FTSZ1 - HALSA - GREMLIN Contacts

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FTSZ1 - Cell division protein FtsZ 1

UniProt:	Q9HS71	Sequences: MDSIVQDAIDEAEESEDSASEPADVAGGGGDTVPTGTMTDNELEDVLQELQTNITVVGCGGAGSNTVDRMATEGIHGADLVAANTDVQHLVDIEADTKILMGQQKTKGRGAGSLPQVGEEAAIESQGEIRDSIAGSDMVFVTAGLGGGTGTGSAPVVAKAAREQGALTIAIVTTPFTAEGEVRRTNAEAGLERLRDVADTVIVVPNDRLLDSVGKLPVREAFKVSDEVLMRSVKGITELITKPGLVNLDFADVRTVMEKGGVAMIGLGEADSDAKAADSVQSALRSPLLDVDISSANSALVNVTGGPGMSIEEAEGVVEQLYDRIDPDARIIWGTSIDEQIQEEMRTMVVVTGVDSPQIYGRNEAAEGDGPAQESTPEPEPEPQAGSEIEDIDYVE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	396 (321)
Sequences:	2803 (1335)
Seq/√Len:	74.5

ECOLI - FTSZ
BACSU - FTSZ
HALSA - FTSZ1 FTSZ2 Q9HSE9 Q9HNV2 Q9HHS0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
83_A	101_M	5.275	1.00
119_E	193_R	4.557	1.00
151_T	190_G	3.968	1.00
126_Q	159_K	3.944	1.00
177_T	207_D	3.898	1.00
269_E	344_E	3.862	1.00
126_Q	160_A	3.829	1.00
193_R	196_D	3.538	1.00
72_T	94_E	3.208	1.00
275_K	313_E	3.195	1.00
59_C	153_S	3.173	1.00
125_S	128_E	3.148	1.00
159_K	197_V	3.018	1.00
170_A	198_A	2.906	1.00
274_A	278_D	2.833	1.00
141_V	154_A	2.780	1.00
198_A	201_V	2.751	1.00
301_V	318_V	2.698	1.00
271_D	344_E	2.635	1.00
307_P	339_E	2.598	1.00
174_T	184_R	2.513	1.00
224_V	227_E	2.471	1.00
131_D	134_A	2.446	1.00
159_K	163_E	2.435	1.00
145_L	191_L	2.360	1.00
181_E	185_T	2.256	1.00
64_S	89_H	2.228	1.00
254_R	258_E	2.180	1.00
55_T	136_S	2.177	1.00
83_A	157_V	2.175	1.00
257_M	352_T	2.122	1.00
305_G	309_M	2.103	1.00
174_T	188_E	2.097	1.00
227_E	230_M	2.088	1.00
119_E	123_I	2.073	1.00
126_Q	130_R	2.039	1.00
130_R	163_E	1.984	1.00
170_A	201_V	1.956	1.00
192_E	196_D	1.897	1.00
120_E	123_I	1.885	1.00
57_V	133_I	1.872	1.00
136_S	139_V	1.852	1.00
130_R	164_Q	1.834	1.00
67_V	82_A	1.814	1.00
87_V	91_V	1.766	1.00
68_D	94_E	1.728	1.00
130_R	160_A	1.716	1.00
270_A	278_D	1.698	1.00
278_D	281_Q	1.697	1.00
133_I	164_Q	1.681	1.00
280_V	321_L	1.670	1.00
123_I	159_K	1.653	1.00
71_A	95_A	1.653	1.00
69_R	226_D	1.649	1.00
269_E	346_R	1.646	1.00
99_I	132_S	1.645	1.00
116_Q	120_E	1.642	1.00
277_A	316_G	1.629	1.00
185_T	189_A	1.618	1.00
314_A	333_W	1.616	1.00
127_G	130_R	1.603	0.99
81_V	97_T	1.598	0.99
230_M	234_K	1.597	0.99
81_V	95_A	1.589	0.99
277_A	281_Q	1.584	0.99
200_T	257_M	1.581	0.99
189_A	193_R	1.577	0.99
215_K	312_E	1.559	0.99
143_A	172_V	1.556	0.99
213_V	224_V	1.553	0.99
244_G	336_S	1.552	0.99
284_L	349_V	1.552	0.99
319_E	323_D	1.534	0.99
139_V	166_A	1.529	0.99
