GREMLIN Database
Q9HS90 - DNA topoisomerase
UniProt: Q9HS90 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 663 (516)
Sequences: 1938 (1194)
Seq/√Len: 52.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_E89_D6.0301.00
84_N87_D4.7401.00
105_S289_E4.5851.00
478_A481_E4.5401.00
479_V482_D4.5011.00
249_V287_V4.1411.00
137_R222_D3.8651.00
170_L174_F3.5921.00
151_I230_V3.4881.00
112_T243_E3.3641.00
479_V484_D3.1171.00
385_I395_V3.0831.00
49_D302_A3.0441.00
518_G521_P3.0421.00
133_Y141_I3.0241.00
49_D304_Q3.0021.00
319_T323_M2.8861.00
170_L173_A2.8811.00
108_R245_A2.8541.00
16_Q21_F2.8211.00
384_A389_E2.7811.00
104_D252_D2.7781.00
434_C437_C2.7731.00
262_G285_P2.7301.00
481_E484_D2.6161.00
128_A226_V2.5281.00
478_A482_D2.5221.00
531_L535_Q2.5121.00
247_L264_R2.4971.00
93_D96_R2.4631.00
441_L463_F2.4011.00
221_E225_A2.3501.00
512_S521_P2.3331.00
114_D241_P2.2901.00
89_D93_D2.2621.00
437_C455_C2.2591.00
480_C483_H2.2391.00
163_D198_D2.2291.00
252_D255_G2.2181.00
228_E232_R2.2041.00
57_L101_A2.1831.00
527_H534_K2.1691.00
391_T394_D2.1691.00
521_P524_G2.1581.00
54_F65_E2.1261.00
110_T243_E2.1161.00
288_E291_D2.1091.00
527_H530_E2.0611.00
430_S440_T2.0591.00
528_G531_L2.0491.00
480_C484_D2.0051.00
468_P471_G1.9951.00
32_L338_L1.9661.00
243_E267_E1.9661.00
35_I344_I1.9651.00
170_L175_Q1.9601.00
92_F96_R1.9561.00
102_V292_T1.9441.00
101_A253_A1.9441.00
39_E310_R1.9421.00
519_P523_C1.9240.99
53_L91_A1.9140.99
95_L298_A1.9120.99
140_S144_D1.9090.99
212_D234_F1.8890.99
528_G532_A1.8820.99
278_D283_H1.8770.99
319_T322_S1.8710.99
486_H502_P1.8700.99
142_A151_I1.8460.99
524_G527_H1.8310.99
509_A513_E1.8310.99
136_G336_E1.8220.99
100_E292_T1.8180.99
504_C508_A1.8040.99
48_D83_W1.7850.99
226_V230_V1.7830.99
439_D457_G1.7720.99
176_Q181_D1.7670.99
481_E501_C1.7630.99
479_V483_H1.7560.99
455_C461_C1.7420.99
244_W265_L1.7310.99
381_D398_E1.7250.99
105_S250_T1.7200.99
104_D257_S1.7130.99
505_A508_A1.7120.99
381_D390_T1.7110.99
473_P477_D1.7090.99
64_F293_L1.6900.99
101_A251_A1.6760.99
144_D148_A1.6660.99
509_A512_S1.6590.98
523_C526_P1.6400.98
436_E463_F1.6300.98
133_Y225_A1.6250.98
150_Y219_L1.6200.98
250_T257_S1.6190.98
50_Y303_K1.6040.98
478_A483_H1.5780.98
434_C455_C1.5700.98
524_G528_G1.5610.98
175_Q186_L1.5530.98
133_Y222_D1.5520.98
137_R140_S1.5410.98
453_V456_D1.5400.98
59_K291_D1.5390.97
336_E340_D1.5260.97
467_L471_G1.5240.97
82_V91_A1.4950.97
56_D299_R1.4920.97
434_C461_C1.4860.97
245_A266_V1.4830.97
526_P531_L1.4770.97
159_T195_T1.4750.97
258_L298_A1.4690.97
437_C461_C1.4600.97
478_A484_D1.4600.97
216_R224_W1.4590.97
94_A254_D1.4530.96
377_Q381_D1.4530.96
531_L534_K1.4500.96
75_D81_R1.4490.96
58_R296_T1.4490.96
