GREMLIN Database
GATB - Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
UniProt: Q9HS93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 495 (466)
Sequences: 3116 (1696)
Seq/√Len: 78.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
443_A491_E4.3711.00
444_E474_K3.7991.00
62_G65_E3.7291.00
112_E123_A3.6021.00
258_Q263_M3.5741.00
114_E123_A3.5661.00
419_R427_A3.4511.00
127_E168_R3.3841.00
12_A252_T3.2881.00
210_M256_R3.2731.00
117_T120_D3.2471.00
183_K318_D3.2291.00
75_D112_E3.0271.00
167_T180_F2.9111.00
486_E490_D2.8991.00
391_R422_D2.7681.00
125_G170_D2.7631.00
439_A491_E2.7581.00
315_E323_R2.6951.00
395_L425_V2.6791.00
439_A490_D2.6551.00
71_G108_C2.5961.00
32_C46_C2.5841.00
391_R420_A2.5691.00
30_C49_C2.5541.00
441_A475_T2.5131.00
351_L360_A2.4641.00
426_D431_G2.4281.00
30_C46_C2.3401.00
11_T211_V2.3211.00
420_A423_E2.3111.00
448_E474_K2.3101.00
32_C49_C2.2831.00
195_D201_S2.2651.00
175_E245_Q2.2351.00
471_V484_V2.2191.00
322_E326_T2.1961.00
215_E228_E2.1641.00
77_D110_D2.1571.00
212_D215_E2.1401.00
440_D444_E2.1281.00
174_A248_L2.1141.00
463_A467_L2.1041.00
20_V188_L2.0881.00
181_L244_A2.0721.00
258_Q265_V2.0641.00
10_L260_E2.0521.00
70_L163_M2.0461.00
444_E448_E2.0401.00
210_M259_L2.0331.00
215_E227_L2.0031.00
174_A249_A2.0011.00
46_C49_C1.9761.00
268_E281_S1.9751.00
63_A131_L1.9511.00
122_R176_E1.9221.00
272_W277_G1.9091.00
62_G66_A1.9031.00
320_R346_D1.8881.00
70_L193_V1.8801.00
423_E427_A1.8701.00
331_G361_A1.8591.00
171_F177_V1.8521.00
325_R332_D1.8511.00
18_V184_L1.8241.00
59_L64_V1.8061.00
452_A463_A1.7771.00
350_E387_D1.7571.00
96_K133_E1.7341.00
436_D439_A1.7341.00
85_H104_D1.7251.00
409_V424_I1.7081.00
452_A455_D1.6831.00
79_P109_Q1.6811.00
413_T428_E1.6731.00
23_E66_A1.6661.00
443_A447_A1.6641.00
115_V124_I1.6621.00
271_H282_M1.6571.00
401_I405_N1.6481.00
76_A110_D1.6471.00
39_A44_H1.6451.00
28_I63_A1.6351.00
9_D213_S1.6271.00
413_T417_E1.6261.00
77_D109_Q1.6201.00
80_E308_K1.6141.00
455_D463_A1.6101.00
125_G168_R1.6091.00
256_R260_E1.5991.00
254_R270_R1.5981.00
325_R335_A1.5901.00
468_V485_N1.5821.00
230_A259_L1.5821.00
437_A440_D1.5791.00
18_V181_L1.5741.00
20_V194_F1.5670.99
114_E121_R1.5670.99
356_D397_A1.5660.99
351_L393_V1.5610.99
94_L97_G1.5430.99
69_K312_P1.5270.99
243_A272_W1.5200.99
350_E353_D1.5140.99
76_A108_C1.5040.99
64_V302_L1.5030.99
172_R229_A1.5020.99
118_A175_E1.5000.99
451_D455_D1.4860.99
28_I59_L1.4850.99
450_P454_A1.4740.99