256_V	298_S	1.528	0.99
239_L	248_L	1.527	0.99
170_A	194_L	1.513	0.99
308_G	342_Q	1.502	0.99
122_A	153_S	1.502	0.99
245_L	335_T	1.476	0.99
68_D	93_I	1.459	0.99
128_E	131_D	1.456	0.99
133_I	139_V	1.439	0.99
315_E	319_E	1.423	0.99
246_V	333_W	1.419	0.99
308_G	343_E	1.406	0.99
107_K	137_D	1.406	0.99
83_A	129_I	1.402	0.99
59_C	157_V	1.384	0.98
160_A	164_Q	1.374	0.98
309_M	345_M	1.372	0.98
217_P	220_E	1.359	0.98
281_Q	285_R	1.316	0.98
213_V	216_L	1.292	0.98
276_A	280_V	1.289	0.98
208_R	211_D	1.289	0.98
299_A	325_I	1.278	0.97
113_S	332_I	1.275	0.97
298_S	329_A	1.266	0.97
113_S	255_T	1.258	0.97
317_V	345_M	1.250	0.97
219_R	307_P	1.249	0.97
55_T	79_D	1.241	0.97
216_L	221_A	1.239	0.97
294_S	324_R	1.207	0.96
182_V	330_R	1.205	0.96
76_H	242_K	1.198	0.96
129_I	160_A	1.197	0.96
82_A	90_L	1.192	0.96
232_S	265_I	1.184	0.96
188_E	192_E	1.178	0.96
264_M	291_V	1.177	0.96
111_A	117_V	1.176	0.96
171_I	233_V	1.169	0.96
219_R	337_I	1.169	0.96
297_N	326_D	1.168	0.96
114_L	255_T	1.159	0.95
302_N	336_S	1.156	0.95
210_L	315_E	1.155	0.95
220_E	223_K	1.152	0.95
193_R	197_V	1.138	0.95
341_I	346_R	1.117	0.94
304_T	336_S	1.108	0.94
81_V	132_S	1.101	0.94
75_I	230_M	1.095	0.94
136_S	166_A	1.091	0.94
325_I	329_A	1.070	0.93
64_S	82_A	1.069	0.93
298_S	326_D	1.065	0.93
58_G	63_G	1.063	0.93
71_A	80_L	1.062	0.93
59_C	141_V	1.062	0.93
116_Q	119_E	1.062	0.93
103_Q	128_E	1.061	0.93
57_V	83_A	1.059	0.93
66_T	70_M	1.055	0.92
216_L	312_E	1.052	0.92
278_D	282_S	1.046	0.92
52_T	137_D	1.044	0.92
138_M	169_I	1.043	0.92
99_I	129_I	1.041	0.92
266_G	283_A	1.038	0.92
309_M	314_A	1.029	0.91
215_K	310_S	1.022	0.91
279_S	347_T	1.019	0.91
60_G	63_G	1.017	0.91
79_D	97_T	1.015	0.91
182_V	186_N	1.000	0.90
218_V	335_T	0.993	0.90
191_L	203_V	0.993	0.90
92_D	319_E	0.988	0.90
256_V	332_I	0.983	0.89
112_G	148_G	0.980	0.89
73_E	230_M	0.971	0.89
320_Q	324_R	0.970	0.89
200_T	260_G	0.969	0.89
139_V	157_V	0.965	0.89
319_E	322_Y	0.963	0.88
110_G	148_G	0.960	0.88
276_A	345_M	0.960	0.88
364_E	367_E	0.950	0.88
82_A	93_I	0.950	0.88
122_A	129_I	0.950	0.88
177_T	319_E	0.947	0.88
268_G	279_S	0.947	0.88
101_M	153_S	0.945	0.88
234_K	238_E	0.942	0.87
304_T	341_I	0.939	0.87
223_K	226_D	0.934	0.87
82_A	95_A	0.931	0.87
72_T	223_K	0.930	0.87
275_K	310_S	0.929	0.87
192_E	195_R	0.925	0.86
189_A	192_E	0.924	0.86
122_A	156_V	0.923	0.86
156_V	160_A	0.920	0.86
114_L	120_E	0.919	0.86
137_D	210_L	0.908	0.85
207_D	210_L	0.906	0.85
69_R	232_S	0.901	0.85
174_T	205_P	0.898	0.85
