GREMLIN Database
Q9HS82 - Uncharacterized protein
UniProt: Q9HS82 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (265)
Sequences: 249 (220)
Seq/√Len: 13.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_Q281_A4.1091.00
157_N226_S3.3730.99
222_T281_A3.1890.98
184_A231_A3.0780.97
147_A223_L3.0450.97
176_K270_S2.9710.97
157_N225_A2.8890.96
17_C20_C2.7250.95
99_G107_I2.5980.93
161_L229_I2.5830.93
102_W158_S2.4240.90
166_P170_D2.4080.90
191_A287_A2.3630.89
192_Q222_T2.3560.89
236_L252_P2.2650.87
161_L177_F2.2610.87
230_A268_F2.2550.87
157_N285_H2.0700.82
224_G292_G2.0590.81
172_I184_A2.0190.80
180_L254_P1.9920.79
146_F173_G1.9910.79
97_F267_I1.9770.78
19_L22_G1.9520.77
128_F225_A1.9410.77
226_S288_G1.9210.76
98_L158_S1.9190.76
139_W296_G1.9030.76
146_F285_H1.9000.75
173_G185_G1.8960.75
107_I265_Y1.8510.73
105_F157_N1.8400.73
125_Y129_T1.8320.73
145_V185_G1.8280.73
228_A288_G1.8130.72
285_H292_G1.8100.72
157_N288_G1.7980.71
225_A228_A1.7980.71
288_G292_G1.7750.70
108_Q147_A1.7680.70
158_S225_A1.7100.67
165_G177_F1.7090.67
153_H173_G1.6670.65
129_T221_A1.6630.65
70_G75_A1.6580.65
144_S189_G1.6390.64
137_Y140_T1.6350.64
146_F287_A1.6280.63
191_A255_L1.6240.63
231_A288_G1.5920.61
149_G223_L1.5440.59
159_I181_F1.5400.59
153_H226_S1.5310.58
148_H285_H1.5200.58
228_A231_A1.5170.58
189_G222_T1.5170.58
101_M104_T1.5060.57
30_L36_C1.4550.54
153_H292_G1.4490.54
81_G86_V1.4470.54
147_A240_N1.4400.54
127_L273_G1.4270.53
228_A284_A1.4270.53
21_G25_C1.4260.53
46_N280_V1.4250.53
177_F185_G1.4230.53
270_S283_L1.4170.52
169_E288_G1.3960.51
18_R21_G1.3930.51
148_H292_G1.3730.50
44_D48_V1.3700.50
141_W189_G1.3640.50
148_H224_G1.3640.50
284_A288_G1.3530.49
98_L225_A1.3470.49
144_S281_A1.3160.47
28_H31_P1.3110.47
297_A301_R1.2980.46
139_W284_A1.2850.45
118_T170_D1.2840.45
218_A221_A1.2760.45
266_S282_Q1.2730.45
234_G237_T1.2620.44
28_H36_C1.2560.44
140_T188_A1.2560.44
139_W169_E1.2530.44
285_H288_G1.2510.44
102_W154_I1.2440.43
106_V263_A1.2360.43
105_F285_H1.2350.43
225_A288_G1.2260.42
247_L252_P1.2210.42
112_A124_W1.2210.42
20_C28_H1.2120.41
226_S285_H1.2070.41
138_V141_W1.2000.41
48_V51_S1.1940.41
185_G228_A1.1910.40
49_F190_L1.1860.40
280_V303_G1.1820.40
131_N134_H1.1740.40
51_S57_V1.1740.40
71_G74_D1.1700.39
100_V155_V1.1580.39
189_G266_S1.1490.38
169_E176_K1.1470.38
155_V191_A1.1380.38
151_F264_A1.1240.37
102_W237_T1.1200.37
64_Q268_F1.1200.37
234_G273_G1.1160.37
150_G270_S1.1110.36
151_F171_R1.1030.36
29_R32_E1.0910.35
98_L161_L1.0910.35
98_L101_M1.0850.35
142_V264_A1.0770.35
28_H38_G1.0760.35
283_L290_G1.0690.34
129_T223_L1.0690.34
139_W143_T1.0660.34
43_G170_D1.0600.34
94_A169_E1.0580.34
146_F165_G1.0560.34
132_T221_A1.0540.34
50_D54_D1.0500.33
101_M161_L1.0480.33
65_S100_V1.0470.33
113_P124_W1.0340.33
148_H153_H1.0300.32
20_C36_C1.0210.32
232_L287_A1.0180.32
24_Y41_N1.0120.32
