Q9HS82 - HALSA - GREMLIN Contacts

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Q9HS82 - Uncharacterized protein

UniProt:	Q9HS82	Sequences: MATCDRCGTQEPMPYQCRLCGGTYCSDHRLPENHDCPGLENWGDPNGVFDSGFDDTVDGQATQQSRGGGGGIADAIPINTGPGGLVAYFRGNAAFLFLGVMWVTFVIQYGIAPLAGITDRSPTWYNLFTLNTAHPEYVWTWVTSVFAHGGFSHIVLNSIVLYFFGPIVEDRIGSKKFVALFLGAGILAGLAQVGASLLANPGPAVIASQNGRLLISDAFSATLGASGAIAALMGVLTLLNPGLRIYLYFVIPMPLWLATGLFAAYSIFVSGTGGIGAGGVAQLAHLAGLGIGLLYGAKLKREGARAPNELQFGGGPGGGMGGPGGPGGPGRRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	333 (265)
Sequences:	249 (220)
Seq/√Len:	13.5

ECOLI - GLPG
BACSU - GLUP
HALSA - Q9HS82

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
192_Q	281_A	4.109	1.00
157_N	226_S	3.373	0.99
222_T	281_A	3.189	0.98
184_A	231_A	3.078	0.97
147_A	223_L	3.045	0.97
176_K	270_S	2.971	0.97
157_N	225_A	2.889	0.96
17_C	20_C	2.725	0.95
99_G	107_I	2.598	0.93
161_L	229_I	2.583	0.93
102_W	158_S	2.424	0.90
166_P	170_D	2.408	0.90
191_A	287_A	2.363	0.89
192_Q	222_T	2.356	0.89
236_L	252_P	2.265	0.87
161_L	177_F	2.261	0.87
230_A	268_F	2.255	0.87
157_N	285_H	2.070	0.82
224_G	292_G	2.059	0.81
172_I	184_A	2.019	0.80
180_L	254_P	1.992	0.79
146_F	173_G	1.991	0.79
97_F	267_I	1.977	0.78
19_L	22_G	1.952	0.77
128_F	225_A	1.941	0.77
226_S	288_G	1.921	0.76
98_L	158_S	1.919	0.76
139_W	296_G	1.903	0.76
146_F	285_H	1.900	0.75
173_G	185_G	1.896	0.75
107_I	265_Y	1.851	0.73
105_F	157_N	1.840	0.73
125_Y	129_T	1.832	0.73
145_V	185_G	1.828	0.73
228_A	288_G	1.813	0.72
285_H	292_G	1.810	0.72
157_N	288_G	1.798	0.71
225_A	228_A	1.798	0.71
288_G	292_G	1.775	0.70
108_Q	147_A	1.768	0.70
158_S	225_A	1.710	0.67
165_G	177_F	1.709	0.67
153_H	173_G	1.667	0.65
129_T	221_A	1.663	0.65
70_G	75_A	1.658	0.65
144_S	189_G	1.639	0.64
137_Y	140_T	1.635	0.64
146_F	287_A	1.628	0.63
191_A	255_L	1.624	0.63
231_A	288_G	1.592	0.61
149_G	223_L	1.544	0.59
159_I	181_F	1.540	0.59
153_H	226_S	1.531	0.58
148_H	285_H	1.520	0.58
228_A	231_A	1.517	0.58
189_G	222_T	1.517	0.58
101_M	104_T	1.506	0.57
30_L	36_C	1.455	0.54
153_H	292_G	1.449	0.54
81_G	86_V	1.447	0.54
147_A	240_N	1.440	0.54
127_L	273_G	1.427	0.53
228_A	284_A	1.427	0.53
21_G	25_C	1.426	0.53
46_N	280_V	1.425	0.53
177_F	185_G	1.423	0.53
270_S	283_L	1.417	0.52
169_E	288_G	1.396	0.51
18_R	21_G	1.393	0.51
148_H	292_G	1.373	0.50
44_D	48_V	1.370	0.50
141_W	189_G	1.364	0.50
148_H	224_G	1.364	0.50
284_A	288_G	1.353	0.49
98_L	225_A	1.347	0.49
144_S	281_A	1.316	0.47
28_H	31_P	1.311	0.47
297_A	301_R	1.298	0.46
139_W	284_A	1.285	0.45
118_T	170_D	1.284	0.45
218_A	221_A	1.276	0.45
