GREMLIN Database
Q9HS79 - Arsenical pump-driving ATPase
UniProt: Q9HS79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (299)
Sequences: 1789 (1087)
Seq/√Len: 62.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_S340_R7.1081.00
85_W153_F5.4971.00
45_S155_R5.3511.00
244_P274_V5.2511.00
315_Q325_R4.4831.00
297_C300_C4.4281.00
26_Y41_T4.3031.00
37_M270_V3.4961.00
37_M326_V3.0531.00
304_W308_Q2.9121.00
50_T154_D2.8131.00
54_V86_A2.7281.00
271_V311_L2.6951.00
77_R80_E2.6671.00
51_N154_D2.6401.00
163_T251_E2.6181.00
71_I78_I2.4981.00
78_I86_A2.4611.00
77_R85_W2.4171.00
71_I86_A2.3471.00
50_T155_R2.2581.00
72_P76_H2.2331.00
42_A54_V2.2141.00
60_A251_E2.2081.00
149_D225_Q2.1721.00
44_A48_D2.1481.00
46_A49_G2.1351.00
253_N317_I2.0691.00
275_M307_Q2.0261.00
65_D307_Q1.9981.00
94_A97_R1.9711.00
249_V314_A1.9671.00
65_D254_R1.9511.00
274_V311_L1.9351.00
308_Q312_A1.8751.00
242_L269_V1.8431.00
39_A63_L1.8031.00
331_E338_P1.8031.00
224_E228_A1.8021.00
232_D235_R1.7951.00
57_T161_A1.7951.00
45_S52_T1.7661.00
57_T169_L1.7510.99
160_T166_T1.7250.99
239_R267_N1.6980.99
274_V325_R1.6900.99
56_S61_H1.6900.99
174_E227_R1.6550.99
67_L86_A1.6540.99
271_V314_A1.6520.99
105_G109_G1.6450.99
240_V256_I1.6450.99
56_S62_S1.6160.99
28_G31_G1.6050.99
144_L158_V1.5940.99
93_D97_R1.5830.99
69_A79_R1.5760.99
245_E303_R1.5590.99
167_L335_G1.5510.99
47_S344_A1.5440.99
166_T169_L1.5290.99
26_Y239_R1.5220.99
170_L173_P1.5160.98
263_G333_V1.5090.98
312_A316_D1.5070.98
276_E307_Q1.4990.98
107_L111_L1.4690.98
36_T342_V1.4550.98
240_V255_L1.4430.98
243_V273_R1.4350.98
245_E248_S1.4240.98
27_G238_F1.3490.97
250_A253_N1.3460.97
64_S88_E1.3440.97
161_A169_L1.3420.97
268_T324_K1.3410.97
94_A143_L1.3220.96
21_A237_D1.3000.96
71_I75_P1.2890.96
249_V310_A1.2860.96
143_L146_E1.2760.96
181_G220_K1.2740.96
96_D105_G1.2670.95
41_T239_R1.2620.95
111_L114_M1.2540.95
43_V336_E1.2500.95
36_T329_L1.2500.95
91_P139_A1.2330.95
77_R82_V1.2280.95
29_K164_G1.2230.94
30_G33_G1.2200.94
36_T333_V1.2090.94
75_P85_W1.1980.94
51_N151_D1.1960.94
309_Q313_D1.1950.94
305_D312_A1.1940.94
39_A54_V1.1930.94
55_V87_V1.1810.93
242_L314_A1.1650.93
24_V155_R1.1570.93
98_T139_A1.1510.92
36_T324_K1.1430.92
195_D199_G1.1410.92
312_A315_Q1.1320.92
60_A162_P1.1280.92
29_K56_S1.1240.91
219_V244_P1.1190.91
34_K251_E1.1190.91
54_V63_L1.1160.91
338_P341_V1.1120.91
110_T113_T1.1080.91