298_S	330_R	0.896	0.85
132_S	136_S	0.895	0.85
318_V	333_W	0.892	0.84
133_I	136_S	0.892	0.84
100_L	103_Q	0.890	0.84
274_A	316_G	0.889	0.84
70_M	80_L	0.888	0.84
130_R	134_A	0.887	0.84
61_G	65_N	0.884	0.84
180_G	331_I	0.879	0.83
174_T	191_L	0.876	0.83
279_S	283_A	0.875	0.83
363_N	367_E	0.872	0.83
105_K	120_E	0.871	0.83
93_I	98_K	0.870	0.83
209_L	225_S	0.870	0.83
338_D	346_R	0.865	0.82
281_Q	320_Q	0.864	0.82
79_D	136_S	0.863	0.82
141_V	158_A	0.855	0.82
208_R	286_S	0.855	0.82
145_L	172_V	0.852	0.82
68_D	92_D	0.851	0.81
207_D	211_D	0.849	0.81
217_P	310_S	0.846	0.81
218_V	222_F	0.842	0.81
82_A	94_E	0.841	0.81
129_I	133_I	0.839	0.81
260_G	267_L	0.839	0.81
277_A	320_Q	0.830	0.80
185_T	188_E	0.829	0.80
363_N	366_A	0.828	0.80
143_A	154_A	0.827	0.80
317_V	347_T	0.826	0.79
97_T	132_S	0.816	0.79
84_N	148_G	0.814	0.78
305_G	314_A	0.810	0.78
195_R	262_V	0.806	0.78
184_R	188_E	0.806	0.78
62_A	354_V	0.802	0.77
214_G	312_E	0.801	0.77
244_G	302_N	0.799	0.77
320_Q	323_D	0.795	0.77
52_T	251_A	0.779	0.75
268_G	283_A	0.777	0.75
174_T	350_V	0.777	0.75
209_L	311_I	0.776	0.75
362_R	365_A	0.773	0.75
103_Q	125_S	0.773	0.75
260_G	298_S	0.771	0.75
138_M	316_G	0.771	0.75
301_V	347_T	0.770	0.75
307_P	337_I	0.769	0.74
66_T	80_L	0.766	0.74
338_D	341_I	0.764	0.74
84_N	112_G	0.763	0.74
214_G	224_V	0.762	0.74
52_T	248_L	0.760	0.74
262_V	301_V	0.760	0.74
127_G	131_D	0.755	0.73
361_G	365_A	0.754	0.73
209_L	226_D	0.752	0.73
138_M	257_M	0.749	0.72
326_D	329_A	0.749	0.72
205_P	244_G	0.748	0.72
134_A	164_Q	0.747	0.72
286_S	354_V	0.745	0.72
178_A	333_W	0.745	0.72
166_A	264_M	0.740	0.72
345_M	357_P	0.738	0.71
160_A	163_E	0.738	0.71
84_N	111_A	0.735	0.71
156_V	159_K	0.731	0.71
245_L	337_I	0.730	0.71
358_Q	361_G	0.726	0.70
245_L	314_A	0.724	0.70
141_V	157_V	0.720	0.69
57_V	166_A	0.719	0.69
350_V	354_V	0.713	0.69
226_D	318_V	0.712	0.69
49_E	94_E	0.711	0.69
140_F	263_A	0.711	0.69
105_K	117_V	0.707	0.68
61_G	86_D	0.705	0.68
205_P	228_V	0.705	0.68
68_D	71_A	0.704	0.68
305_G	337_I	0.703	0.68
91_V	98_K	0.702	0.68
55_T	81_V	0.701	0.67
309_M	333_W	0.699	0.67
360_Y	365_A	0.699	0.67
213_V	217_P	0.697	0.67
299_A	351_V	0.693	0.67
69_R	83_A	0.691	0.66
234_K	267_L	0.684	0.66
73_E	223_K	0.683	0.65
127_G	132_S	0.681	0.65
305_G	345_M	0.680	0.65
88_Q	109_R	0.677	0.65
298_S	353_G	0.674	0.64
256_V	329_A	0.673	0.64
142_T	229_L	0.670	0.64
262_V	355_D	0.669	0.64
182_V	185_T	0.666	0.63
75_I	238_E	0.666	0.63
82_A	98_K	0.666	0.63
66_T	229_L	0.661	0.63
142_T	215_K	0.658	0.63
