GREMLIN Database
Q9HS69 - Cation antiporter
UniProt: Q9HS69 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (301)
Sequences: 5320 (3748)
Seq/√Len: 216.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_D132_D4.9451.00
133_G261_A4.3091.00
83_A87_L4.1701.00
122_L132_D3.5771.00
83_A219_F3.5701.00
145_A149_R3.1471.00
47_T50_A3.1361.00
86_G283_F2.9641.00
203_M209_D2.7921.00
197_G200_G2.6151.00
69_G209_D2.5341.00
93_A302_G2.5091.00
134_V138_A2.4931.00
41_A237_E2.4821.00
177_Y181_V2.4231.00
192_R196_T2.4211.00
282_G286_L2.3391.00
11_I197_G2.2721.00
174_A178_V2.2661.00
293_V301_E2.2461.00
115_A254_L2.2041.00
140_L255_A2.1981.00
280_M284_T2.1831.00
198_G217_I2.1391.00
137_L141_A2.0831.00
12_L201_V2.0551.00
207_F211_F2.0471.00
94_L306_I2.0341.00
22_G186_L2.0251.00
15_G18_L1.9711.00
96_R236_D1.9681.00
189_G193_A1.9071.00
21_V25_L1.8981.00
141_A145_A1.8951.00
175_R179_V1.8761.00
71_S269_T1.8461.00
119_L253_V1.8341.00
53_T225_E1.8161.00
90_G302_G1.7781.00
86_G305_L1.7761.00
298_T301_E1.7681.00
12_L197_G1.7621.00
94_L303_A1.7531.00
29_A183_A1.7421.00
61_S76_N1.7241.00
201_V205_F1.7241.00
134_V262_I1.7171.00
93_A297_I1.7021.00
112_M116_A1.6551.00
173_T177_Y1.6441.00
87_L219_F1.6391.00
112_M284_T1.6001.00
137_L262_I1.5721.00
22_G190_G1.5671.00
9_G13_V1.5581.00
172_A175_R1.5551.00
21_V24_E1.5531.00
310_G314_Y1.5401.00
84_N249_N1.5381.00
136_L140_L1.5221.00
32_A176_D1.5201.00
202_L212_I1.5191.00
114_A118_A1.5031.00
229_S244_N1.4991.00
91_T230_V1.4971.00
81_N252_N1.4921.00
178_V182_G1.4871.00
25_L179_V1.4801.00
117_L121_G1.4551.00
29_A180_L1.4421.00
307_G311_G1.4411.00
36_S173_T1.4361.00
69_G199_R1.4361.00
12_L194_L1.4221.00
162_D166_M1.4191.00
77_I257_I1.4151.00
11_I193_A1.4111.00
51_F55_A1.4071.00
26_L187_L1.4001.00
62_T263_L1.3931.00
54_T248_S1.3881.00
252_N256_V1.3881.00
294_G301_E1.3751.00
133_G258_G1.3631.00
129_G132_D1.3581.00
10_G14_A1.3211.00
33_L180_L1.3181.00
15_G190_G1.3131.00
30_A49_V1.3041.00
118_A122_L1.2931.00
33_L176_D1.2851.00
72_I213_G1.2821.00
71_S75_G1.2771.00
149_R153_Q1.2681.00
51_F251_Y1.2631.00
9_G205_F1.2581.00
25_L182_G1.2541.00
63_V67_T1.2491.00
62_T66_I1.2421.00
49_V240_F1.2401.00
285_V289_G1.2361.00
130_A262_I1.2341.00
59_F191_S1.2011.00
97_P299_R1.1881.00
118_A139_L1.1841.00
218_A222_S1.1821.00
200_G204_E1.1811.00
184_I188_L1.1771.00
201_V204_E1.1571.00
272_T275_F1.1531.00
280_M290_M1.1501.00
207_F212_I1.1441.00
