GREMLIN Database
Q9HS75 - Acyl-CoA dehydrogenase
UniProt: Q9HS75 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 456 (374)
Sequences: 29025 (15888)
Seq/√Len: 821.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_E294_R3.9961.00
226_N292_D3.7911.00
367_E405_A3.4371.00
99_H120_A3.3481.00
219_D294_R2.9131.00
188_P193_D2.8781.00
218_R297_E2.8711.00
179_P183_D2.8491.00
270_E291_D2.8211.00
258_S300_L2.7611.00
93_R151_E2.6831.00
106_E110_S2.5981.00
141_D144_Q2.5661.00
188_P194_Q2.4421.00
360_S409_Q2.4151.00
339_D343_D2.3831.00
245_A260_F2.1721.00
303_T306_G2.1631.00
94_A98_E2.1151.00
341_V413_F2.1121.00
179_P182_K2.0991.00
228_E289_V2.0731.00
219_D222_E2.0551.00
380_E384_A2.0481.00
350_T353_D2.0451.00
132_G174_E1.9921.00
178_T181_Q1.9891.00
331_A372_R1.9871.00
306_G309_M1.9841.00
421_T426_A1.9521.00
82_P85_A1.8541.00
150_E372_R1.8451.00
218_R304_E1.8381.00
300_L304_E1.8201.00
401_E442_N1.8071.00
241_V264_T1.7831.00
228_E287_H1.7701.00
85_A144_Q1.7641.00
120_A123_D1.7571.00
426_A430_R1.7431.00
201_S231_W1.7421.00
356_S359_H1.7311.00
334_F368_F1.7231.00
235_G286_A1.7111.00
223_Y260_F1.6961.00
331_A335_E1.6921.00
345_A350_T1.6851.00
197_G241_V1.6531.00
119_E123_D1.6301.00
341_V357_V1.6251.00
217_E226_N1.6111.00
266_T293_C1.6021.00
224_V294_R1.5971.00
381_K391_W1.5941.00
219_D224_V1.5831.00
370_S398_K1.5731.00
296_P299_N1.5611.00
346_G354_F1.5581.00
225_L260_F1.5551.00
263_P299_N1.5461.00
349_R353_D1.5421.00
417_R423_R1.5381.00
85_A141_D1.5331.00
154_R335_E1.5321.00
336_E424_R1.5301.00
86_R89_K1.5221.00
183_D187_T1.5101.00
297_E300_L1.5071.00
188_P191_N1.5041.00
218_R222_E1.5001.00
248_G251_D1.4991.00
364_M406_N1.4951.00
223_Y297_E1.4931.00
184_R298_A1.4911.00
90_Q94_A1.4871.00
151_E154_R1.4861.00
377_R381_K1.4791.00
236_V286_A1.4751.00
371_A399_A1.4731.00
87_A90_Q1.4661.00
176_Y313_D1.4651.00
184_R188_P1.4631.00
357_V413_F1.4451.00
397_T442_N1.4401.00
133_E139_G1.4381.00
96_A155_A1.4331.00
226_N291_D1.4281.00
135_Y182_K1.4241.00
87_A91_D1.4101.00
221_D297_E1.4061.00
222_E297_E1.4011.00
263_P266_T1.3991.00
216_A260_F1.3941.00
272_E287_H1.3931.00
180_A184_R1.3651.00
369_E377_R1.3641.00
336_E339_D1.3641.00
270_E289_V1.3631.00
404_T436_V1.3611.00
89_K151_E1.3571.00
333_A407_A1.3471.00
363_D446_R1.3461.00
338_W342_H1.3381.00
223_Y304_E1.3341.00
405_A409_Q1.3321.00
364_M409_Q1.3271.00
225_L243_V1.3181.00
272_E289_V1.3161.00
295_V299_N1.3141.00
