GREMLIN Database
Q9HS89 - Uncharacterized protein
UniProt: Q9HS89 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (389)
Sequences: 207 (176)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_T350_I5.7921.00
273_H346_H4.7671.00
65_V228_V4.7350.99
346_H350_I3.8050.97
30_A35_Y3.5220.96
209_M252_T3.4740.95
251_D255_Q3.4730.95
30_A36_E3.3570.95
342_G380_R3.1980.93
279_G365_D3.1700.93
347_L354_A3.1520.92
282_Y374_Q3.1290.92
191_P221_Q3.1140.92
260_T348_S3.0660.91
197_T203_W2.9890.90
31_A35_Y2.9890.90
31_A36_E2.9010.89
328_Y337_Y2.8490.88
390_A396_A2.7500.86
209_M226_L2.7430.86
194_V225_V2.6880.84
83_V87_A2.5540.81
188_P191_P2.5340.81
370_V374_Q2.5320.81
116_L418_V2.5070.80
289_G355_K2.4680.79
265_P351_G2.4540.78
60_A89_P2.4490.78
202_D237_R2.4280.78
325_R329_V2.3970.77
81_S85_G2.3840.76
273_H350_I2.2880.73
366_Y382_A2.2600.72
81_S87_A2.2360.71
291_W342_G2.1950.70
82_P175_P2.1430.68
270_V393_F2.0980.66
366_Y374_Q2.0420.64
285_V400_I1.8870.58
332_T335_A1.8760.57
217_L221_Q1.8670.57
262_R322_Y1.7780.53
138_R318_A1.7630.52
253_V257_L1.7200.50
254_G344_L1.6980.49
271_T387_P1.6660.48
250_D377_E1.6530.47
299_K362_V1.6360.47
301_P305_W1.6150.46
193_Y215_R1.6100.46
306_N325_R1.6080.46
85_G397_V1.6040.45
60_A82_P1.5920.45
295_L332_T1.5780.44
83_V86_D1.5600.43
32_E40_F1.5550.43
284_V366_Y1.5520.43
66_F337_Y1.5260.42
66_F328_Y1.5250.42
70_S238_R1.5140.42
335_A374_Q1.5120.41
301_P306_N1.4950.41
154_S180_E1.4920.41
145_R362_V1.4840.40
298_M375_V1.4830.40
127_H130_W1.4490.39
90_A261_I1.4440.39
209_M397_V1.4410.38
238_R267_V1.4320.38
329_V337_Y1.4260.38
295_L335_A1.4130.37
80_L251_D1.4000.37
335_A375_V1.3970.37
59_G175_P1.3940.37
153_L177_A1.3920.37
187_N254_G1.3910.36
127_H134_V1.3850.36
66_F372_V1.3830.36
265_P285_V1.3830.36
226_L252_T1.3830.36
366_Y422_Q1.3750.36
358_V366_Y1.3700.36
276_E281_R1.3670.36
278_M358_V1.3660.35
219_V301_P1.3620.35
273_H319_S1.3600.35
115_L175_P1.3600.35
81_S86_D1.3560.35
150_E187_N1.3550.35
250_D376_R1.3490.35
78_G139_E1.3460.35
423_S427_E1.3410.34
96_G226_L1.3400.34
95_S298_M1.3310.34
79_I117_N1.3240.34
226_L340_R1.3190.34
264_A357_L1.3170.34
337_Y372_V1.3150.33
148_D238_R1.3120.33
339_A400_I1.3050.33
422_Q428_F1.3030.33
225_V251_D1.2880.32
66_F79_I1.2860.32
147_V188_P1.2830.32
293_H318_A1.2750.32
295_L366_Y1.2660.32
77_A370_V1.2650.32
96_G220_Y1.2630.31
333_A365_D1.2540.31
329_V333_A1.2540.31
139_E251_D1.2530.31
284_V382_A1.2510.31
195_E198_L1.2500.31
345_E380_R1.2490.31
