Q9HS69 - HALSA - GREMLIN Contacts

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Q9HS69 - Cation antiporter

UniProt:	Q9HS69	Sequences: MADSLLVNGGILVAGILLLYVGAELLVSAASALALSHGIKAATVGVTVVAFATTAPELFVSTVGGITAGDSIALGNIVGSNIANIGLVLGTAALLRPMDVDKTLLYHHGPFMLAAALALVGLSLDGTLGALDGVALLALLAVFTAYIYRHAQQDDDDVSLPDDVDMDDDATATARDYVVLVGAILLLLGGSRALITGGRGVLMEFGFSDLFIGLTVIAFGTSVPELATSVVSALRDEADFSIGNVVGSNIYNVLAVIGIVAILVPITVTKGTLAFELPVMLGFTVLALGMMAVGDRITRVEGAVLIGSYGGFVYFLVP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	318 (301)
Sequences:	5320 (3748)
Seq/√Len:	216.1

ECOLI - YRBG CHAA
BACSU - CHAA
HALSA - Q9HS69 Q9HN44
SULSO - Q97YX8 Q97U31

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
125_D	132_D	4.945	1.00
133_G	261_A	4.309	1.00
83_A	87_L	4.170	1.00
122_L	132_D	3.577	1.00
83_A	219_F	3.570	1.00
145_A	149_R	3.147	1.00
47_T	50_A	3.136	1.00
86_G	283_F	2.964	1.00
203_M	209_D	2.792	1.00
197_G	200_G	2.615	1.00
69_G	209_D	2.534	1.00
93_A	302_G	2.509	1.00
134_V	138_A	2.493	1.00
41_A	237_E	2.482	1.00
177_Y	181_V	2.423	1.00
192_R	196_T	2.421	1.00
282_G	286_L	2.339	1.00
11_I	197_G	2.272	1.00
174_A	178_V	2.266	1.00
293_V	301_E	2.246	1.00
115_A	254_L	2.204	1.00
140_L	255_A	2.198	1.00
280_M	284_T	2.183	1.00
198_G	217_I	2.139	1.00
137_L	141_A	2.083	1.00
12_L	201_V	2.055	1.00
207_F	211_F	2.047	1.00
94_L	306_I	2.034	1.00
22_G	186_L	2.025	1.00
15_G	18_L	1.971	1.00
96_R	236_D	1.968	1.00
189_G	193_A	1.907	1.00
21_V	25_L	1.898	1.00
141_A	145_A	1.895	1.00
175_R	179_V	1.876	1.00
71_S	269_T	1.846	1.00
119_L	253_V	1.834	1.00
53_T	225_E	1.816	1.00
90_G	302_G	1.778	1.00
86_G	305_L	1.776	1.00
298_T	301_E	1.768	1.00
12_L	197_G	1.762	1.00
94_L	303_A	1.753	1.00
29_A	183_A	1.742	1.00
61_S	76_N	1.724	1.00
201_V	205_F	1.724	1.00
134_V	262_I	1.717	1.00
93_A	297_I	1.702	1.00
112_M	116_A	1.655	1.00
173_T	177_Y	1.644	1.00
87_L	219_F	1.639	1.00
112_M	284_T	1.600	1.00
137_L	262_I	1.572	1.00
22_G	190_G	1.567	1.00
9_G	13_V	1.558	1.00
172_A	175_R	1.555	1.00
21_V	24_E	1.553	1.00
310_G	314_Y	1.540	1.00
84_N	249_N	1.538	1.00
136_L	140_L	1.522	1.00
32_A	176_D	1.520	1.00
202_L	212_I	1.519	1.00
114_A	118_A	1.503	1.00
229_S	244_N	1.499	1.00
91_T	230_V	1.497	1.00
81_N	252_N	1.492	1.00
178_V	182_G	1.487	1.00
25_L	179_V	1.480	1.00
117_L	121_G	1.455	1.00
29_A	180_L	1.442	1.00