336_E340_R1.1030.91
314_A318_F1.0990.91
161_A166_T1.0960.90
71_I87_V1.0910.90
58_D272_N1.0880.90
240_V252_S1.0840.90
28_G33_G1.0830.90
43_V340_R1.0830.90
166_T170_L1.0770.90
156_V304_W1.0770.90
58_D251_E1.0720.89
234_Q316_D1.0570.89
69_A86_A1.0540.89
89_I157_V1.0500.88
298_A301_A1.0470.88
57_T259_L1.0450.88
46_A90_D1.0380.88
56_S88_E1.0340.88
160_T248_S1.0230.87
139_A172_L1.0220.87
75_P169_L1.0190.87
67_L71_I1.0170.87
46_A170_L1.0140.87
32_V162_P0.9960.86
242_L271_V0.9950.86
32_V60_A0.9930.85
61_H65_D0.9900.85
76_H86_A0.9890.85
124_G180_V0.9810.85
29_K32_V0.9800.85
32_V251_E0.9800.85
242_L248_S0.9720.84
221_E224_E0.9660.84
60_A163_T0.9660.84
87_V147_Y0.9540.83
34_K60_A0.9510.83
135_A139_A0.9510.83
61_H251_E0.9480.83
256_I266_V0.9460.83
62_S65_D0.9450.82
57_T163_T0.9320.82
313_D317_I0.9270.81
57_T166_T0.9260.81
59_P160_T0.9190.81
38_A72_P0.9140.80
326_V342_V0.9130.80
75_P87_V0.9100.80
295_E304_W0.9090.80
339_L343_A0.9090.80
34_K163_T0.9070.80
306_V310_A0.9050.80
97_R146_E0.9040.80
152_R341_V0.9030.79
127_G193_M0.8960.79
60_A164_G0.8940.79
160_T247_L0.8910.79
160_T165_H0.8870.78
225_Q228_A0.8870.78
53_L89_I0.8770.77
38_A180_V0.8770.77
326_V329_L0.8770.77
164_G247_L0.8760.77
29_K61_H0.8730.77
191_G213_M0.8660.77
77_R81_N0.8640.76
167_L254_R0.8630.76
152_R277_P0.8610.76
337_R340_R0.8580.76
252_S256_I0.8560.76
25_L158_V0.8520.75
115_L121_A0.8480.75
47_S336_E0.8460.75
35_T335_G0.8450.75
238_F303_R0.8440.75
30_G34_K0.8390.74
162_P251_E0.8290.73
88_E252_S0.8290.73
39_A238_F0.8280.73
61_H164_G0.8270.73
43_V47_S0.8240.73
32_V163_T0.8230.73
109_G298_A0.8190.72
29_K62_S0.8130.72
60_A173_P0.8110.72
276_E304_W0.8110.72
28_G32_V0.8110.72
43_V339_L0.8100.72
57_T164_G0.8070.71
29_K34_K0.8060.71
54_V96_D0.8050.71
239_R261_E0.8030.71
58_D164_G0.8020.71
166_T251_E0.7990.71
38_A45_S0.7960.70
257_T261_E0.7940.70
93_D96_D0.7890.70
161_A164_G0.7860.69
129_A165_H0.7830.69
228_A305_D0.7830.69
62_S254_R0.7780.69
195_D214_G0.7760.68
63_L244_P0.7680.68
44_A343_A0.7680.68
237_D267_N0.7670.67
304_W307_Q0.7640.67
249_V255_L0.7640.67
44_A47_S0.7640.67
110_T116_G0.7630.67
50_T54_V0.7590.67
315_Q323_V0.7590.67
183_L186_V0.7530.66
62_S164_G0.7520.66
138_A158_V0.7520.66
177_D220_K0.7500.66
129_A262_Y0.7480.66
65_D167_L0.7460.65
60_A65_D0.7460.65
239_R268_T0.7430.65
25_L141_M0.7380.64
195_D200_M0.7380.64
195_D207_A0.7350.64
53_L153_F0.7350.64