199_A232_I1.3141.00
264_T269_Y1.3131.00
109_A276_E1.3071.00
202_E229_K1.3071.00
408_E433_R1.3051.00
129_Q148_I1.2911.00
408_E436_V1.2881.00
107_Y282_A1.2831.00
85_A147_A1.2671.00
332_A336_E1.2671.00
334_F338_W1.2621.00
204_E213_Q1.2601.00
115_W119_E1.2601.00
92_A126_L1.2511.00
269_Y293_C1.2501.00
83_E87_A1.2441.00
247_T258_S1.2411.00
154_R331_A1.2331.00
381_K386_D1.2321.00
316_N389_G1.2271.00
180_A298_A1.2261.00
86_R90_Q1.2261.00
83_E86_R1.2251.00
91_D124_A1.2201.00
360_S443_E1.2141.00
224_V292_D1.2111.00
131_I190_A1.2101.00
185_L240_W1.2071.00
368_F406_N1.2061.00
276_E421_T1.2011.00
142_L383_A1.2001.00
189_V196_T1.2001.00
336_E414_H1.1961.00
308_F312_T1.1911.00
269_Y288_I1.1871.00
349_R354_F1.1791.00
243_V262_V1.1701.00
120_A124_A1.1701.00
214_T225_L1.1701.00
221_D294_R1.1681.00
194_Q239_D1.1681.00
330_A368_F1.1671.00
181_Q261_A1.1601.00
89_K147_A1.1591.00
393_A445_Q1.1581.00
218_R223_Y1.1561.00
410_G425_I1.1551.00
119_E193_D1.1541.00
403_A432_V1.1501.00
79_D380_E1.1451.00
433_R436_V1.1451.00
337_A410_G1.1411.00
244_Y259_L1.1371.00
103_H107_Y1.1361.00
324_G375_A1.1341.00
366_I394_M1.1291.00
264_T271_A1.1281.00
182_K186_L1.1281.00
187_T191_N1.1261.00
318_G439_E1.1221.00
266_T299_N1.1211.00
244_Y257_Y1.1181.00
141_D383_A1.1151.00
180_A183_D1.1121.00
146_L379_A1.1091.00
150_E376_Y1.1041.00
377_R380_E1.0981.00
268_G293_C1.0981.00
404_T408_E1.0951.00
181_Q185_L1.0901.00
215_T226_N1.0901.00
365_R369_E1.0861.00
371_A402_V1.0781.00
223_Y247_T1.0751.00
436_V442_N1.0751.00
177_G181_Q1.0741.00
258_S304_E1.0741.00
91_D126_L1.0721.00
217_E224_V1.0651.00
404_T429_Y1.0611.00
243_V290_L1.0561.00
140_L144_Q1.0551.00
330_A406_N1.0531.00
153_F160_A1.0491.00
92_A96_A1.0431.00
225_L245_A1.0411.00
134_D183_D1.0411.00
131_I170_A1.0381.00
184_R299_N1.0361.00
401_E436_V1.0351.00
122_M127_V1.0341.00
119_E122_M1.0341.00
196_T240_W1.0311.00
169_G196_T1.0311.00
199_A241_V1.0261.00
199_A290_L1.0231.00
175_E313_D1.0191.00
146_L324_G1.0151.00
103_H106_E1.0071.00
95_F120_A1.0031.00
367_E402_V1.0001.00
397_T446_R0.9991.00
96_A152_F0.9861.00
184_R263_P0.9831.00
332_A428_V0.9791.00
216_A245_A0.9781.00
150_E331_A0.9761.00
407_A432_V0.9751.00
294_R297_E0.9751.00
105_E109_A0.9741.00
241_V269_Y0.9741.00
338_W361_L0.9741.00
143_T380_E0.9671.00
241_V288_I0.9671.00
367_E409_Q0.9661.00
333_A428_V0.9641.00
156_D159_I0.9631.00
208_N211_G0.9621.00
217_E292_D0.9601.00
