GREMLIN Database
NFI - Endonuclease V
UniProt: Q9HS81 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (207)
Sequences: 856 (578)
Seq/√Len: 40.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_Q201_A3.8131.00
173_P224_Y3.4811.00
147_A151_T3.3871.00
67_V94_I3.1531.00
205_Y237_A3.1391.00
180_P185_T3.1391.00
71_V120_V3.1101.00
135_V253_T2.7621.00
257_D261_A2.7241.00
209_S223_L2.6241.00
96_R259_Y2.5201.00
89_R243_T2.4611.00
133_L239_L2.3891.00
227_P233_A2.3511.00
141_R151_T2.2851.00
49_P52_Q2.2391.00
124_L157_F2.1950.99
182_P211_Q2.1940.99
232_S235_T2.1740.99
209_S244_C2.1170.99
134_L161_A2.0910.99
158_D230_R2.0730.99
202_V205_Y2.0140.99
162_V240_V2.0070.99
95_E128_S1.9760.99
44_G47_E1.9120.99
83_S88_I1.9010.98
124_L134_L1.8990.98
75_F103_L1.8870.98
168_L206_A1.8830.98
139_S142_I1.8720.98
52_Q56_G1.8610.98
141_R227_P1.8320.98
56_G155_V1.8060.98
51_E55_L1.7880.98
52_Q55_L1.6970.97
173_P176_A1.6690.96
42_R111_L1.6610.96
85_A88_I1.6490.96
117_G153_V1.6080.96
74_A260_A1.5870.95
207_L241_E1.5830.95
205_Y233_A1.5780.95
122_D125_S1.5440.94
168_L189_I1.5020.94
206_A224_Y1.4880.93
182_P185_T1.4870.93
136_V153_V1.4850.93
153_V157_F1.4470.92
186_R205_Y1.4450.92
181_L185_T1.4370.92
101_A122_D1.4220.92
53_A56_G1.4220.92
135_V164_V1.4190.92
202_V233_A1.3720.90
60_T232_S1.3710.90
146_Q198_P1.3690.90
101_A119_A1.3570.90
46_D111_L1.3500.89
189_I206_A1.3430.89
105_V257_D1.3230.88
181_L219_H1.3130.88
74_A261_A1.3070.88
165_A255_L1.2950.87
73_Q120_V1.2950.87
58_A227_P1.2710.86
136_V252_P1.2630.86
45_L49_P1.2470.85
186_R237_A1.2380.85
257_D260_A1.2300.84
142_I204_G1.2290.84
139_S167_S1.2060.83
170_C203_V1.1720.81
135_V243_T1.1660.81
76_R79_E1.1560.80
211_Q220_I1.1540.80
135_V240_V1.1490.80
162_V239_L1.1340.79
50_G53_A1.1300.79
173_P187_V1.1260.79
134_L159_V1.1010.77
142_I189_I1.0890.76
48_P51_E1.0750.75
176_A187_V1.0750.75
41_E44_G1.0680.75
175_A181_L1.0650.75
41_E49_P1.0650.75
41_E45_L1.0640.75
73_Q223_L1.0530.74
71_V153_V1.0530.74
139_S165_A1.0510.74
88_I127_L1.0490.74
198_P203_V1.0430.73
47_E50_G1.0410.73
49_P56_G1.0290.72
65_A239_L1.0190.71
110_G152_H1.0170.71
124_L153_V1.0070.70
210_R244_C1.0050.70
210_R220_I1.0000.70
149_L169_L0.9970.70
95_E129_V0.9970.70
165_A253_T0.9880.69
239_L242_A0.9720.68
65_A132_D0.9700.68
82_V119_A0.9700.68
139_S171_G0.9680.67
74_A257_D0.9570.66
252_P255_L0.9550.66
134_L153_V0.9530.66
45_L48_P0.9470.66
227_P236_A0.9470.66
198_P201_A0.9400.65
111_L142_I0.9390.65
56_G227_P0.9390.65
71_V134_L0.9360.65
51_E54_A0.9320.64
251_A254_R0.9320.64
222_P254_R0.9250.64
78_D87_A0.9240.64
124_L130_E0.9220.64
82_V85_A0.9220.64
183_A246_Q0.9200.63
76_R83_S0.9100.62
239_L252_P0.9060.62
188_A205_Y0.9040.62
74_A82_V0.9040.62
97_A126_S0.9010.62
121_I157_F0.9010.62
74_A83_S0.9000.62
40_P48_P0.8970.61
99_G126_S0.8950.61
62_G65_A0.8880.61
139_S169_L0.8850.60
46_D49_P0.8810.60
210_R252_P0.8800.60
151_T161_A0.8610.58
83_S261_A0.8610.58
207_L244_C0.8590.58
71_V112_L0.8490.57
88_I129_V0.8480.57
44_G49_P0.8450.57
75_F83_S0.8410.56
120_V136_V0.8390.56
77_D80_V0.8370.56
53_A68_V0.8360.56
123_A127_L0.8300.55
42_R46_D0.8250.55
59_T62_G0.8240.55
164_V248_K0.8170.54
59_T235_T0.8080.53
209_S241_E0.8080.53
59_T232_S0.8060.53
237_A241_E0.8000.53
48_P111_L0.7970.52
55_L59_T0.7940.52
68_V71_V0.7940.52
172_T197_A0.7920.52
103_L260_A0.7860.51
86_V124_L0.7840.51
111_L155_V0.7830.51
82_V103_L0.7820.51
79_E82_V0.7780.51
