Q9HS87 - HALSA - GREMLIN Contacts

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Q9HS87 - Uncharacterized protein

UniProt:	Q9HS87	Sequences: MTSATSYRPQLRAVGIAVLLTIVAIAFGSILAVSLLIGYMRLTPAATGNVGPIVEIGVSLIALQGLSFPLVAWAYLRWRGDGWSLLNVSVPSLRDIGYVLGGFFASFTGLFIISIVLTALSVETAPNSVGETAAQNPGIIPLLVVCQFLLVGPGEELLFRGIIQGSLRERFSAGPAILLASMMFAPIHILALSGGLPAAAATIAILFVPSIVFGVLYEKTGNLAVPALTHGLYNGTLFGLTYLSTTVDAPELIHLF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	256 (216)
Sequences:	4808 (4349)
Seq/√Len:	295.9

BACSU - YDIL YYAK YPBD
HALSA - Q9HS87 Q9HNQ5 Q9HMZ0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
185_A	207_F	4.468	1.00
177_I	214_G	4.327	1.00
164_Q	218_E	3.659	1.00
149_L	235_G	3.419	1.00
159_F	187_I	2.956	1.00
217_Y	226_P	2.895	1.00
233_Y	237_L	2.710	1.00
222_N	225_V	2.630	1.00
153_P	231_G	2.615	1.00
215_V	219_K	2.596	1.00
185_A	210_S	2.525	1.00
216_L	229_T	2.488	1.00
185_A	206_L	2.487	1.00
182_M	207_F	2.485	1.00
168_R	218_E	2.422	1.00
199_A	202_T	2.378	1.00
73_W	77_R	2.377	1.00
164_Q	214_G	2.309	1.00
173_A	218_E	2.291	1.00
181_S	214_G	2.291	1.00
152_G	231_G	2.229	1.00
209_P	213_F	2.201	1.00
180_A	214_G	2.082	1.00
177_I	218_E	2.050	1.00
154_G	227_A	2.047	1.00
177_I	211_I	2.040	1.00
202_T	206_L	2.029	1.00
72_A	76_L	2.010	1.00
172_S	175_P	1.997	1.00
210_S	214_G	1.990	1.00
181_S	211_I	1.946	1.00
181_S	207_F	1.926	1.00
164_Q	180_A	1.793	1.00
149_L	152_G	1.679	1.00
173_A	177_I	1.662	1.00
164_Q	176_A	1.625	1.00
25_I	29_S	1.581	1.00
217_Y	220_T	1.566	1.00
216_L	225_V	1.540	1.00
22_I	25_I	1.535	1.00
175_P	179_L	1.497	1.00
101_G	105_A	1.496	1.00
99_V	103_F	1.492	1.00
165_G	168_R	1.467	1.00
100_L	104_F	1.465	1.00
171_F	175_P	1.449	1.00
153_P	234_N	1.417	1.00
149_L	153_P	1.403	1.00
176_A	180_A	1.386	1.00
211_I	214_G	1.358	1.00
97_G	101_G	1.356	1.00
203_I	206_L	1.333	1.00
152_G	227_A	1.330	1.00
224_A	227_A	1.323	1.00
96_I	99_V	1.320	1.00
181_S	185_A	1.279	1.00
217_Y	222_N	1.273	1.00
165_G	217_Y	1.270	1.00
171_F	176_A	1.269	1.00
164_Q	168_R	1.243	1.00
174_G	178_L	1.242	1.00
213_F	226_P	1.239	1.00
51_G	54_V	1.236	1.00
223_L	227_A	1.233	1.00
228_L	232_L	1.226	1.00
163_I	180_A	1.218	1.00
185_A	203_I	1.214	1.00
168_R	221_G	1.213	1.00
25_I	28_G	1.209	1.00
98_Y	102_G	1.198	1.00
231_G	235_G	1.193	1.00
172_S	176_A	1.174	1.00
21_T	24_A	1.173	1.00
214_G	218_E	1.166	1.00
207_F	211_I	1.162	1.00
103_F	232_L	1.152	1.00
164_Q	217_Y	1.139	1.00
213_F	229_T	1.138	1.00
74_A	78_W	1.127	1.00
178_L	211_I	1.118	1.00
167_L	179_L	1.110	1.00
75_Y	79_R	1.106	1.00
177_I	215_V	1.105	1.00
150_L	231_G	1.099	1.00
148_F	152_G	1.089	1.00
168_R	173_A	1.080	1.00
161_G	223_L	1.079	1.00
144_V	148_F	1.076	1.00
225_V	228_L	1.076	1.00
181_S	210_S	1.075	1.00
21_T	25_I	1.074	1.00
145_V	149_L	1.071	1.00
216_L	226_P	1.066	1.00
227_A	231_G	1.062	1.00
161_G	165_G	1.058	1.00