342_H352_S0.9571.00
231_W417_R0.9571.00
373_A377_R0.9451.00
341_V352_S0.9441.00
327_L368_F0.9431.00
116_E119_E0.9431.00
442_N446_R0.9421.00
134_D179_P0.9371.00
378_A395_A0.9351.00
225_L295_V0.9341.00
181_Q299_N0.9331.00
327_L375_A0.9331.00
176_Y310_M0.9211.00
400_T442_N0.9211.00
365_R394_M0.9191.00
341_V351_V0.9181.00
169_G242_T0.9131.00
388_P391_W0.9131.00
231_W420_F0.9091.00
95_F124_A0.9071.00
220_G294_R0.9071.00
207_S444_I0.9061.00
197_G238_A0.9041.00
230_Y287_H0.9041.00
358_Q447_N0.9031.00
402_V405_A0.9031.00
235_G271_A0.9021.00
199_A243_V0.9001.00
92_A148_I0.8991.00
278_M429_Y0.8991.00
339_D342_H0.8991.00
267_D294_R0.8981.00
115_W239_D0.8941.00
248_G256_N0.8941.00
401_E446_R0.8921.00
359_H447_N0.8901.00
93_R97_A0.8901.00
248_G252_D0.8901.00
401_E405_A0.8891.00
97_A154_R0.8881.00
212_M257_Y0.8831.00
260_F300_L0.8811.00
197_G264_T0.8751.00
95_F121_A0.8731.00
223_Y300_L0.8721.00
158_G282_A0.8711.00
109_A421_T0.8711.00
341_V361_L0.8711.00
326_G435_P0.8651.00
280_M434_I0.8621.00
239_D265_D0.8621.00
402_V406_N0.8601.00
266_T269_Y0.8571.00
411_M429_Y0.8561.00
135_Y179_P0.8551.00
367_E398_K0.8541.00
132_G135_Y0.8541.00
260_F295_V0.8531.00
240_W263_P0.8531.00
322_V439_E0.8531.00
240_W261_A0.8531.00
185_L261_A0.8511.00
363_D367_E0.8511.00
81_V85_A0.8371.00
411_M425_I0.8341.00
408_E429_Y0.8331.00
216_A247_T0.8331.00
330_A402_V0.8311.00
360_S413_F0.8281.00
198_L311_L0.8271.00
222_E298_A0.8271.00
108_Y430_R0.8271.00
222_E296_P0.8261.00
407_A428_V0.8261.00
105_E427_R0.8221.00
404_T433_R0.8201.00
121_A126_L0.8201.00
200_V315_F0.8191.00
366_I397_T0.8181.00
212_M244_Y0.8161.00
337_A413_F0.8121.00
246_K257_Y0.8121.00
278_M426_A0.8051.00
199_A288_I0.8041.00
374_L394_M0.8041.00
217_E248_G0.8021.00
435_P438_Y0.8011.00
89_K93_R0.8001.00
248_G305_G0.7951.00
407_A429_Y0.7931.00
258_S305_G0.7931.00
434_I438_Y0.7931.00
252_D255_M0.7921.00
91_D94_A0.7911.00
134_D137_G0.7901.00
337_A341_V0.7901.00
334_F365_R0.7891.00
194_Q240_W0.7881.00
337_A414_H0.7881.00
242_T259_L0.7881.00
258_S302_G0.7841.00
178_T182_K0.7781.00
327_L371_A0.7761.00
242_T301_I0.7741.00
366_I398_K0.7731.00
116_E120_A0.7721.00
335_E339_D0.7701.00
244_Y311_L0.7661.00
103_H116_E0.7631.00
300_L303_T0.7621.00
253_R256_N0.7611.00
96_A100_I0.7611.00
200_V209_L0.7611.00
306_G310_M0.7591.00
219_D297_E0.7581.00
323_A395_A0.7571.00
398_K402_V0.7541.00
143_T376_Y0.7531.00
246_K249_D0.7521.00