11_I15_G1.1411.00
182_G186_L1.1381.00
146_Y150_H1.1311.00
133_G140_L1.1311.00
280_M287_A1.1291.00
80_S84_N1.1281.00
307_G314_Y1.1241.00
77_I260_V1.1201.00
30_A44_V1.1201.00
300_V303_A1.1181.00
115_A250_I1.1171.00
130_A265_P1.1041.00
279_V283_F1.1011.00
46_V52_A1.0931.00
121_G125_D1.0871.00
279_V282_G1.0861.00
46_V49_V1.0811.00
24_E28_S1.0811.00
161_P165_D1.0801.00
200_G203_M1.0751.00
167_D170_A1.0691.00
130_A134_V1.0691.00
300_V304_V1.0641.00
58_L256_V1.0621.00
58_L62_T1.0481.00
222_S226_L1.0471.00
196_T200_G1.0401.00
36_S41_A1.0341.00
215_T218_A1.0311.00
193_A197_G1.0301.00
274_A277_L1.0191.00
149_R152_Q1.0171.00
25_L186_L1.0151.00
199_R203_M1.0121.00
171_T175_R1.0101.00
25_L28_S1.0081.00
102_K106_Y1.0041.00
171_T176_D1.0031.00
58_L84_N0.9991.00
179_V182_G0.9871.00
23_A31_S0.9851.00
57_E225_E0.9821.00
290_M304_V0.9801.00
276_E312_F0.9791.00
22_G183_A0.9791.00
228_T232_S0.9751.00
57_E224_P0.9741.00
132_D135_A0.9731.00
58_L77_I0.9721.00
11_I14_A0.9601.00
53_T224_P0.9571.00
92_A229_S0.9551.00
248_S251_Y0.9541.00
84_N248_S0.9511.00
88_V226_L0.9501.00
51_F140_L0.9471.00
286_L290_M0.9461.00
127_T131_L0.9411.00
80_S249_N0.9411.00
57_E221_T0.9370.99
13_V17_L0.9360.99
251_Y255_A0.9340.99
29_A179_V0.9330.99
46_V50_A0.9270.99
163_D167_D0.9240.99
59_F188_L0.9220.99
43_T148_Y0.9220.99
18_L193_A0.9210.99
203_M212_I0.9170.99
35_L44_V0.9150.99
144_T148_Y0.9150.99
162_D167_D0.9120.99
131_L314_Y0.9100.99
189_G192_R0.9090.99
301_E305_L0.9070.99
188_L192_R0.9060.99
105_L109_G0.9040.99
31_S237_E0.9000.99
162_D165_D0.9000.99
272_T276_E0.8970.99
222_S252_N0.8970.99
92_A233_A0.8970.99
287_A291_M0.8910.99
128_L132_D0.8900.99
290_M293_V0.8810.99
94_L302_G0.8760.99
85_I248_S0.8730.99
281_L288_L0.8730.99
19_L27_V0.8690.99
224_P249_N0.8640.99
32_A36_S0.8640.99
131_L135_A0.8630.99
119_L257_I0.8610.99
15_G197_G0.8610.99
284_T291_M0.8570.99
139_L143_F0.8560.99
166_M170_A0.8550.99
230_V234_L0.8540.99
271_G275_F0.8480.99
282_G285_V0.8460.99
221_T224_P0.8450.99
164_V167_D0.8360.99
276_E280_M0.8350.99
80_S222_S0.8270.99
275_F278_P0.8260.99
193_A196_T0.8230.99
42_A46_V0.8150.99
72_I217_I0.8140.99
148_Y152_Q0.8100.99
23_A52_A0.8090.99
274_A278_P0.8070.99
272_T278_P0.8050.98
302_G306_I0.8040.98
270_K274_A0.7990.98
83_A86_G0.7950.98
213_G218_A0.7950.98
165_D168_D0.7940.98
243_G247_G0.7930.98
18_L190_G0.7930.98
161_P164_V0.7920.98
65_G260_V0.7910.98
175_R178_V0.7890.98