79_E83_S0.7750.50
87_A93_V0.7710.50
248_K254_R0.7670.50
241_E244_C0.7580.49
49_P55_L0.7470.48
69_V167_S0.7470.48
164_V260_A0.7460.48
73_Q117_G0.7270.46
70_G115_R0.7120.45
120_V153_V0.7120.45
44_G54_A0.7120.45
205_Y227_P0.7110.44
48_P52_Q0.7090.44
137_D166_K0.7080.44
224_Y234_G0.7060.44
255_L258_Q0.7040.44
62_G234_G0.6960.43
68_V92_A0.6920.43
126_S156_L0.6910.43
94_I247_Y0.6910.43
65_A167_S0.6890.43
82_V121_I0.6880.42
47_E54_A0.6870.42
65_A231_V0.6780.42
184_G241_E0.6770.41
161_A175_A0.6750.41
202_V225_V0.6730.41
133_L249_L0.6720.41
71_V124_L0.6690.41
57_G62_G0.6680.41
160_P236_A0.6650.40
259_Y262_D0.6650.40
84_A87_A0.6650.40
223_L240_V0.6610.40
60_T235_T0.6600.40
165_A203_V0.6590.40
180_P187_V0.6590.40
48_P56_G0.6550.39
117_G252_P0.6550.39
57_G61_S0.6540.39
207_L237_A0.6530.39
98_A259_Y0.6500.39
245_T252_P0.6500.39
118_S208_Q0.6460.39
42_R45_L0.6460.39
67_V132_D0.6400.38
39_T221_N0.6390.38
155_V229_H0.6380.38
164_V209_S0.6380.38
113_A260_A0.6370.38
180_P241_E0.6360.38
168_L205_Y0.6330.38
69_V132_D0.6330.38
154_G229_H0.6310.37
99_G122_D0.6300.37
240_V248_K0.6280.37
113_A139_S0.6270.37
72_D166_K0.6240.37
208_Q220_I0.6190.36
133_L162_V0.6190.36
66_P129_V0.6180.36
135_V157_F0.6170.36
46_D50_G0.6150.36
61_S232_S0.6140.36
86_V93_V0.6120.36
49_P53_A0.6040.35
113_A261_A0.5980.35
141_R147_A0.5950.34
131_P184_G0.5920.34
56_G61_S0.5900.34
75_F261_A0.5900.34
113_A199_D0.5890.34
51_E225_V0.5890.34
123_A210_R0.5890.34
74_A258_Q0.5880.34
258_Q262_D0.5880.34
222_P248_K0.5880.34
227_P230_R0.5860.34
73_Q149_L0.5820.33
83_S260_A0.5820.33
76_R100_N0.5810.33
133_L257_D0.5800.33
92_A175_A0.5800.33
79_E202_V0.5760.33
225_V231_V0.5760.33
135_V158_D0.5740.33
107_Y112_L0.5730.33
101_A232_S0.5720.32
208_Q233_A0.5720.32
71_V161_A0.5700.32
152_H156_L0.5690.32
67_V129_V0.5680.32
43_I46_D0.5670.32
77_D159_V0.5650.32
73_Q80_V0.5640.32
99_G123_A0.5630.32
127_L131_P0.5600.32
85_A260_A0.5570.31
95_E126_S0.5570.31
83_S119_A0.5560.31
105_V261_A0.5550.31
153_V159_V0.5530.31
170_C198_P0.5530.31
184_G220_I0.5520.31
164_V261_A0.5510.31
81_S85_A0.5510.31
103_L119_A0.5500.31
122_D126_S0.5490.31
167_S210_R0.5470.30
107_Y115_R0.5470.30
48_P55_L0.5470.30
135_V162_V0.5460.30
76_R82_V0.5450.30
207_L231_V0.5440.30
56_G60_T0.5400.30
105_V108_V0.5390.30
48_P53_A0.5380.30
85_A98_A0.5370.30
131_P152_H0.5340.29
180_P207_L0.5320.29
94_I161_A0.5310.29
131_P248_K0.5290.29
70_G253_T0.5270.29
255_L259_Y0.5240.29
71_V77_D0.5230.29
110_G114_F0.5220.29
154_G251_A0.5220.29
112_L165_A0.5210.29
120_V124_L0.5200.28
123_A249_L0.5190.28
74_A253_T0.5190.28
113_A152_H0.5170.28
117_G159_V0.5170.28
73_Q249_L0.5160.28
66_P133_L0.5160.28
236_A244_C0.5160.28
83_S86_V0.5160.28
57_G60_T0.5140.28
189_I224_Y0.5090.28
234_G238_D0.5080.28
160_P257_D0.5060.27
79_E112_L0.5040.27
183_A238_D0.5040.27
44_G55_L0.5020.27
45_L52_Q0.5010.27
121_I156_L0.5000.27
119_A188_A0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ga2A 1 0.8371 100 0.283 Contact Map
4nspA 1 0.822 100 0.305 Contact Map
2w36A 1 0.8258 100 0.374 Contact Map
3gocA 2 0.822 100 0.406 Contact Map
2qh9A 2 0.6477 100 0.527 Contact Map
2nrrA 1 0.5189 96.7 0.923 Contact Map
2ygkA 2 0.8598 94.4 0.934 Contact Map
3c65A 1 0.5417 94 0.936 Contact Map
2nrtA 1 0.7386 91.6 0.94 Contact Map
1yvuA 1 0.8144 70.6 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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