GREMLIN Database
Q9HS87 - Uncharacterized protein
UniProt: Q9HS87 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (216)
Sequences: 4808 (4349)
Seq/√Len: 295.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_A207_F4.4681.00
177_I214_G4.3271.00
164_Q218_E3.6591.00
149_L235_G3.4191.00
159_F187_I2.9561.00
217_Y226_P2.8951.00
233_Y237_L2.7101.00
222_N225_V2.6301.00
153_P231_G2.6151.00
215_V219_K2.5961.00
185_A210_S2.5251.00
216_L229_T2.4881.00
185_A206_L2.4871.00
182_M207_F2.4851.00
168_R218_E2.4221.00
199_A202_T2.3781.00
73_W77_R2.3771.00
164_Q214_G2.3091.00
173_A218_E2.2911.00
181_S214_G2.2911.00
152_G231_G2.2291.00
209_P213_F2.2011.00
180_A214_G2.0821.00
177_I218_E2.0501.00
154_G227_A2.0471.00
177_I211_I2.0401.00
202_T206_L2.0291.00
72_A76_L2.0101.00
172_S175_P1.9971.00
210_S214_G1.9901.00
181_S211_I1.9461.00
181_S207_F1.9261.00
164_Q180_A1.7931.00
149_L152_G1.6791.00
173_A177_I1.6621.00
164_Q176_A1.6251.00
25_I29_S1.5811.00
217_Y220_T1.5661.00
216_L225_V1.5401.00
22_I25_I1.5351.00
175_P179_L1.4971.00
101_G105_A1.4961.00
99_V103_F1.4921.00
165_G168_R1.4671.00
100_L104_F1.4651.00
171_F175_P1.4491.00
153_P234_N1.4171.00
149_L153_P1.4031.00
176_A180_A1.3861.00
211_I214_G1.3581.00
97_G101_G1.3561.00
203_I206_L1.3331.00
152_G227_A1.3301.00
224_A227_A1.3231.00
96_I99_V1.3201.00
181_S185_A1.2791.00
217_Y222_N1.2731.00
165_G217_Y1.2701.00
171_F176_A1.2691.00
164_Q168_R1.2431.00
174_G178_L1.2421.00
213_F226_P1.2391.00
51_G54_V1.2361.00
223_L227_A1.2331.00
228_L232_L1.2261.00
163_I180_A1.2181.00
185_A203_I1.2141.00
168_R221_G1.2131.00
25_I28_G1.2091.00
98_Y102_G1.1981.00
231_G235_G1.1931.00
172_S176_A1.1741.00
21_T24_A1.1731.00
214_G218_E1.1661.00
207_F211_I1.1621.00
103_F232_L1.1521.00
164_Q217_Y1.1391.00
213_F229_T1.1381.00
74_A78_W1.1271.00
178_L211_I1.1181.00
167_L179_L1.1101.00
75_Y79_R1.1061.00
177_I215_V1.1051.00
150_L231_G1.0991.00
148_F152_G1.0891.00
168_R173_A1.0801.00
161_G223_L1.0791.00
144_V148_F1.0761.00
225_V228_L1.0761.00
181_S210_S1.0751.00
21_T25_I1.0741.00
145_V149_L1.0711.00
216_L226_P1.0661.00
227_A231_G1.0621.00
161_G165_G1.0581.00
24_A28_G1.0461.00
94_R97_G1.0431.00
38_G41_R1.0361.00
203_I207_F1.0341.00
112_I116_V1.0311.00
76_L79_R1.0271.00
34_S38_G1.0231.00
22_I26_A1.0141.00
19_L22_I1.0101.00
206_L210_S0.9961.00
45_A48_G0.9931.00
128_S131_E0.9921.00
69_P72_A0.9891.00
29_S33_V0.9861.00
149_L238_F0.9851.00
235_G239_G0.9811.00
21_T29_S0.9741.00
199_A206_L0.9731.00
128_S132_T0.9601.00
66_L69_P0.9491.00
154_G231_G0.9451.00
99_V102_G0.9451.00
222_N226_P0.9421.00
106_S110_L0.9141.00
180_A210_S0.9121.00
180_A217_Y0.9101.00
56_I59_S0.9091.00
202_T205_I0.9021.00
125_A128_S0.9021.00
77_R80_G0.8941.00
168_R176_A0.8911.00
150_L154_G0.8901.00
117_L120_L0.8881.00
130_G134_A0.8841.00
115_I119_A0.8831.00
64_Q68_F0.8811.00
167_L171_F0.8751.00
102_G106_S0.8741.00
123_E126_P0.8731.00
204_A208_V0.8731.00
144_V152_G0.8721.00
162_I166_S0.8671.00
82_G85_L0.8611.00
189_I203_I0.8591.00
19_L23_V0.8581.00
184_F188_H0.8561.00
26_A30_I0.8561.00
174_G177_I0.8511.00
99_V229_T0.8511.00
188_H230_H0.8491.00
103_F106_S0.8491.00
175_P178_L0.8451.00
131_E134_A0.8431.00
127_N130_G0.8341.00
54_V59_S0.8321.00
164_Q177_I0.8301.00
233_Y236_T0.8291.00
94_R98_Y0.8231.00
29_S32_A0.8171.00
143_L147_Q0.8111.00
167_L176_A0.8101.00
95_D98_Y0.8061.00
213_F217_Y0.8041.00
161_G222_N0.8031.00
126_P130_G0.8011.00
223_L226_P0.7970.99
72_A75_Y0.7970.99
30_I34_S0.7920.99
209_P233_Y0.7880.99
32_A36_L0.7880.99
145_V238_F0.7860.99
53_I56_I0.7850.99
52_P55_E0.7830.99