24_A	28_G	1.046	1.00
94_R	97_G	1.043	1.00
38_G	41_R	1.036	1.00
203_I	207_F	1.034	1.00
112_I	116_V	1.031	1.00
76_L	79_R	1.027	1.00
34_S	38_G	1.023	1.00
22_I	26_A	1.014	1.00
19_L	22_I	1.010	1.00
206_L	210_S	0.996	1.00
45_A	48_G	0.993	1.00
128_S	131_E	0.992	1.00
69_P	72_A	0.989	1.00
29_S	33_V	0.986	1.00
149_L	238_F	0.985	1.00
235_G	239_G	0.981	1.00
21_T	29_S	0.974	1.00
199_A	206_L	0.973	1.00
128_S	132_T	0.960	1.00
66_L	69_P	0.949	1.00
154_G	231_G	0.945	1.00
99_V	102_G	0.945	1.00
222_N	226_P	0.942	1.00
106_S	110_L	0.914	1.00
180_A	210_S	0.912	1.00
180_A	217_Y	0.910	1.00
56_I	59_S	0.909	1.00
202_T	205_I	0.902	1.00
125_A	128_S	0.902	1.00
77_R	80_G	0.894	1.00
168_R	176_A	0.891	1.00
150_L	154_G	0.890	1.00
117_L	120_L	0.888	1.00
130_G	134_A	0.884	1.00
115_I	119_A	0.883	1.00
64_Q	68_F	0.881	1.00
167_L	171_F	0.875	1.00
102_G	106_S	0.874	1.00
123_E	126_P	0.873	1.00
204_A	208_V	0.873	1.00
144_V	152_G	0.872	1.00
162_I	166_S	0.867	1.00
82_G	85_L	0.861	1.00
189_I	203_I	0.859	1.00
19_L	23_V	0.858	1.00
184_F	188_H	0.856	1.00
26_A	30_I	0.856	1.00
174_G	177_I	0.851	1.00
99_V	229_T	0.851	1.00
188_H	230_H	0.849	1.00
103_F	106_S	0.849	1.00
175_P	178_L	0.845	1.00
131_E	134_A	0.843	1.00
127_N	130_G	0.834	1.00
54_V	59_S	0.832	1.00
164_Q	177_I	0.830	1.00
233_Y	236_T	0.829	1.00
94_R	98_Y	0.823	1.00
29_S	32_A	0.817	1.00
143_L	147_Q	0.811	1.00
167_L	176_A	0.810	1.00
95_D	98_Y	0.806	1.00
213_F	217_Y	0.804	1.00
161_G	222_N	0.803	1.00
126_P	130_G	0.801	1.00
223_L	226_P	0.797	0.99
72_A	75_Y	0.797	0.99
30_I	34_S	0.792	0.99
209_P	233_Y	0.788	0.99
32_A	36_L	0.788	0.99
145_V	238_F	0.786	0.99
53_I	56_I	0.785	0.99
52_P	55_E	0.783	0.99
109_G	113_I	0.783	0.99
159_F	184_F	0.781	0.99
148_F	238_F	0.779	0.99
201_A	204_A	0.774	0.99
70_L	74_A	0.773	0.99
70_L	78_W	0.766	0.99
171_F	179_L	0.758	0.99
19_L	24_A	0.757	0.99
105_A	108_T	0.757	0.99
166_S	200_A	0.745	0.99
89_S	92_S	0.743	0.99
221_G	226_P	0.737	0.99
71_V	76_L	0.737	0.99
166_S	169_E	0.737	0.99
159_F	183_M	0.733	0.99
63_L	71_V	0.732	0.99
138_G	142_L	0.731	0.99
103_F	229_T	0.727	0.99
64_Q	67_S	0.723	0.99
126_P	129_V	0.723	0.99
118_T	121_S	0.720	0.99
75_Y	78_W	0.720	0.99
206_L	209_P	0.719	0.99
187_I	238_F	0.718	0.99
142_L	146_C	0.718	0.99
115_I	118_T	0.716	0.99
162_I	234_N	0.714	0.99
205_I	208_V	0.712	0.99
163_I	183_M	0.712	0.99
48_G	59_S	0.709	0.99
63_L	66_L	0.709	0.99
157_L	162_I	0.708	0.99
217_Y	221_G	0.707	0.99
107_F	111_F	0.699	0.99
150_L	153_P	0.695	0.99
28_G	32_A	0.687	0.98
238_F	242_Y	0.686	0.98
24_A	33_V	0.685	0.98
48_G	51_G	0.683	0.98
108_T	112_I	0.683	0.98
205_I	237_L	0.677	0.98
81_D	85_L	0.671	0.98
24_A	29_S	0.670	0.98
21_T	33_V	0.669	0.98
104_F	108_T	0.664	0.98
34_S	37_I	0.660	0.98
26_A	29_S	0.659	0.98
224_A	228_L	0.657	0.98
64_Q	71_V	0.656	0.98
213_F	216_L	0.655	0.98
81_D	84_S	0.655	0.98
107_F	110_L	0.654	0.98