333_A375_V1.2460.31
422_Q425_L1.2430.31
32_E332_T1.2400.31
243_R360_R1.2270.30
237_R285_V1.2250.30
226_L231_L1.2200.30
333_A378_S1.2130.30
264_A348_S1.2070.29
230_A307_P1.2060.29
66_F69_R1.2010.29
279_G363_S1.2000.29
66_F78_G1.1990.29
328_Y336_Y1.1920.29
137_Q303_S1.1870.29
298_M335_A1.1850.29
249_V362_V1.1830.29
243_R352_R1.1760.28
261_I296_V1.1750.28
358_V382_A1.1740.28
269_E389_E1.1690.28
75_V124_V1.1520.27
153_L370_V1.1470.27
90_A120_R1.1470.27
243_R305_W1.1400.27
262_R325_R1.1390.27
94_T357_L1.1370.27
294_E415_S1.1370.27
265_P386_Q1.1360.27
187_N190_V1.1350.27
392_T403_H1.1310.27
281_R332_T1.1290.27
93_A223_N1.1260.27
258_R262_R1.1240.27
157_P177_A1.1220.26
306_N335_A1.1200.26
167_P346_H1.1180.26
75_V264_A1.1170.26
188_P353_Q1.1160.26
78_G251_D1.1150.26
302_G358_V1.1070.26
328_Y372_V1.1040.26
304_I366_Y1.1010.26
203_W211_Y1.1000.26
328_Y340_R1.0980.26
208_A393_F1.0970.26
180_E256_Y1.0970.26
171_A318_A1.0940.26
66_F318_A1.0930.26
32_E329_V1.0910.25
253_V348_S1.0870.25
254_G332_T1.0850.25
67_V71_A1.0830.25
292_E355_K1.0740.25
273_H282_Y1.0710.25
118_S151_I1.0710.25
170_N176_N1.0700.25
159_F362_V1.0630.25
79_I140_V1.0580.24
32_E35_Y1.0570.24
82_P324_G1.0530.24
168_A365_D1.0470.24
79_I89_P1.0470.24
264_A351_G1.0470.24
335_A378_S1.0440.24
408_L421_V1.0430.24
372_V375_V1.0420.24
58_V61_T1.0410.24
332_T411_L1.0400.24
151_I166_S1.0370.24
352_R392_T1.0320.24
102_G427_E1.0320.24
195_E268_D1.0240.23
67_V396_A1.0240.23
30_A299_K1.0210.23
143_A188_P1.0210.23
294_E376_R1.0210.23
71_A125_N1.0200.23
291_W335_A1.0180.23
261_I407_S1.0150.23
259_G386_Q1.0130.23
318_A372_V1.0120.23
86_D89_P1.0110.23
113_T268_D1.0030.23
417_M420_G1.0000.23
254_G295_L0.9970.22
335_A365_D0.9960.22
105_I295_L0.9950.22
268_D389_E0.9920.22
391_E398_A0.9920.22
56_T70_S0.9920.22
209_M261_I0.9900.22
237_R250_D0.9830.22
343_V356_A0.9800.22
175_P239_L0.9780.22
86_D397_V0.9750.22
226_L368_A0.9710.22
380_R411_L0.9680.22
237_R377_E0.9650.22
390_A399_E0.9620.21
30_A40_F0.9620.21
224_R339_A0.9590.21
191_P195_E0.9590.21
316_A366_Y0.9560.21
295_L374_Q0.9540.21
98_W112_R0.9540.21
156_A362_V0.9540.21
254_G327_G0.9530.21
299_K373_W0.9490.21
167_P170_N0.9470.21
102_G293_H0.9470.21
250_D342_G0.9450.21
250_D291_W0.9440.21
174_G248_A0.9400.21
252_T338_A0.9350.21
107_N208_A0.9310.21
195_E225_V0.9260.20
339_A401_S0.9220.20
217_L303_S0.9210.20
353_Q361_E0.9200.20
238_R352_R0.9170.20
202_D250_D0.9150.20
58_V148_D0.9120.20
69_R306_N0.9100.20
318_A328_Y0.9050.20
