GREMLIN Database
Q9HS95 - Chromosome partition protein Smc
UniProt: Q9HS95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 1190 (1153)
Sequences: 2420 (2067)
Seq/√Len: 60.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
648_N651_T5.0831.00
1054_R1140_E4.5091.00
85_E116_T4.2261.00
242_K977_V3.9801.00
241_E976_N3.7551.00
551_L574_V3.7061.00
633_A637_S3.2321.00
820_E823_E3.2111.00
976_N979_R3.1401.00
1002_A1006_D3.0441.00
553_G627_D2.9931.00
851_E855_E2.8961.00
646_V661_L2.8171.00
4_E114_T2.7981.00
881_D884_A2.7911.00
577_D580_V2.7871.00
402_F409_L2.7391.00
1038_M1042_E2.7381.00
85_E118_K2.6681.00
956_D959_V2.6411.00
507_L702_I2.6411.00
369_E373_Q2.6361.00
724_D727_R2.6311.00
905_D909_D2.6141.00
781_T785_E2.6131.00
647_E651_T2.6041.00
492_E495_Q2.5571.00
405_L408_A2.5451.00
83_S120_R2.5391.00
576_D580_V2.5221.00
630_E633_A2.5141.00
323_G327_R2.5051.00
562_C622_A2.5011.00
474_K478_N2.4781.00
1059_T1080_Q2.4551.00
44_I1118_A2.4531.00
969_D972_V2.4531.00
952_V955_L2.4401.00
804_E808_A2.3911.00
510_A514_Y2.3911.00
855_E859_A2.3731.00
327_R330_D2.3701.00
704_G708_D2.3691.00
552_G636_F2.3521.00
410_A413_K2.3311.00
406_K410_A2.3001.00
955_L959_V2.2911.00
403_D406_K2.2891.00
698_V702_I2.2861.00
117_I148_L2.2761.00
470_D474_K2.2701.00
812_I816_T2.2621.00
876_E879_N2.2601.00
315_K322_K2.2571.00
893_E900_E2.2521.00
963_D966_E2.2341.00
736_Q739_T2.2291.00
827_V831_G2.2271.00
1045_N1061_G2.1981.00
284_E288_T2.1921.00
424_N428_R2.1901.00
948_L955_L2.1871.00
514_Y695_L2.1771.00
834_D838_G2.1671.00
411_D415_A2.1661.00
824_A828_D2.1621.00
912_E916_D2.1571.00
796_I800_I2.1541.00
959_V962_Y2.1411.00
586_E590_Q2.1401.00
692_K696_E2.1321.00
513_E517_L2.1181.00
1069_D1072_D2.1171.00
691_G698_V2.1101.00
295_D298_A2.1021.00
317_E320_E2.0971.00
134_L144_I2.0951.00
931_V935_R2.0921.00
889_L893_E2.0831.00
834_D837_D2.0781.00
649_M669_V2.0771.00
322_K329_E2.0751.00
697_R701_R2.0641.00
925_D932_E2.0541.00
452_E455_R2.0521.00
601_I635_V2.0511.00
958_A962_Y2.0501.00
836_L843_L2.0481.00
948_L952_V2.0481.00
951_E955_L2.0471.00
953_A956_D2.0461.00
951_E954_E2.0381.00
881_D885_K2.0271.00
903_L910_R2.0201.00
862_A865_E2.0141.00
379_A383_E2.0111.00
860_D864_A1.9951.00
956_D962_Y1.9931.00
362_A366_D1.9861.00
883_E886_Q1.9691.00
956_D960_G1.9611.00
1013_A1017_E1.9571.00
545_H576_D1.9531.00
894_A898_D1.9491.00
955_L964_P1.9451.00
402_F408_A1.9441.00
888_E891_E1.9341.00
417_E421_R1.9321.00
900_E904_A1.9311.00
720_D727_R1.9311.00
432_R436_E1.9291.00
848_E852_D1.9261.00
952_V959_V1.9221.00
755_V759_A1.9211.00
481_Q485_V1.9211.00
341_D345_E1.9121.00
277_G281_E1.9081.00
263_A267_D1.8961.00
802_S806_E1.8861.00