266_S	282_Q	1.273	0.45
234_G	237_T	1.262	0.44
28_H	36_C	1.256	0.44
140_T	188_A	1.256	0.44
139_W	169_E	1.253	0.44
285_H	288_G	1.251	0.44
102_W	154_I	1.244	0.43
106_V	263_A	1.236	0.43
105_F	285_H	1.235	0.43
225_A	288_G	1.226	0.42
247_L	252_P	1.221	0.42
112_A	124_W	1.221	0.42
20_C	28_H	1.212	0.41
226_S	285_H	1.207	0.41
138_V	141_W	1.200	0.41
48_V	51_S	1.194	0.41
185_G	228_A	1.191	0.40
49_F	190_L	1.186	0.40
280_V	303_G	1.182	0.40
131_N	134_H	1.174	0.40
51_S	57_V	1.174	0.40
71_G	74_D	1.170	0.39
100_V	155_V	1.158	0.39
189_G	266_S	1.149	0.38
169_E	176_K	1.147	0.38
155_V	191_A	1.138	0.38
151_F	264_A	1.124	0.37
102_W	237_T	1.120	0.37
64_Q	268_F	1.120	0.37
234_G	273_G	1.116	0.37
150_G	270_S	1.111	0.36
151_F	171_R	1.103	0.36
29_R	32_E	1.091	0.35
98_L	161_L	1.091	0.35
98_L	101_M	1.085	0.35
142_V	264_A	1.077	0.35
28_H	38_G	1.076	0.35
283_L	290_G	1.069	0.34
129_T	223_L	1.069	0.34
139_W	143_T	1.066	0.34
43_G	170_D	1.060	0.34
94_A	169_E	1.058	0.34
146_F	165_G	1.056	0.34
132_T	221_A	1.054	0.34
50_D	54_D	1.050	0.33
101_M	161_L	1.048	0.33
65_S	100_V	1.047	0.33
113_P	124_W	1.034	0.33
148_H	153_H	1.030	0.32
20_C	36_C	1.021	0.32
232_L	287_A	1.018	0.32
24_Y	41_N	1.012	0.32
176_K	194_G	1.010	0.32
86_V	90_R	1.003	0.31
106_V	186_I	1.002	0.31
181_F	281_A	1.001	0.31
109_Y	150_G	0.997	0.31
21_G	29_R	0.995	0.31
270_S	282_Q	0.993	0.31
33_N	47_G	0.992	0.31
133_A	233_M	0.991	0.31
27_D	181_F	0.990	0.31
281_A	287_A	0.984	0.30
161_L	185_G	0.984	0.30
74_D	78_I	0.971	0.30
52_G	58_D	0.968	0.30
20_C	34_H	0.963	0.29
17_C	21_G	0.963	0.29
184_A	288_G	0.963	0.29
132_T	257_L	0.958	0.29
109_Y	112_A	0.945	0.29
18_R	22_G	0.936	0.28
188_A	300_K	0.935	0.28
34_H	37_P	0.934	0.28
88_Y	168_V	0.934	0.28
224_G	288_G	0.930	0.28
27_D	87_A	0.927	0.28
23_T	27_D	0.926	0.28
146_F	185_G	0.926	0.28
53_F	57_V	0.925	0.28
137_Y	297_A	0.924	0.28
287_A	290_G	0.922	0.28
17_C	29_R	0.920	0.28
126_N	268_F	0.920	0.28
83_G	90_R	0.919	0.28
49_F	54_D	0.916	0.27
129_T	280_V	0.915	0.27
153_H	227_G	0.908	0.27
101_M	281_A	0.906	0.27
151_F	265_Y	0.904	0.27
121_S	126_N	0.904	0.27
234_G	284_A	0.901	0.27
21_G	28_H	0.900	0.27
43_G	46_N	0.900	0.27
79_N	86_V	0.899	0.27
97_F	283_L	0.894	0.26
100_V	272_T	0.892	0.26
16_Q	22_G	0.886	0.26
150_G	197_L	0.883	0.26
133_A	232_L	0.879	0.26
128_F	157_N	0.872	0.26
19_L	24_Y	0.871	0.26
25_C	32_E	0.870	0.25
92_N	174_S	0.862	0.25
20_C	29_R	0.854	0.25
249_F	264_A	0.853	0.25
55_D	170_D	0.852	0.25
154_I	158_S	0.852	0.25
273_G	283_L	0.847	0.25
29_R	36_C	0.847	0.25
72_I	290_G	0.841	0.24
42_W	49_F	0.838	0.24
144_S	239_L	0.838	0.24
136_E	150_G	0.834	0.24
