GREMLIN Database
Q9HS96 - Uncharacterized protein
UniProt: Q9HS96 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (234)
Sequences: 230 (173)
Seq/√Len: 11.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_I77_L3.7570.99
31_L35_A3.7140.99
92_D268_L3.0800.96
146_R262_D3.0260.95
94_D270_V2.7550.92
52_D248_V2.7180.91
21_D196_A2.3890.85
184_G188_R2.3800.85
24_A27_P2.3440.84
77_L81_S2.3240.83
30_V247_A2.2830.82
51_T81_S2.2370.81
52_D80_K2.2360.81
54_F65_T2.1370.77
66_S80_K2.1060.76
66_S76_L2.0770.75
54_F151_A2.0600.75
47_I76_L2.0270.73
76_L80_K2.0220.73
27_P117_P2.0050.72
183_S186_A1.9850.72
124_E132_K1.9740.71
38_G63_L1.9310.70
64_R148_L1.9310.70
218_L268_L1.9170.69
64_R78_R1.8670.67
226_R230_L1.8170.65
32_V68_R1.7860.63
35_A63_L1.7670.62
246_L254_R1.7200.60
54_F57_A1.7120.60
242_V257_V1.7010.59
41_E270_V1.6930.59
139_Q143_E1.6850.59
186_A190_A1.6790.58
47_I66_S1.6790.58
26_E62_D1.6380.56
93_A96_G1.6000.54
63_L127_R1.5990.54
73_A141_L1.5770.53
32_V64_R1.5500.52
92_D220_A1.5500.52
52_D76_L1.5090.50
105_P216_G1.5090.50
65_T149_R1.5060.50
101_A268_L1.5040.50
84_M247_A1.4990.50
58_L114_A1.4950.49
35_A52_D1.4930.49
114_A220_A1.4880.49
86_D97_D1.4750.48
71_F75_V1.4620.48
38_G127_R1.4520.47
62_D198_T1.4350.46
55_L76_L1.4220.46
147_E245_F1.4170.46
96_G270_V1.4110.45
87_D189_M1.4020.45
206_D209_A1.4010.45
33_R37_R1.4000.45
213_D270_V1.4000.45
50_V69_A1.4000.45
35_A76_L1.3820.44
105_P114_A1.3800.44
69_A245_F1.3560.43
54_F181_Y1.3450.42
35_A38_G1.3420.42
55_L145_V1.3400.42
52_D66_S1.3340.42
89_D110_D1.3140.41
31_L76_L1.2750.39
31_L145_V1.2660.38
203_H234_I1.2590.38
255_G265_F1.2440.37
25_V149_R1.2420.37
34_L67_G1.2400.37
102_P219_A1.2370.37
129_L160_S1.2260.37
51_T250_F1.2240.36
27_P54_F1.2140.36
47_I69_A1.2100.36
45_I117_P1.2070.36
42_P261_Q1.2050.36
43_W261_Q1.2050.36
82_E86_D1.2050.36
52_D121_L1.2040.36
94_D97_D1.1960.35
72_Y130_D1.1780.34
184_G187_G1.1740.34
29_A78_R1.1720.34
196_A245_F1.1700.34
202_A205_E1.1640.34
54_F212_T1.1630.34
79_M130_D1.1630.34
41_E73_A1.1520.33
52_D63_L1.1520.33
50_V74_S1.1510.33
72_Y189_M1.1350.33
95_D105_P1.1200.32
151_A214_V1.1180.32
63_L128_R1.1180.32
54_F193_P1.1080.31
68_R250_F1.1030.31
34_L272_A1.1020.31
47_I81_S1.0970.31
153_R267_D1.0950.31
49_A271_Q1.0880.31
140_T249_L1.0860.30
197_E207_I1.0850.30
100_R114_A1.0790.30
101_A104_E1.0770.30
28_V265_F1.0740.30
93_A209_A1.0690.30
35_A74_S1.0650.30
91_E129_L1.0560.29
50_V76_L1.0540.29
48_V74_S1.0520.29
71_F145_V1.0380.29
62_D94_D1.0360.28
22_G125_M1.0280.28