412_R416_D1.4740.99
61_E307_W1.4680.99
75_D123_A1.4630.99
439_A487_L1.4530.99
344_V369_L1.4510.99
391_R421_P1.4450.99
185_T189_E1.4440.99
342_K346_D1.4420.99
178_R245_Q1.4410.99
206_A244_A1.4390.99
138_L153_V1.4260.99
100_I296_E1.4200.99
110_D126_I1.4110.99
483_Q486_E1.4090.99
452_A467_L1.4060.99
178_R182_A1.4060.99
98_F296_E1.4050.99
442_V487_L1.3880.99
110_D168_R1.3870.99
454_A458_D1.3790.99
70_L74_I1.3790.99
445_A471_V1.3760.99
439_A443_A1.3680.99
368_V382_V1.3580.99
438_V475_T1.3500.98
22_L163_M1.3460.98
337_K365_A1.3440.98
400_E431_G1.3390.98
464_L489_R1.3380.98
65_E307_W1.3290.98
65_E310_E1.3260.98
250_Y279_T1.3110.98
442_V491_E1.3020.98
432_K480_D1.2930.98
422_D426_D1.2880.98
83_R104_D1.2850.98
21_Q197_E1.2850.98
252_T256_R1.2710.98
461_G489_R1.2480.97
485_N489_R1.2470.97
245_Q249_A1.2470.97
250_Y278_V1.2430.97
211_V215_E1.2400.97
377_L381_D1.2370.97
328_Y352_A1.2350.97
70_L188_L1.2340.97
45_T50_L1.2310.97
479_A484_V1.2170.97
419_R423_E1.2160.97
467_L488_L1.2150.97
23_E192_G1.2020.97
363_W406_A1.1930.97
392_L414_M1.1870.97
385_R388_E1.1860.97
243_A274_E1.1810.96
188_L196_A1.1810.96
81_R303_E1.1790.96
167_T171_F1.1760.96
395_L421_P1.1740.96
272_W276_R1.1720.96
354_E360_A1.1700.96
71_G78_I1.1670.96
113_L126_I1.1670.96
266_A281_S1.1670.96
324_F328_Y1.1600.96
129_A163_M1.1560.96
18_V167_T1.1490.96
212_D228_E1.1420.96
331_G365_A1.1370.96
441_A445_A1.1270.95
446_I453_V1.1260.95
445_A470_Q1.1250.95
359_L397_A1.1200.95
24_T63_A1.1190.95
68_V311_I1.1180.95
209_S230_A1.1110.95
110_D127_E1.1080.95
323_R349_E1.1070.95
464_L488_L1.1060.95
13_I172_R1.1040.95
394_E398_E1.0920.94
185_T202_L1.0920.94
446_I450_P1.0890.94
463_A466_F1.0890.94
70_L191_L1.0850.94
333_E337_K1.0850.94
88_N294_F1.0710.94
273_D280_V1.0690.94
243_A246_K1.0680.94
343_A380_D1.0660.94
378_S381_D1.0620.94
482_G486_E1.0620.94
399_D434_S1.0610.94
375_R416_D1.0600.94
25_D62_G1.0590.94
423_E426_D1.0590.94
108_C129_A1.0590.94
445_A467_L1.0560.93
320_R349_E1.0540.93
352_A355_Y1.0530.93
351_L386_D1.0510.93
231_N267_Q1.0490.93
34_T44_H1.0440.93
402_T432_K1.0430.93
211_V229_A1.0420.93
11_T172_R1.0420.93
438_V478_S1.0420.93
24_T161_P1.0400.93
333_E365_A1.0340.93
197_E201_S1.0240.92
440_D443_A1.0240.92
460_E463_A1.0210.92
315_E320_R1.0200.92
421_P425_V1.0180.92
436_D483_Q1.0170.92
320_R324_F1.0130.92
101_T296_E1.0120.92
67_A107_I1.0040.92
465_N485_N0.9970.91
68_V307_W0.9970.91
181_L204_V0.9960.91
172_R211_V0.9950.91