79_R322_T0.7330.64
132_M139_A0.7310.64
222_R266_V0.7290.64
163_T259_L0.7280.63
66_T335_G0.7280.63
188_E210_E0.7190.62
112_E116_G0.7190.62
310_A313_D0.7170.62
105_G112_E0.7160.62
29_K254_R0.7130.62
53_L169_L0.7130.62
61_H161_A0.7110.62
42_A157_V0.7070.61
38_A73_S0.7050.61
37_M222_R0.7020.61
71_I76_H0.7020.61
158_V226_L0.6990.60
228_A232_D0.6990.60
140_A219_V0.6930.60
163_T254_R0.6910.59
269_V305_D0.6890.59
277_P309_Q0.6890.59
54_V62_S0.6870.59
227_R231_T0.6860.59
144_L244_P0.6860.59
98_T127_G0.6850.59
341_V344_A0.6830.59
55_V91_P0.6820.58
43_V81_N0.6800.58
245_E252_S0.6790.58
224_E231_T0.6780.58
245_E310_A0.6780.58
181_G333_V0.6770.58
133_P307_Q0.6760.58
305_D308_Q0.6750.58
236_T336_E0.6730.57
301_A344_A0.6710.57
180_V220_K0.6710.57
61_H88_E0.6700.57
52_T243_V0.6700.57
61_H163_T0.6680.57
29_K168_R0.6680.57
251_E254_R0.6660.57
57_T137_E0.6660.57
121_A124_G0.6640.56
332_E335_G0.6630.56
246_E313_D0.6620.56
128_S267_N0.6620.56
214_G263_G0.6610.56
232_D236_T0.6580.56
37_M339_L0.6540.55
188_E191_G0.6540.55
137_E163_T0.6530.55
163_T167_L0.6520.55
31_G35_T0.6510.55
209_A212_T0.6510.55
99_G130_A0.6510.55
297_C304_W0.6500.55
128_S138_A0.6500.55
163_T168_R0.6500.55
191_G252_S0.6480.55
27_G57_T0.6470.54
191_G195_D0.6440.54
166_T259_L0.6440.54
132_M240_V0.6440.54
246_E250_A0.6420.54
73_S143_L0.6420.54
221_E278_L0.6400.54
168_R173_P0.6350.53
36_T341_V0.6350.53
157_V298_A0.6340.53
34_K65_D0.6330.53
59_P255_L0.6330.53
25_L62_S0.6330.53
77_R337_R0.6330.53
313_D316_D0.6320.53
301_A305_D0.6310.53
46_A317_I0.6310.53
24_V41_T0.6300.52
136_D163_T0.6300.52
163_T255_L0.6280.52
73_S319_R0.6250.52
61_H247_L0.6210.51
32_V57_T0.6200.51
36_T255_L0.6190.51
33_G36_T0.6190.51
113_T156_V0.6190.51
117_G124_G0.6170.51
45_S50_T0.6150.51
129_A141_M0.6150.51
252_S264_V0.6110.50
139_A226_L0.6100.50
59_P137_E0.6100.50
180_V217_D0.6080.50
340_R344_A0.6080.50
302_R331_E0.6070.50
167_L307_Q0.6040.50
162_P173_P0.6040.50
78_I308_Q0.6020.49
196_G202_G0.6020.49
59_P122_P0.6020.49
29_K88_E0.6010.49
157_V183_L0.5990.49
74_R341_V0.5990.49
48_D93_D0.5990.49
254_R307_Q0.5990.49
62_S251_E0.5970.49
30_G35_T0.5960.49
122_P125_G0.5960.49
64_S307_Q0.5940.48
162_P166_T0.5930.48
137_E168_R0.5900.48
89_I276_E0.5880.48
218_A338_P0.5880.48
160_T173_P0.5880.48
219_V223_V0.5880.48
230_L251_E0.5840.47
62_S88_E0.5840.47
22_E235_R0.5830.47
160_T251_E0.5830.47