217_P	230_M	0.657	0.62
163_E	255_T	0.657	0.62
186_N	189_A	0.657	0.62
235_G	265_I	0.655	0.62
243_P	336_S	0.653	0.62
75_I	241_T	0.652	0.62
235_G	348_M	0.647	0.61
242_K	336_S	0.647	0.61
204_V	361_G	0.646	0.61
226_D	333_W	0.643	0.61
185_T	328_D	0.636	0.60
238_E	241_T	0.636	0.60
83_A	132_S	0.635	0.60
92_D	243_P	0.635	0.60
361_G	364_E	0.634	0.60
169_I	352_T	0.634	0.60
162_R	259_K	0.633	0.60
49_E	91_V	0.633	0.60
294_S	327_P	0.632	0.59
204_V	255_T	0.632	0.59
207_D	315_E	0.631	0.59
183_R	332_I	0.631	0.59
62_A	173_T	0.630	0.59
255_T	332_I	0.630	0.59
113_S	186_N	0.629	0.59
218_V	333_W	0.629	0.59
65_N	151_T	0.627	0.59
87_V	264_M	0.624	0.58
141_V	170_A	0.624	0.58
80_L	145_L	0.621	0.58
172_V	203_V	0.621	0.58
181_E	327_P	0.620	0.58
84_N	108_G	0.620	0.58
75_I	234_K	0.620	0.58
213_V	311_I	0.619	0.58
245_L	303_V	0.619	0.58
235_G	248_L	0.616	0.57
226_D	314_A	0.616	0.57
123_I	126_Q	0.614	0.57
71_A	96_D	0.614	0.57
304_T	352_T	0.614	0.57
275_K	309_M	0.613	0.57
235_G	329_A	0.613	0.57
120_E	124_E	0.611	0.57
297_N	353_G	0.609	0.57
154_A	194_L	0.608	0.57
57_V	139_V	0.606	0.56
79_D	96_D	0.603	0.56
56_V	209_L	0.602	0.56
135_G	166_A	0.601	0.56
162_R	199_D	0.600	0.56
48_Q	51_Q	0.600	0.56
239_L	273_D	0.599	0.55
137_D	251_A	0.598	0.55
154_A	157_V	0.598	0.55
242_K	335_T	0.597	0.55
210_L	312_E	0.597	0.55
118_G	148_G	0.596	0.55
81_V	300_L	0.594	0.55
325_I	331_I	0.591	0.54
133_I	290_D	0.590	0.54
182_V	328_D	0.590	0.54
234_K	338_D	0.590	0.54
282_S	328_D	0.589	0.54
205_P	290_D	0.588	0.54
266_G	352_T	0.588	0.54
271_D	343_E	0.586	0.54
75_I	145_L	0.585	0.54
265_I	298_S	0.585	0.54
232_S	290_D	0.585	0.54
315_E	322_Y	0.584	0.54
95_A	156_V	0.583	0.53
73_E	227_E	0.583	0.53
200_T	263_A	0.583	0.53
360_Y	364_E	0.583	0.53
104_Q	124_E	0.582	0.53
50_L	87_V	0.582	0.53
115_P	151_T	0.581	0.53
74_G	347_T	0.581	0.53
301_V	312_E	0.581	0.53
83_A	133_I	0.580	0.53
60_G	175_P	0.580	0.53
80_L	226_D	0.579	0.53
66_T	351_V	0.578	0.53
178_A	222_F	0.575	0.52
69_R	73_E	0.575	0.52
291_V	301_V	0.573	0.52
306_G	339_E	0.573	0.52
239_L	350_V	0.572	0.52
167_L	250_F	0.572	0.52
66_T	142_T	0.572	0.52
227_E	231_R	0.571	0.52
56_V	80_L	0.569	0.52
117_V	120_E	0.569	0.52
108_G	148_G	0.568	0.52
359_I	362_R	0.568	0.52
251_A	254_R	0.567	0.51
359_I	363_N	0.566	0.51
126_Q	163_E	0.566	0.51
356_S	359_I	0.565	0.51
360_Y	363_N	0.565	0.51
52_T	109_R	0.562	0.51
162_R	345_M	0.561	0.51
84_N	88_Q	0.560	0.51
282_S	294_S	0.560	0.51
49_E	248_L	0.559	0.50
110_G	118_G	0.556	0.50
280_V	303_V	0.556	0.50