30_C47_P0.9840.91
196_A201_S0.9810.91
273_D276_R0.9810.91
183_K186_S0.9740.90
375_R415_L0.9740.90
142_G148_A0.9710.90
83_R105_A0.9680.90
414_M417_E0.9660.90
304_V307_W0.9640.90
395_L422_D0.9620.90
413_T418_D0.9510.89
18_V180_F0.9500.89
9_D212_D0.9500.89
324_F345_A0.9490.89
33_S44_H0.9480.89
185_T196_A0.9450.89
122_R172_R0.9440.89
315_E349_E0.9430.89
466_F470_Q0.9400.89
190_Y320_R0.9400.89
445_A474_K0.9400.89
215_E229_A0.9370.88
334_T358_A0.9360.88
470_Q473_A0.9350.88
210_M252_T0.9280.88
35_D39_A0.9270.88
9_D260_E0.9200.88
461_G464_L0.9200.88
97_G158_A0.9190.88
124_I171_F0.9170.87
321_R325_R0.9170.87
181_L241_H0.9140.87
48_V55_A0.9140.87
254_R268_E0.9120.87
434_S438_V0.9090.87
451_D454_A0.9060.87
11_T213_S0.9040.87
487_L490_D0.9040.87
48_V58_T0.8980.86
75_D319_A0.8960.86
72_K308_K0.8960.86
235_V238_I0.8950.86
402_T405_N0.8940.86
367_N407_E0.8880.86
246_K277_G0.8850.85
404_K408_E0.8850.85
366_D369_L0.8840.85
40_D43_T0.8840.85
455_D460_E0.8820.85
36_T199_D0.8810.85
52_L55_A0.8800.85
11_T214_A0.8790.85
425_V431_G0.8780.85
344_V364_V0.8770.85
271_H280_V0.8770.85
307_W311_I0.8760.85
115_V122_R0.8740.85
372_L382_V0.8740.85
456_Y461_G0.8730.85
355_Y394_E0.8730.85
414_M421_P0.8680.84
358_A362_T0.8670.84
388_E418_D0.8640.84
433_T475_T0.8630.84
424_I428_E0.8630.84
352_A357_A0.8630.84
235_V279_T0.8560.84
472_M477_G0.8560.84
454_A457_H0.8550.83
449_N470_Q0.8510.83
84_F131_L0.8490.83
324_F349_E0.8480.83
487_L491_E0.8470.83
364_V368_V0.8470.83
233_T270_R0.8460.83
190_Y342_K0.8450.83
419_R424_I0.8450.83
101_T104_D0.8440.83
242_R246_K0.8430.83
67_A163_M0.8430.83
213_S228_E0.8420.83
14_I171_F0.8420.83
208_I252_T0.8410.82
453_V492_L0.8400.82
189_E343_A0.8380.82
455_D467_L0.8370.82
442_V471_V0.8360.82
307_W310_E0.8340.82
70_L76_A0.8310.82
254_R258_Q0.8300.82
178_R241_H0.8280.81
367_N371_E0.8220.81
61_E65_E0.8190.81
347_L351_L0.8190.81
408_E428_E0.8190.81
138_L151_T0.8190.81
267_Q288_E0.8180.81
449_N466_F0.8170.81
370_G374_Y0.8140.80
412_R415_L0.8130.80
65_E68_V0.8130.80
465_N468_V0.8110.80
306_D310_E0.8100.80
391_R394_E0.8080.80
354_E393_V0.8060.80
142_G149_D0.8060.80
270_R279_T0.8040.80
453_V457_H0.8040.80
438_V487_L0.8030.79
445_A475_T0.8020.79
471_V488_L0.8010.79
422_D425_V0.8010.79
453_V456_Y0.7980.79
185_T241_H0.7970.79
395_L400_E0.7960.79
351_L390_E0.7920.78
371_E375_R0.7900.78
140_H151_T0.7880.78
189_E196_A0.7880.78
354_E397_A0.7860.78
360_A393_V0.7840.78
83_R101_T0.7820.78
450_P464_L0.7820.78
