GREMLIN Database
Q9HS77 - Uncharacterized protein
UniProt: Q9HS77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 171 (151)
Sequences: 4579 (3486)
Seq/√Len: 283.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_G49_Y2.6891.00
83_A103_T2.6741.00
23_H98_W2.6671.00
68_S85_Q2.5321.00
63_L69_R2.3761.00
71_H85_Q2.3481.00
36_I102_T2.2731.00
19_R48_A2.2381.00
26_A96_T2.1201.00
71_H82_V2.0411.00
69_R73_D1.9711.00
75_H81_P1.9281.00
80_E84_R1.9241.00
33_G41_T1.9091.00
121_Y141_R1.8931.00
38_S42_D1.8411.00
91_R125_A1.8181.00
35_L156_A1.7721.00
37_G50_F1.7131.00
39_L156_A1.7071.00
23_H97_T1.6541.00
52_R64_D1.6161.00
52_R94_A1.6101.00
121_Y139_V1.5831.00
84_R139_V1.5641.00
124_V162_V1.5071.00
35_L38_S1.4881.00
72_L77_A1.4751.00
56_T86_M1.4731.00
38_S152_K1.4681.00
90_V99_G1.4611.00
161_T165_A1.4591.00
80_E121_Y1.4581.00
68_S71_H1.4381.00
37_G55_V1.4361.00
111_G114_E1.4321.00
84_R88_R1.4271.00
52_R61_A1.4261.00
59_Y77_A1.4081.00
42_D152_K1.4081.00
28_A65_H1.4001.00
44_P109_D1.3761.00
88_R137_T1.3621.00
24_T51_D1.3521.00
27_T36_I1.3271.00
91_R127_A1.3221.00
147_D150_A1.3051.00
36_I159_A1.2931.00
98_W126_Y1.2931.00
11_E39_L1.2881.00
105_I115_K1.2781.00
17_A164_A1.2701.00
28_A90_V1.2591.00
51_D60_D1.2381.00
87_A125_A1.2271.00
25_V40_L1.2201.00
35_L152_K1.2061.00
15_G43_V1.2051.00
64_D95_G1.2011.00
13_S164_A1.1951.00
122_I142_R1.1681.00
40_L50_F1.1671.00
70_E74_E1.1501.00
56_T61_A1.1421.00
17_A21_A1.1401.00
142_R158_A1.1331.00
97_T127_A1.1171.00
161_T164_A1.1131.00
54_Y94_A1.1011.00
61_A94_A1.0941.00
18_L23_H1.0931.00
119_T141_R1.0901.00
158_A161_T1.0831.00
54_Y90_V1.0781.00
75_H79_S1.0751.00
41_T50_F1.0751.00
51_D96_T1.0711.00
27_T50_F1.0691.00
98_W163_L1.0601.00
138_T166_E1.0581.00
124_V166_E1.0581.00
66_G93_Q1.0491.00
125_A137_T1.0481.00
26_A90_V1.0451.00
105_I110_G1.0341.00
12_Q16_D1.0181.00
102_T155_I1.0121.00
24_T97_T1.0081.00
38_S156_A0.9941.00
25_V163_L0.9891.00
84_R137_T0.9851.00
17_A20_D0.9811.00
146_G151_V0.9791.00
14_L164_A0.9791.00
27_T53_S0.9711.00
15_G40_L0.9581.00
14_L163_L0.9561.00
37_G53_S0.9401.00
122_I158_A0.9371.00
101_A123_G0.9321.00
9_P12_Q0.9231.00
126_Y129_D0.9231.00
16_D19_R0.9191.00
67_V89_G0.9141.00
119_T143_E0.9061.00
27_T37_G0.9031.00
102_T159_A0.8991.00
120_A155_I0.8801.00
91_R99_G0.8801.00
76_G115_K0.8791.00
140_V162_V0.8791.00
51_D58_S0.8651.00
139_V144_F0.8611.00
14_L160_L0.8551.00
87_A123_G0.8531.00
149_Q152_K0.8381.00
140_V158_A0.8321.00
150_A154_Q0.8221.00
100_I163_L0.8211.00
15_G19_R0.8191.00
100_I159_A0.8181.00
