GREMLIN Database
FTSZ1 - Cell division protein FtsZ 1
UniProt: Q9HS71 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (321)
Sequences: 2803 (1335)
Seq/√Len: 74.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_A101_M5.2751.00
119_E193_R4.5571.00
151_T190_G3.9681.00
126_Q159_K3.9441.00
177_T207_D3.8981.00
269_E344_E3.8621.00
126_Q160_A3.8291.00
193_R196_D3.5381.00
72_T94_E3.2081.00
275_K313_E3.1951.00
59_C153_S3.1731.00
125_S128_E3.1481.00
159_K197_V3.0181.00
170_A198_A2.9061.00
274_A278_D2.8331.00
141_V154_A2.7801.00
198_A201_V2.7511.00
301_V318_V2.6981.00
271_D344_E2.6351.00
307_P339_E2.5981.00
174_T184_R2.5131.00
224_V227_E2.4711.00
131_D134_A2.4461.00
159_K163_E2.4351.00
145_L191_L2.3601.00
181_E185_T2.2561.00
64_S89_H2.2281.00
254_R258_E2.1801.00
55_T136_S2.1771.00
83_A157_V2.1751.00
257_M352_T2.1221.00
305_G309_M2.1031.00
174_T188_E2.0971.00
227_E230_M2.0881.00
119_E123_I2.0731.00
126_Q130_R2.0391.00
130_R163_E1.9841.00
170_A201_V1.9561.00
192_E196_D1.8971.00
120_E123_I1.8851.00
57_V133_I1.8721.00
136_S139_V1.8521.00
130_R164_Q1.8341.00
67_V82_A1.8141.00
87_V91_V1.7661.00
68_D94_E1.7281.00
130_R160_A1.7161.00
270_A278_D1.6981.00
278_D281_Q1.6971.00
133_I164_Q1.6811.00
280_V321_L1.6701.00
123_I159_K1.6531.00
71_A95_A1.6531.00
69_R226_D1.6491.00
269_E346_R1.6461.00
99_I132_S1.6451.00
116_Q120_E1.6421.00
277_A316_G1.6291.00
185_T189_A1.6181.00
314_A333_W1.6161.00
127_G130_R1.6030.99
81_V97_T1.5980.99
230_M234_K1.5970.99
81_V95_A1.5890.99
277_A281_Q1.5840.99
200_T257_M1.5810.99
189_A193_R1.5770.99
215_K312_E1.5590.99
143_A172_V1.5560.99
213_V224_V1.5530.99
244_G336_S1.5520.99
284_L349_V1.5520.99
319_E323_D1.5340.99
139_V166_A1.5290.99
256_V298_S1.5280.99
239_L248_L1.5270.99
170_A194_L1.5130.99
308_G342_Q1.5020.99
122_A153_S1.5020.99
245_L335_T1.4760.99
68_D93_I1.4590.99
128_E131_D1.4560.99
133_I139_V1.4390.99
315_E319_E1.4230.99
246_V333_W1.4190.99
308_G343_E1.4060.99
107_K137_D1.4060.99
83_A129_I1.4020.99
59_C157_V1.3840.98
160_A164_Q1.3740.98
309_M345_M1.3720.98
217_P220_E1.3590.98
281_Q285_R1.3160.98
213_V216_L1.2920.98
276_A280_V1.2890.98
208_R211_D1.2890.98
299_A325_I1.2780.97
113_S332_I1.2750.97
298_S329_A1.2660.97
113_S255_T1.2580.97
317_V345_M1.2500.97
219_R307_P1.2490.97
55_T79_D1.2410.97
216_L221_A1.2390.97
294_S324_R1.2070.96
182_V330_R1.2050.96
76_H242_K1.1980.96
129_I160_A1.1970.96
82_A90_L1.1920.96
232_S265_I1.1840.96
188_E192_E1.1780.96
264_M291_V1.1770.96
111_A117_V1.1760.96
171_I233_V1.1690.96
219_R337_I1.1690.96
297_N326_D1.1680.96
114_L255_T1.1590.95
302_N336_S1.1560.95