278_M366_Y0.9050.20
139_E186_E0.9040.20
357_L406_V0.9020.20
109_L361_E0.8990.20
157_P418_V0.8980.20
190_V195_E0.8920.19
211_Y224_R0.8870.19
271_T293_H0.8850.19
293_H339_A0.8840.19
62_A361_E0.8840.19
239_L282_Y0.8840.19
64_S71_A0.8840.19
112_R200_D0.8820.19
316_A333_A0.8820.19
217_L237_R0.8790.19
270_V389_E0.8730.19
301_P380_R0.8730.19
179_A182_A0.8710.19
295_L363_S0.8690.19
295_L333_A0.8680.19
261_I346_H0.8680.19
116_L278_M0.8650.19
74_D238_R0.8650.19
82_P222_I0.8620.19
333_A372_V0.8620.19
134_V184_L0.8590.19
325_R415_S0.8560.19
318_A337_Y0.8550.18
329_V332_T0.8550.18
250_D305_W0.8520.18
299_K304_I0.8520.18
35_Y299_K0.8500.18
331_E370_V0.8500.18
299_K332_T0.8480.18
258_R261_I0.8480.18
192_R312_D0.8420.18
37_I56_T0.8410.18
66_F293_H0.8370.18
338_A373_W0.8360.18
209_M382_A0.8330.18
199_A336_Y0.8300.18
191_P254_G0.8290.18
281_R370_V0.8290.18
66_F117_N0.8280.18
191_P217_L0.8270.18
251_D333_A0.8260.18
41_V368_A0.8230.18
301_P325_R0.8180.18
166_S406_V0.8170.18
106_D409_A0.8160.17
115_L239_L0.8140.17
363_S366_Y0.8110.17
120_R245_S0.8110.17
335_A366_Y0.8100.17
299_K364_D0.8090.17
70_S356_A0.8070.17
115_L372_V0.8070.17
129_V322_Y0.8050.17
114_G282_Y0.8040.17
78_G359_L0.8010.17
78_G108_V0.8010.17
270_V285_V0.8000.17
224_R375_V0.7990.17
306_N333_A0.7970.17
282_Y411_L0.7970.17
181_S261_I0.7940.17
138_R230_A0.7930.17
105_I289_G0.7930.17
278_M304_I0.7930.17
318_A335_A0.7910.17
81_S370_V0.7910.17
108_V359_L0.7900.17
85_G122_A0.7850.17
254_G396_A0.7830.17
49_T351_G0.7810.17
59_G73_P0.7770.17
285_V397_V0.7750.16
111_Y220_Y0.7750.16
279_G374_Q0.7740.16
54_G255_Q0.7720.16
286_L383_F0.7720.16
267_V386_Q0.7710.16
121_A413_R0.7710.16
140_V313_L0.7690.16
71_A384_D0.7670.16
204_A401_S0.7640.16
281_R329_V0.7640.16
192_R238_R0.7630.16
80_L249_V0.7630.16
258_R374_Q0.7620.16
278_M343_V0.7590.16
382_A422_Q0.7550.16
140_V367_W0.7540.16
369_P382_A0.7530.16
48_V238_R0.7500.16
54_G208_A0.7490.16
35_Y40_F0.7480.16
345_E352_R0.7470.16
80_L363_S0.7470.16
255_Q282_Y0.7470.16
337_Y353_Q0.7470.16
230_A291_W0.7460.16
86_D358_V0.7420.16
136_T139_E0.7390.16
188_P344_L0.7380.16
114_G147_V0.7380.16
381_N384_D0.7380.16
117_N411_L0.7360.16
341_L373_W0.7360.16
351_G401_S0.7340.16
78_G245_S0.7330.16
284_V428_F0.7330.16
261_I273_H0.7310.15
207_G428_F0.7290.15
109_L406_V0.7260.15
106_D148_D0.7260.15
32_E295_L0.7250.15
260_T351_G0.7250.15
107_N153_L0.7220.15
69_R375_V0.7220.15
188_P254_G0.7210.15
293_H333_A0.7190.15
353_Q372_V0.7160.15