351_V355_R1.8841.00
731_Q734_T1.8811.00
578_D602_T1.8781.00
896_V900_E1.8741.00
886_Q890_A1.8661.00
519_A523_Q1.8661.00
402_F405_L1.8521.00
467_E471_E1.8411.00
376_S380_E1.8321.00
265_R269_D1.8231.00
956_D963_D1.8191.00
422_E429_E1.8151.00
499_D502_A1.8121.00
785_E788_A1.8091.00
946_Q949_S1.8011.00
795_A799_E1.7971.00
555_R627_D1.7760.99
899_L902_E1.7740.99
898_D902_E1.7710.99
998_Y1002_A1.7650.99
401_E404_E1.7640.99
877_A881_D1.7600.99
952_V962_Y1.7590.99
958_A961_E1.7550.99
713_R720_D1.7530.99
738_R741_Q1.7520.99
821_D825_T1.7510.99
960_G963_D1.7480.99
947_T951_E1.7400.99
360_I364_E1.7370.99
1079_A1100_T1.7350.99
703_Q706_E1.7280.99
718_E722_R1.7280.99
855_E858_Q1.7190.99
22_F1148_V1.7160.99
626_V640_L1.7150.99
565_A643_T1.7100.99
462_D466_D1.7100.99
790_Q794_A1.7010.99
900_E907_K1.6990.99
895_A898_D1.6950.99
576_D631_R1.6910.99
364_E368_R1.6840.99
932_E935_R1.6840.99
500_L503_V1.6840.99
746_A750_D1.6830.99
458_L462_D1.6800.99
291_R295_D1.6710.99
315_K319_E1.6640.99
5_E19_R1.6630.99
622_A645_V1.6610.99
1113_P1117_Y1.6610.99
660_R668_L1.6560.99
405_L412_E1.6540.99
787_D791_E1.6540.99
405_L409_L1.6530.99
628_F633_A1.6520.99
716_V720_D1.6520.99
311_Q315_K1.6520.99
340_Q344_A1.6500.99
167_T170_I1.6500.99
418_D422_E1.6480.99
249_A970_A1.6470.99
763_T767_E1.6460.99
774_A778_E1.6460.99
473_E476_T1.6450.99
694_Q698_V1.6450.99
833_V836_L1.6390.99
245_Y973_V1.6380.99
396_E399_D1.6360.99
406_K413_K1.6340.99
874_R877_A1.6310.99
948_L951_E1.6280.99
319_E323_G1.6270.99
727_R734_T1.6260.99
398_V401_E1.6240.99
788_A792_T1.6220.99
701_R704_G1.6200.99
831_G834_D1.6200.99
465_L468_L1.6190.99
223_D226_A1.6170.99
921_E925_D1.6150.99
446_D450_D1.6140.99
956_D961_E1.6080.99
368_R371_K1.6080.99
820_E824_A1.6080.99
403_D413_K1.6040.99
330_D334_A1.6030.99
750_D753_A1.6010.99
907_K914_K1.5980.99
789_Q796_I1.5950.99
408_A412_E1.5930.99
825_T829_L1.5860.99
705_L709_R1.5840.99
312_L315_K1.5780.99
4_E89_N1.5770.99
621_F624_D1.5760.99
365_T369_E1.5720.99
413_K420_K1.5720.99
410_A417_E1.5710.99
957_D960_G1.5700.99
286_R293_E1.5690.99
812_I819_K1.5650.99
340_Q343_D1.5600.99
792_T795_A1.5540.99
837_D841_N1.5540.99
406_K409_L1.5530.99
298_A302_E1.5490.99
537_L540_D1.5480.99
833_V837_D1.5470.99
626_V636_F1.5460.99
776_D780_Q1.5460.99
814_E818_E1.5440.99
949_S954_E1.5440.99
916_D920_A1.5380.98
759_A763_T1.5350.98
959_V963_D1.5320.98
924_R928_A1.5300.98
377_V380_E1.5290.98
780_Q784_A1.5270.98
991_N994_A1.5240.98
778_E781_T1.5220.98
847_K851_E1.5200.98
267_D270_E1.5170.98
751_R755_V1.5160.98
356_K360_I1.5130.98
212_E1012_R1.5110.98
732_D736_Q1.5110.98
410_A421_R1.5070.98
947_T954_E1.5070.98
461_V464_T1.5030.98