183_K321_R0.7810.78
405_N430_L0.7790.77
21_Q271_H0.7790.77
209_S232_R0.7780.77
363_W393_V0.7770.77
471_V475_T0.7700.77
355_Y360_A0.7700.77
16_L206_A0.7700.77
210_M260_E0.7700.77
13_I211_V0.7700.77
456_Y489_R0.7660.76
210_M258_Q0.7650.76
255_Q265_V0.7640.76
13_I229_A0.7600.76
32_C47_P0.7580.75
456_Y464_L0.7570.75
334_T365_A0.7570.75
403_A407_E0.7570.75
71_G129_A0.7550.75
284_S289_K0.7540.75
363_W396_V0.7540.75
371_E410_V0.7540.75
10_L212_D0.7540.75
175_E179_S0.7520.75
116_G321_R0.7510.75
270_R281_S0.7500.75
135_P138_L0.7470.74
233_T265_V0.7460.74
206_A248_L0.7440.74
439_A486_E0.7440.74
103_Y288_E0.7420.74
449_N452_A0.7370.73
12_A173_A0.7370.73
104_D128_R0.7350.73
438_V479_A0.7340.73
12_A210_M0.7320.73
456_Y492_L0.7300.73
266_A284_S0.7290.73
233_T258_Q0.7270.72
444_E447_A0.7230.72
59_L63_A0.7230.72
33_S39_A0.7220.72
355_Y390_E0.7220.72
409_V425_V0.7200.72
235_V247_A0.7150.71
188_L191_L0.7140.71
446_I464_L0.7140.71
351_L389_F0.7120.71
47_P52_L0.7110.71
125_G169_P0.7100.71
204_V244_A0.7100.71
68_V304_V0.7090.70
272_W278_V0.7060.70
213_S227_L0.7050.70
211_V228_E0.7050.70
367_N370_G0.7020.70
352_A360_A0.7020.70
76_A129_A0.7010.70
304_V308_K0.7000.69
14_I252_T0.6980.69
230_A265_V0.6970.69
452_A466_F0.6970.69
188_L192_G0.6960.69
361_A365_A0.6950.69
50_L155_Y0.6930.69
174_A245_Q0.6930.69
391_R423_E0.6910.68
344_V379_L0.6910.68
388_E420_A0.6900.68
74_I126_I0.6900.68
82_T302_L0.6890.68
81_R105_A0.6890.68
405_N428_E0.6890.68
347_L379_L0.6870.68
436_D486_E0.6830.68
320_R323_R0.6800.67
366_D370_G0.6760.67
371_E415_L0.6760.67
59_L299_I0.6750.67
453_V467_L0.6730.66
65_E69_K0.6720.66
163_M193_V0.6680.66
445_A466_F0.6670.66
258_Q270_R0.6660.66
305_S309_D0.6660.66
106_P130_H0.6650.65
34_T160_T0.6650.65
341_R344_V0.6640.65
20_V165_I0.6630.65
197_E271_H0.6620.65
233_T254_R0.6620.65
68_V78_I0.6610.65
401_I425_V0.6600.65
388_E421_P0.6590.65
68_V71_G0.6590.65
25_D35_D0.6590.65
238_I243_A0.6590.65
21_Q196_A0.6590.65
15_G19_H0.6580.65
72_K313_I0.6580.65
74_I129_A0.6560.64
388_E391_R0.6560.64
356_D359_L0.6540.64
163_M199_D0.6530.64
359_L396_V0.6530.64
335_A339_T0.6520.64
13_I175_E0.6520.64
471_V479_A0.6520.64
190_Y345_A0.6520.64
456_Y467_L0.6490.64
392_L409_V0.6480.63
371_E412_R0.6470.63
346_D350_E0.6460.63
324_F348_F0.6450.63
328_Y348_F0.6440.63
22_L161_P0.6440.63
183_K187_V0.6440.63
352_A356_D0.6430.63
354_E394_E0.6420.63
209_S231_N0.6410.63
103_Y128_R0.6410.63
400_E422_D0.6400.63
69_K311_I0.6380.62