307_G	311_G	1.441	1.00
36_S	173_T	1.436	1.00
69_G	199_R	1.436	1.00
12_L	194_L	1.422	1.00
162_D	166_M	1.419	1.00
77_I	257_I	1.415	1.00
11_I	193_A	1.411	1.00
51_F	55_A	1.407	1.00
26_L	187_L	1.400	1.00
62_T	263_L	1.393	1.00
54_T	248_S	1.388	1.00
252_N	256_V	1.388	1.00
294_G	301_E	1.375	1.00
133_G	258_G	1.363	1.00
129_G	132_D	1.358	1.00
10_G	14_A	1.321	1.00
33_L	180_L	1.318	1.00
15_G	190_G	1.313	1.00
30_A	49_V	1.304	1.00
118_A	122_L	1.293	1.00
33_L	176_D	1.285	1.00
72_I	213_G	1.282	1.00
71_S	75_G	1.277	1.00
149_R	153_Q	1.268	1.00
51_F	251_Y	1.263	1.00
9_G	205_F	1.258	1.00
25_L	182_G	1.254	1.00
63_V	67_T	1.249	1.00
62_T	66_I	1.242	1.00
49_V	240_F	1.240	1.00
285_V	289_G	1.236	1.00
130_A	262_I	1.234	1.00
59_F	191_S	1.201	1.00
97_P	299_R	1.188	1.00
118_A	139_L	1.184	1.00
218_A	222_S	1.182	1.00
200_G	204_E	1.181	1.00
184_I	188_L	1.177	1.00
201_V	204_E	1.157	1.00
272_T	275_F	1.153	1.00
280_M	290_M	1.150	1.00
207_F	212_I	1.144	1.00
11_I	15_G	1.141	1.00
182_G	186_L	1.138	1.00
146_Y	150_H	1.131	1.00
133_G	140_L	1.131	1.00
280_M	287_A	1.129	1.00
80_S	84_N	1.128	1.00
307_G	314_Y	1.124	1.00
77_I	260_V	1.120	1.00
30_A	44_V	1.120	1.00
300_V	303_A	1.118	1.00
115_A	250_I	1.117	1.00
130_A	265_P	1.104	1.00
279_V	283_F	1.101	1.00
46_V	52_A	1.093	1.00
121_G	125_D	1.087	1.00
279_V	282_G	1.086	1.00
46_V	49_V	1.081	1.00
24_E	28_S	1.081	1.00
161_P	165_D	1.080	1.00
200_G	203_M	1.075	1.00
167_D	170_A	1.069	1.00
130_A	134_V	1.069	1.00
300_V	304_V	1.064	1.00
58_L	256_V	1.062	1.00
58_L	62_T	1.048	1.00
222_S	226_L	1.047	1.00
196_T	200_G	1.040	1.00
36_S	41_A	1.034	1.00
215_T	218_A	1.031	1.00
193_A	197_G	1.030	1.00
274_A	277_L	1.019	1.00
149_R	152_Q	1.017	1.00
25_L	186_L	1.015	1.00
199_R	203_M	1.012	1.00
171_T	175_R	1.010	1.00
25_L	28_S	1.008	1.00
102_K	106_Y	1.004	1.00
171_T	176_D	1.003	1.00
58_L	84_N	0.999	1.00
179_V	182_G	0.987	1.00
23_A	31_S	0.985	1.00
57_E	225_E	0.982	1.00
290_M	304_V	0.980	1.00
276_E	312_F	0.979	1.00
22_G	183_A	0.979	1.00
228_T	232_S	0.975	1.00
57_E	224_P	0.974	1.00
132_D	135_A	0.973	1.00
58_L	77_I	0.972	1.00
11_I	14_A	0.960	1.00
53_T	224_P	0.957	1.00
92_A	229_S	0.955	1.00
248_S	251_Y	0.954	1.00
84_N	248_S	0.951	1.00
88_V	226_L	0.950	1.00
51_F	140_L	0.947	1.00
286_L	290_M	0.946	1.00
127_T	131_L	0.941	1.00
80_S	249_N	0.941	1.00
57_E	221_T	0.937	0.99