384_R387_E1.5030.98
404_E408_A1.5020.98
938_L942_Q1.4990.98
891_E895_A1.4980.98
398_V402_F1.4960.98
1032_Q1036_T1.4910.98
529_Y532_A1.4850.98
378_T382_Q1.4850.98
421_R425_D1.4840.98
952_V956_D1.4800.98
947_T955_L1.4780.98
750_D754_A1.4780.98
245_Y976_N1.4770.98
895_A899_L1.4760.98
819_K826_V1.4740.98
797_E801_E1.4740.98
962_Y965_A1.4720.98
409_L412_E1.4710.98
798_A802_S1.4670.98
431_D434_L1.4630.98
738_R745_E1.4620.98
775_V779_M1.4620.98
1051_I1055_L1.4590.98
950_E953_A1.4570.98
375_A378_T1.4570.98
308_E312_L1.4540.98
793_I800_I1.4530.98
734_T738_R1.4510.98
857_L861_V1.4480.98
234_E238_L1.4470.98
1084_K1096_E1.4420.98
780_Q783_D1.4410.98
903_L907_K1.4390.98
841_N845_L1.4380.98
711_D715_E1.4360.98
815_L818_E1.4350.98
865_E869_A1.4330.98
460_E464_T1.4320.98
382_Q385_R1.4320.98
739_T743_D1.4320.98
417_E420_K1.4320.98
346_R350_V1.4300.98
760_D764_R1.4290.98
419_A423_R1.4260.97
949_S955_L1.4250.97
436_E440_R1.4230.97
499_D503_V1.4210.97
801_E804_E1.4110.97
917_L921_E1.4100.97
907_K910_R1.4080.97
819_K823_E1.4070.97
909_D913_R1.4040.97
383_E387_E1.4040.97
1006_D1010_A1.4040.97
758_I762_E1.4030.97
879_N883_E1.4010.97
402_F410_A1.4000.97
729_R732_D1.3980.97
803_L807_L1.3960.97
846_E849_Y1.3950.97
921_E945_A1.3930.97
947_T950_E1.3890.97
31_G36_G1.3880.97
952_V957_D1.3850.97
800_I804_E1.3830.97
401_E405_L1.3790.97
308_E322_K1.3750.97
430_Q437_A1.3750.97
270_E274_E1.3740.97
826_V830_E1.3730.97
955_L962_Y1.3730.97
773_E777_A1.3650.97
437_A441_S1.3630.97
849_Y853_A1.3630.97
773_E776_D1.3620.97
31_G37_K1.3590.97
544_V573_V1.3580.97
429_E432_R1.3560.97
198_F202_D1.3560.97
158_Y166_V1.3550.97
948_L959_V1.3550.97
959_V965_A1.3520.97
466_D469_A1.3500.96
517_L520_Q1.3480.96
747_A750_D1.3450.96
468_L472_L1.3430.96
513_E520_Q1.3420.96
262_S266_A1.3410.96
330_D333_A1.3390.96
322_K330_D1.3380.96
517_L521_A1.3350.96
804_E807_L1.3350.96
984_M990_V1.3340.96
459_P462_D1.3330.96
753_A757_R1.3320.96
749_A753_A1.3300.96
575_V581_G1.3290.96
762_E766_E1.3290.96
450_D454_A1.3280.96
883_E887_A1.3280.96
118_K133_Y1.3220.96
835_E839_E1.3190.96
670_E673_G1.3190.96
344_A348_E1.3190.96
10_N16_G1.3190.96
501_A504_E1.3180.96
887_A890_A1.3180.96
1055_L1103_A1.3150.96
708_D711_D1.3130.96
832_R839_E1.3110.96
557_Q664_L1.3030.96
438_K442_E1.3010.96
772_R776_D1.3010.96
785_E789_Q1.3010.96
932_E955_L1.3000.96
746_A754_A1.2980.96
93_G113_D1.2980.96
402_F417_E1.2960.96
896_V903_L1.2950.96
777_A781_T1.2950.96
764_R771_E1.2940.96
935_R939_E1.2940.96
31_G34_G1.2930.95
1012_R1016_T1.2930.95
958_A965_A1.2910.95
273_R277_G1.2870.95
979_R983_R1.2850.95
821_D824_A1.2800.95
217_E1004_T1.2790.95
670_E674_A1.2790.95