68_V308_K0.6380.62
437_A441_A0.6370.62
434_S480_D0.6360.62
184_L188_L0.6340.62
306_D309_D0.6340.62
232_R265_V0.6330.62
413_T424_I0.6320.62
230_A255_Q0.6320.62
348_F352_A0.6310.61
333_E336_S0.6310.61
475_T479_A0.6290.61
441_A474_K0.6260.61
66_A69_K0.6260.61
178_R244_A0.6260.61
35_D44_H0.6260.61
115_V179_S0.6250.61
116_G119_D0.6240.61
401_I409_V0.6240.61
413_T416_D0.6240.61
209_S229_A0.6220.60
10_L259_L0.6210.60
175_E249_A0.6210.60
109_Q127_E0.6190.60
414_M419_R0.6190.60
82_T304_V0.6180.60
67_A131_L0.6160.60
117_T179_S0.6160.60
97_G272_W0.6160.60
186_S340_S0.6150.59
392_L431_G0.6140.59
345_A349_E0.6140.59
393_V396_V0.6120.59
174_A178_R0.6120.59
240_S243_A0.6110.59
31_G46_C0.6110.59
330_V361_A0.6110.59
232_R238_I0.6080.59
28_I133_E0.6080.59
21_Q160_T0.6080.59
302_L307_W0.6080.59
328_Y353_D0.6070.58
259_L265_V0.6070.58
69_K192_G0.6060.58
55_A158_A0.6060.58
246_K272_W0.6050.58
182_A202_L0.6050.58
233_T268_E0.6040.58
68_V163_M0.6040.58
73_A191_L0.6020.58
24_T163_M0.6020.58
28_I96_K0.6020.58
21_Q97_G0.6010.58
446_I491_E0.6000.58
393_V403_A0.5990.57
141_V148_A0.5980.57
443_A490_D0.5970.57
232_R267_Q0.5950.57
351_L364_V0.5950.57
455_D458_D0.5940.57
178_R181_L0.5940.57
414_M424_I0.5930.57
387_D391_R0.5920.57
233_T266_A0.5920.57
198_R202_L0.5920.57
230_A267_Q0.5910.56
190_Y339_T0.5910.56
372_L379_L0.5910.56
66_A193_V0.5910.56
49_C55_A0.5880.56
29_F84_F0.5880.56
125_G229_A0.5880.56
113_L187_V0.5870.56
79_P82_T0.5870.56
85_H103_Y0.5860.56
182_A185_T0.5860.56
436_D440_D0.5850.56
396_V405_N0.5850.56
409_V413_T0.5840.56
116_G121_R0.5830.55
292_R298_D0.5810.55
321_R336_S0.5800.55
441_A471_V0.5800.55
320_R345_A0.5800.55
23_E194_F0.5800.55
396_V406_A0.5790.55
365_A369_L0.5790.55
331_G334_T0.5790.55
209_S265_V0.5780.55
396_V403_A0.5770.55
391_R395_L0.5760.55
439_A442_V0.5740.54
325_R331_G0.5720.54
321_R332_D0.5720.54
286_E292_R0.5720.54
115_V120_D0.5720.54
66_A191_L0.5710.54
50_L161_P0.5700.54
347_L385_R0.5700.54
75_D114_E0.5700.54
437_A478_S0.5690.54
30_C55_A0.5680.54
139_Q142_G0.5680.54
50_L96_K0.5680.54
443_A446_I0.5670.53
117_T175_E0.5660.53
384_D414_M0.5650.53
349_E353_D0.5650.53
117_T121_R0.5640.53
80_E304_V0.5640.53
79_P105_A0.5630.53
10_L256_R0.5620.53
88_N293_Y0.5610.53
85_H273_D0.5610.53
12_A171_F0.5590.52
483_Q490_D0.5580.52
352_A390_E0.5580.52
88_N296_E0.5580.52
379_L382_V0.5580.52
359_L403_A0.5570.52
392_L410_V0.5560.52
103_Y293_Y0.5550.52
371_E374_Y0.5550.52
181_L202_L0.5550.52