53_T221_T0.7870.98
16_I20_Y0.7870.98
83_A226_L0.7870.98
284_T289_G0.7820.98
48_V180_L0.7780.98
269_T276_E0.7780.98
54_T249_N0.7720.98
138_A142_V0.7690.98
35_L41_A0.7680.98
154_D159_S0.7650.98
11_I196_T0.7640.98
232_S240_F0.7600.98
166_M171_T0.7580.98
15_G193_A0.7480.98
64_G73_A0.7480.98
186_L189_G0.7460.98
210_L213_G0.7460.98
84_N221_T0.7430.97
14_A17_L0.7420.97
54_T81_N0.7410.97
21_V28_S0.7350.97
83_A222_S0.7340.97
130_A137_L0.7310.97
19_L88_V0.7290.97
175_R182_G0.7250.97
269_T272_T0.7250.97
133_G136_L0.7250.97
292_A296_R0.7230.97
89_L242_I0.7210.97
233_A238_A0.7190.97
73_A76_N0.7190.97
131_L134_V0.7180.97
143_F146_Y0.7170.97
273_L278_P0.7150.97
123_S275_F0.7130.97
18_L186_L0.7130.97
78_V119_L0.7120.97
163_D166_M0.7090.97
123_S268_V0.7090.97
86_G90_G0.7080.97
30_A232_S0.7060.97
81_N248_S0.7050.96
104_L108_H0.7030.96
120_V281_L0.7030.96
270_K273_L0.7020.96
65_G264_V0.7010.96
281_L285_V0.7010.96
30_A34_A0.7000.96
154_D160_L0.6980.96
163_D168_D0.6980.96
140_L143_F0.6980.96
140_L151_A0.6970.96
57_E84_N0.6960.96
186_L190_G0.6960.96
145_A153_Q0.6950.96
202_L213_G0.6940.96
139_L142_V0.6940.96
33_L37_H0.6930.96
236_D241_S0.6920.96
119_L122_L0.6880.96
86_G92_A0.6850.96
280_M289_G0.6830.96
143_F250_I0.6820.96
276_E284_T0.6810.96
50_A53_T0.6790.96
294_G300_V0.6790.96
288_L292_A0.6790.96
10_G13_V0.6750.96
54_T84_N0.6750.96
163_D170_A0.6730.95
185_L188_L0.6700.95
224_P244_N0.6690.95
55_A59_F0.6680.95
54_T222_S0.6670.95
191_S255_A0.6660.95
121_G124_L0.6660.95
123_S132_D0.6640.95
280_M285_V0.6640.95
289_G293_V0.6640.95
273_L276_E0.6630.95
96_R99_D0.6630.95
116_A284_T0.6620.95
72_I198_G0.6580.95
161_P166_M0.6550.95
146_Y149_R0.6540.95
87_L306_I0.6540.95
267_T274_A0.6530.95
160_L163_D0.6530.95
119_L123_S0.6520.95
142_V146_Y0.6500.95
62_T260_V0.6500.95
179_V183_A0.6490.94
138_A141_A0.6470.94
84_N224_P0.6460.94
179_V186_L0.6460.94
172_A176_D0.6430.94
241_S257_I0.6420.94
43_T147_I0.6410.94
63_V192_R0.6410.94
209_D213_G0.6400.94
198_G221_T0.6370.94
109_G246_V0.6370.94
98_M139_L0.6360.94
169_D172_A0.6330.94
309_Y312_F0.6280.93
61_S260_V0.6280.93
229_S241_S0.6260.93
59_F187_L0.6220.93
91_T226_L0.6210.93
91_T95_L0.6170.93
210_L260_V0.6150.93
36_S176_D0.6120.93
67_T192_R0.6120.93
28_S235_R0.6070.92
303_A307_G0.6050.92
221_T244_N0.6030.92
125_D129_G0.6030.92
120_V123_S0.6000.92
59_F63_V0.5990.92
20_Y24_E0.5990.92
267_T270_K0.5950.92
99_D296_R0.5950.92