103_V	265_Y	0.834	0.24
68_G	73_A	0.833	0.24
219_F	269_V	0.832	0.24
125_Y	154_I	0.820	0.24
94_A	179_A	0.817	0.23
34_H	38_G	0.816	0.23
129_T	147_A	0.813	0.23
32_E	38_G	0.810	0.23
47_G	291_I	0.803	0.23
153_H	224_G	0.797	0.23
85_L	88_Y	0.794	0.23
147_A	169_E	0.791	0.22
168_V	284_A	0.790	0.22
273_G	290_G	0.790	0.22
140_T	150_G	0.790	0.22
119_D	231_A	0.789	0.22
146_F	177_F	0.788	0.22
239_L	289_L	0.787	0.22
30_L	34_H	0.787	0.22
35_D	150_G	0.783	0.22
122_P	271_G	0.782	0.22
271_G	301_R	0.776	0.22
24_Y	82_P	0.776	0.22
28_H	32_E	0.774	0.22
128_F	249_F	0.773	0.22
25_C	286_L	0.772	0.22
46_N	68_G	0.771	0.22
157_N	301_R	0.770	0.22
260_G	264_A	0.767	0.22
142_V	186_I	0.767	0.22
193_V	222_T	0.763	0.21
67_G	74_D	0.761	0.21
196_S	221_A	0.759	0.21
25_C	31_P	0.758	0.21
253_M	267_I	0.757	0.21
181_F	185_G	0.757	0.21
236_L	247_L	0.753	0.21
146_F	281_A	0.749	0.21
17_C	28_H	0.747	0.21
251_I	254_P	0.747	0.21
16_Q	19_L	0.746	0.21
168_V	288_G	0.746	0.21
21_G	32_E	0.745	0.21
25_C	29_R	0.745	0.21
40_E	58_D	0.745	0.21
142_V	161_L	0.744	0.21
108_Q	112_A	0.743	0.21
254_P	257_L	0.741	0.21
44_D	47_G	0.735	0.20
234_G	289_L	0.733	0.20
49_F	53_F	0.731	0.20
182_L	231_A	0.730	0.20
221_A	299_L	0.729	0.20
95_F	294_L	0.726	0.20
17_C	36_C	0.722	0.20
172_I	185_G	0.721	0.20
68_G	294_L	0.715	0.20
267_I	277_A	0.714	0.20
39_L	52_G	0.714	0.20
16_Q	41_N	0.714	0.20
20_C	30_L	0.712	0.20
94_A	182_L	0.712	0.20
58_D	73_A	0.710	0.20
128_F	177_F	0.710	0.20
42_W	53_F	0.708	0.19
176_K	218_A	0.708	0.19
180_L	188_A	0.704	0.19
149_G	266_S	0.701	0.19
240_N	256_W	0.691	0.19
69_G	277_A	0.691	0.19
71_G	75_A	0.686	0.19
193_V	269_V	0.685	0.19
157_N	284_A	0.684	0.19
132_T	218_A	0.682	0.19
22_G	26_S	0.681	0.19
67_G	77_P	0.678	0.19
63_Q	79_N	0.677	0.18
230_A	271_G	0.676	0.18
42_W	62_T	0.676	0.18
99_G	265_Y	0.671	0.18
189_G	284_A	0.670	0.18
144_S	222_T	0.667	0.18
20_C	32_E	0.666	0.18
154_I	231_A	0.665	0.18
152_S	290_G	0.663	0.18
32_E	286_L	0.658	0.18
43_G	56_T	0.657	0.18
259_T	266_S	0.654	0.18
100_V	131_N	0.654	0.18
21_G	31_P	0.652	0.18
110_G	143_T	0.651	0.18
182_L	186_I	0.649	0.18
45_P	48_V	0.648	0.18
47_G	52_G	0.646	0.17
228_A	281_A	0.641	0.17
21_G	50_D	0.640	0.17
140_T	241_P	0.636	0.17
120_R	133_A	0.634	0.17
185_G	281_A	0.633	0.17
253_M	257_L	0.633	0.17
170_D	269_V	0.633	0.17
123_T	264_A	0.632	0.17
272_T	280_V	0.632	0.17
161_L	244_R	0.629	0.17
20_C	24_Y	0.629	0.17
180_L	195_A	0.628	0.17
104_T	108_Q	0.624	0.17
60_Q	180_L	0.624	0.17
60_Q	106_V	0.623	0.17
48_V	52_G	0.623	0.17
120_R	127_L	0.620	0.17
78_I	87_A	0.619	0.17
100_V	300_K	0.618	0.17