333_A410_G0.7441.00
364_M410_G0.7441.00
247_T304_E0.7421.00
202_E214_T0.7371.00
95_F99_H0.7371.00
143_T383_A0.7321.00
130_D145_M0.7311.00
290_L293_C0.7301.00
326_G400_T0.7291.00
351_V354_F0.7291.00
369_E372_R0.7281.00
329_L403_A0.7281.00
239_D264_T0.7271.00
97_A101_A0.7241.00
369_E373_A0.7241.00
185_L299_N0.7231.00
340_F417_R0.7211.00
212_M246_K0.7211.00
246_K256_N0.7211.00
407_A425_I0.7201.00
374_L395_A0.7201.00
97_A155_A0.7191.00
214_T229_K0.7181.00
225_L262_V0.7181.00
271_A288_I0.7171.00
134_D182_K0.7151.00
358_Q450_Y0.7151.00
154_R332_A0.7121.00
363_D405_A0.7101.00
323_A399_A0.7051.00
405_A408_E0.7021.00
329_L432_V0.6971.00
412_Q433_R0.6951.00
355_Q359_H0.6921.00
215_T249_D0.6911.00
185_L194_Q0.6901.00
336_E428_V0.6901.00
216_A223_Y0.6891.00
359_H363_D0.6861.00
279_G431_D0.6851.00
81_V86_R0.6851.00
429_Y433_R0.6841.00
329_L428_V0.6821.00
280_M438_Y0.6811.00
354_F358_Q0.6801.00
334_F453_S0.6801.00
81_V147_A0.6771.00
100_I117_V0.6771.00
88_V144_Q0.6761.00
85_A143_T0.6701.00
265_D269_Y0.6701.00
337_A364_M0.6691.00
370_S374_L0.6671.00
323_A375_A0.6661.00
411_M418_S0.6651.00
88_V148_I0.6651.00
375_A399_A0.6631.00
394_M449_V0.6621.00
363_D409_Q0.6611.00
297_E304_E0.6601.00
390_L452_Q0.6591.00
218_R224_V0.6591.00
94_A97_A0.6571.00
220_G224_V0.6571.00
143_T147_A0.6541.00
374_L398_K0.6541.00
189_V240_W0.6501.00
89_K150_E0.6471.00
134_D139_G0.6471.00
132_G137_G0.6461.00
170_A189_V0.6461.00
371_A398_K0.6451.00
445_Q448_L0.6441.00
369_E374_L0.6431.00
403_A407_A0.6411.00
357_V360_S0.6401.00
279_G419_N0.6391.00
447_N451_R0.6381.00
441_A444_I0.6371.00
303_T310_M0.6361.00
84_H87_A0.6351.00
236_V284_K0.6341.00
331_A365_R0.6321.00
84_H144_Q0.6321.00
344_R347_F0.6301.00
115_W195_L0.6301.00
414_H425_I0.6301.00
276_E281_R0.6281.00
346_G351_V0.6241.00
117_V159_I0.6221.00
106_E109_A0.6211.00
347_F354_F0.6201.00
247_T256_N0.6191.00
203_P228_E0.6191.00
221_D298_A0.6141.00
260_F297_E0.6131.00
81_V376_Y0.6111.00
367_E370_S0.6101.00
185_L263_P0.6091.00
105_E424_R0.6061.00
117_V120_A0.6051.00
320_V379_A0.6041.00
232_I288_I0.6041.00
93_R155_A0.6011.00
261_A301_I0.6001.00
397_T449_V0.6001.00
172_L314_F0.6001.00
170_A186_L0.5971.00
88_V92_A0.5961.00
93_R154_R0.5951.00
172_L176_Y0.5941.00
129_Q140_L0.5921.00
360_S412_Q0.5911.00
100_I159_I0.5901.00
316_N392_A0.5881.00
147_A151_E0.5881.00
371_A395_A0.5871.00
397_T401_E0.5871.00
101_A104_A0.5861.00
260_F299_N0.5861.00