176_K194_G1.0100.32
86_V90_R1.0030.31
106_V186_I1.0020.31
181_F281_A1.0010.31
109_Y150_G0.9970.31
21_G29_R0.9950.31
270_S282_Q0.9930.31
33_N47_G0.9920.31
133_A233_M0.9910.31
27_D181_F0.9900.31
281_A287_A0.9840.30
161_L185_G0.9840.30
74_D78_I0.9710.30
52_G58_D0.9680.30
20_C34_H0.9630.29
17_C21_G0.9630.29
184_A288_G0.9630.29
132_T257_L0.9580.29
109_Y112_A0.9450.29
18_R22_G0.9360.28
188_A300_K0.9350.28
34_H37_P0.9340.28
88_Y168_V0.9340.28
224_G288_G0.9300.28
27_D87_A0.9270.28
23_T27_D0.9260.28
146_F185_G0.9260.28
53_F57_V0.9250.28
137_Y297_A0.9240.28
287_A290_G0.9220.28
17_C29_R0.9200.28
126_N268_F0.9200.28
83_G90_R0.9190.28
49_F54_D0.9160.27
129_T280_V0.9150.27
153_H227_G0.9080.27
101_M281_A0.9060.27
151_F265_Y0.9040.27
121_S126_N0.9040.27
234_G284_A0.9010.27
21_G28_H0.9000.27
43_G46_N0.9000.27
79_N86_V0.8990.27
97_F283_L0.8940.26
100_V272_T0.8920.26
16_Q22_G0.8860.26
150_G197_L0.8830.26
133_A232_L0.8790.26
128_F157_N0.8720.26
19_L24_Y0.8710.26
25_C32_E0.8700.25
92_N174_S0.8620.25
20_C29_R0.8540.25
249_F264_A0.8530.25
55_D170_D0.8520.25
154_I158_S0.8520.25
273_G283_L0.8470.25
29_R36_C0.8470.25
72_I290_G0.8410.24
42_W49_F0.8380.24
144_S239_L0.8380.24
136_E150_G0.8340.24
103_V265_Y0.8340.24
68_G73_A0.8330.24
219_F269_V0.8320.24
125_Y154_I0.8200.24
94_A179_A0.8170.23
34_H38_G0.8160.23
129_T147_A0.8130.23
32_E38_G0.8100.23
47_G291_I0.8030.23
153_H224_G0.7970.23
85_L88_Y0.7940.23
147_A169_E0.7910.22
168_V284_A0.7900.22
273_G290_G0.7900.22
140_T150_G0.7900.22
119_D231_A0.7890.22
146_F177_F0.7880.22
239_L289_L0.7870.22
30_L34_H0.7870.22
35_D150_G0.7830.22
122_P271_G0.7820.22
271_G301_R0.7760.22
24_Y82_P0.7760.22
28_H32_E0.7740.22
128_F249_F0.7730.22
25_C286_L0.7720.22
46_N68_G0.7710.22
157_N301_R0.7700.22
260_G264_A0.7670.22
142_V186_I0.7670.22
193_V222_T0.7630.21
67_G74_D0.7610.21
196_S221_A0.7590.21
25_C31_P0.7580.21
253_M267_I0.7570.21
181_F185_G0.7570.21
236_L247_L0.7530.21
146_F281_A0.7490.21
17_C28_H0.7470.21
251_I254_P0.7470.21
16_Q19_L0.7460.21
168_V288_G0.7460.21
21_G32_E0.7450.21
25_C29_R0.7450.21
40_E58_D0.7450.21
142_V161_L0.7440.21
108_Q112_A0.7430.21
254_P257_L0.7410.21
44_D47_G0.7350.20
234_G289_L0.7330.20
49_F53_F0.7310.20
182_L231_A0.7300.20
221_A299_L0.7290.20
95_F294_L0.7260.20
17_C36_C0.7220.20
172_I185_G0.7210.20
68_G294_L0.7150.20
267_I277_A0.7140.20
39_L52_G0.7140.20
16_Q41_N0.7140.20
20_C30_L0.7120.20
94_A182_L0.7120.20
58_D73_A0.7100.20
128_F177_F0.7100.20
42_W53_F0.7080.19
176_K218_A0.7080.19
180_L188_A0.7040.19
149_G266_S0.7010.19
240_N256_W0.6910.19
69_G277_A0.6910.19
71_G75_A0.6860.19
193_V269_V0.6850.19
157_N284_A0.6840.19
132_T218_A0.6820.19
22_G26_S0.6810.19
67_G77_P0.6780.19
63_Q79_N0.6770.18
230_A271_G0.6760.18
42_W62_T0.6760.18
99_G265_Y0.6710.18
189_G284_A0.6700.18
144_S222_T0.6670.18
20_C32_E0.6660.18
154_I231_A0.6650.18