148_H	288_G	0.616	0.17
170_D	232_L	0.615	0.17
140_T	162_Y	0.614	0.17
17_C	25_C	0.612	0.16
170_D	185_G	0.611	0.16
143_T	169_E	0.608	0.16
152_S	287_A	0.608	0.16
167_I	255_L	0.606	0.16
94_A	229_I	0.602	0.16
301_R	306_A	0.602	0.16
106_V	302_E	0.602	0.16
147_A	261_L	0.601	0.16
34_H	54_D	0.600	0.16
67_G	73_A	0.600	0.16
149_G	160_V	0.598	0.16
36_C	241_P	0.597	0.16
140_T	278_G	0.597	0.16
280_V	284_A	0.593	0.16
106_V	278_G	0.592	0.16
168_V	287_A	0.591	0.16
27_D	73_A	0.590	0.16
94_A	184_A	0.588	0.16
153_H	285_H	0.587	0.16
224_G	227_G	0.584	0.16
227_G	285_H	0.582	0.16
101_M	158_S	0.580	0.16
110_G	219_F	0.579	0.16
151_F	154_I	0.579	0.16
148_H	157_N	0.577	0.15
98_L	281_A	0.574	0.15
150_G	169_E	0.571	0.15
38_G	67_G	0.569	0.15
233_M	261_L	0.568	0.15
85_L	89_F	0.568	0.15
21_G	30_L	0.566	0.15
42_W	45_P	0.565	0.15
139_W	228_A	0.563	0.15
161_L	188_A	0.562	0.15
28_H	34_H	0.561	0.15
48_V	60_Q	0.560	0.15
190_L	231_A	0.556	0.15
28_H	264_A	0.555	0.15
144_S	228_A	0.555	0.15
41_N	110_G	0.554	0.15
142_V	179_A	0.554	0.15
153_H	288_G	0.552	0.15
40_E	59_G	0.551	0.15
53_F	56_T	0.546	0.15
24_Y	32_E	0.546	0.15
271_G	277_A	0.545	0.15
156_L	290_G	0.545	0.15
229_I	262_F	0.544	0.15
144_S	159_I	0.544	0.15
158_S	181_F	0.541	0.14
132_T	136_E	0.540	0.14
39_L	142_V	0.540	0.14
20_C	31_P	0.538	0.14
37_P	72_I	0.537	0.14
175_K	297_A	0.536	0.14
106_V	218_A	0.532	0.14
186_I	218_A	0.531	0.14
149_G	264_A	0.531	0.14
166_P	263_A	0.530	0.14
25_C	28_H	0.527	0.14
270_S	273_G	0.524	0.14
161_L	245_I	0.523	0.14
149_G	169_E	0.523	0.14
185_G	188_A	0.523	0.14
69_G	75_A	0.523	0.14
125_Y	136_E	0.523	0.14
172_I	225_A	0.522	0.14
110_G	294_L	0.521	0.14
140_T	143_T	0.520	0.14
158_S	161_L	0.520	0.14
164_F	286_L	0.518	0.14
101_M	181_F	0.516	0.14
108_Q	127_L	0.516	0.14
102_W	145_V	0.513	0.14
46_N	151_F	0.512	0.14
39_L	286_L	0.512	0.14
290_G	304_A	0.511	0.14
84_G	233_M	0.511	0.14
131_N	182_L	0.510	0.14
108_Q	144_S	0.507	0.14
174_S	178_V	0.507	0.14
35_D	39_L	0.506	0.14
105_F	296_G	0.505	0.14
141_W	240_N	0.501	0.13
106_V	195_A	0.501	0.13
114_L	267_I	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nr9A	2	0.5766	100	0.596	Contact Map
4njnA	4	0.5315	100	0.603	Contact Map
2xovA	1	0.5285	100	0.615	Contact Map
1wffA	1	0.1772	95.9	0.923	Contact Map
1wfeA	1	0.1802	94.7	0.929	Contact Map
1wysA	1	0.1802	94.2	0.93	Contact Map
1x4vA	1	0.1502	93.8	0.932	Contact Map
1wflA	1	0.1471	93.6	0.932	Contact Map
1wfhA	1	0.1471	93.4	0.933	Contact Map
1wfpA	1	0.1471	93	0.933	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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