82_I312_F0.5940.91
222_S249_N0.5940.91
225_E256_V0.5930.91
14_A18_L0.5920.91
120_V277_L0.5900.91
30_A48_V0.5900.91
88_V222_S0.5880.91
52_A184_I0.5870.91
201_V212_I0.5870.91
286_L308_S0.5860.91
26_L33_L0.5860.91
114_A165_D0.5850.91
25_L29_A0.5830.91
137_L259_I0.5830.91
306_I310_G0.5820.91
187_L227_A0.5800.90
55_A251_Y0.5780.90
78_V86_G0.5760.90
61_S249_N0.5750.90
116_A280_M0.5740.90
24_E231_V0.5720.90
90_G95_L0.5720.90
60_V187_L0.5710.90
53_T56_P0.5670.89
257_I260_V0.5650.89
112_M246_V0.5650.89
294_G298_T0.5630.89
196_T199_R0.5630.89
167_D171_T0.5590.89
187_L255_A0.5550.88
27_V221_T0.5540.88
50_A54_T0.5540.88
110_P116_A0.5530.88
140_L144_T0.5530.88
63_V66_I0.5500.88
76_N221_T0.5490.88
142_V149_R0.5450.88
280_M291_M0.5450.88
210_L272_T0.5430.87
159_S162_D0.5430.87
302_G305_L0.5430.87
91_T306_I0.5430.87
57_E217_I0.5430.87
95_L234_L0.5420.87
127_T134_V0.5410.87
112_M119_L0.5410.87
89_L297_I0.5400.87
255_A259_I0.5400.87
139_L254_L0.5390.87
283_F291_M0.5370.87
59_F236_D0.5350.87
195_I214_L0.5350.87
100_V236_D0.5340.86
177_Y182_G0.5310.86
23_A28_S0.5310.86
170_A173_T0.5310.86
122_L135_A0.5300.86
18_L21_V0.5290.86
284_T288_L0.5290.86
245_V249_N0.5280.86
44_V225_E0.5280.86
52_A248_S0.5280.86
284_T293_V0.5270.86
50_A56_P0.5270.86
144_T251_Y0.5240.85
144_T151_A0.5240.85
307_G315_F0.5210.85
299_R302_G0.5210.85
159_S165_D0.5200.85
69_G72_I0.5200.85
137_L255_A0.5190.85
61_S65_G0.5180.85
84_N252_N0.5180.85
33_L177_Y0.5180.85
208_S216_V0.5170.85
215_T313_V0.5160.85
41_A44_V0.5140.84
101_D239_D0.5130.84
128_L257_I0.5120.84
116_A281_L0.5100.84
35_L169_D0.5100.84
164_V170_A0.5090.84
231_V234_L0.5090.84
132_D143_F0.5070.84
15_G23_A0.5070.84
72_I279_V0.5070.84
92_A228_T0.5050.83
221_T249_N0.5050.83
31_S41_A0.5040.83
311_G314_Y0.5030.83
249_N252_N0.5030.83
164_V169_D0.5020.83
28_S63_V0.5010.83
212_I216_V0.5010.83
171_T179_V0.5000.83
78_V257_I0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v5uA 1 0.9245 100 0.201 Contact Map
4k1cA 4 0.9874 100 0.233 Contact Map
4kjrA 3 0.9119 100 0.235 Contact Map
4kppA 1 0.9843 100 0.251 Contact Map
3o7qA 1 0.4465 39.5 0.945 Contact Map
3giaA 1 0.478 22.9 0.951 Contact Map
4b4aA 1 0.4654 18 0.954 Contact Map
3zuxA 1 0.4403 17.7 0.954 Contact Map
4ikvA 1 0.5126 14.6 0.955 Contact Map
4pgrA 1 0.4214 14.6 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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