91_A95_L1.4480.96
418_G425_L1.4410.96
454_G458_Y1.4360.96
94_A256_E1.4240.96
47_P304_Q1.4220.96
144_D223_E1.4210.96
251_A293_L1.4190.96
182_D243_E1.4120.96
111_R246_H1.4060.96
56_D297_D1.4020.96
378_L395_V1.3960.96
43_E356_E1.3950.95
77_T81_R1.3940.95
520_C523_C1.3880.95
64_F287_V1.3840.95
345_E352_T1.3810.95
522_D525_E1.3790.95
528_G534_K1.3770.95
111_R244_W1.3680.95
119_F127_A1.3650.95
526_P529_G1.3610.95
185_S272_A1.3590.95
222_D225_A1.3560.95
124_F138_A1.3490.95
532_A535_Q1.3480.95
491_L505_A1.3470.95
171_L235_F1.3380.94
527_H535_Q1.3340.94
455_C458_Y1.3330.94
240_A267_E1.3280.94
57_L258_L1.3240.94
523_C529_G1.3140.94
37_D372_E1.3020.93
527_H531_L1.2890.93
526_P530_E1.2880.93
134_S137_R1.2860.93
59_K293_L1.2860.93
522_D526_P1.2830.93
493_G496_T1.2770.93
312_G350_R1.2750.93
240_A243_E1.2700.93
397_T401_E1.2690.93
220_S223_E1.2620.92
56_D63_T1.2480.92
185_S267_E1.2470.92
418_G424_S1.2440.92
467_L476_M1.2360.92
98_A254_D1.2230.91
528_G535_Q1.2170.91
85_E302_A1.2150.91
36_V351_P1.2090.91
279_S283_H1.2090.91
462_Q465_L1.2090.91
133_Y137_R1.2050.91
384_A390_T1.2010.90
57_L251_A1.1880.90
471_G476_M1.1860.90
480_C487_D1.1830.90
527_H532_A1.1830.90
504_C507_E1.1830.90
411_T415_A1.1820.90
262_G284_V1.1760.89
432_G441_L1.1750.89
474_L477_D1.1680.89
142_A226_V1.1580.89
246_H263_K1.1520.88
59_K62_T1.1510.88
108_R247_L1.1490.88
53_L97_Q1.1450.88
179_F228_E1.1310.87
95_L253_A1.1300.87
102_V252_D1.1270.87
523_C527_H1.1250.87
484_D501_C1.1240.87
40_R44_A1.1210.87
317_I332_H1.1210.87
123_Q126_R1.1210.87
433_P440_T1.1190.87
88_A300_L1.1160.87
320_M334_T1.1140.87
242_A271_H1.1080.86
90_A94_A1.1080.86
89_D92_F1.1040.86
488_V519_P1.0970.86
501_C504_C1.0960.86
83_W87_D1.0950.86
125_I332_H1.0950.86
513_E516_L1.0900.85
441_L453_V1.0780.85
459_P464_T1.0770.85
278_D320_M1.0760.85
461_C471_G1.0750.85
130_S276_Y1.0710.84
110_T266_V1.0670.84
278_D282_N1.0670.84
515_R518_G1.0670.84
179_F277_Y1.0660.84
192_L195_T1.0640.84
63_T296_T1.0610.84
461_C476_M1.0600.84
407_F411_T1.0580.84
164_D223_E1.0580.84
434_C439_D1.0550.84
23_S28_Q1.0540.83
173_A177_T1.0530.83
108_R264_R1.0520.83
56_D65_E1.0520.83
523_C530_E1.0520.83
6_L369_V1.0500.83
480_C490_M1.0490.83
507_E513_E1.0480.83
525_E528_G1.0420.83
471_G474_L1.0410.83
40_R360_E1.0390.83
248_R261_N1.0390.83
495_N498_V1.0390.83
462_Q467_L1.0370.82
466_P471_G1.0340.82
512_S515_R1.0260.82
411_T414_R1.0240.82
510_D513_E1.0190.81
406_V410_L1.0150.81
86_G90_A1.0060.81
473_P476_M1.0010.80
454_G457_G1.0000.80
439_D456_D0.9990.80
133_Y138_A0.9980.80
242_A265_L0.9960.80
441_L455_C0.9950.80
501_C530_E0.9940.80
256_E320_M0.9910.80
252_D257_S0.9900.79
4_A24_V0.9860.79
170_L211_T0.9830.79
173_A176_Q0.9820.79