210_L315_E1.1550.95
220_E223_K1.1520.95
193_R197_V1.1380.95
341_I346_R1.1170.94
304_T336_S1.1080.94
81_V132_S1.1010.94
75_I230_M1.0950.94
136_S166_A1.0910.94
325_I329_A1.0700.93
64_S82_A1.0690.93
298_S326_D1.0650.93
58_G63_G1.0630.93
71_A80_L1.0620.93
59_C141_V1.0620.93
116_Q119_E1.0620.93
103_Q128_E1.0610.93
57_V83_A1.0590.93
66_T70_M1.0550.92
216_L312_E1.0520.92
278_D282_S1.0460.92
52_T137_D1.0440.92
138_M169_I1.0430.92
99_I129_I1.0410.92
266_G283_A1.0380.92
309_M314_A1.0290.91
215_K310_S1.0220.91
279_S347_T1.0190.91
60_G63_G1.0170.91
79_D97_T1.0150.91
182_V186_N1.0000.90
218_V335_T0.9930.90
191_L203_V0.9930.90
92_D319_E0.9880.90
256_V332_I0.9830.89
112_G148_G0.9800.89
73_E230_M0.9710.89
320_Q324_R0.9700.89
200_T260_G0.9690.89
139_V157_V0.9650.89
319_E322_Y0.9630.88
110_G148_G0.9600.88
276_A345_M0.9600.88
364_E367_E0.9500.88
82_A93_I0.9500.88
122_A129_I0.9500.88
177_T319_E0.9470.88
268_G279_S0.9470.88
101_M153_S0.9450.88
234_K238_E0.9420.87
304_T341_I0.9390.87
223_K226_D0.9340.87
82_A95_A0.9310.87
72_T223_K0.9300.87
275_K310_S0.9290.87
192_E195_R0.9250.86
189_A192_E0.9240.86
122_A156_V0.9230.86
156_V160_A0.9200.86
114_L120_E0.9190.86
137_D210_L0.9080.85
207_D210_L0.9060.85
69_R232_S0.9010.85
174_T205_P0.8980.85
298_S330_R0.8960.85
132_S136_S0.8950.85
318_V333_W0.8920.84
133_I136_S0.8920.84
100_L103_Q0.8900.84
274_A316_G0.8890.84
70_M80_L0.8880.84
130_R134_A0.8870.84
61_G65_N0.8840.84
180_G331_I0.8790.83
174_T191_L0.8760.83
279_S283_A0.8750.83
363_N367_E0.8720.83
105_K120_E0.8710.83
93_I98_K0.8700.83
209_L225_S0.8700.83
338_D346_R0.8650.82
281_Q320_Q0.8640.82
79_D136_S0.8630.82
141_V158_A0.8550.82
208_R286_S0.8550.82
145_L172_V0.8520.82
68_D92_D0.8510.81
207_D211_D0.8490.81
217_P310_S0.8460.81
218_V222_F0.8420.81
82_A94_E0.8410.81
129_I133_I0.8390.81
260_G267_L0.8390.81
277_A320_Q0.8300.80
185_T188_E0.8290.80
363_N366_A0.8280.80
143_A154_A0.8270.80
317_V347_T0.8260.79
97_T132_S0.8160.79
84_N148_G0.8140.78
305_G314_A0.8100.78
195_R262_V0.8060.78
184_R188_E0.8060.78
62_A354_V0.8020.77
214_G312_E0.8010.77
244_G302_N0.7990.77
320_Q323_D0.7950.77
52_T251_A0.7790.75
268_G283_A0.7770.75
174_T350_V0.7770.75
209_L311_I0.7760.75
362_R365_A0.7730.75
103_Q125_S0.7730.75
260_G298_S0.7710.75
138_M316_G0.7710.75
301_V347_T0.7700.75
307_P337_I0.7690.74
66_T80_L0.7660.74
338_D341_I0.7640.74
84_N112_G0.7630.74
214_G224_V0.7620.74
52_T248_L0.7600.74
262_V301_V0.7600.74
127_G131_D0.7550.73
361_G365_A0.7540.73
209_L226_D0.7520.73
138_M257_M0.7490.72
326_D329_A0.7490.72
205_P244_G0.7480.72
134_A164_Q0.7470.72
286_S354_V0.7450.72