166_S332_T0.7150.15
272_V286_L0.7120.15
171_A366_Y0.7110.15
69_R372_V0.7110.15
92_F140_V0.7100.15
97_E404_L0.7080.15
225_V303_S0.7080.15
108_V296_V0.7070.15
148_D205_A0.7010.15
155_D411_L0.7000.15
200_D253_V0.7000.15
318_A333_A0.6990.15
116_L207_G0.6990.15
268_D391_E0.6960.15
311_G395_G0.6950.15
120_R268_D0.6950.15
192_R236_H0.6940.15
305_W359_L0.6940.15
103_L156_A0.6930.15
107_N164_Y0.6920.15
60_A257_L0.6900.15
191_P231_L0.6890.15
146_P338_A0.6880.15
119_R362_V0.6870.14
295_L383_F0.6850.14
290_R351_G0.6840.14
33_K114_G0.6840.14
66_F333_A0.6830.14
80_L366_Y0.6820.14
106_D339_A0.6820.14
298_M363_S0.6810.14
192_R395_G0.6800.14
107_N263_D0.6790.14
97_E236_H0.6740.14
296_V301_P0.6720.14
361_E375_V0.6710.14
333_A367_W0.6670.14
107_N315_M0.6660.14
237_R349_D0.6650.14
281_R366_Y0.6630.14
80_L329_V0.6620.14
219_V325_R0.6610.14
32_E36_E0.6590.14
143_A148_D0.6570.14
289_G292_E0.6550.14
71_A392_T0.6550.14
295_L357_L0.6530.14
29_L220_Y0.6530.14
305_W377_E0.6530.14
264_A426_S0.6510.14
282_Y305_W0.6510.14
48_V195_E0.6500.14
177_A366_Y0.6500.14
34_S366_Y0.6500.14
289_G321_G0.6500.14
154_S344_L0.6490.14
113_T198_L0.6470.14
356_A403_H0.6460.14
193_Y211_Y0.6450.14
96_G103_L0.6450.14
238_R351_G0.6440.14
387_P411_L0.6440.14
236_H395_G0.6410.14
125_N192_R0.6410.14
333_A337_Y0.6390.13
272_V354_A0.6380.13
34_S405_P0.6370.13
227_S372_V0.6370.13
53_Q156_A0.6340.13
55_D398_A0.6340.13
49_T145_R0.6340.13
124_V201_D0.6330.13
59_G376_R0.6330.13
226_L245_S0.6320.13
149_V394_H0.6280.13
303_S344_L0.6270.13
68_G73_P0.6260.13
298_M333_A0.6240.13
218_D253_V0.6240.13
57_L419_A0.6220.13
348_S351_G0.6210.13
74_D260_T0.6210.13
99_Y335_A0.6200.13
284_V358_V0.6200.13
108_V128_D0.6180.13
300_A306_N0.6180.13
143_A331_E0.6170.13
358_V379_V0.6160.13
213_Y219_V0.6150.13
41_V48_V0.6130.13
316_A362_V0.6130.13
209_M418_V0.6120.13
291_W306_N0.6110.13
221_Q300_A0.6100.13
111_Y115_L0.6090.13
325_R359_L0.6080.13
226_L343_V0.6060.13
251_D293_H0.6030.13
196_K211_Y0.6020.13
60_A362_V0.6020.13
265_P412_R0.6000.13
262_R304_I0.6000.13
190_V222_I0.6000.13
143_A195_E0.5990.13
93_A282_Y0.5980.13
286_L356_A0.5980.13
33_K76_S0.5980.13
257_L357_L0.5980.13
272_V404_L0.5970.13
275_N306_N0.5950.13
79_I318_A0.5920.13
254_G366_Y0.5920.13
57_L192_R0.5910.13
239_L344_L0.5910.13
385_G409_A0.5910.13
48_V191_P0.5870.12
393_F396_A0.5870.12
186_E281_R0.5860.12
130_W391_E0.5830.12
353_Q393_F0.5830.12
265_P352_R0.5810.12
194_V261_I0.5800.12
57_L224_R0.5790.12
181_S287_A0.5740.12