150_Y230_V0.9810.79
288_E397_T0.9780.79
6_L24_V0.9760.78
136_G140_S0.9750.78
486_H501_C0.9730.78
133_Y226_V0.9720.78
250_T259_K0.9700.78
106_V249_V0.9700.78
236_A274_Y0.9670.78
482_D487_D0.9660.78
53_L300_L0.9590.77
399_S403_L0.9580.77
467_L470_T0.9550.77
410_L413_S0.9540.77
243_E349_P0.9520.77
505_A510_D0.9510.77
110_T245_A0.9500.77
530_E534_K0.9470.76
500_G503_L0.9420.76
526_P534_K0.9400.76
280_S283_H0.9390.76
484_D523_C0.9390.76
519_P522_D0.9360.75
10_L24_V0.9350.75
471_G477_D0.9310.75
502_P506_A0.9310.75
524_G532_A0.9300.75
159_T197_G0.9260.75
467_L477_D0.9220.74
295_I298_A0.9220.74
529_G532_A0.9210.74
529_G533_I0.9210.74
55_A101_A0.9200.74
462_Q466_P0.9190.74
103_V251_A0.9190.74
56_D296_T0.9160.74
394_D397_T0.9150.74
127_A229_L0.9140.74
343_Y351_P0.9130.74
467_L473_P0.9130.74
110_T247_L0.9080.73
408_D411_T0.9030.73
214_P219_L0.8990.72
92_F300_L0.8990.72
347_D350_R0.8990.72
521_P526_P0.8980.72
120_N195_T0.8950.72
66_A260_A0.8930.72
493_G498_V0.8910.72
103_V258_L0.8900.72
500_G505_A0.8890.72
499_H504_C0.8840.71
53_L95_L0.8830.71
26_R375_T0.8820.71
127_A276_Y0.8820.71
478_A499_H0.8810.71
142_A230_V0.8800.71
452_F455_C0.8790.71
489_K500_G0.8740.70
178_V215_D0.8730.70
268_A272_A0.8720.70
231_V235_F0.8710.70
458_Y461_C0.8680.70
16_Q22_I0.8660.70
150_Y218_Q0.8660.70
505_A513_E0.8650.70
135_A332_H0.8640.69
128_A229_L0.8590.69
58_R63_T0.8590.69
499_H505_A0.8570.69
508_A517_I0.8560.69
69_F259_K0.8550.69
174_F212_D0.8510.68
166_D192_L0.8500.68
47_P220_S0.8500.68
128_A138_A0.8500.68
62_T291_D0.8490.68
319_T324_D0.8470.68
286_P291_D0.8450.68
461_C477_D0.8450.68
246_H261_N0.8450.68
526_P532_A0.8440.68
465_L474_L0.8400.67
530_E533_I0.8360.67
525_E529_G0.8350.67
171_L175_Q0.8300.66
499_H503_L0.8290.66
511_E515_R0.8260.66
121_T139_M0.8230.66
189_Q194_P0.8230.66
337_K341_R0.8170.65
453_V457_G0.8140.65
144_D220_S0.8110.65
521_P525_E0.8090.64
480_C501_C0.8080.64
162_P165_L0.8070.64
89_D300_L0.8060.64
279_S282_N0.8040.64
110_T264_R0.8040.64
113_D270_Y0.8010.64
461_C464_T0.7990.63
130_S277_Y0.7990.63
287_V291_D0.7990.63
339_Y346_N0.7980.63
523_C528_G0.7960.63
464_T473_P0.7950.63
513_E521_P0.7950.63
38_K41_E0.7940.63
529_G535_Q0.7910.63
260_A274_Y0.7900.62
31_T320_M0.7900.62
430_S442_L0.7880.62
96_R297_D0.7870.62
479_V487_D0.7870.62
5_S404_D0.7870.62
121_T149_G0.7860.62
264_R286_P0.7840.62
518_G522_D0.7840.62
92_F298_A0.7840.62
139_M151_I0.7820.62
462_Q469_S0.7820.62
530_E535_Q0.7800.61
106_V287_V0.7800.61
462_Q474_L0.7770.61
508_A513_E0.7750.61
489_K503_L0.7750.61
57_L95_L0.7740.61
461_C465_L0.7700.60
201_T208_H0.7690.60
103_V293_L0.7690.60
478_A488_V0.7670.60
503_L506_A0.7660.60
101_A293_L0.7630.60
462_Q476_M0.7560.59
492_A505_A0.7560.59
