GREMLIN Database
Q9HS73 - Transcription elongation factor Spt5
UniProt: Q9HS73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (127)
Sequences: 470 (295)
Seq/√Len: 26.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_D54_T3.8561.00
40_Y118_T2.6000.99
48_T52_E2.5110.99
20_I41_V2.4580.99
55_M61_A2.4460.99
12_Q15_T2.3310.98
103_E124_A2.3250.98
3_V77_F2.2380.98
83_D119_V2.1420.97
16_V60_H2.1120.97
103_E126_V2.0830.96
3_V74_V2.0150.96
43_V61_A1.8890.94
94_E123_E1.8780.94
20_I23_R1.8600.93
106_Q120_E1.8230.93
42_M69_S1.8080.92
93_V105_A1.7760.92
94_E124_A1.6940.90
94_E100_F1.6860.89
98_G102_G1.6780.89
28_I54_T1.6720.89
17_A31_V1.6400.88
95_L98_G1.6080.87
94_E104_K1.5860.86
103_E123_E1.5660.85
100_F103_E1.5560.85
3_V75_E1.4870.82
23_R28_I1.4380.80
94_E103_E1.3820.77
54_T57_E1.3780.77
72_S75_E1.3190.74
4_F48_T1.2580.70
104_K123_E1.2490.70
45_A82_P1.2390.69
11_S23_R1.2330.69
19_M121_L1.2140.67
81_K105_A1.1950.66
6_V43_V1.1700.65
58_I90_N1.1680.64
42_M126_V1.1580.64
16_V58_I1.1550.63
43_V114_K1.1440.63
5_A40_Y1.1420.63
105_A121_L1.1260.61
92_I107_V1.1140.61
68_E108_Q1.0970.59
15_T117_V1.0930.59
70_G73_E1.0920.59
17_A33_A1.0850.59
12_Q60_H1.0850.59
76_H102_G1.0830.58
24_E53_R1.0750.58
6_V55_M1.0750.58
55_M110_I1.0690.57
111_D114_K1.0640.57
123_E126_V1.0630.57
41_V57_E1.0600.57
100_F124_A1.0520.56
39_S44_E1.0440.56
76_H86_G1.0440.56
111_D118_T1.0380.55
93_V107_V1.0280.54
27_T46_E1.0270.54
5_A77_F1.0270.54
23_R57_E1.0210.54
96_I103_E1.0180.54
87_I111_D1.0150.53
14_Q35_D1.0150.53
87_I107_V1.0150.53
89_E105_A0.9950.52
32_L77_F0.9790.51
41_V45_A0.9780.51
92_I123_E0.9770.51
48_T58_I0.9760.51
79_S87_I0.9670.50
10_A42_M0.9670.50
20_I64_L0.9560.49
103_E120_E0.9490.49
22_N79_S0.9370.48
16_V40_Y0.9350.48
62_R95_L0.9340.47
14_Q31_V0.9290.47
39_S117_V0.9250.47
29_H48_T0.9130.46
30_A112_E0.9120.46
115_D125_T0.9120.46
95_L102_G0.9090.46
27_T50_A0.9040.45
9_T62_R0.9020.45
20_I43_V0.8950.45
83_D90_N0.8930.44
32_L124_A0.8930.44
92_I124_A0.8870.44
75_E78_L0.8810.44
41_V113_G0.8680.43
39_S116_Q0.8560.42
40_Y91_D0.8500.41
18_S41_V0.8500.41
60_H64_L0.8470.41
18_S101_K0.8380.40
45_A50_A0.8250.40
34_P37_L0.8230.39
72_S85_E0.8190.39
72_S80_P0.8170.39
84_V119_V0.8020.38
78_L95_L0.7980.38
12_Q77_F0.7930.37
6_V26_D0.7920.37
74_V77_F0.7900.37
96_I124_A0.7840.37
13_E39_S0.7820.37
95_L105_A0.7690.36
100_F104_K0.7680.36
14_Q18_S0.7650.35
97_A107_V0.7630.35
94_E126_V0.7550.35
37_L42_M0.7500.34
32_L75_E0.7480.34
57_E122_Y0.7420.34
48_T72_S0.7370.33
99_P106_Q0.7270.33
79_S127_P0.7250.33
30_A57_E0.7250.33
69_S106_Q0.7240.33
16_V93_V0.7240.33
31_V92_I0.7160.32
9_T12_Q0.7150.32
7_K40_Y0.7140.32
51_I70_G0.7100.32
40_Y58_I0.7060.31
96_I100_F0.7040.31
66_P93_V0.7010.31
57_E61_A0.6900.30
3_V37_L0.6890.30
72_S87_I0.6880.30
99_P119_V0.6870.30
55_M88_A0.6810.30
20_I61_A0.6760.30
41_V74_V0.6690.29
115_D127_P0.6630.29
21_A69_S0.6610.29
59_P95_L0.6590.29
100_F123_E0.6590.29
15_T113_G0.6460.28
25_E39_S0.6440.28
60_H109_R0.6400.27
100_F105_A0.6350.27
4_F104_K0.6320.27
12_Q32_L0.6300.27
23_R80_P0.6280.27
25_E50_A0.6280.27
5_A86_G0.6200.26
33_A37_L0.6200.26
14_Q73_E0.6170.26
42_M104_K0.6100.26
104_K124_A0.6090.26
87_I91_D0.6050.25
35_D73_E0.5990.25
19_M100_F0.5970.25
46_E102_G0.5920.25
61_A82_P0.5900.25
31_V105_A0.5810.24
49_A87_I0.5780.24
69_S107_V0.5750.24
91_D95_L0.5730.24
82_P110_I0.5700.23
13_E31_V0.5550.23
8_T13_E0.5530.23
90_N102_G0.5520.23
17_A32_L0.5460.22
120_E129_P0.5430.22
38_T43_V0.5420.22
21_A106_Q0.5410.22
118_T128_I0.5400.22
92_I104_K0.5400.22
7_K22_N0.5380.22
45_A57_E0.5330.22
59_P80_P0.5320.22
89_E108_Q0.5310.21
98_G111_D0.5300.21
51_I55_M0.5280.21
18_S23_R0.5280.21
29_H51_I0.5260.21
49_A76_H0.5260.21
83_D92_I0.5230.21
84_V108_Q0.5170.21
93_V111_D0.5150.21
34_P39_S0.5020.20
68_E71_I0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3p8bB 2 0.9862 99.9 0.478 Contact Map
3h7hB 1 0.5724 99.9 0.478 Contact Map
2exuA 2 0.5724 99.9 0.499 Contact Map
2lq8A 1 0.9724 99.7 0.59 Contact Map
2jvvA 1 0.3931 99.7 0.612 Contact Map
2ougA 1 0.8069 99.6 0.645 Contact Map
1m1hA 1 0.5517 99.5 0.652 Contact Map
3lpeA 1 0.5517 99.4 0.683 Contact Map
2xhcA 1 0.931 99.3 0.695 Contact Map
1nz8A 1 0.5862 97.8 0.812 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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