292_E423_S0.5740.12
370_V406_V0.5730.12
188_P338_A0.5730.12
130_W134_V0.5730.12
326_T337_Y0.5720.12
53_Q256_Y0.5710.12
98_W227_S0.5690.12
261_I386_Q0.5690.12
93_A96_G0.5680.12
54_G186_E0.5680.12
175_P257_L0.5670.12
69_R220_Y0.5650.12
68_G243_R0.5650.12
69_R171_A0.5650.12
99_Y277_Y0.5630.12
190_V327_G0.5620.12
284_V343_V0.5620.12
79_I138_R0.5620.12
116_L284_V0.5610.12
31_A40_F0.5600.12
58_V185_G0.5590.12
82_P227_S0.5590.12
278_M378_S0.5570.12
341_L380_R0.5570.12
38_L231_L0.5550.12
65_V274_V0.5540.12
37_I69_R0.5530.12
153_L157_P0.5510.12
157_P175_P0.5510.12
304_I382_A0.5490.12
204_A213_Y0.5480.12
44_V145_R0.5470.12
204_A236_H0.5470.12
300_A406_V0.5460.12
275_N366_Y0.5450.12
191_P303_S0.5450.12
134_V372_V0.5450.12
209_M391_E0.5440.12
74_D395_G0.5440.12
177_A383_F0.5440.12
184_L192_R0.5430.12
69_R411_L0.5420.12
65_V273_H0.5410.12
296_V375_V0.5400.12
61_T139_E0.5390.12
150_E303_S0.5370.12
329_V335_A0.5370.12
66_F291_W0.5360.12
94_T208_A0.5360.12
108_V251_D0.5360.12
352_R394_H0.5350.12
342_G377_E0.5350.12
190_V362_V0.5340.12
114_G281_R0.5310.11
69_R333_A0.5310.11
145_R226_L0.5300.11
298_M306_N0.5300.11
206_E289_G0.5290.11
72_Y116_L0.5290.11
326_T400_I0.5280.11
209_M276_E0.5270.11
293_H402_D0.5250.11
167_P319_S0.5250.11
416_D421_V0.5240.11
38_L312_D0.5240.11
116_L222_I0.5230.11
43_D255_Q0.5230.11
122_A339_A0.5220.11
178_S335_A0.5210.11
48_V388_G0.5200.11
208_A243_R0.5200.11
219_V316_A0.5200.11
66_F294_E0.5190.11
175_P237_R0.5170.11
360_R375_V0.5170.11
75_V125_N0.5160.11
94_T143_A0.5160.11
81_S194_V0.5160.11
98_W361_E0.5150.11
48_V207_G0.5140.11
296_V359_L0.5140.11
79_I372_V0.5140.11
340_R352_R0.5140.11
143_A257_L0.5130.11
56_T183_A0.5110.11
284_V296_V0.5090.11
138_R337_Y0.5090.11
167_P305_W0.5080.11
64_S93_A0.5070.11
307_P325_R0.5060.11
145_R386_Q0.5050.11
78_G255_Q0.5050.11
181_S253_V0.5050.11
104_G385_G0.5040.11
103_L111_Y0.5040.11
31_A143_A0.5030.11
78_G382_A0.5010.11
93_A359_L0.5000.11
28_Q195_E0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qgpA 1 0.1608 16.2 0.984 Contact Map
4redA 4 0.1515 15.1 0.984 Contact Map
3zheB 1 0.1585 9.9 0.985 Contact Map
1qhkA 1 0.1072 9.7 0.985 Contact Map
2yy0A 6 0.0839 9.4 0.985 Contact Map
1sc3B 2 0.1795 8.4 0.986 Contact Map
2kjfA 1 0.1329 7.9 0.986 Contact Map
4dgfA 1 0.2727 5.9 0.987 Contact Map
2ofkA 1 0.2424 5.9 0.987 Contact Map
3iq2A 1 0.2075 5.9 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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