163_D192_L0.7550.59
464_T467_L0.7550.59
249_V291_D0.7550.59
491_L500_G0.7540.59
58_R61_Q0.7530.59
191_R195_T0.7520.59
509_A521_P0.7510.59
408_D412_A0.7500.58
517_I525_E0.7490.58
91_A298_A0.7490.58
36_V356_E0.7470.58
521_P531_L0.7460.58
424_S428_D0.7460.58
248_R287_V0.7440.58
205_P208_H0.7440.58
483_H501_C0.7430.58
433_P438_G0.7430.58
101_A295_I0.7420.58
32_L355_A0.7420.58
506_A529_G0.7400.57
93_D254_D0.7370.57
406_V409_E0.7360.57
433_P437_C0.7350.57
466_P476_M0.7340.57
24_V498_V0.7330.57
509_A517_I0.7320.57
23_S341_R0.7300.56
503_L510_D0.7290.56
462_Q472_D0.7280.56
442_L458_Y0.7280.56
522_D529_G0.7280.56
36_V343_Y0.7240.56
24_V310_R0.7230.56
528_G533_I0.7220.56
502_P505_A0.7210.55
107_S289_E0.7200.55
57_L66_A0.7190.55
55_A258_L0.7190.55
522_D530_E0.7120.55
76_G81_R0.7120.55
407_F414_R0.7120.55
109_R314_S0.7110.54
318_E322_S0.7100.54
143_E147_T0.7100.54
282_N299_R0.7090.54
116_P275_P0.7090.54
512_S518_G0.7090.54
289_E416_E0.7040.54
144_D222_D0.7040.54
507_E510_D0.7040.54
199_E386_A0.7040.54
464_T471_G0.7030.54
491_L501_C0.7020.53
491_L499_H0.7020.53
470_T474_L0.7000.53
104_D250_T0.6980.53
171_L212_D0.6980.53
369_V382_M0.6970.53
469_S476_M0.6940.53
120_N197_G0.6930.53
505_A511_E0.6930.53
469_S477_D0.6920.52
35_I254_D0.6920.52
417_I425_L0.6920.52
55_A251_A0.6910.52
165_L200_E0.6890.52
311_Y319_T0.6860.52
116_P276_Y0.6850.52
434_C458_Y0.6850.52
463_F466_P0.6820.51
262_G274_Y0.6820.51
170_L176_Q0.6810.51
144_D218_Q0.6800.51
165_L376_S0.6780.51
61_Q216_R0.6760.51
247_L263_K0.6750.51
120_N334_T0.6740.51
443_L453_V0.6740.51
86_G288_E0.6730.50
381_D384_A0.6720.50
524_G529_G0.6700.50
117_A192_L0.6690.50
247_L346_N0.6680.50
360_E364_D0.6660.50
513_E517_I0.6650.50
98_A253_A0.6650.50
8_R11_S0.6640.50
142_A343_Y0.6640.50
443_L473_P0.6640.50
510_D514_D0.6630.49
504_C529_G0.6630.49
68_Y256_E0.6630.49
463_F476_M0.6630.49
471_G475_V0.6620.49
54_F301_D0.6620.49
494_R497_F0.6620.49
34_L319_T0.6610.49
488_V526_P0.6590.49
8_R327_T0.6590.49
29_S203_D0.6580.49
57_L295_I0.6570.49
127_A277_Y0.6550.49
171_L174_F0.6540.48
154_P327_T0.6510.48
410_L414_R0.6510.48
452_F458_Y0.6510.48
51_W219_L0.6510.48
468_P476_M0.6490.48
94_A298_A0.6490.48
9_F366_A0.6470.48
487_D509_A0.6470.48
161_Y206_P0.6450.48
463_F468_P0.6450.48
461_C467_L0.6450.48
122_T203_D0.6440.47
55_A98_A0.6440.47
35_I345_E0.6430.47
465_L477_D0.6430.47
439_D458_Y0.6420.47
437_C458_Y0.6410.47
215_D218_Q0.6400.47
469_S474_L0.6400.47
35_I384_A0.6390.47
468_P475_V0.6390.47
143_E206_P0.6390.47
504_C510_D0.6380.47
523_C534_K0.6380.47
522_D527_H0.6370.47
161_Y234_F0.6350.46
409_E413_S0.6320.46
283_H286_P0.6300.46
129_G406_V0.6280.46
309_R350_R0.6280.46
503_L508_A0.6280.46