13_V	17_L	0.936	0.99
251_Y	255_A	0.934	0.99
29_A	179_V	0.933	0.99
46_V	50_A	0.927	0.99
163_D	167_D	0.924	0.99
59_F	188_L	0.922	0.99
43_T	148_Y	0.922	0.99
18_L	193_A	0.921	0.99
203_M	212_I	0.917	0.99
35_L	44_V	0.915	0.99
144_T	148_Y	0.915	0.99
162_D	167_D	0.912	0.99
131_L	314_Y	0.910	0.99
189_G	192_R	0.909	0.99
301_E	305_L	0.907	0.99
188_L	192_R	0.906	0.99
105_L	109_G	0.904	0.99
31_S	237_E	0.900	0.99
162_D	165_D	0.900	0.99
272_T	276_E	0.897	0.99
222_S	252_N	0.897	0.99
92_A	233_A	0.897	0.99
287_A	291_M	0.891	0.99
128_L	132_D	0.890	0.99
290_M	293_V	0.881	0.99
94_L	302_G	0.876	0.99
85_I	248_S	0.873	0.99
281_L	288_L	0.873	0.99
19_L	27_V	0.869	0.99
224_P	249_N	0.864	0.99
32_A	36_S	0.864	0.99
131_L	135_A	0.863	0.99
119_L	257_I	0.861	0.99
15_G	197_G	0.861	0.99
284_T	291_M	0.857	0.99
139_L	143_F	0.856	0.99
166_M	170_A	0.855	0.99
230_V	234_L	0.854	0.99
271_G	275_F	0.848	0.99
282_G	285_V	0.846	0.99
221_T	224_P	0.845	0.99
164_V	167_D	0.836	0.99
276_E	280_M	0.835	0.99
80_S	222_S	0.827	0.99
275_F	278_P	0.826	0.99
193_A	196_T	0.823	0.99
42_A	46_V	0.815	0.99
72_I	217_I	0.814	0.99
148_Y	152_Q	0.810	0.99
23_A	52_A	0.809	0.99
274_A	278_P	0.807	0.99
272_T	278_P	0.805	0.98
302_G	306_I	0.804	0.98
270_K	274_A	0.799	0.98
83_A	86_G	0.795	0.98
213_G	218_A	0.795	0.98
165_D	168_D	0.794	0.98
243_G	247_G	0.793	0.98
18_L	190_G	0.793	0.98
161_P	164_V	0.792	0.98
65_G	260_V	0.791	0.98
175_R	178_V	0.789	0.98
53_T	221_T	0.787	0.98
16_I	20_Y	0.787	0.98
83_A	226_L	0.787	0.98
284_T	289_G	0.782	0.98
48_V	180_L	0.778	0.98
269_T	276_E	0.778	0.98
54_T	249_N	0.772	0.98
138_A	142_V	0.769	0.98
35_L	41_A	0.768	0.98
154_D	159_S	0.765	0.98
11_I	196_T	0.764	0.98
232_S	240_F	0.760	0.98
166_M	171_T	0.758	0.98
15_G	193_A	0.748	0.98
64_G	73_A	0.748	0.98
186_L	189_G	0.746	0.98
210_L	213_G	0.746	0.98
84_N	221_T	0.743	0.97
14_A	17_L	0.742	0.97
54_T	81_N	0.741	0.97
21_V	28_S	0.735	0.97
83_A	222_S	0.734	0.97
130_A	137_L	0.731	0.97
19_L	88_V	0.729	0.97
175_R	182_G	0.725	0.97
269_T	272_T	0.725	0.97
133_G	136_L	0.725	0.97
292_A	296_R	0.723	0.97
89_L	242_I	0.721	0.97
233_A	238_A	0.719	0.97
73_A	76_N	0.719	0.97
131_L	134_V	0.718	0.97
143_F	146_Y	0.717	0.97
273_L	278_P	0.715	0.97
123_S	275_F	0.713	0.97
18_L	186_L	0.713	0.97
78_V	119_L	0.712	0.97
163_D	166_M	0.709	0.97
123_S	268_V	0.709	0.97