133_P303_R0.5820.47
157_V244_P0.5810.47
55_V314_A0.5780.47
189_R344_A0.5780.47
48_D109_G0.5780.47
253_N302_R0.5770.46
115_L211_Q0.5770.46
308_Q315_Q0.5760.46
239_R270_V0.5760.46
67_L158_V0.5750.46
113_T117_G0.5740.46
22_E148_L0.5740.46
54_V85_W0.5730.46
166_T247_L0.5720.46
253_N257_T0.5710.46
328_L332_E0.5700.46
113_T174_E0.5680.45
142_Q158_V0.5660.45
269_V307_Q0.5660.45
238_F333_V0.5650.45
90_D182_Q0.5650.45
45_S157_V0.5630.45
159_D272_N0.5620.45
57_T158_V0.5620.45
300_C307_Q0.5620.45
163_T173_P0.5610.45
221_E309_Q0.5610.45
77_R152_R0.5600.44
180_V209_A0.5600.44
34_K58_D0.5590.44
204_D207_A0.5580.44
107_L115_L0.5580.44
38_A157_V0.5570.44
94_A140_A0.5560.44
42_A51_N0.5540.44
75_P78_I0.5530.44
22_E237_D0.5500.43
214_G308_Q0.5500.43
56_S60_A0.5490.43
173_P259_L0.5490.43
23_Y148_L0.5490.43
254_R335_G0.5480.43
235_R309_Q0.5470.43
111_L126_D0.5460.43
98_T158_V0.5450.43
168_R175_V0.5440.43
312_A336_E0.5440.43
56_S65_D0.5430.43
191_G194_M0.5430.43
226_L306_V0.5420.42
21_A144_L0.5410.42
42_A276_E0.5410.42
65_D252_S0.5400.42
34_K161_A0.5380.42
123_G157_V0.5370.42
55_V216_L0.5360.42
26_Y40_A0.5360.42
256_I260_D0.5350.42
59_P165_H0.5350.42
218_A334_R0.5320.41
54_V176_M0.5320.41
69_A76_H0.5310.41
56_S167_L0.5290.41
73_S93_D0.5290.41
24_V310_A0.5280.41
160_T164_G0.5280.41
179_M299_F0.5270.41
42_A67_L0.5270.41
65_D275_M0.5270.41
62_S161_A0.5260.41
65_D164_G0.5260.41
161_A165_H0.5260.41
308_Q337_R0.5230.40
202_G207_A0.5220.40
124_G139_A0.5210.40
139_A147_Y0.5200.40
61_H254_R0.5190.40
305_D309_Q0.5180.40
179_M216_L0.5170.40
108_S113_T0.5170.40
88_E164_G0.5170.40
176_M223_V0.5160.40
80_E157_V0.5140.39
229_V235_R0.5100.39
42_A64_S0.5080.39
233_P265_P0.5080.39
237_D265_P0.5080.39
195_D209_A0.5070.39
238_F255_L0.5070.39
251_E259_L0.5040.38
53_L133_P0.5020.38
99_G131_M0.5020.38
162_P245_E0.5020.38
93_D225_Q0.5010.38
196_G204_D0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iqwA 2 0.7291 100 0.396 Contact Map
3io3A 2 0.611 100 0.404 Contact Map
2wojA 2 0.8415 100 0.412 Contact Map
2wooA 5 0.8617 100 0.426 Contact Map
3igfA 2 0.7378 100 0.473 Contact Map
3ug7A 4 0.9049 100 0.505 Contact Map
3zq6A 2 0.8703 100 0.512 Contact Map
1ihuA 3 0.8242 100 0.532 Contact Map
3kjhA 2 0.6945 99.8 0.78 Contact Map
5aunB 2 0.6888 99.8 0.782 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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