54_F67_Q0.6270.46
129_G314_S0.6260.46
27_V375_T0.6250.45
484_D530_E0.6250.45
55_A253_A0.6240.45
141_I226_V0.6240.45
274_Y285_P0.6230.45
265_L396_T0.6230.45
410_L474_L0.6230.45
327_T331_R0.6220.45
55_A298_A0.6220.45
314_S318_E0.6220.45
263_K281_E0.6210.45
31_T338_L0.6200.45
224_W228_E0.6200.45
260_A285_P0.6200.45
517_I526_P0.6200.45
406_V411_T0.6200.45
430_S433_P0.6200.45
141_I215_D0.6200.45
287_V293_L0.6190.45
52_E301_D0.6180.45
36_V285_P0.6170.45
205_P327_T0.6150.44
499_H502_P0.6150.44
425_L434_C0.6140.44
346_N350_R0.6140.44
390_T398_E0.6130.44
503_L507_E0.6130.44
467_L490_M0.6130.44
410_L415_A0.6130.44
461_C473_P0.6130.44
486_H503_L0.6130.44
188_D294_A0.6120.44
499_H526_P0.6120.44
127_A274_Y0.6120.44
24_V328_K0.6110.44
103_V159_T0.6110.44
92_F301_D0.6110.44
59_K283_H0.6100.44
5_S338_L0.6100.44
325_I341_R0.6090.44
97_Q254_D0.6070.44
132_G349_P0.6050.43
65_E176_Q0.6040.43
124_F332_H0.6040.43
108_R289_E0.6040.43
520_C524_G0.6030.43
120_N159_T0.6030.43
139_M149_G0.6020.43
394_D398_E0.6010.43
139_M329_S0.6010.43
505_A509_A0.6000.43
121_T237_T0.5990.43
511_E518_G0.5970.43
472_D475_V0.5960.42
413_S416_E0.5960.42
490_M497_F0.5960.42
150_Y214_P0.5940.42
33_K399_S0.5940.42
335_I439_D0.5920.42
52_E303_K0.5910.42
323_M372_E0.5910.42
200_E208_H0.5910.42
509_A514_D0.5910.42
514_D517_I0.5890.42
529_G534_K0.5890.42
377_Q380_A0.5890.42
60_D288_E0.5880.42
27_V157_D0.5870.41
310_R383_T0.5860.41
60_D291_D0.5860.41
464_T477_D0.5840.41
29_S201_T0.5830.41
247_L262_G0.5830.41
524_G531_L0.5810.41
189_Q192_L0.5810.41
58_R100_E0.5800.41
171_L337_K0.5800.41
26_R331_R0.5800.41
15_G21_F0.5770.40
466_P470_T0.5770.40
201_T327_T0.5770.40
201_T374_M0.5760.40
220_S318_E0.5750.40
65_E280_S0.5740.40
24_V351_P0.5740.40
405_R408_D0.5730.40
357_A361_A0.5720.40
172_E175_Q0.5720.40
45_F308_P0.5720.40
161_Y223_E0.5700.40
525_E530_E0.5700.40
35_I335_I0.5700.40
462_Q477_D0.5690.40
201_T205_P0.5690.40
82_V88_A0.5690.40
61_Q104_D0.5680.40
461_C466_P0.5680.40
500_G506_A0.5670.39
483_H504_C0.5670.39
384_A387_D0.5650.39
62_T163_D0.5640.39
102_V255_G0.5640.39
452_F456_D0.5640.39
465_L471_G0.5640.39
483_H523_C0.5640.39
232_R274_Y0.5630.39
140_S336_E0.5630.39
84_N408_D0.5630.39
174_F178_V0.5630.39
236_A262_G0.5620.39
34_L323_M0.5610.39
85_E289_E0.5610.39
27_V233_R0.5600.39
100_E294_A0.5590.39
389_E394_D0.5590.39
5_S407_F0.5580.39
523_C532_A0.5580.39
311_Y322_S0.5580.39
202_T331_R0.5560.38
86_G97_Q0.5550.38
85_E300_L0.5550.38
502_P507_E0.5550.38
272_A389_E0.5540.38
338_L344_I0.5530.38
30_P359_V0.5530.38
500_G525_E0.5530.38
524_G533_I0.5520.38
512_S524_G0.5520.38
137_R220_S0.5500.38
260_A284_V0.5490.38
381_D413_S0.5490.38
465_L476_M0.5470.37
490_M499_H0.5470.37