178_A333_W0.7450.72
166_A264_M0.7400.72
345_M357_P0.7380.71
160_A163_E0.7380.71
84_N111_A0.7350.71
156_V159_K0.7310.71
245_L337_I0.7300.71
358_Q361_G0.7260.70
245_L314_A0.7240.70
141_V157_V0.7200.69
57_V166_A0.7190.69
350_V354_V0.7130.69
226_D318_V0.7120.69
49_E94_E0.7110.69
140_F263_A0.7110.69
105_K117_V0.7070.68
61_G86_D0.7050.68
205_P228_V0.7050.68
68_D71_A0.7040.68
305_G337_I0.7030.68
91_V98_K0.7020.68
55_T81_V0.7010.67
309_M333_W0.6990.67
360_Y365_A0.6990.67
213_V217_P0.6970.67
299_A351_V0.6930.67
69_R83_A0.6910.66
234_K267_L0.6840.66
73_E223_K0.6830.65
127_G132_S0.6810.65
305_G345_M0.6800.65
88_Q109_R0.6770.65
298_S353_G0.6740.64
256_V329_A0.6730.64
142_T229_L0.6700.64
262_V355_D0.6690.64
182_V185_T0.6660.63
75_I238_E0.6660.63
82_A98_K0.6660.63
66_T229_L0.6610.63
142_T215_K0.6580.63
217_P230_M0.6570.62
163_E255_T0.6570.62
186_N189_A0.6570.62
235_G265_I0.6550.62
243_P336_S0.6530.62
75_I241_T0.6520.62
235_G348_M0.6470.61
242_K336_S0.6470.61
204_V361_G0.6460.61
226_D333_W0.6430.61
185_T328_D0.6360.60
238_E241_T0.6360.60
83_A132_S0.6350.60
92_D243_P0.6350.60
361_G364_E0.6340.60
169_I352_T0.6340.60
162_R259_K0.6330.60
49_E91_V0.6330.60
294_S327_P0.6320.59
204_V255_T0.6320.59
207_D315_E0.6310.59
183_R332_I0.6310.59
62_A173_T0.6300.59
255_T332_I0.6300.59
113_S186_N0.6290.59
218_V333_W0.6290.59
65_N151_T0.6270.59
87_V264_M0.6240.58
141_V170_A0.6240.58
80_L145_L0.6210.58
172_V203_V0.6210.58
181_E327_P0.6200.58
84_N108_G0.6200.58
75_I234_K0.6200.58
213_V311_I0.6190.58
245_L303_V0.6190.58
235_G248_L0.6160.57
226_D314_A0.6160.57
123_I126_Q0.6140.57
71_A96_D0.6140.57
304_T352_T0.6140.57
275_K309_M0.6130.57
235_G329_A0.6130.57
120_E124_E0.6110.57
297_N353_G0.6090.57
154_A194_L0.6080.57
57_V139_V0.6060.56
79_D96_D0.6030.56
56_V209_L0.6020.56
135_G166_A0.6010.56
162_R199_D0.6000.56
48_Q51_Q0.6000.56
239_L273_D0.5990.55
137_D251_A0.5980.55
154_A157_V0.5980.55
242_K335_T0.5970.55
210_L312_E0.5970.55
118_G148_G0.5960.55
81_V300_L0.5940.55
325_I331_I0.5910.54
133_I290_D0.5900.54
182_V328_D0.5900.54
234_K338_D0.5900.54
282_S328_D0.5890.54
205_P290_D0.5880.54
266_G352_T0.5880.54
271_D343_E0.5860.54
75_I145_L0.5850.54
265_I298_S0.5850.54
232_S290_D0.5850.54
315_E322_Y0.5840.54
95_A156_V0.5830.53
73_E227_E0.5830.53
200_T263_A0.5830.53
360_Y364_E0.5830.53
104_Q124_E0.5820.53
50_L87_V0.5820.53
115_P151_T0.5810.53
74_G347_T0.5810.53
301_V312_E0.5810.53
83_A133_I0.5800.53
60_G175_P0.5800.53
80_L226_D0.5790.53
66_T351_V0.5780.53
178_A222_F0.5750.52
69_R73_E0.5750.52
291_V301_V0.5730.52
306_G339_E0.5730.52
239_L350_V0.5720.52