109_G113_I0.7830.99
159_F184_F0.7810.99
148_F238_F0.7790.99
201_A204_A0.7740.99
70_L74_A0.7730.99
70_L78_W0.7660.99
171_F179_L0.7580.99
19_L24_A0.7570.99
105_A108_T0.7570.99
166_S200_A0.7450.99
89_S92_S0.7430.99
221_G226_P0.7370.99
71_V76_L0.7370.99
166_S169_E0.7370.99
159_F183_M0.7330.99
63_L71_V0.7320.99
138_G142_L0.7310.99
103_F229_T0.7270.99
64_Q67_S0.7230.99
126_P129_V0.7230.99
118_T121_S0.7200.99
75_Y78_W0.7200.99
206_L209_P0.7190.99
187_I238_F0.7180.99
142_L146_C0.7180.99
115_I118_T0.7160.99
162_I234_N0.7140.99
205_I208_V0.7120.99
163_I183_M0.7120.99
48_G59_S0.7090.99
63_L66_L0.7090.99
157_L162_I0.7080.99
217_Y221_G0.7070.99
107_F111_F0.6990.99
150_L153_P0.6950.99
28_G32_A0.6870.98
238_F242_Y0.6860.98
24_A33_V0.6850.98
48_G51_G0.6830.98
108_T112_I0.6830.98
205_I237_L0.6770.98
81_D85_L0.6710.98
24_A29_S0.6700.98
21_T33_V0.6690.98
104_F108_T0.6640.98
34_S37_I0.6600.98
26_A29_S0.6590.98
224_A228_L0.6570.98
64_Q71_V0.6560.98
213_F216_L0.6550.98
81_D84_S0.6550.98
107_F110_L0.6540.98
129_V132_T0.6520.98
43_T46_A0.6480.98
165_G169_E0.6480.98
137_P140_I0.6480.98
95_D99_V0.6470.98
22_I29_S0.6460.98
131_E135_Q0.6450.98
25_I31_L0.6450.98
160_R184_F0.6430.98
199_A233_Y0.6410.98
64_Q72_A0.6410.98
50_V54_V0.6400.98
103_F113_I0.6390.98
51_G55_E0.6380.98
33_V37_I0.6370.98
36_L39_Y0.6360.98
174_G215_V0.6330.97
114_S118_T0.6320.97
83_W90_V0.6310.97
126_P134_A0.6300.97
88_V157_L0.6290.97
71_V74_A0.6290.97
26_A31_L0.6280.97
44_P47_T0.6270.97
129_V133_A0.6270.97
93_L97_G0.6240.97
73_W76_L0.6240.97
67_S71_V0.6230.97
177_I181_S0.6220.97
103_F110_L0.6220.97
205_I233_Y0.6210.97
184_F230_H0.6200.97
185_A202_T0.6190.97
83_W87_N0.6190.97
64_Q76_L0.6180.97
111_F115_I0.6180.97
67_S70_L0.6170.97
64_Q79_R0.6140.97
147_Q151_V0.6120.97
35_L38_G0.6110.97
68_F72_A0.6110.97
111_F114_S0.6070.97
55_E59_S0.6070.97
21_T28_G0.6020.97
27_F31_L0.6000.96
74_A77_R0.5980.96
189_I199_A0.5970.96
211_I215_V0.5960.96
157_L227_A0.5950.96
88_V91_P0.5950.96
217_Y225_V0.5940.96
20_L26_A0.5920.96
30_I39_Y0.5910.96
228_L231_G0.5910.96
59_S64_Q0.5900.96
174_G211_I0.5820.96
219_K225_V0.5770.96
168_R172_S0.5750.96
173_A176_A0.5730.95
149_L231_G0.5690.95
232_L235_G0.5690.95
38_G43_T0.5690.95
206_L233_Y0.5670.95
21_T30_I0.5660.95
21_T26_A0.5640.95
53_I57_G0.5580.95
170_R173_A0.5580.95
201_A205_I0.5540.95
113_I208_V0.5490.94
153_P217_Y0.5480.94
49_N55_E0.5470.94
199_A203_I0.5390.94
28_G31_L0.5390.94
49_N52_P0.5360.94
23_V34_S0.5350.94
20_L25_I0.5340.93
41_R68_F0.5330.93
26_A33_V0.5310.93
19_L26_A0.5310.93
109_G112_I0.5300.93
99_V228_L0.5280.93
108_T115_I0.5270.93
96_I100_L0.5260.93
112_I115_I0.5260.93
147_Q152_G0.5250.93
155_E188_H0.5240.93
186_P189_I0.5230.93
23_V26_A0.5220.93
217_Y224_A0.5210.93
105_A109_G0.5210.93
27_F32_A0.5200.93
129_V134_A0.5180.92
205_I209_P0.5140.92
82_G89_S0.5130.92
126_P133_A0.5130.92
78_W81_D0.5110.92
164_Q173_A0.5100.92
76_L80_G0.5090.92
23_V30_I0.5090.92
237_L241_T0.5090.92
108_T111_F0.5040.91
69_P73_W0.5020.91
154_G223_L0.5010.91
155_E230_H0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cadC 1 0.8789 99.8 0.54 Contact Map
2wswA 3 0.7383 17.9 0.936 Contact Map
4c7rA 3 0.707 12 0.941 Contact Map
3j1zP 8 0.8125 11.5 0.941 Contact Map
4rp9A 2 0.9219 9.4 0.944 Contact Map
4lz6A 1 0.9141 8.2 0.945 Contact Map
3mktA 1 0.9414 8.1 0.945 Contact Map
3d31C 2 0.8281 6.8 0.947 Contact Map
4ev6A 3 0.2812 6.3 0.948 Contact Map
4n6hA 1 0.3633 5.5 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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