86_G	90_G	0.708	0.97
30_A	232_S	0.706	0.97
81_N	248_S	0.705	0.96
104_L	108_H	0.703	0.96
120_V	281_L	0.703	0.96
270_K	273_L	0.702	0.96
65_G	264_V	0.701	0.96
281_L	285_V	0.701	0.96
30_A	34_A	0.700	0.96
154_D	160_L	0.698	0.96
163_D	168_D	0.698	0.96
140_L	143_F	0.698	0.96
140_L	151_A	0.697	0.96
57_E	84_N	0.696	0.96
186_L	190_G	0.696	0.96
145_A	153_Q	0.695	0.96
202_L	213_G	0.694	0.96
139_L	142_V	0.694	0.96
33_L	37_H	0.693	0.96
236_D	241_S	0.692	0.96
119_L	122_L	0.688	0.96
86_G	92_A	0.685	0.96
280_M	289_G	0.683	0.96
143_F	250_I	0.682	0.96
276_E	284_T	0.681	0.96
50_A	53_T	0.679	0.96
294_G	300_V	0.679	0.96
288_L	292_A	0.679	0.96
10_G	13_V	0.675	0.96
54_T	84_N	0.675	0.96
163_D	170_A	0.673	0.95
185_L	188_L	0.670	0.95
224_P	244_N	0.669	0.95
55_A	59_F	0.668	0.95
54_T	222_S	0.667	0.95
191_S	255_A	0.666	0.95
121_G	124_L	0.666	0.95
123_S	132_D	0.664	0.95
280_M	285_V	0.664	0.95
289_G	293_V	0.664	0.95
273_L	276_E	0.663	0.95
96_R	99_D	0.663	0.95
116_A	284_T	0.662	0.95
72_I	198_G	0.658	0.95
161_P	166_M	0.655	0.95
146_Y	149_R	0.654	0.95
87_L	306_I	0.654	0.95
267_T	274_A	0.653	0.95
160_L	163_D	0.653	0.95
119_L	123_S	0.652	0.95
142_V	146_Y	0.650	0.95
62_T	260_V	0.650	0.95
179_V	183_A	0.649	0.94
138_A	141_A	0.647	0.94
84_N	224_P	0.646	0.94
179_V	186_L	0.646	0.94
172_A	176_D	0.643	0.94
241_S	257_I	0.642	0.94
43_T	147_I	0.641	0.94
63_V	192_R	0.641	0.94
209_D	213_G	0.640	0.94
198_G	221_T	0.637	0.94
109_G	246_V	0.637	0.94
98_M	139_L	0.636	0.94
169_D	172_A	0.633	0.94
309_Y	312_F	0.628	0.93
61_S	260_V	0.628	0.93
229_S	241_S	0.626	0.93
59_F	187_L	0.622	0.93
91_T	226_L	0.621	0.93
91_T	95_L	0.617	0.93
210_L	260_V	0.615	0.93
36_S	176_D	0.612	0.93
67_T	192_R	0.612	0.93
28_S	235_R	0.607	0.92
303_A	307_G	0.605	0.92
221_T	244_N	0.603	0.92
125_D	129_G	0.603	0.92
120_V	123_S	0.600	0.92
59_F	63_V	0.599	0.92
20_Y	24_E	0.599	0.92
267_T	270_K	0.595	0.92
99_D	296_R	0.595	0.92
82_I	312_F	0.594	0.91
222_S	249_N	0.594	0.91
225_E	256_V	0.593	0.91
14_A	18_L	0.592	0.91
120_V	277_L	0.590	0.91
30_A	48_V	0.590	0.91
88_V	222_S	0.588	0.91
52_A	184_I	0.587	0.91
201_V	212_I	0.587	0.91
286_L	308_S	0.586	0.91
26_L	33_L	0.586	0.91
114_A	165_D	0.585	0.91
25_L	29_A	0.583	0.91
137_L	259_I	0.583	0.91
306_I	310_G	0.582	0.91
187_L	227_A	0.580	0.90
55_A	251_Y	0.578	0.90
78_V	86_G	0.576	0.90