306_G	310_S	0.556	0.50
282_S	285_R	0.556	0.50
88_Q	247_N	0.556	0.50
222_F	246_V	0.556	0.50
266_G	279_S	0.555	0.50
260_G	352_T	0.554	0.50
139_V	161_A	0.553	0.50
300_L	346_R	0.552	0.50
101_M	219_R	0.552	0.50
306_G	337_I	0.552	0.50
88_Q	180_G	0.552	0.50
171_I	229_L	0.552	0.50
131_D	181_E	0.551	0.49
200_T	216_L	0.551	0.49
133_I	161_A	0.549	0.49
218_V	256_V	0.549	0.49
212_S	216_L	0.549	0.49
314_A	335_T	0.548	0.49
125_S	336_S	0.547	0.49
248_L	332_I	0.547	0.49
345_M	358_Q	0.547	0.49
172_V	194_L	0.546	0.49
94_E	97_T	0.546	0.49
337_I	342_Q	0.545	0.49
257_M	298_S	0.544	0.49
125_S	130_R	0.543	0.48
219_R	245_L	0.543	0.48
211_D	277_A	0.542	0.48
89_H	113_S	0.542	0.48
362_R	366_A	0.541	0.48
52_T	311_I	0.541	0.48
246_V	335_T	0.538	0.48
321_L	324_R	0.538	0.48
74_G	234_K	0.537	0.48
360_Y	367_E	0.536	0.48
312_E	318_V	0.536	0.48
65_N	112_G	0.536	0.48
195_R	355_D	0.536	0.48
195_R	359_I	0.536	0.48
66_T	232_S	0.534	0.47
270_A	276_A	0.532	0.47
304_T	310_S	0.532	0.47
270_A	347_T	0.531	0.47
239_L	310_S	0.531	0.47
77_G	163_E	0.531	0.47
83_A	220_E	0.530	0.47
67_V	70_M	0.530	0.47
65_N	247_N	0.530	0.47
170_A	191_L	0.530	0.47
297_N	355_D	0.530	0.47
203_V	211_D	0.529	0.47
213_V	225_S	0.528	0.47
218_V	260_G	0.527	0.46
113_S	233_V	0.527	0.46
292_D	299_A	0.527	0.46
186_N	314_A	0.525	0.46
126_Q	164_Q	0.525	0.46
318_V	330_R	0.525	0.46
232_S	267_L	0.524	0.46
148_G	152_G	0.523	0.46
138_M	202_I	0.522	0.46
90_L	116_Q	0.521	0.46
233_V	256_V	0.521	0.46
101_M	125_S	0.520	0.46
210_L	213_V	0.520	0.46
142_T	225_S	0.519	0.45
88_Q	289_L	0.519	0.45
219_R	239_L	0.518	0.45
183_R	245_L	0.516	0.45
214_G	267_L	0.515	0.45
174_T	290_D	0.514	0.45
53_N	135_G	0.514	0.45
57_V	157_V	0.512	0.45
63_G	175_P	0.512	0.45
129_I	315_E	0.510	0.44
247_N	252_D	0.509	0.44
84_N	109_R	0.508	0.44
216_L	354_V	0.508	0.44
162_R	282_S	0.508	0.44
104_Q	271_D	0.505	0.44
68_D	359_I	0.505	0.44
259_K	297_N	0.502	0.43
76_H	128_E	0.502	0.43
158_A	194_L	0.501	0.43
211_D	217_P	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vapA	1	0.846	100	0.284	Contact Map
2r751	1	0.8106	100	0.298	Contact Map
1rq2A	2	0.7576	100	0.308	Contact Map
2vawA	1	0.7904	100	0.31	Contact Map
1w5fA	2	0.7854	100	0.31	Contact Map
4m8iA	1	0.7828	100	0.31	Contact Map
2vxyA	2	0.7702	100	0.312	Contact Map
1ofuA	1	0.7702	100	0.317	Contact Map
4ei7A	1	0.8485	100	0.322	Contact Map
4b45A	1	0.7904	100	0.362	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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