167_L250_F0.5720.52
66_T142_T0.5720.52
227_E231_R0.5710.52
56_V80_L0.5690.52
117_V120_E0.5690.52
108_G148_G0.5680.52
359_I362_R0.5680.52
251_A254_R0.5670.51
359_I363_N0.5660.51
126_Q163_E0.5660.51
356_S359_I0.5650.51
360_Y363_N0.5650.51
52_T109_R0.5620.51
162_R345_M0.5610.51
84_N88_Q0.5600.51
282_S294_S0.5600.51
49_E248_L0.5590.50
110_G118_G0.5560.50
280_V303_V0.5560.50
306_G310_S0.5560.50
282_S285_R0.5560.50
88_Q247_N0.5560.50
222_F246_V0.5560.50
266_G279_S0.5550.50
260_G352_T0.5540.50
139_V161_A0.5530.50
300_L346_R0.5520.50
101_M219_R0.5520.50
306_G337_I0.5520.50
88_Q180_G0.5520.50
171_I229_L0.5520.50
131_D181_E0.5510.49
200_T216_L0.5510.49
133_I161_A0.5490.49
218_V256_V0.5490.49
212_S216_L0.5490.49
314_A335_T0.5480.49
125_S336_S0.5470.49
248_L332_I0.5470.49
345_M358_Q0.5470.49
172_V194_L0.5460.49
94_E97_T0.5460.49
337_I342_Q0.5450.49
257_M298_S0.5440.49
125_S130_R0.5430.48
219_R245_L0.5430.48
211_D277_A0.5420.48
89_H113_S0.5420.48
362_R366_A0.5410.48
52_T311_I0.5410.48
246_V335_T0.5380.48
321_L324_R0.5380.48
74_G234_K0.5370.48
360_Y367_E0.5360.48
312_E318_V0.5360.48
65_N112_G0.5360.48
195_R355_D0.5360.48
195_R359_I0.5360.48
66_T232_S0.5340.47
270_A276_A0.5320.47
304_T310_S0.5320.47
270_A347_T0.5310.47
239_L310_S0.5310.47
77_G163_E0.5310.47
83_A220_E0.5300.47
67_V70_M0.5300.47
65_N247_N0.5300.47
170_A191_L0.5300.47
297_N355_D0.5300.47
203_V211_D0.5290.47
213_V225_S0.5280.47
218_V260_G0.5270.46
113_S233_V0.5270.46
292_D299_A0.5270.46
186_N314_A0.5250.46
126_Q164_Q0.5250.46
318_V330_R0.5250.46
232_S267_L0.5240.46
148_G152_G0.5230.46
138_M202_I0.5220.46
90_L116_Q0.5210.46
233_V256_V0.5210.46
101_M125_S0.5200.46
210_L213_V0.5200.46
142_T225_S0.5190.45
88_Q289_L0.5190.45
219_R239_L0.5180.45
183_R245_L0.5160.45
214_G267_L0.5150.45
174_T290_D0.5140.45
53_N135_G0.5140.45
57_V157_V0.5120.45
63_G175_P0.5120.45
129_I315_E0.5100.44
247_N252_D0.5090.44
84_N109_R0.5080.44
216_L354_V0.5080.44
162_R282_S0.5080.44
104_Q271_D0.5050.44
68_D359_I0.5050.44
259_K297_N0.5020.43
76_H128_E0.5020.43
158_A194_L0.5010.43
211_D217_P0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vapA 1 0.846 100 0.284 Contact Map
2r751 1 0.8106 100 0.298 Contact Map
1rq2A 2 0.7576 100 0.308 Contact Map
2vawA 1 0.7904 100 0.31 Contact Map
1w5fA 2 0.7854 100 0.31 Contact Map
4m8iA 1 0.7828 100 0.31 Contact Map
2vxyA 2 0.7702 100 0.312 Contact Map
1ofuA 1 0.7702 100 0.317 Contact Map
4ei7A 1 0.8485 100 0.322 Contact Map
4b45A 1 0.7904 100 0.362 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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