61_S	249_N	0.575	0.90
116_A	280_M	0.574	0.90
24_E	231_V	0.572	0.90
90_G	95_L	0.572	0.90
60_V	187_L	0.571	0.90
53_T	56_P	0.567	0.89
257_I	260_V	0.565	0.89
112_M	246_V	0.565	0.89
294_G	298_T	0.563	0.89
196_T	199_R	0.563	0.89
167_D	171_T	0.559	0.89
187_L	255_A	0.555	0.88
27_V	221_T	0.554	0.88
50_A	54_T	0.554	0.88
110_P	116_A	0.553	0.88
140_L	144_T	0.553	0.88
63_V	66_I	0.550	0.88
76_N	221_T	0.549	0.88
142_V	149_R	0.545	0.88
280_M	291_M	0.545	0.88
210_L	272_T	0.543	0.87
159_S	162_D	0.543	0.87
302_G	305_L	0.543	0.87
91_T	306_I	0.543	0.87
57_E	217_I	0.543	0.87
95_L	234_L	0.542	0.87
127_T	134_V	0.541	0.87
112_M	119_L	0.541	0.87
89_L	297_I	0.540	0.87
255_A	259_I	0.540	0.87
139_L	254_L	0.539	0.87
283_F	291_M	0.537	0.87
59_F	236_D	0.535	0.87
195_I	214_L	0.535	0.87
100_V	236_D	0.534	0.86
177_Y	182_G	0.531	0.86
23_A	28_S	0.531	0.86
170_A	173_T	0.531	0.86
122_L	135_A	0.530	0.86
18_L	21_V	0.529	0.86
284_T	288_L	0.529	0.86
245_V	249_N	0.528	0.86
44_V	225_E	0.528	0.86
52_A	248_S	0.528	0.86
284_T	293_V	0.527	0.86
50_A	56_P	0.527	0.86
144_T	251_Y	0.524	0.85
144_T	151_A	0.524	0.85
307_G	315_F	0.521	0.85
299_R	302_G	0.521	0.85
159_S	165_D	0.520	0.85
69_G	72_I	0.520	0.85
137_L	255_A	0.519	0.85
61_S	65_G	0.518	0.85
84_N	252_N	0.518	0.85
33_L	177_Y	0.518	0.85
208_S	216_V	0.517	0.85
215_T	313_V	0.516	0.85
41_A	44_V	0.514	0.84
101_D	239_D	0.513	0.84
128_L	257_I	0.512	0.84
116_A	281_L	0.510	0.84
35_L	169_D	0.510	0.84
164_V	170_A	0.509	0.84
231_V	234_L	0.509	0.84
132_D	143_F	0.507	0.84
15_G	23_A	0.507	0.84
72_I	279_V	0.507	0.84
92_A	228_T	0.505	0.83
221_T	249_N	0.505	0.83
31_S	41_A	0.504	0.83
311_G	314_Y	0.503	0.83
249_N	252_N	0.503	0.83
164_V	169_D	0.502	0.83
28_S	63_V	0.501	0.83
212_I	216_V	0.501	0.83
171_T	179_V	0.500	0.83
78_V	257_I	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3v5uA	1	0.9245	100	0.201	Contact Map
4k1cA	4	0.9874	100	0.233	Contact Map
4kjrA	3	0.9119	100	0.235	Contact Map
4kppA	1	0.9843	100	0.251	Contact Map
3o7qA	1	0.4465	39.5	0.945	Contact Map
3giaA	1	0.478	22.9	0.951	Contact Map
4b4aA	1	0.4654	18	0.954	Contact Map
3zuxA	1	0.4403	17.7	0.954	Contact Map
4ikvA	1	0.5126	14.6	0.955	Contact Map
4pgrA	1	0.4214	14.6	0.955	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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