214_T290_L0.5851.00
259_L311_L0.5851.00
357_V361_L0.5851.00
214_T243_V0.5841.00
249_D252_D0.5831.00
235_G288_I0.5821.00
332_A424_R0.5791.00
131_I135_Y0.5791.00
115_W237_E0.5781.00
332_A335_E0.5781.00
82_P144_Q0.5781.00
364_M413_F0.5771.00
172_L310_M0.5771.00
330_A333_A0.5771.00
214_T245_A0.5761.00
344_R416_G0.5751.00
330_A371_A0.5741.00
374_L378_A0.5731.00
345_A353_D0.5721.00
112_E115_W0.5721.00
173_V177_G0.5701.00
372_R376_Y0.5701.00
157_A329_L0.5691.00
379_A383_A0.5691.00
200_V244_Y0.5681.00
278_M430_R0.5671.00
111_G281_R0.5671.00
128_A190_A0.5651.00
412_Q443_E0.5651.00
214_T227_G0.5651.00
228_E272_E0.5631.00
427_R431_D0.5621.00
277_K285_Q0.5621.00
237_E284_K0.5591.00
131_I174_E0.5571.00
145_M321_V0.5551.00
377_R391_W0.5541.00
223_Y295_V0.5541.00
218_R260_F0.5531.00
444_I447_N0.5511.00
80_V86_R0.5511.00
155_A332_A0.5491.00
331_A368_F0.5471.00
243_V293_C0.5471.00
265_D271_A0.5461.00
145_M167_S0.5441.00
169_G189_V0.5411.00
259_L310_M0.5411.00
161_L280_M0.5411.00
147_A376_Y0.5401.00
247_T260_F0.5401.00
79_D377_R0.5401.00
126_L148_I0.5391.00
248_G253_R0.5361.00
91_D138_R0.5351.00
364_M402_V0.5331.00
142_L382_V0.5331.00
340_F343_D0.5311.00
354_F357_V0.5301.00
360_S363_D0.5301.00
177_G182_K0.5301.00
324_G328_G0.5291.00
361_L453_S0.5281.00
81_V143_T0.5271.00
222_E299_N0.5261.00
218_R294_R0.5231.00
218_R221_D0.5221.00
424_R428_V0.5211.00
345_A348_G0.5211.00
345_A349_R0.5191.00
404_T432_V0.5191.00
266_T295_V0.5191.00
445_Q449_V0.5191.00
210_A254_Y0.5171.00
122_M192_N0.5161.00
233_G285_Q0.5151.00
366_I370_S0.5151.00
135_Y187_T0.5151.00
240_W299_N0.5151.00
367_E401_E0.5151.00
146_L376_Y0.5111.00
302_G305_G0.5111.00
271_A286_A0.5101.00
403_A435_P0.5091.00
174_E182_K0.5081.00
262_V293_C0.5081.00
365_R453_S0.5071.00
416_G419_N0.5061.00
338_W453_S0.5061.00
95_F117_V0.5041.00
169_G172_L0.5041.00
356_S360_S0.5021.00
205_V213_Q0.5011.00
233_G283_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jifA 4 0.8311 100 0.221 Contact Map
2d29A 4 0.8355 100 0.224 Contact Map
2z1qA 2 0.8575 100 0.226 Contact Map
4l1fA 4 0.8311 100 0.228 Contact Map
3owaA 3 0.8596 100 0.228 Contact Map
1rx0A 4 0.8399 100 0.228 Contact Map
3pfdA 4 0.8092 100 0.229 Contact Map
1ivhA 4 0.8399 100 0.23 Contact Map
1bucA 4 0.8289 100 0.231 Contact Map
1ukwA 4 0.8311 100 0.231 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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