207_I218_L1.0270.28
38_G128_R1.0230.28
182_R186_A1.0200.28
58_L132_K1.0150.28
94_D229_V1.0050.27
31_L50_V1.0020.27
53_K264_L1.0010.27
103_W213_D0.9950.27
45_I79_M0.9910.27
119_A132_K0.9900.27
49_A95_D0.9860.26
31_L140_T0.9760.26
89_D112_Q0.9700.26
144_L251_L0.9630.26
97_D236_A0.9620.26
69_A80_K0.9600.26
95_D100_R0.9560.25
259_L268_L0.9400.25
143_E195_T0.9350.25
102_P164_D0.9350.25
30_V148_L0.9320.24
89_D219_A0.9310.24
52_D127_R0.9280.24
69_A76_L0.9270.24
76_L148_L0.9250.24
95_D212_T0.9250.24
27_P132_K0.9240.24
57_A247_A0.9220.24
79_M147_E0.9210.24
103_W161_R0.9110.24
240_S256_A0.9090.24
76_L145_V0.9070.24
90_D268_L0.9070.24
139_Q251_L0.9070.24
41_E239_P0.8990.23
63_L141_L0.8980.23
241_R262_D0.8920.23
252_A256_A0.8900.23
147_E264_L0.8860.23
47_I74_S0.8840.23
255_G270_V0.8810.23
46_D50_V0.8780.23
100_R267_D0.8770.23
46_D203_H0.8650.22
205_E209_A0.8630.22
63_L68_R0.8600.22
48_V244_T0.8550.22
79_M118_V0.8550.22
126_E263_E0.8500.22
182_R187_G0.8390.21
51_T64_R0.8390.21
21_D101_A0.8390.21
217_A221_Q0.8350.21
118_V241_R0.8350.21
95_D197_E0.8310.21
41_E104_E0.8310.21
35_A152_E0.8300.21
93_A146_R0.8300.21
80_K148_L0.8300.21
44_D259_L0.8280.21
133_Q245_F0.8270.21
40_I267_D0.8200.21
112_Q274_E0.8160.21
93_A204_G0.8140.20
104_E114_A0.8070.20
29_A79_M0.8010.20
182_R188_R0.7990.20
218_L251_L0.7940.20
54_F63_L0.7870.20
35_A248_V0.7870.20
137_S147_E0.7820.19
48_V151_A0.7810.19
46_D250_F0.7800.19
47_I80_K0.7780.19
208_E211_I0.7760.19
104_E259_L0.7730.19
55_L80_K0.7710.19
159_E262_D0.7700.19
54_F216_G0.7690.19
55_L248_V0.7680.19
185_D220_A0.7650.19
133_Q247_A0.7630.19
125_M196_A0.7610.19
104_E260_A0.7590.19
25_V60_E0.7590.19
86_D96_G0.7520.19
70_L268_L0.7500.19
124_E129_L0.7500.19
198_T265_F0.7500.19
46_D78_R0.7490.19
38_G80_K0.7410.18
49_A223_E0.7370.18
191_D220_A0.7360.18
141_L259_L0.7320.18
161_R230_L0.7320.18
197_E214_V0.7310.18
74_S80_K0.7280.18
62_D115_S0.7260.18
40_I80_K0.7260.18
42_P144_L0.7250.18
43_W144_L0.7250.18
144_L261_Q0.7250.18
41_E247_A0.7210.18
24_A268_L0.7190.18
136_G269_W0.7150.18
129_L163_Y0.7150.18
251_L261_Q0.7140.17
43_W251_L0.7140.17
42_P251_L0.7140.17
39_E66_S0.7140.17
127_R241_R0.7130.17
139_Q192_E0.7130.17
62_D135_R0.7110.17
117_P124_E0.7080.17
96_G219_A0.7040.17
35_A148_L0.7030.17
102_P105_P0.7010.17
58_L128_R0.7000.17
31_L55_L0.6990.17
263_E267_D0.6990.17
96_G260_A0.6970.17
122_E128_R0.6910.17
35_A40_I0.6900.17
75_V264_L0.6860.17
184_G266_G0.6860.17
210_T247_A0.6800.17
36_E270_V0.6800.17
66_S74_S0.6800.17