129_V	132_T	0.652	0.98
43_T	46_A	0.648	0.98
165_G	169_E	0.648	0.98
137_P	140_I	0.648	0.98
95_D	99_V	0.647	0.98
22_I	29_S	0.646	0.98
131_E	135_Q	0.645	0.98
25_I	31_L	0.645	0.98
160_R	184_F	0.643	0.98
199_A	233_Y	0.641	0.98
64_Q	72_A	0.641	0.98
50_V	54_V	0.640	0.98
103_F	113_I	0.639	0.98
51_G	55_E	0.638	0.98
33_V	37_I	0.637	0.98
36_L	39_Y	0.636	0.98
174_G	215_V	0.633	0.97
114_S	118_T	0.632	0.97
83_W	90_V	0.631	0.97
126_P	134_A	0.630	0.97
88_V	157_L	0.629	0.97
71_V	74_A	0.629	0.97
26_A	31_L	0.628	0.97
44_P	47_T	0.627	0.97
129_V	133_A	0.627	0.97
93_L	97_G	0.624	0.97
73_W	76_L	0.624	0.97
67_S	71_V	0.623	0.97
177_I	181_S	0.622	0.97
103_F	110_L	0.622	0.97
205_I	233_Y	0.621	0.97
184_F	230_H	0.620	0.97
185_A	202_T	0.619	0.97
83_W	87_N	0.619	0.97
64_Q	76_L	0.618	0.97
111_F	115_I	0.618	0.97
67_S	70_L	0.617	0.97
64_Q	79_R	0.614	0.97
147_Q	151_V	0.612	0.97
35_L	38_G	0.611	0.97
68_F	72_A	0.611	0.97
111_F	114_S	0.607	0.97
55_E	59_S	0.607	0.97
21_T	28_G	0.602	0.97
27_F	31_L	0.600	0.96
74_A	77_R	0.598	0.96
189_I	199_A	0.597	0.96
211_I	215_V	0.596	0.96
157_L	227_A	0.595	0.96
88_V	91_P	0.595	0.96
217_Y	225_V	0.594	0.96
20_L	26_A	0.592	0.96
30_I	39_Y	0.591	0.96
228_L	231_G	0.591	0.96
59_S	64_Q	0.590	0.96
174_G	211_I	0.582	0.96
219_K	225_V	0.577	0.96
168_R	172_S	0.575	0.96
173_A	176_A	0.573	0.95
149_L	231_G	0.569	0.95
232_L	235_G	0.569	0.95
38_G	43_T	0.569	0.95
206_L	233_Y	0.567	0.95
21_T	30_I	0.566	0.95
21_T	26_A	0.564	0.95
53_I	57_G	0.558	0.95
170_R	173_A	0.558	0.95
201_A	205_I	0.554	0.95
113_I	208_V	0.549	0.94
153_P	217_Y	0.548	0.94
49_N	55_E	0.547	0.94
199_A	203_I	0.539	0.94
28_G	31_L	0.539	0.94
49_N	52_P	0.536	0.94
23_V	34_S	0.535	0.94
20_L	25_I	0.534	0.93
41_R	68_F	0.533	0.93
26_A	33_V	0.531	0.93
19_L	26_A	0.531	0.93
109_G	112_I	0.530	0.93
99_V	228_L	0.528	0.93
108_T	115_I	0.527	0.93
96_I	100_L	0.526	0.93
112_I	115_I	0.526	0.93
147_Q	152_G	0.525	0.93
155_E	188_H	0.524	0.93
186_P	189_I	0.523	0.93
23_V	26_A	0.522	0.93
217_Y	224_A	0.521	0.93
105_A	109_G	0.521	0.93
27_F	32_A	0.520	0.93
129_V	134_A	0.518	0.92
205_I	209_P	0.514	0.92
82_G	89_S	0.513	0.92
126_P	133_A	0.513	0.92
78_W	81_D	0.511	0.92
164_Q	173_A	0.510	0.92
76_L	80_G	0.509	0.92
23_V	30_I	0.509	0.92
237_L	241_T	0.509	0.92
108_T	111_F	0.504	0.91
69_P	73_W	0.502	0.91
154_G	223_L	0.501	0.91
155_E	230_H	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cadC	1	0.8789	99.8	0.54	Contact Map
2wswA	3	0.7383	17.9	0.936	Contact Map
4c7rA	3	0.707	12	0.941	Contact Map
3j1zP	8	0.8125	11.5	0.941	Contact Map
4rp9A	2	0.9219	9.4	0.944	Contact Map
4lz6A	1	0.9141	8.2	0.945	Contact Map
3mktA	1	0.9414	8.1	0.945	Contact Map
3d31C	2	0.8281	6.8	0.947	Contact Map
4ev6A	3	0.2812	6.3	0.948	Contact Map
4n6hA	1	0.3633	5.5	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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