152_S290_G0.6630.18
32_E286_L0.6580.18
43_G56_T0.6570.18
259_T266_S0.6540.18
100_V131_N0.6540.18
21_G31_P0.6520.18
110_G143_T0.6510.18
182_L186_I0.6490.18
45_P48_V0.6480.18
47_G52_G0.6460.17
228_A281_A0.6410.17
21_G50_D0.6400.17
140_T241_P0.6360.17
120_R133_A0.6340.17
185_G281_A0.6330.17
253_M257_L0.6330.17
170_D269_V0.6330.17
123_T264_A0.6320.17
272_T280_V0.6320.17
161_L244_R0.6290.17
20_C24_Y0.6290.17
180_L195_A0.6280.17
104_T108_Q0.6240.17
60_Q180_L0.6240.17
60_Q106_V0.6230.17
48_V52_G0.6230.17
120_R127_L0.6200.17
78_I87_A0.6190.17
100_V300_K0.6180.17
148_H288_G0.6160.17
170_D232_L0.6150.17
140_T162_Y0.6140.17
17_C25_C0.6120.16
170_D185_G0.6110.16
143_T169_E0.6080.16
152_S287_A0.6080.16
167_I255_L0.6060.16
94_A229_I0.6020.16
301_R306_A0.6020.16
106_V302_E0.6020.16
147_A261_L0.6010.16
34_H54_D0.6000.16
67_G73_A0.6000.16
149_G160_V0.5980.16
36_C241_P0.5970.16
140_T278_G0.5970.16
280_V284_A0.5930.16
106_V278_G0.5920.16
168_V287_A0.5910.16
27_D73_A0.5900.16
94_A184_A0.5880.16
153_H285_H0.5870.16
224_G227_G0.5840.16
227_G285_H0.5820.16
101_M158_S0.5800.16
110_G219_F0.5790.16
151_F154_I0.5790.16
148_H157_N0.5770.15
98_L281_A0.5740.15
150_G169_E0.5710.15
38_G67_G0.5690.15
233_M261_L0.5680.15
85_L89_F0.5680.15
21_G30_L0.5660.15
42_W45_P0.5650.15
139_W228_A0.5630.15
161_L188_A0.5620.15
28_H34_H0.5610.15
48_V60_Q0.5600.15
190_L231_A0.5560.15
28_H264_A0.5550.15
144_S228_A0.5550.15
41_N110_G0.5540.15
142_V179_A0.5540.15
153_H288_G0.5520.15
40_E59_G0.5510.15
53_F56_T0.5460.15
24_Y32_E0.5460.15
271_G277_A0.5450.15
156_L290_G0.5450.15
229_I262_F0.5440.15
144_S159_I0.5440.15
158_S181_F0.5410.14
132_T136_E0.5400.14
39_L142_V0.5400.14
20_C31_P0.5380.14
37_P72_I0.5370.14
175_K297_A0.5360.14
106_V218_A0.5320.14
186_I218_A0.5310.14
149_G264_A0.5310.14
166_P263_A0.5300.14
25_C28_H0.5270.14
270_S273_G0.5240.14
161_L245_I0.5230.14
149_G169_E0.5230.14
185_G188_A0.5230.14
69_G75_A0.5230.14
125_Y136_E0.5230.14
172_I225_A0.5220.14
110_G294_L0.5210.14
140_T143_T0.5200.14
158_S161_L0.5200.14
164_F286_L0.5180.14
101_M181_F0.5160.14
108_Q127_L0.5160.14
102_W145_V0.5130.14
46_N151_F0.5120.14
39_L286_L0.5120.14
290_G304_A0.5110.14
84_G233_M0.5110.14
131_N182_L0.5100.14
108_Q144_S0.5070.14
174_S178_V0.5070.14
35_D39_L0.5060.14
105_F296_G0.5050.14
141_W240_N0.5010.13
106_V195_A0.5010.13
114_L267_I0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nr9A 2 0.5766 100 0.596 Contact Map
4njnA 4 0.5315 100 0.603 Contact Map
2xovA 1 0.5285 100 0.615 Contact Map
1wffA 1 0.1772 95.9 0.923 Contact Map
1wfeA 1 0.1802 94.7 0.929 Contact Map
1wysA 1 0.1802 94.2 0.93 Contact Map
1x4vA 1 0.1502 93.8 0.932 Contact Map
1wflA 1 0.1471 93.6 0.932 Contact Map
1wfhA 1 0.1471 93.4 0.933 Contact Map
1wfpA 1 0.1471 93 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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