93_D218_Q0.5470.37
53_L92_F0.5470.37
468_P477_D0.5460.37
33_K325_I0.5460.37
105_S243_E0.5460.37
404_D408_D0.5450.37
12_L411_T0.5450.37
437_C441_L0.5450.37
123_Q318_E0.5450.37
503_L509_A0.5440.37
87_D90_A0.5440.37
51_W172_E0.5440.37
101_A254_D0.5440.37
176_Q294_A0.5420.37
11_S327_T0.5420.37
482_D523_C0.5420.37
255_G292_T0.5410.37
506_A510_D0.5410.37
106_V247_L0.5400.37
53_L287_V0.5400.37
53_L58_R0.5390.37
78_E81_R0.5380.37
249_V272_A0.5370.37
407_F413_S0.5370.37
103_V189_Q0.5370.37
9_F395_V0.5360.36
181_D438_G0.5360.36
463_F477_D0.5360.36
490_M495_N0.5350.36
177_T181_D0.5320.36
78_E132_G0.5320.36
240_A265_L0.5310.36
132_G225_A0.5310.36
463_F467_L0.5300.36
60_D63_T0.5300.36
103_V106_V0.5300.36
87_D91_A0.5300.36
27_V39_E0.5290.36
200_E331_R0.5280.36
281_E299_R0.5270.36
391_T397_T0.5270.36
339_Y387_D0.5270.36
42_I210_T0.5270.36
487_D499_H0.5260.35
5_S244_W0.5240.35
518_G523_C0.5240.35
76_G80_E0.5240.35
88_A310_R0.5240.35
294_A397_T0.5230.35
181_D299_R0.5220.35
431_L511_E0.5220.35
363_E370_V0.5220.35
251_A295_I0.5220.35
77_T80_E0.5210.35
357_A488_V0.5210.35
63_T97_Q0.5210.35
463_F470_T0.5200.35
361_A369_V0.5200.35
436_E462_Q0.5200.35
377_Q394_D0.5190.35
58_R294_A0.5190.35
37_D41_E0.5190.35
480_C504_C0.5190.35
342_G402_M0.5180.35
5_S111_R0.5180.35
105_S291_D0.5160.34
306_Q367_D0.5160.34
517_I522_D0.5150.34
115_P314_S0.5150.34
433_P436_E0.5140.34
428_D464_T0.5140.34
64_F251_A0.5130.34
488_V499_H0.5130.34
441_L459_P0.5130.34
480_C486_H0.5130.34
465_L468_P0.5120.34
521_P527_H0.5120.34
377_Q390_T0.5120.34
34_L152_T0.5120.34
453_V458_Y0.5110.34
417_I424_S0.5110.34
40_R43_E0.5110.34
28_Q156_T0.5110.34
208_H331_R0.5110.34
39_E233_R0.5110.34
64_F249_V0.5100.34
469_S473_P0.5100.34
510_D518_G0.5100.34
508_A514_D0.5090.34
12_L275_P0.5090.34
132_G268_A0.5090.34
116_P132_G0.5090.34
2_W392_L0.5090.34
109_R246_H0.5080.34
511_E514_D0.5080.34
7_T122_T0.5070.34
166_D194_P0.5060.34
301_D320_M0.5060.34
129_G133_Y0.5050.33
208_H327_T0.5050.33
66_A394_D0.5030.33
513_E525_E0.5020.33
60_D287_V0.5020.33
317_I335_I0.5020.33
157_D375_T0.5020.33
518_G531_L0.5010.33
317_I331_R0.5010.33
125_I143_E0.5010.33
524_G534_K0.5000.33
525_E531_L0.5000.33
16_Q355_A0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cgyA 1 0.6229 100 0.3 Contact Map
2gaiA 1 0.6395 100 0.35 Contact Map
1i7dA 1 0.6244 100 0.376 Contact Map
1mw9X 1 0.6033 100 0.394 Contact Map
4dduA 1 0.537 100 0.454 Contact Map
1gkuB 1 0.5219 100 0.462 Contact Map
1wcnA 1 0.092 96.1 0.966 Contact Map
1u9lA 1 0.0905 94.3 0.97 Contact Map
1b22A 1 0.0965 93.6 0.97 Contact Map
2z43A 1 0.083 91.9 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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