60_D64_D0.8130.99
115_K119_T0.8130.99
144_F158_A0.8090.99
48_A109_D0.8090.99
11_E43_V0.8070.99
146_G150_A0.8050.99
41_T46_A0.8020.99
26_A94_A0.7980.99
63_L72_L0.7950.99
11_E42_D0.7940.99
35_L39_L0.7930.99
42_D149_Q0.7920.99
31_C102_T0.7870.99
27_T100_I0.7770.99
36_I156_A0.7720.99
31_C120_A0.7710.99
110_G116_P0.7700.99
162_V166_E0.7640.99
15_G46_A0.7640.99
41_T152_K0.7570.99
88_R125_A0.7530.99
39_L42_D0.7480.99
91_R126_Y0.7430.99
65_H86_M0.7380.99
117_V151_V0.7380.99
67_V82_V0.7370.99
71_H81_P0.7360.99
90_V94_A0.7350.99
23_H126_Y0.7300.99
54_Y93_Q0.7290.99
126_Y166_E0.7120.99
10_I164_A0.7110.99
120_A151_V0.7080.99
16_D20_D0.7040.99
105_I111_G0.7030.99
11_E15_G0.6990.98
67_V71_H0.6860.98
158_A162_V0.6840.98
88_R92_D0.6790.98
64_D93_Q0.6740.98
151_V155_I0.6730.98
18_L98_W0.6700.98
111_G117_V0.6670.98
149_Q153_A0.6630.98
45_G148_R0.6630.98
39_L157_R0.6550.98
146_G154_Q0.6530.98
88_R91_R0.6530.98
15_G18_L0.6530.98
18_L25_V0.6510.98
59_Y76_G0.6440.97
59_Y111_G0.6370.97
54_Y65_H0.6360.97
145_D154_Q0.6260.97
87_A99_G0.6250.97
13_S16_D0.6240.97
39_L153_A0.6230.97
24_T96_T0.6210.97
80_E141_R0.6140.97
79_S82_V0.6140.97
109_D117_V0.6100.96
71_H75_H0.6090.96
19_R49_Y0.6080.96
80_E139_V0.6070.96
58_S76_G0.6070.96
31_C111_G0.6060.96
46_A49_Y0.5990.96
154_Q161_T0.5930.96
13_S17_A0.5930.96
153_A157_R0.5920.96
111_G119_T0.5900.96
122_I159_A0.5840.95
54_Y61_A0.5740.95
162_V165_A0.5690.95
154_Q157_R0.5670.95
110_G114_E0.5630.94
27_T40_L0.5600.94
71_H79_S0.5600.94
36_I40_L0.5600.94
123_G139_V0.5550.94
77_A115_K0.5540.94
110_G117_V0.5540.94
86_M101_A0.5490.94
72_L82_V0.5490.94
85_Q89_G0.5470.94
110_G113_P0.5430.93
10_I14_L0.5420.93
138_T165_A0.5420.93
76_G105_I0.5390.93
83_A101_A0.5370.93
98_W127_A0.5330.93
35_L149_Q0.5330.93
38_S149_Q0.5310.93
157_R161_T0.5310.93
81_P85_Q0.5310.93
66_G92_D0.5200.92
36_I160_L0.5190.92
144_F154_Q0.5150.91
87_A139_V0.5100.91
105_I116_P0.5080.91
36_I155_I0.5070.91
56_T65_H0.5060.91
148_R152_K0.5040.90
31_C155_I0.5020.90
87_A91_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a9sA 2 0.9591 100 0.122 Contact Map
4uuwA 2 0.9064 100 0.171 Contact Map
3wvaA 2 0.807 96.9 0.866 Contact Map
4a37A 1 0.4971 13.2 0.949 Contact Map
1z5rA 1 0.5205 12.6 0.949 Contact Map
2c1cA 1 0.5439 11.9 0.95 Contact Map
2a1jA 1 0.3567 10.7 0.951 Contact Map
3zdoA 3 0.2222 10.3 0.951 Contact Map
1kwmA 1 0.5263 9.8 0.952 Contact Map
2phnA 2 0.8772 9.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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