482_I485_V1.2790.95
936_H945_A1.2780.95
952_V958_A1.2770.95
1114_A1123_D1.2760.95
237_D241_E1.2760.95
853_A857_L1.2740.95
783_D787_D1.2740.95
403_D407_A1.2730.95
845_L849_Y1.2720.95
409_L416_L1.2700.95
690_S694_Q1.2680.95
350_V354_D1.2680.95
167_T1097_K1.2660.95
326_S329_E1.2640.95
878_L889_L1.2620.95
410_A414_T1.2600.95
585_I598_F1.2590.95
1061_G1078_K1.2570.95
323_G330_D1.2540.95
932_E938_L1.2540.95
29_I1118_A1.2530.95
449_A453_D1.2530.95
95_V115_I1.2520.95
516_R520_Q1.2520.95
835_E838_G1.2480.95
413_K417_E1.2470.94
1005_L1009_E1.2460.94
811_R815_L1.2430.94
472_L479_R1.2410.94
858_Q862_A1.2400.94
813_P816_T1.2390.94
722_R725_S1.2370.94
937_R944_A1.2370.94
815_L819_K1.2360.94
373_Q377_V1.2350.94
929_A932_E1.2350.94
40_I1166_V1.2350.94
831_G838_G1.2310.94
7_V17_T1.2300.94
117_I144_I1.2300.94
953_A958_A1.2290.94
893_E910_R1.2280.94
620_D624_D1.2260.94
238_L983_R1.2260.94
742_A746_A1.2260.94
827_V830_E1.2250.94
757_R760_D1.2250.94
226_A230_E1.2240.94
887_A891_E1.2230.94
846_E860_D1.2230.94
859_A863_D1.2220.94
246_E981_G1.2210.94
420_K423_R1.2180.94
518_E699_A1.2160.94
499_D708_D1.2090.94
345_E349_A1.2080.94
424_N427_Q1.2060.93
226_A998_Y1.2060.93
512_E516_R1.2050.93
1089_L1097_K1.2050.93
691_G695_L1.2020.93
812_I815_L1.2000.93
485_V488_D1.2000.93
34_G37_K1.1960.93
921_E924_R1.1950.93
955_L958_A1.1950.93
835_E842_S1.1930.93
775_V778_E1.1920.93
338_R341_D1.1880.93
892_K895_A1.1870.93
953_A959_V1.1860.93
793_I796_I1.1840.93
331_T334_A1.1840.93
793_I797_E1.1830.93
924_R938_L1.1820.93
910_R914_K1.1810.93
826_V829_L1.1800.93
1101_A1108_I1.1800.93
740_I743_D1.1770.93
963_D967_I1.1760.93
848_E851_E1.1740.93
477_R481_Q1.1740.93
811_R814_E1.1710.92
794_A798_A1.1700.92
962_Y966_E1.1700.92
730_R734_T1.1690.92
497_Q501_A1.1670.92
701_R705_L1.1670.92
403_D410_A1.1670.92
392_E398_V1.1670.92
718_E721_Q1.1640.92
904_A921_E1.1610.92
409_L421_R1.1580.92
836_L842_S1.1580.92
946_Q953_A1.1540.92
825_T828_D1.1530.92
936_H939_E1.1520.92
1057_A1060_G1.1490.92
771_E775_V1.1480.92
1038_M1070_P1.1470.92
408_A411_D1.1470.92
402_F406_K1.1470.92
925_D928_A1.1460.92
355_R359_R1.1440.92
162_M165_D1.1430.91
442_E446_D1.1430.91
218_K222_L1.1420.91
925_D929_A1.1420.91
752_E755_V1.1410.91
943_A952_V1.1400.91
358_E362_A1.1390.91
444_L451_L1.1390.91
949_S956_D1.1380.91
158_Y162_M1.1370.91
929_A947_T1.1360.91
772_R779_M1.1350.91
864_A868_K1.1350.91
863_D867_R1.1330.91
397_S401_E1.1290.91
546_G551_L1.1280.91
778_E785_E1.1250.91
33_N36_G1.1240.91
427_Q436_E1.1240.91
950_E955_L1.1220.91
87_V116_T1.1220.91
1058_G1064_L1.1210.91
402_F411_D1.1210.91
451_L454_A1.1200.91
950_E956_D1.1200.91
421_R424_N1.1180.91