332_D336_S0.5540.52
246_K274_E0.5530.52
30_C48_V0.5520.51
399_D482_G0.5520.51
51_G96_K0.5510.51
48_V96_K0.5510.51
348_F364_V0.5500.51
452_A460_E0.5490.51
441_A444_E0.5490.51
89_Y93_D0.5480.51
75_D110_D0.5460.51
101_T163_M0.5450.51
124_I167_T0.5450.51
116_G183_K0.5440.50
125_G167_T0.5440.50
320_R342_K0.5440.50
179_S183_K0.5440.50
333_E358_A0.5430.50
408_E412_R0.5430.50
415_L418_D0.5430.50
256_R259_L0.5420.50
188_L193_V0.5420.50
233_T255_Q0.5400.50
80_E303_E0.5400.50
189_E197_E0.5390.50
456_Y466_F0.5390.50
406_A410_V0.5380.50
77_D80_E0.5370.50
80_E309_D0.5360.49
267_Q287_E0.5360.49
85_H271_H0.5360.49
396_V401_I0.5350.49
96_K193_V0.5350.49
321_R339_T0.5350.49
96_K158_A0.5340.49
412_R417_E0.5340.49
325_R330_V0.5330.49
95_P155_Y0.5330.49
238_I270_R0.5330.49
130_H166_V0.5320.49
482_G489_R0.5310.49
286_E294_F0.5310.49
433_T478_S0.5300.49
324_F338_L0.5300.49
451_D463_A0.5300.49
204_V238_I0.5300.49
401_I406_A0.5290.49
85_H194_F0.5280.48
121_R322_E0.5280.48
233_T259_L0.5260.48
470_Q474_K0.5260.48
334_T337_K0.5260.48
182_A241_H0.5260.48
433_T438_V0.5240.48
126_I170_D0.5230.48
305_S310_E0.5220.48
348_F357_A0.5220.48
38_D199_D0.5210.48
110_D125_G0.5210.48
108_C131_L0.5200.47
456_Y463_A0.5190.47
384_D389_F0.5190.47
26_T96_K0.5180.47
50_L133_E0.5180.47
171_F180_F0.5170.47
206_A238_I0.5160.47
447_A474_K0.5150.47
79_P300_P0.5120.46
16_L181_L0.5120.46
246_K249_A0.5110.46
350_E386_D0.5100.46
390_E394_E0.5100.46
186_S321_R0.5090.46
12_A232_R0.5080.46
359_L393_V0.5080.46
258_Q261_R0.5080.46
20_V129_A0.5080.46
347_L382_V0.5080.46
232_R284_S0.5070.46
284_S287_E0.5060.46
126_I167_T0.5060.46
306_D322_E0.5060.46
250_Y272_W0.5050.45
165_I180_F0.5050.45
155_Y158_A0.5050.45
399_D480_D0.5040.45
404_K425_V0.5030.45
188_L194_F0.5030.45
341_R378_S0.5030.45
467_L470_Q0.5030.45
467_L492_L0.5020.45
70_L129_A0.5020.45
66_A70_L0.5010.45
347_L368_V0.5010.45
214_A228_E0.5000.45
25_D61_E0.5000.45
35_D38_D0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3al0B 1 0.9596 100 0.04 Contact Map
3ip4B 1 0.9475 100 0.041 Contact Map
3h0lB 1 0.8162 100 0.041 Contact Map
3kfuF 2 0.7778 100 0.116 Contact Map
4wj3B 2 0.7939 100 0.117 Contact Map
2d6fC 1 0.6545 100 0.173 Contact Map
1zq1C 1 0.6667 100 0.175 Contact Map
4n0hB 1 0.5434 100 0.314 Contact Map
2hz7A 1 0.204 100 0.771 Contact Map
1ng6A 1 0.2848 99.4 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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