72_Y154_G0.6780.17
134_A254_R0.6780.17
127_R248_V0.6750.16
68_R264_L0.6690.16
40_I66_S0.6680.16
240_S243_E0.6670.16
32_V63_L0.6660.16
164_D266_G0.6660.16
201_N207_I0.6650.16
105_P164_D0.6650.16
31_L152_E0.6630.16
24_A117_P0.6600.16
105_P219_A0.6580.16
105_P112_Q0.6540.16
31_L63_L0.6540.16
81_S221_Q0.6520.16
244_T248_V0.6520.16
208_E263_E0.6500.16
30_V271_Q0.6460.16
41_E251_L0.6310.15
34_L37_R0.6290.15
117_P198_T0.6290.15
96_G232_A0.6290.15
30_V149_R0.6260.15
242_V272_A0.6250.15
28_V77_L0.6250.15
250_F266_G0.6240.15
71_F76_L0.6230.15
227_D233_E0.6210.15
184_G256_A0.6180.15
143_E256_A0.6150.15
58_L264_L0.6140.15
114_A232_A0.6100.15
45_I71_F0.6090.15
29_A67_G0.6050.15
118_V152_E0.6040.15
63_L147_E0.6040.15
80_K259_L0.6040.15
187_G213_D0.6030.15
31_L80_K0.6010.15
35_A80_K0.5990.14
37_R112_Q0.5970.14
211_I269_W0.5970.14
34_L143_E0.5960.14
135_R270_V0.5960.14
47_I252_A0.5960.14
188_R192_E0.5960.14
53_K67_G0.5950.14
227_D274_E0.5940.14
101_A224_A0.5930.14
37_R57_A0.5910.14
180_E203_H0.5910.14
59_D194_T0.5900.14
31_L128_R0.5880.14
26_E95_D0.5880.14
191_D194_T0.5800.14
131_R155_S0.5800.14
67_G137_S0.5780.14
36_E214_V0.5770.14
103_W219_A0.5770.14
103_W111_A0.5740.14
40_I265_F0.5700.14
49_A255_G0.5690.14
35_A147_E0.5690.14
36_E255_G0.5680.14
158_K164_D0.5670.14
40_I63_L0.5640.14
151_A269_W0.5640.14
32_V67_G0.5610.14
28_V58_L0.5580.14
57_A154_G0.5570.14
67_G263_E0.5560.13
211_I219_A0.5540.13
236_A259_L0.5540.13
82_E226_R0.5530.13
218_L274_E0.5490.13
43_W249_L0.5450.13
249_L261_Q0.5450.13
42_P249_L0.5450.13
69_A74_S0.5430.13
60_E254_R0.5420.13
36_E97_D0.5420.13
150_E215_R0.5380.13
38_G52_D0.5380.13
264_L267_D0.5380.13
221_Q254_R0.5370.13
216_G237_A0.5340.13
223_E247_A0.5330.13
55_L70_L0.5330.13
91_E97_D0.5310.13
32_V135_R0.5230.13
142_D181_Y0.5200.13
29_A273_T0.5180.13
121_L128_R0.5140.13
45_I246_L0.5140.13
111_A220_A0.5110.12
31_L48_V0.5080.12
21_D56_A0.5070.12
190_A271_Q0.5060.12
47_I50_V0.5040.12
112_Q224_A0.5030.12
32_V152_E0.5020.12
183_S187_G0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zgxC 2 0.2238 99.5 0.821 Contact Map
4i98A 1 0.465 99.5 0.828 Contact Map
3w6jA 1 0.4371 99.4 0.835 Contact Map
4i99C 1 0.2378 98.8 0.87 Contact Map
1w1wE 1 0.2308 95.7 0.927 Contact Map
2l01A 2 0.2622 25.5 0.964 Contact Map
2l02A 2 0.2692 23.9 0.965 Contact Map
4p6zV 1 0.035 7.9 0.971 Contact Map
4g9jC 1 0.035 3 0.977 Contact Map
2kp7A 1 0.2622 2.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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