326_S330_D1.1170.91
907_K911_E1.1170.91
856_D860_D1.1160.90
924_R935_R1.1160.90
599_L635_V1.1160.90
930_A937_R1.1150.90
769_Q773_E1.1150.90
479_R483_V1.1130.90
413_K421_R1.1130.90
959_V966_E1.1120.90
828_D832_R1.1120.90
414_T418_D1.1110.90
826_V838_G1.1110.90
702_I706_E1.1100.90
528_S532_A1.1090.90
644_L659_F1.1090.90
327_R334_A1.1050.90
880_G884_A1.1030.90
174_A1074_G1.1030.90
391_I394_E1.1030.90
829_L833_V1.1020.90
486_V723_L1.1020.90
158_Y1105_I1.1010.90
756_E759_A1.0990.90
407_A412_E1.0980.90
33_N37_K1.0940.90
620_D625_L1.0930.90
719_I722_R1.0920.89
778_E782_V1.0910.89
354_D357_R1.0900.89
886_Q893_E1.0890.89
829_L836_L1.0890.89
514_Y518_E1.0890.89
493_K716_V1.0870.89
743_D750_D1.0870.89
710_E713_R1.0850.89
300_N303_I1.0830.89
429_E436_E1.0810.89
205_E1019_A1.0800.89
946_Q954_E1.0780.89
913_R920_A1.0770.89
933_D936_H1.0770.89
811_R816_T1.0760.89
817_A821_D1.0750.89
187_V1033_K1.0740.89
1097_K1109_Q1.0720.89
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1081_P1168_M0.5130.38
1137_L1153_R0.5130.38
1111_H1123_D0.5130.38
386_D390_D0.5130.38
405_L416_L0.5130.38
512_E523_Q0.5120.38
444_L448_E0.5120.38
50_L61_L0.5120.38
81_E120_R0.5120.38
1033_K1125_F0.5120.38
155_P1123_D0.5110.38
433_L436_E0.5110.38
723_L757_R0.5110.38
1014_T1056_S0.5110.38
62_T1055_L0.5110.38
35_S1033_K0.5110.38
922_D938_L0.5100.38
48_L1047_H0.5100.38
159_N1117_Y0.5100.38
731_Q738_R0.5090.38
1033_K1105_I0.5090.38
141_L1011_Q0.5090.38
155_P1145_A0.5090.38
1056_S1091_A0.5090.38
12_K182_D0.5090.38
858_Q861_V0.5080.38
413_K436_E0.5080.38
484_D488_D0.5070.38
561_A662_V0.5070.38
832_R836_L0.5070.38
401_E408_A0.5060.38
815_L830_E0.5060.38
818_E822_I0.5060.38
923_A927_Q0.5060.38
748_E752_E0.5060.38
757_R761_L0.5060.38
149_A159_N0.5060.38
670_E676_T0.5060.38
351_V486_V0.5050.37
156_E1123_D0.5050.37
516_R521_A0.5040.37
749_A760_D0.5040.37
735_E738_R0.5040.37
65_I82_A0.5030.37
729_R736_Q0.5030.37
185_A1040_A0.5030.37
1048_F1098_S0.5030.37
940_R943_A0.5020.37
954_E966_E0.5020.37
806_E1044_I0.5020.37
327_R331_T0.5010.37
1102_L1117_Y0.5010.37
456_A459_P0.5010.37
328_L339_V0.5000.37
447_A451_L0.5000.37
122_K1156_M0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ux3A 1 0.3622 100 0.707 Contact Map
3zgxA 2 0.2941 100 0.721 Contact Map
1w1wA 2 0.2697 100 0.757 Contact Map
4ad8A 1 0.3504 100 0.786 Contact Map
4i99A 2 0.2731 100 0.802 Contact Map
4rsiB 1 0.3168 100 0.81 Contact Map
3auyA 2 0.2992 100 0.814 Contact Map
4rsiA 1 0.2261 100 0.826 Contact Map
3ktaB 1 0.1336 100 0.836 Contact Map
4abyA 1 0.2832 100 0.852 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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