15
118_V	152_E	0.604	0.15
63_L	147_E	0.604	0.15
80_K	259_L	0.604	0.15
187_G	213_D	0.603	0.15
31_L	80_K	0.601	0.15
35_A	80_K	0.599	0.14
37_R	112_Q	0.597	0.14
211_I	269_W	0.597	0.14
34_L	143_E	0.596	0.14
135_R	270_V	0.596	0.14
47_I	252_A	0.596	0.14
188_R	192_E	0.596	0.14
53_K	67_G	0.595	0.14
227_D	274_E	0.594	0.14
101_A	224_A	0.593	0.14
37_R	57_A	0.591	0.14
180_E	203_H	0.591	0.14
59_D	194_T	0.590	0.14
31_L	128_R	0.588	0.14
26_E	95_D	0.588	0.14
191_D	194_T	0.580	0.14
131_R	155_S	0.580	0.14
67_G	137_S	0.578	0.14
36_E	214_V	0.577	0.14
103_W	219_A	0.577	0.14
103_W	111_A	0.574	0.14
40_I	265_F	0.570	0.14
49_A	255_G	0.569	0.14
35_A	147_E	0.569	0.14
36_E	255_G	0.568	0.14
158_K	164_D	0.567	0.14
40_I	63_L	0.564	0.14
151_A	269_W	0.564	0.14
32_V	67_G	0.561	0.14
28_V	58_L	0.558	0.14
57_A	154_G	0.557	0.14
67_G	263_E	0.556	0.13
211_I	219_A	0.554	0.13
236_A	259_L	0.554	0.13
82_E	226_R	0.553	0.13
218_L	274_E	0.549	0.13
43_W	249_L	0.545	0.13
249_L	261_Q	0.545	0.13
42_P	249_L	0.545	0.13
69_A	74_S	0.543	0.13
60_E	254_R	0.542	0.13
36_E	97_D	0.542	0.13
150_E	215_R	0.538	0.13
38_G	52_D	0.538	0.13
264_L	267_D	0.538	0.13
221_Q	254_R	0.537	0.13
216_G	237_A	0.534	0.13
223_E	247_A	0.533	0.13
55_L	70_L	0.533	0.13
91_E	97_D	0.531	0.13
32_V	135_R	0.523	0.13
142_D	181_Y	0.520	0.13
29_A	273_T	0.518	0.13
121_L	128_R	0.514	0.13
45_I	246_L	0.514	0.13
111_A	220_A	0.511	0.12
31_L	48_V	0.508	0.12
21_D	56_A	0.507	0.12
190_A	271_Q	0.506	0.12
47_I	50_V	0.504	0.12
112_Q	224_A	0.503	0.12
32_V	152_E	0.502	0.12
183_S	187_G	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zgxC	2	0.2238	99.5	0.821	Contact Map
4i98A	1	0.465	99.5	0.828	Contact Map
3w6jA	1	0.4371	99.4	0.835	Contact Map
4i99C	1	0.2378	98.8	0.87	Contact Map
1w1wE	1	0.2308	95.7	0.927	Contact Map
2l01A	2	0.2622	25.5	0.964	Contact Map
2l02A	2	0.2692	23.9	0.965	Contact Map
4p6zV	1	0.035	7.9	0.971	Contact Map
4g9jC	1	0.035	3	0.977	Contact Map
2kp7A	1	0.2622	2.7	0.977	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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